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The map label for this gene is emrY [H]

Identifier: 94313914

GI number: 94313914

Start: 1670370

End: 1671884

Strand: Reverse

Name: emrY [H]

Synonym: Rmet_4992

Alternate gene names: 94313914

Gene position: 1671884-1670370 (Counterclockwise)

Preceding gene: 291481551

Following gene: 94313913

Centisome position: 64.8

GC content: 65.81

Gene sequence:

>1515_bases
ATGCCAAGCAAGCCCTTGCTGAGCCAGCATCCGGAGTTGTCCGCAGTGCGGGTCTACATGATCGGCCTGGCCCTCGGTTG
CTCGACGGGGGTCGACTTCTGGGCGTCCGCGATGATGGGCGTGGCCGGCACCCACATTCGCGGTGGCGTGCACGCATCCC
CCGAGGACTTTCTCTGGACACTGACGTCGTACGCGGCGGCTGCGGTGGTGGCCAACCTGATGCTGCGGCGTCTCGCGCAC
GACATCAGCTACCGTGGCTTCACCATGGCGGGGCTGGTTATCGCCGCCGCTGGCGCGGCGCTTTGCGCGCTGAGCCGCAA
TCCGCTCGAGCTTGCGCTGGCCCGCGCGGTGCAGGGCTTCGGCGCGGGCGGGCTGTTCGCCGCATCGCGCATCATCATCC
AGCTTGCTGCCGCGCGCGAGGAGCGCCGGCCATTGTTCATCGGATTCAATATCGGCAGCATGGGTCTGCCGGCGGCGGCA
CCGTGGATCACGGCGCAACTGGTCGAGAACGCCGAATGGCAGATGGTGTTCGTGCTCCAGGCGGGGATCGCGCTGGCCAC
GCTGCTGTTCGTCGTGCTCACCTATCCCCCCCGGCTGACGGTCACGCTGGCGCCGTGGGACGTCGACTATCACGCGATGG
ACTGGGTGACGGTGATCCTGTTCGGGGCGGGCGCGCTGACGCTGCTACATGGCCTGGGAGACCTGCGGTTCTACGAACTG
GCGAACTCGCCCTCGGTGGCGTTCACGCCGATCGCCGGCATCGCGCTTTTCGCAGCGGGCATGGTGTATCTGCGCCGCCA
TCCGGACCCGTGGCTCAACCCGAAGCTGCTGCTGGGGCGGCGCTTCCTGATCGGGCTGTCGTTCTACGCCATCTATTACC
TGCTGAACGGGCTGTGGACCTACGTCATCTCCACGATGTTGCAGAACGGTATGGGGTTCACGTTCCAGACCACCGGCACG
GTGCTCACCACGACGTCGTTGCTGGGCTTCGCAGCGGCGGCCGCGTTCACGTTCTGGGGCACATCGCTGCCCGGCTCGCG
GCGGTATATCGCGCTGGGCTATCTGATTTTCGCCATGGCCGCGTGGCTGCTCTCGCAACGGATGATGCCCGGTGCCTCGC
TCGAGGTCATCCTGCCGGTGCTCGTGCTGCAGAACCTGACGCTGCCCTTCGTGCTGATGCTGGTGGCTGGCCTGACGTGG
GCGGAGTTCAGCGTGGACGACTTCGCCCATGGCTACCAGTTCAAGAATATCGTGCGCCAGATCGCATCGGCGGCGGGGAC
TGGGCTGGCCAGCCTGTGGCTGCAATATGACGAAGCGATCGCGCGTACGCAACTGGTTGCGCACGTGACGCCGTTTGAAT
TCCAGCAGGGTATCGACCCGGCCGAACTGGCACGCCTGTCACGGCTGATCGACCAGCAGGCGACGCTGATCGGCACCGCC
AATCTGCTGATGTTGCTGGCGGGCGCGTGTTGTGTCATCGCGATCGTCGCGGTTTCGCAACGCGCGTTGAAGTAG

Upstream 100 bases:

>100_bases
GCATCTGCTATGCTGATTTCGTCGCGTCCGACGCGCCCCCGCGCGCCGTGACCGGCCAGTGCCCCCATCCGTCCAACGGT
CAGAACGGTGGTCGCCCCCC

Downstream 100 bases:

>100_bases
TTCGGCAAAACGGGCGTTCAACACATACGCTTGGTTCAGGCAGGCACGTCGGTGGCCTGGCGAACATCCGCAGTGTGGGC
AGTACCGGAAGATTGTCTGG

Product: putative multidrug resistance protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MPSKPLLSQHPELSAVRVYMIGLALGCSTGVDFWASAMMGVAGTHIRGGVHASPEDFLWTLTSYAAAAVVANLMLRRLAH
DISYRGFTMAGLVIAAAGAALCALSRNPLELALARAVQGFGAGGLFAASRIIIQLAAAREERRPLFIGFNIGSMGLPAAA
PWITAQLVENAEWQMVFVLQAGIALATLLFVVLTYPPRLTVTLAPWDVDYHAMDWVTVILFGAGALTLLHGLGDLRFYEL
ANSPSVAFTPIAGIALFAAGMVYLRRHPDPWLNPKLLLGRRFLIGLSFYAIYYLLNGLWTYVISTMLQNGMGFTFQTTGT
VLTTTSLLGFAAAAAFTFWGTSLPGSRRYIALGYLIFAMAAWLLSQRMMPGASLEVILPVLVLQNLTLPFVLMLVAGLTW
AEFSVDDFAHGYQFKNIVRQIASAAGTGLASLWLQYDEAIARTQLVAHVTPFEFQQGIDPAELARLSRLIDQQATLIGTA
NLLMLLAGACCVIAIVAVSQRALK

Sequences:

>Translated_504_residues
MPSKPLLSQHPELSAVRVYMIGLALGCSTGVDFWASAMMGVAGTHIRGGVHASPEDFLWTLTSYAAAAVVANLMLRRLAH
DISYRGFTMAGLVIAAAGAALCALSRNPLELALARAVQGFGAGGLFAASRIIIQLAAAREERRPLFIGFNIGSMGLPAAA
PWITAQLVENAEWQMVFVLQAGIALATLLFVVLTYPPRLTVTLAPWDVDYHAMDWVTVILFGAGALTLLHGLGDLRFYEL
ANSPSVAFTPIAGIALFAAGMVYLRRHPDPWLNPKLLLGRRFLIGLSFYAIYYLLNGLWTYVISTMLQNGMGFTFQTTGT
VLTTTSLLGFAAAAAFTFWGTSLPGSRRYIALGYLIFAMAAWLLSQRMMPGASLEVILPVLVLQNLTLPFVLMLVAGLTW
AEFSVDDFAHGYQFKNIVRQIASAAGTGLASLWLQYDEAIARTQLVAHVTPFEFQQGIDPAELARLSRLIDQQATLIGTA
NLLMLLAGACCVIAIVAVSQRALK
>Mature_503_residues
PSKPLLSQHPELSAVRVYMIGLALGCSTGVDFWASAMMGVAGTHIRGGVHASPEDFLWTLTSYAAAAVVANLMLRRLAHD
ISYRGFTMAGLVIAAAGAALCALSRNPLELALARAVQGFGAGGLFAASRIIIQLAAAREERRPLFIGFNIGSMGLPAAAP
WITAQLVENAEWQMVFVLQAGIALATLLFVVLTYPPRLTVTLAPWDVDYHAMDWVTVILFGAGALTLLHGLGDLRFYELA
NSPSVAFTPIAGIALFAAGMVYLRRHPDPWLNPKLLLGRRFLIGLSFYAIYYLLNGLWTYVISTMLQNGMGFTFQTTGTV
LTTTSLLGFAAAAAFTFWGTSLPGSRRYIALGYLIFAMAAWLLSQRMMPGASLEVILPVLVLQNLTLPFVLMLVAGLTWA
EFSVDDFAHGYQFKNIVRQIASAAGTGLASLWLQYDEAIARTQLVAHVTPFEFQQGIDPAELARLSRLIDQQATLIGTAN
LLMLLAGACCVIAIVAVSQRALK

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the major facilitator superfamily. EmrB family [H]

Homologues:

Organism=Escherichia coli, GI1788710, Length=449, Percent_Identity=20.9354120267261, Blast_Score=72, Evalue=1e-13,
Organism=Escherichia coli, GI87081983, Length=316, Percent_Identity=25.6329113924051, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1790195, Length=379, Percent_Identity=24.0105540897098, Blast_Score=63, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004638
- InterPro:   IPR020846
- InterPro:   IPR011701
- InterPro:   IPR016196 [H]

Pfam domain/function: PF07690 MFS_1 [H]

EC number: NA

Molecular weight: Translated: 54332; Mature: 54200

Theoretical pI: Translated: 8.56; Mature: 8.56

Prosite motif: PS50850 MFS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPSKPLLSQHPELSAVRVYMIGLALGCSTGVDFWASAMMGVAGTHIRGGVHASPEDFLWT
CCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
LTSYAAAAVVANLMLRRLAHDISYRGFTMAGLVIAAAGAALCALSRNPLELALARAVQGF
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
GAGGLFAASRIIIQLAAAREERRPLFIGFNIGSMGLPAAAPWITAQLVENAEWQMVFVLQ
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEHHH
AGIALATLLFVVLTYPPRLTVTLAPWDVDYHAMDWVTVILFGAGALTLLHGLGDLRFYEL
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
ANSPSVAFTPIAGIALFAAGMVYLRRHPDPWLNPKLLLGRRFLIGLSFYAIYYLLNGLWT
CCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVISTMLQNGMGFTFQTTGTVLTTTSLLGFAAAAAFTFWGTSLPGSRRYIALGYLIFAMA
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AWLLSQRMMPGASLEVILPVLVLQNLTLPFVLMLVAGLTWAEFSVDDFAHGYQFKNIVRQ
HHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHH
IASAAGTGLASLWLQYDEAIARTQLVAHVTPFEFQQGIDPAELARLSRLIDQQATLIGTA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NLLMLLAGACCVIAIVAVSQRALK
HHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PSKPLLSQHPELSAVRVYMIGLALGCSTGVDFWASAMMGVAGTHIRGGVHASPEDFLWT
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHH
LTSYAAAAVVANLMLRRLAHDISYRGFTMAGLVIAAAGAALCALSRNPLELALARAVQGF
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCC
GAGGLFAASRIIIQLAAAREERRPLFIGFNIGSMGLPAAAPWITAQLVENAEWQMVFVLQ
CCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHCCCCCEEEEHHH
AGIALATLLFVVLTYPPRLTVTLAPWDVDYHAMDWVTVILFGAGALTLLHGLGDLRFYEL
HHHHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEE
ANSPSVAFTPIAGIALFAAGMVYLRRHPDPWLNPKLLLGRRFLIGLSFYAIYYLLNGLWT
CCCCCEEEHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
YVISTMLQNGMGFTFQTTGTVLTTTSLLGFAAAAAFTFWGTSLPGSRRYIALGYLIFAMA
HHHHHHHHCCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHH
AWLLSQRMMPGASLEVILPVLVLQNLTLPFVLMLVAGLTWAEFSVDDFAHGYQFKNIVRQ
HHHHHHHCCCCCHHHHHHHHHHHHCCHHHHHHHHHHCCCHHHCCHHHHHHHHHHHHHHHH
IASAAGTGLASLWLQYDEAIARTQLVAHVTPFEFQQGIDPAELARLSRLIDQQATLIGTA
HHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHH
NLLMLLAGACCVIAIVAVSQRALK
HHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]