Click here to switch to the map view.

The map label for this gene is lysP2 [H]

Identifier: 94313850

GI number: 94313850

Start: 1590919

End: 1592451

Strand: Direct

Name: lysP2 [H]

Synonym: Rmet_4928

Alternate gene names: 94313850

Gene position: 1590919-1592451 (Clockwise)

Preceding gene: 94313849

Following gene: 94313851

Centisome position: 61.66

GC content: 64.71

Gene sequence:

>1533_bases
ATGTCCAATACCAATACAACACCAGCCGTCCCCGTTCCCGGCCTGCGCCGCGAACTGCGCGCGCGCCATCTGACCATGAT
CGCCATCGGCGGGTCGATTGGCACCGGACTCTTCGTCGCCTCAGGCGCCACGATCGCCCAGGCCGGCCCCGGCGGCGCGC
TGGCCGCCTACATCCTGATCGGCGCGATGGTCTACTTCCTGATGACCAGCCTGGGCGAACTGGCCGCGTACATGCCCGTG
TCCGGGTCCTTTGCCACCTATGGCGCGCTGTACGTCGACGAGGGCTTCGGTTTCGCGCTTGGCTGGAACTACTGGTACAA
CTGGGCCGTCACGATCGCCGTGGAGCTGGCCGCGGCGCAGCTCGTCATGCAGTACTGGTTCCCCGACACGCCAGGCGTGC
TATGGAGCGCCCTGTTCCTTGGCCTCATGTTCGCGCTCAACGCGATCTCCGTGCGCGGTTTCGGCGAAGCGGAATACTGG
TGCGCGCTGATCAAGGTCCTCACGGTGATCGCCTTCATCGTCATCGGTACCTTGATGATCTTCGGCATCATGCGCGGTGA
TTTCTCCCACGCAGGCGGACTGGCCAACCTCACCACCGGCGATGCGCCGTTCGTCGGCGGCCTGCCCGCCATGATCGGGG
TGGCGATGATCGCGGGCTTCTCGTTCCAGGGCACCGAACTGATCGGCGTGGCCGCCGGGGAATCCGACGAGCCGGCCAAG
AACATCCCGCGCGCGGTGCGTCAGGTGTTCTGGCGCATCCTGCTGTTCTACGTGCTGGCGATCCTGATCATCGGCATCCT
GATTCCGTACACCGACCCCAGCCTGCTCAAGACCGACGTGGAAACCGTAGGCGTAAGCCCGTTCACGCTGGTGTTCCGCC
ATGCGGGTCTTGCGTTTGCCGCGGGCGTGATGAACGCCGTGATCCTGACTGCCGTGCTCTCGGCCGGCAATTCCGGCATG
TACGCGTCCACGCGGATGCTCTACAACCTGGCCACCGAGGGCCGCGCGCCGCGTATCTTCGCGCAACTCACCCGCAACGG
CGTGCCCCTGGTCGCGCTGCTGGCCACCACCGCCGTCGGCGGCCTGTGCTTCCTGACGTCGCTGTTCGAAAGCAAGTCGG
TCTACCTGTGGCTGCTGAACCTGTCGGGCATGACCGGCTTCATTGCGTGGCTGGGCATCGCGGTGAGCCACTACCGGTTT
CGCCGGGGCTTCATGGCGCAGAGCCTCGACCTGAACCGCCTGCCCTATCGCTCACCGTTCTTTCCTTACGGGCCGATCTT
CGCGTTCGTGCTGTGCATGATCGTCACACTCGGCCAGAACTACCAGGCCTTCAGCGAAGGCAAGATCGACTGGGTGGCCG
TGACGGCCACCTATGTGGGCATTCCGATCTTCCTGCTGATCTGGCTCGGCTACCGGCTCGTGCGCAAGTCGCGCTTCGTG
CCGTATGCCGAAATGAAATTCCCGGCCCTGCCTGAGATCGAAAAGGACGATTCACCCGTGACGCGGCCTCTGGCCCCGGC
ATCGGCCGAATAG

Upstream 100 bases:

>100_bases
CACGCCTTTGCAGTCACAAGGCCACCCTCGGGTGGCCTTGTTCTTTTCCCGTCCGGCGTTTTTGTCTTATGATGCCGCCC
ACCTCCATGGCCGGCAGCCT

Downstream 100 bases:

>100_bases
CACGGCATACCGAAGCGCCCGAGTGACCGGGCGCTTCGGCAACCTTCCGCCGAAGCGTTTACCATCCTCGTCTAGCCTTC
AACGTTACGAGGATCTCATG

Product: lysine-specific permease

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 510; Mature: 509

Protein sequence:

>510_residues
MSNTNTTPAVPVPGLRRELRARHLTMIAIGGSIGTGLFVASGATIAQAGPGGALAAYILIGAMVYFLMTSLGELAAYMPV
SGSFATYGALYVDEGFGFALGWNYWYNWAVTIAVELAAAQLVMQYWFPDTPGVLWSALFLGLMFALNAISVRGFGEAEYW
CALIKVLTVIAFIVIGTLMIFGIMRGDFSHAGGLANLTTGDAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESDEPAK
NIPRAVRQVFWRILLFYVLAILIIGILIPYTDPSLLKTDVETVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNSGM
YASTRMLYNLATEGRAPRIFAQLTRNGVPLVALLATTAVGGLCFLTSLFESKSVYLWLLNLSGMTGFIAWLGIAVSHYRF
RRGFMAQSLDLNRLPYRSPFFPYGPIFAFVLCMIVTLGQNYQAFSEGKIDWVAVTATYVGIPIFLLIWLGYRLVRKSRFV
PYAEMKFPALPEIEKDDSPVTRPLAPASAE

Sequences:

>Translated_510_residues
MSNTNTTPAVPVPGLRRELRARHLTMIAIGGSIGTGLFVASGATIAQAGPGGALAAYILIGAMVYFLMTSLGELAAYMPV
SGSFATYGALYVDEGFGFALGWNYWYNWAVTIAVELAAAQLVMQYWFPDTPGVLWSALFLGLMFALNAISVRGFGEAEYW
CALIKVLTVIAFIVIGTLMIFGIMRGDFSHAGGLANLTTGDAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESDEPAK
NIPRAVRQVFWRILLFYVLAILIIGILIPYTDPSLLKTDVETVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNSGM
YASTRMLYNLATEGRAPRIFAQLTRNGVPLVALLATTAVGGLCFLTSLFESKSVYLWLLNLSGMTGFIAWLGIAVSHYRF
RRGFMAQSLDLNRLPYRSPFFPYGPIFAFVLCMIVTLGQNYQAFSEGKIDWVAVTATYVGIPIFLLIWLGYRLVRKSRFV
PYAEMKFPALPEIEKDDSPVTRPLAPASAE
>Mature_509_residues
SNTNTTPAVPVPGLRRELRARHLTMIAIGGSIGTGLFVASGATIAQAGPGGALAAYILIGAMVYFLMTSLGELAAYMPVS
GSFATYGALYVDEGFGFALGWNYWYNWAVTIAVELAAAQLVMQYWFPDTPGVLWSALFLGLMFALNAISVRGFGEAEYWC
ALIKVLTVIAFIVIGTLMIFGIMRGDFSHAGGLANLTTGDAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESDEPAKN
IPRAVRQVFWRILLFYVLAILIIGILIPYTDPSLLKTDVETVGVSPFTLVFRHAGLAFAAGVMNAVILTAVLSAGNSGMY
ASTRMLYNLATEGRAPRIFAQLTRNGVPLVALLATTAVGGLCFLTSLFESKSVYLWLLNLSGMTGFIAWLGIAVSHYRFR
RGFMAQSLDLNRLPYRSPFFPYGPIFAFVLCMIVTLGQNYQAFSEGKIDWVAVTATYVGIPIFLLIWLGYRLVRKSRFVP
YAEMKFPALPEIEKDDSPVTRPLAPASAE

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=488, Percent_Identity=75.4098360655738, Blast_Score=748, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=464, Percent_Identity=40.0862068965517, Blast_Score=333, Evalue=2e-92,
Organism=Escherichia coli, GI48994972, Length=453, Percent_Identity=37.3068432671082, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1786789, Length=428, Percent_Identity=36.4485981308411, Blast_Score=259, Evalue=2e-70,
Organism=Escherichia coli, GI1786302, Length=401, Percent_Identity=36.4089775561097, Blast_Score=256, Evalue=3e-69,
Organism=Escherichia coli, GI1789017, Length=432, Percent_Identity=32.8703703703704, Blast_Score=237, Evalue=1e-63,
Organism=Escherichia coli, GI87081915, Length=503, Percent_Identity=32.8031809145129, Blast_Score=228, Evalue=7e-61,
Organism=Escherichia coli, GI1790653, Length=336, Percent_Identity=37.5, Blast_Score=224, Evalue=1e-59,
Organism=Escherichia coli, GI1786602, Length=405, Percent_Identity=34.0740740740741, Blast_Score=206, Evalue=2e-54,
Organism=Escherichia coli, GI87081869, Length=235, Percent_Identity=24.2553191489362, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532491, Length=396, Percent_Identity=24.4949494949495, Blast_Score=65, Evalue=6e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=476, Percent_Identity=35.2941176470588, Blast_Score=330, Evalue=3e-91,
Organism=Saccharomyces cerevisiae, GI6324061, Length=506, Percent_Identity=33.9920948616601, Blast_Score=319, Evalue=6e-88,
Organism=Saccharomyces cerevisiae, GI6324990, Length=511, Percent_Identity=31.8982387475538, Blast_Score=306, Evalue=6e-84,
Organism=Saccharomyces cerevisiae, GI6322892, Length=491, Percent_Identity=36.4562118126273, Blast_Score=296, Evalue=4e-81,
Organism=Saccharomyces cerevisiae, GI6324059, Length=479, Percent_Identity=35.9081419624217, Blast_Score=294, Evalue=2e-80,
Organism=Saccharomyces cerevisiae, GI6324924, Length=512, Percent_Identity=31.640625, Blast_Score=282, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6324553, Length=493, Percent_Identity=33.4685598377282, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6321629, Length=484, Percent_Identity=30.5785123966942, Blast_Score=256, Evalue=7e-69,
Organism=Saccharomyces cerevisiae, GI6319824, Length=486, Percent_Identity=29.4238683127572, Blast_Score=252, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6322967, Length=470, Percent_Identity=34.2553191489362, Blast_Score=250, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6320717, Length=482, Percent_Identity=28.6307053941909, Blast_Score=243, Evalue=5e-65,
Organism=Saccharomyces cerevisiae, GI6319543, Length=502, Percent_Identity=29.0836653386454, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6320251, Length=471, Percent_Identity=27.8131634819533, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6319542, Length=475, Percent_Identity=27.5789473684211, Blast_Score=226, Evalue=5e-60,
Organism=Saccharomyces cerevisiae, GI6324981, Length=470, Percent_Identity=34.468085106383, Blast_Score=223, Evalue=5e-59,
Organism=Saccharomyces cerevisiae, GI6321053, Length=494, Percent_Identity=28.9473684210526, Blast_Score=221, Evalue=3e-58,
Organism=Saccharomyces cerevisiae, GI6319608, Length=504, Percent_Identity=29.1666666666667, Blast_Score=214, Evalue=3e-56,
Organism=Saccharomyces cerevisiae, GI6320364, Length=566, Percent_Identity=25.6183745583039, Blast_Score=181, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 54998; Mature: 54867

Theoretical pI: Translated: 8.64; Mature: 8.64

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNTNTTPAVPVPGLRRELRARHLTMIAIGGSIGTGLFVASGATIAQAGPGGALAAYILI
CCCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCCCEEEECCCEEECCCCCHHHHHHHHH
GAMVYFLMTSLGELAAYMPVSGSFATYGALYVDEGFGFALGWNYWYNWAVTIAVELAAAQ
HHHHHHHHHHHHHHHHHCCCCCCCHHHCEEEEECCCCEEEECHHHHHHHHHHHHHHHHHH
LVMQYWFPDTPGVLWSALFLGLMFALNAISVRGFGEAEYWCALIKVLTVIAFIVIGTLMI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FGIMRGDFSHAGGLANLTTGDAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESDEPAK
HHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHH
NIPRAVRQVFWRILLFYVLAILIIGILIPYTDPSLLKTDVETVGVSPFTLVFRHAGLAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AGVMNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPRIFAQLTRNGVPLVALLATTAVG
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHH
GLCFLTSLFESKSVYLWLLNLSGMTGFIAWLGIAVSHYRFRRGFMAQSLDLNRLPYRSPF
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
FPYGPIFAFVLCMIVTLGQNYQAFSEGKIDWVAVTATYVGIPIFLLIWLGYRLVRKSRFV
CCCHHHHHHHHHHHHHHCCCCCHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCC
PYAEMKFPALPEIEKDDSPVTRPLAPASAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
SNTNTTPAVPVPGLRRELRARHLTMIAIGGSIGTGLFVASGATIAQAGPGGALAAYILI
CCCCCCCCCCCCHHHHHHHHHHEEEEEECCCCCCCEEEECCCEEECCCCCHHHHHHHHH
GAMVYFLMTSLGELAAYMPVSGSFATYGALYVDEGFGFALGWNYWYNWAVTIAVELAAAQ
HHHHHHHHHHHHHHHHHCCCCCCCHHHCEEEEECCCCEEEECHHHHHHHHHHHHHHHHHH
LVMQYWFPDTPGVLWSALFLGLMFALNAISVRGFGEAEYWCALIKVLTVIAFIVIGTLMI
HHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
FGIMRGDFSHAGGLANLTTGDAPFVGGLPAMIGVAMIAGFSFQGTELIGVAAGESDEPAK
HHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHH
NIPRAVRQVFWRILLFYVLAILIIGILIPYTDPSLLKTDVETVGVSPFTLVFRHAGLAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHH
AGVMNAVILTAVLSAGNSGMYASTRMLYNLATEGRAPRIFAQLTRNGVPLVALLATTAVG
HHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHH
GLCFLTSLFESKSVYLWLLNLSGMTGFIAWLGIAVSHYRFRRGFMAQSLDLNRLPYRSPF
HHHHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
FPYGPIFAFVLCMIVTLGQNYQAFSEGKIDWVAVTATYVGIPIFLLIWLGYRLVRKSRFV
CCCHHHHHHHHHHHHHHCCCCCHHCCCCEEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCC
PYAEMKFPALPEIEKDDSPVTRPLAPASAE
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]