Click here to switch to the map view.

The map label for this gene is rpfC [H]

Identifier: 94313777

GI number: 94313777

Start: 1513014

End: 1514789

Strand: Direct

Name: rpfC [H]

Synonym: Rmet_4855

Alternate gene names: 94313777

Gene position: 1513014-1514789 (Clockwise)

Preceding gene: 94313776

Following gene: 94313778

Centisome position: 58.64

GC content: 65.93

Gene sequence:

>1776_bases
ATGTGGTCCTCCGTGCTGCCTCACTATGACGAGCCGCGCCTGCTTGCGGCGCAGATGGAGCTGATCGACCAGAGCTTCGG
CATCGCGATGCTTGGCTGCTCGCTTGCGGCGATCATCCTGGCAGTCGGCCTGACGGTCACGGGTGGACACCCCGGCGCCA
TGCCATGGGCCGCGGCGATGGTCGTGCTCTGCGCCATCGCCCATTTCGGCCGGCTGGCCGTGCCCGATCGTCTGACCGAG
GCGCGCGCGGGACGTTACGCGCGCGCCATGACCGTCATGCTAGTGCTGATCGGCAGCCTGTGGGGACTGGTGGCCTGGCT
CTACCTAGATATCCGGTCGCCCGCCGTGGTGATCTGCGTGCTGTCGCTGATTGCCGGCATGAGCGCGGCGGCGCTGGCGA
TCTTCTCGGCCTGTCTGCCGGTGGCCATCGGTTTCTTCATTCCCGCGATCCTGCCCGTATGGATCGTATTCCTGCTCACG
CATGACATTGCCTACCTGCCGATGTTCTTTGGTACGCCGCTGTATCTGGTGGTGCTGCTGATCTTCGCGCGCAACTACTC
GCGCGTGGCGTGTCATTCGATTGCGCTGCGCTTCGAGAATGTCGAACTGATCTCGCAGCTACGCGACCAGACCGCGCGCG
CCGGACAGGCTTTGCGCGAGGCCGAGAACGCAAATCGCGCCAAATCGGTGTTCCTGGCATCGGCCAGCCATGACCTGCGC
CAGCCCCTCCATGCGCTGGGCCTGTTTCTCGTGTCACTCGGGCGCACGCCGCTGGATGCGCACCAGCGCCAGTTGCTGGA
CCACATCGAGGCGTCGTCCGGCGCGGCGCGGGAGATGCTCAACACGCTGCTCGATTTCTCGAAGCTCGAGGCAGGTGTGA
TCACCGCGCGACCGCGCCCGTTCAGGCTGCAGCCGATGCTGCACAAGCTTGAGAACGAGTTCGCGCCGCAGGCGAATGCG
CGTGGACTGGTCTATCGCACCCGCGATACCACGGCTACGCTGTTTGGCGACCCGGCGCTGGTCGAACTGATCCTGCGTAA
CCTGATCGCCAACGCGATCCGCTACACGCATACCGGCGGCGTGCTGATCGCCTGCCGGCCCCGGCGCTTCCATGCTTCGA
TCGAGGTCTGGGATACCGGCATCGGTATTCCCATCGCGCAGCACCGCGAGATCTTTCGCGAGTTTCACCAGCTCGGCAAC
CCGGAGCGCGACCAGCGCAAGGGGCTTGGGCTAGGTCTGGCTATCGTCGACGGGTTGGCGCGCACGATGCAGACCCGCGT
AACGCTGGATTCGATACCGGAACGCGGCTCGGTATTCCGTCTGCAACTGCCACTGGCCTGGGCCGCGCCCGAGGAAGTCA
CGTTCCCAGGCAGCGTGATCCGCCTGGATGGCCTGCGCGTGCTTGTCATCGACGACGATCCGGCAATCCGCCAGGCAATG
GCCGAACTGCTGGCGGCCTGGGATTGCGACTGCCGGCCCGCCGAATCCGAGGACGAGGCGCTGGGCCTGCTCGGCACCTT
CACCCCCGACCTGATCCTGGCCGACTACCGGCTGCGTGGCCATCGCAACGGCCACGAAGCCATTGCGGCGATCCGCGAGC
GCACCAGCCAGGCGCTGCCGGCCATCATCATCACCGGCGATACGGCGGCGGATCAGCTTCGCAACGTTCACGCGGGTGGC
ACCGCGCTGCTCCACAAGCCCGTGGTCCCGGGCGAACTCCATTCGGCCATTGGCGCCCTGCTCCGGGGCTCCGAATGGTA
TCGGGTCCAACAATAA

Upstream 100 bases:

>100_bases
GGCGATTCTCGACCACCTCGGCGTGGTCAGCCGCGTGGAAGCCATTCTCGAAGCCCAGCGCCGCGGTCTGGTGCAGGCAC
AACGCTGACGCACGCCCGGC

Downstream 100 bases:

>100_bases
GCATCAGCCACATTCATGCATTCAAAGCATGAATAGATCAATCCTATTAATTGGACTTAGGTCTGGCGGCCCACCACACT
GCAAGGCACTGCGGGCCTGA

Product: putative two-component hybrid histidine kinase, periplasmic sensor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 591; Mature: 591

Protein sequence:

>591_residues
MWSSVLPHYDEPRLLAAQMELIDQSFGIAMLGCSLAAIILAVGLTVTGGHPGAMPWAAAMVVLCAIAHFGRLAVPDRLTE
ARAGRYARAMTVMLVLIGSLWGLVAWLYLDIRSPAVVICVLSLIAGMSAAALAIFSACLPVAIGFFIPAILPVWIVFLLT
HDIAYLPMFFGTPLYLVVLLIFARNYSRVACHSIALRFENVELISQLRDQTARAGQALREAENANRAKSVFLASASHDLR
QPLHALGLFLVSLGRTPLDAHQRQLLDHIEASSGAAREMLNTLLDFSKLEAGVITARPRPFRLQPMLHKLENEFAPQANA
RGLVYRTRDTTATLFGDPALVELILRNLIANAIRYTHTGGVLIACRPRRFHASIEVWDTGIGIPIAQHREIFREFHQLGN
PERDQRKGLGLGLAIVDGLARTMQTRVTLDSIPERGSVFRLQLPLAWAAPEEVTFPGSVIRLDGLRVLVIDDDPAIRQAM
AELLAAWDCDCRPAESEDEALGLLGTFTPDLILADYRLRGHRNGHEAIAAIRERTSQALPAIIITGDTAADQLRNVHAGG
TALLHKPVVPGELHSAIGALLRGSEWYRVQQ

Sequences:

>Translated_591_residues
MWSSVLPHYDEPRLLAAQMELIDQSFGIAMLGCSLAAIILAVGLTVTGGHPGAMPWAAAMVVLCAIAHFGRLAVPDRLTE
ARAGRYARAMTVMLVLIGSLWGLVAWLYLDIRSPAVVICVLSLIAGMSAAALAIFSACLPVAIGFFIPAILPVWIVFLLT
HDIAYLPMFFGTPLYLVVLLIFARNYSRVACHSIALRFENVELISQLRDQTARAGQALREAENANRAKSVFLASASHDLR
QPLHALGLFLVSLGRTPLDAHQRQLLDHIEASSGAAREMLNTLLDFSKLEAGVITARPRPFRLQPMLHKLENEFAPQANA
RGLVYRTRDTTATLFGDPALVELILRNLIANAIRYTHTGGVLIACRPRRFHASIEVWDTGIGIPIAQHREIFREFHQLGN
PERDQRKGLGLGLAIVDGLARTMQTRVTLDSIPERGSVFRLQLPLAWAAPEEVTFPGSVIRLDGLRVLVIDDDPAIRQAM
AELLAAWDCDCRPAESEDEALGLLGTFTPDLILADYRLRGHRNGHEAIAAIRERTSQALPAIIITGDTAADQLRNVHAGG
TALLHKPVVPGELHSAIGALLRGSEWYRVQQ
>Mature_591_residues
MWSSVLPHYDEPRLLAAQMELIDQSFGIAMLGCSLAAIILAVGLTVTGGHPGAMPWAAAMVVLCAIAHFGRLAVPDRLTE
ARAGRYARAMTVMLVLIGSLWGLVAWLYLDIRSPAVVICVLSLIAGMSAAALAIFSACLPVAIGFFIPAILPVWIVFLLT
HDIAYLPMFFGTPLYLVVLLIFARNYSRVACHSIALRFENVELISQLRDQTARAGQALREAENANRAKSVFLASASHDLR
QPLHALGLFLVSLGRTPLDAHQRQLLDHIEASSGAAREMLNTLLDFSKLEAGVITARPRPFRLQPMLHKLENEFAPQANA
RGLVYRTRDTTATLFGDPALVELILRNLIANAIRYTHTGGVLIACRPRRFHASIEVWDTGIGIPIAQHREIFREFHQLGN
PERDQRKGLGLGLAIVDGLARTMQTRVTLDSIPERGSVFRLQLPLAWAAPEEVTFPGSVIRLDGLRVLVIDDDPAIRQAM
AELLAAWDCDCRPAESEDEALGLLGTFTPDLILADYRLRGHRNGHEAIAAIRERTSQALPAIIITGDTAADQLRNVHAGG
TALLHKPVVPGELHSAIGALLRGSEWYRVQQ

Specific function: Involved in the positive regulation of synthesis of extracellular enzymes and polysaccharide, and hence in pathogenicity. Can restore function to the non-pathogenic mutant 8237 [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI87081816, Length=274, Percent_Identity=35.036496350365, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI1789149, Length=393, Percent_Identity=28.7531806615776, Blast_Score=130, Evalue=3e-31,
Organism=Escherichia coli, GI145693157, Length=261, Percent_Identity=32.9501915708812, Blast_Score=127, Evalue=2e-30,
Organism=Escherichia coli, GI48994928, Length=360, Percent_Identity=28.6111111111111, Blast_Score=105, Evalue=7e-24,
Organism=Escherichia coli, GI1788713, Length=396, Percent_Identity=24.7474747474747, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790861, Length=243, Percent_Identity=27.1604938271605, Blast_Score=73, Evalue=5e-14,
Organism=Escherichia coli, GI1786912, Length=253, Percent_Identity=28.0632411067194, Blast_Score=71, Evalue=2e-13,
Organism=Escherichia coli, GI87082128, Length=221, Percent_Identity=27.1493212669683, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1788393, Length=241, Percent_Identity=25.7261410788382, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI1786600, Length=220, Percent_Identity=25.9090909090909, Blast_Score=64, Evalue=3e-11,
Organism=Escherichia coli, GI1790346, Length=220, Percent_Identity=26.8181818181818, Blast_Score=62, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF01627 Hpt; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 64636; Mature: 64636

Theoretical pI: Translated: 7.48; Mature: 7.48

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MWSSVLPHYDEPRLLAAQMELIDQSFGIAMLGCSLAAIILAVGLTVTGGHPGAMPWAAAM
CCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHH
VVLCAIAHFGRLAVPDRLTEARAGRYARAMTVMLVLIGSLWGLVAWLYLDIRSPAVVICV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LSLIAGMSAAALAIFSACLPVAIGFFIPAILPVWIVFLLTHDIAYLPMFFGTPLYLVVLL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
IFARNYSRVACHSIALRFENVELISQLRDQTARAGQALREAENANRAKSVFLASASHDLR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCHHHH
QPLHALGLFLVSLGRTPLDAHQRQLLDHIEASSGAAREMLNTLLDFSKLEAGVITARPRP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCCC
FRLQPMLHKLENEFAPQANARGLVYRTRDTTATLFGDPALVELILRNLIANAIRYTHTGG
CCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHEECCCC
VLIACRPRRFHASIEVWDTGIGIPIAQHREIFREFHQLGNPERDQRKGLGLGLAIVDGLA
EEEEECCCHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHH
RTMQTRVTLDSIPERGSVFRLQLPLAWAAPEEVTFPGSVIRLDGLRVLVIDDDPAIRQAM
HHHHHHHHHHCCCCCCCEEEEEECEEECCCCCCCCCCCEEEECCEEEEEECCCHHHHHHH
AELLAAWDCDCRPAESEDEALGLLGTFTPDLILADYRLRGHRNGHEAIAAIRERTSQALP
HHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHEEHHHHCCCCCHHHHHHHHHHHHHHCCC
AIIITGDTAADQLRNVHAGGTALLHKPVVPGELHSAIGALLRGSEWYRVQQ
EEEEECCHHHHHHHHCCCCCHHEEECCCCCHHHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure
MWSSVLPHYDEPRLLAAQMELIDQSFGIAMLGCSLAAIILAVGLTVTGGHPGAMPWAAAM
CCCCCCCCCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCEEECCCCCCCHHHHHH
VVLCAIAHFGRLAVPDRLTEARAGRYARAMTVMLVLIGSLWGLVAWLYLDIRSPAVVICV
HHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
LSLIAGMSAAALAIFSACLPVAIGFFIPAILPVWIVFLLTHDIAYLPMFFGTPLYLVVLL
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHH
IFARNYSRVACHSIALRFENVELISQLRDQTARAGQALREAENANRAKSVFLASASHDLR
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHEEECCCHHHH
QPLHALGLFLVSLGRTPLDAHQRQLLDHIEASSGAAREMLNTLLDFSKLEAGVITARPRP
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCCC
FRLQPMLHKLENEFAPQANARGLVYRTRDTTATLFGDPALVELILRNLIANAIRYTHTGG
CCHHHHHHHHHHHCCCCCCCCEEEEEECCCEEEECCCHHHHHHHHHHHHHHHHHEECCCC
VLIACRPRRFHASIEVWDTGIGIPIAQHREIFREFHQLGNPERDQRKGLGLGLAIVDGLA
EEEEECCCHHCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHCCCCCHHHHHHHHH
RTMQTRVTLDSIPERGSVFRLQLPLAWAAPEEVTFPGSVIRLDGLRVLVIDDDPAIRQAM
HHHHHHHHHHCCCCCCCEEEEEECEEECCCCCCCCCCCEEEECCEEEEEECCCHHHHHHH
AELLAAWDCDCRPAESEDEALGLLGTFTPDLILADYRLRGHRNGHEAIAAIRERTSQALP
HHHHHHCCCCCCCCCCCCHHHHHHHCCCHHHHEEHHHHCCCCCHHHHHHHHHHHHHHCCC
AIIITGDTAADQLRNVHAGGTALLHKPVVPGELHSAIGALLRGSEWYRVQQ
EEEEECCHHHHHHHHCCCCCHHEEECCCCCHHHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1645442 [H]