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The map label for this gene is tdcB [H]

Identifier: 94313747

GI number: 94313747

Start: 1477335

End: 1478303

Strand: Direct

Name: tdcB [H]

Synonym: Rmet_4825

Alternate gene names: 94313747

Gene position: 1477335-1478303 (Clockwise)

Preceding gene: 94313746

Following gene: 94313751

Centisome position: 57.26

GC content: 64.81

Gene sequence:

>969_bases
ATGACGACCCTGCAACTGCCCACCTACGCCGACGTCGAAGCCGCCGCCAAACGGATCGAAGGCTTTGCCAACCGCACGCC
GGTCAACACGTCGCGCACGCTCAACGAAATGCTCGGCGCGGAAGTCTTCTTCAAGTGCGAGAACTTCCAGCGCATGGGCG
CCTTCAAGTTCCGAGGCGCGTTCAACGCGCTGGCGAAGTTCACCGCCGAGCAACGCCGTGGCGGCGTGGTCGCGTTCTCG
TCCGGCAATCACGCGCAGGGCATCGCGCTGTCCGCGAAGCTGCTGAACATGCCCGCCACGATCGTGATGCCCCACGACGC
TCCGGCCTTGAAGGTAGCGGCGACGCGGGGGTATGGCGCGACCGTGGTGAGCTATGACCGCTACAAGGAAGACCGTGAAG
CCATCGGCCGCGATCTGGCCGAAAAGCACGGCATGACGCTGATCCCGCCGTATGACCATCCGGATGTGCTGACGGGCCAG
GGCACCGCCGCCAAGGAACTGTTCGAGGAAGTGGGCGCGCTCGACGCCATCTTCACCCCGCTGGGCGGCGGCGGACTGCT
CTCCGGCACCGCATTGACCACGCGCGCGCTGGCGCCACAGTGCCAGATCTACGGCGTGGAGCCCGAGGCGGGCAACGACG
GCCAGCAATCGTTCCGCAGTGGTTCGATCGTCCATATCGACACCCCGCAGACCATTGCCGATGGCGCTCAGACGCAGCAC
CTGGGTCAGTACACGTTCAGCATCATCAAGCGTGACGTGACTGATATCCTGACCGCAACAGACGCGCAACTGGTCGAGGC
CATGCGCTTCTACGCCGAACGGATGAAGATGATTGTCGAGCCGACCGGCTGCCTGGGCCTGGCGGCGGTCATGCAGATGA
AGGACGCGCTCAAGGGCAAGCGCGTGGGCGTAGTGATCAGCGGCGGCAACGTCGACCTGGAGCGATTCTGCTCGCTGCTG
TCAGCCTGA

Upstream 100 bases:

>100_bases
ACCTGACGGTCGCCCGCTTCCTGGACCAACGCGCGCGGGCCGACGGCACCGGCACACGCCTGGCCTGGCCCTGGTAACAA
CTCTCCTCTCCCTGCCCATC

Downstream 100 bases:

>100_bases
TCCTTCCGCGCATCAAACCGAACGTCAGGCACTCGGGCCGGGAATCGCATCCCCGGCCTGCTTCAAACCTCCCCACCCTG
CTTCACGTCTTCCCTGGCCT

Product: serine/threonine dehydratase

Products: NA

Alternate protein names: Threonine deaminase [H]

Number of amino acids: Translated: 322; Mature: 321

Protein sequence:

>322_residues
MTTLQLPTYADVEAAAKRIEGFANRTPVNTSRTLNEMLGAEVFFKCENFQRMGAFKFRGAFNALAKFTAEQRRGGVVAFS
SGNHAQGIALSAKLLNMPATIVMPHDAPALKVAATRGYGATVVSYDRYKEDREAIGRDLAEKHGMTLIPPYDHPDVLTGQ
GTAAKELFEEVGALDAIFTPLGGGGLLSGTALTTRALAPQCQIYGVEPEAGNDGQQSFRSGSIVHIDTPQTIADGAQTQH
LGQYTFSIIKRDVTDILTATDAQLVEAMRFYAERMKMIVEPTGCLGLAAVMQMKDALKGKRVGVVISGGNVDLERFCSLL
SA

Sequences:

>Translated_322_residues
MTTLQLPTYADVEAAAKRIEGFANRTPVNTSRTLNEMLGAEVFFKCENFQRMGAFKFRGAFNALAKFTAEQRRGGVVAFS
SGNHAQGIALSAKLLNMPATIVMPHDAPALKVAATRGYGATVVSYDRYKEDREAIGRDLAEKHGMTLIPPYDHPDVLTGQ
GTAAKELFEEVGALDAIFTPLGGGGLLSGTALTTRALAPQCQIYGVEPEAGNDGQQSFRSGSIVHIDTPQTIADGAQTQH
LGQYTFSIIKRDVTDILTATDAQLVEAMRFYAERMKMIVEPTGCLGLAAVMQMKDALKGKRVGVVISGGNVDLERFCSLL
SA
>Mature_321_residues
TTLQLPTYADVEAAAKRIEGFANRTPVNTSRTLNEMLGAEVFFKCENFQRMGAFKFRGAFNALAKFTAEQRRGGVVAFSS
GNHAQGIALSAKLLNMPATIVMPHDAPALKVAATRGYGATVVSYDRYKEDREAIGRDLAEKHGMTLIPPYDHPDVLTGQG
TAAKELFEEVGALDAIFTPLGGGGLLSGTALTTRALAPQCQIYGVEPEAGNDGQQSFRSGSIVHIDTPQTIADGAQTQHL
GQYTFSIIKRDVTDILTATDAQLVEAMRFYAERMKMIVEPTGCLGLAAVMQMKDALKGKRVGVVISGGNVDLERFCSLLS
A

Specific function: Acts on both serine and threonine, and properly considered as a hydroxy amino acid deaminase [H]

COG id: COG1171

COG function: function code E; Threonine dehydratase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the serine/threonine dehydratase family [H]

Homologues:

Organism=Homo sapiens, GI11345492, Length=313, Percent_Identity=39.9361022364217, Blast_Score=233, Evalue=3e-61,
Organism=Homo sapiens, GI19923959, Length=151, Percent_Identity=33.7748344370861, Blast_Score=78, Evalue=1e-14,
Organism=Homo sapiens, GI33469958, Length=315, Percent_Identity=25.7142857142857, Blast_Score=76, Evalue=4e-14,
Organism=Escherichia coli, GI1789505, Length=320, Percent_Identity=37.1875, Blast_Score=186, Evalue=2e-48,
Organism=Escherichia coli, GI1790207, Length=300, Percent_Identity=34, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17508781, Length=309, Percent_Identity=35.2750809061489, Blast_Score=184, Evalue=6e-47,
Organism=Caenorhabditis elegans, GI71991565, Length=309, Percent_Identity=33.6569579288026, Blast_Score=159, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI17537387, Length=306, Percent_Identity=33.9869281045752, Blast_Score=135, Evalue=2e-32,
Organism=Saccharomyces cerevisiae, GI6322631, Length=316, Percent_Identity=68.6708860759494, Blast_Score=447, Evalue=1e-126,
Organism=Saccharomyces cerevisiae, GI6320930, Length=303, Percent_Identity=34.3234323432343, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6319788, Length=262, Percent_Identity=27.0992366412214, Blast_Score=84, Evalue=4e-17,
Organism=Drosophila melanogaster, GI21355833, Length=313, Percent_Identity=34.5047923322684, Blast_Score=153, Evalue=2e-37,
Organism=Drosophila melanogaster, GI24645328, Length=215, Percent_Identity=31.1627906976744, Blast_Score=84, Evalue=2e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR005789 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.3.1.19 [H]

Molecular weight: Translated: 34540; Mature: 34409

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLQLPTYADVEAAAKRIEGFANRTPVNTSRTLNEMLGAEVFFKCENFQRMGAFKFRGA
CCEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHEEEEECCHHHCCCHHHHHH
FNALAKFTAEQRRGGVVAFSSGNHAQGIALSAKLLNMPATIVMPHDAPALKVAATRGYGA
HHHHHHHHHHHHCCCEEEECCCCCCCCEEEEHHHHCCCEEEEECCCCCCEEEEEECCCCC
TVVSYDRYKEDREAIGRDLAEKHGMTLIPPYDHPDVLTGQGTAAKELFEEVGALDAIFTP
EEEEHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHCHHHHHHCC
LGGGGLLSGTALTTRALAPQCQIYGVEPEAGNDGQQSFRSGSIVHIDTPQTIADGAQTQH
CCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCEEEECCCCHHHCCHHHHH
LGQYTFSIIKRDVTDILTATDAQLVEAMRFYAERMKMIVEPTGCLGLAAVMQMKDALKGK
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
RVGVVISGGNVDLERFCSLLSA
EEEEEEECCCCCHHHHHHHHCC
>Mature Secondary Structure 
TTLQLPTYADVEAAAKRIEGFANRTPVNTSRTLNEMLGAEVFFKCENFQRMGAFKFRGA
CEECCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHCHHEEEEECCHHHCCCHHHHHH
FNALAKFTAEQRRGGVVAFSSGNHAQGIALSAKLLNMPATIVMPHDAPALKVAATRGYGA
HHHHHHHHHHHHCCCEEEECCCCCCCCEEEEHHHHCCCEEEEECCCCCCEEEEEECCCCC
TVVSYDRYKEDREAIGRDLAEKHGMTLIPPYDHPDVLTGQGTAAKELFEEVGALDAIFTP
EEEEHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCHHHHHHHHHHCHHHHHHCC
LGGGGLLSGTALTTRALAPQCQIYGVEPEAGNDGQQSFRSGSIVHIDTPQTIADGAQTQH
CCCCCCCCCHHHHHHHCCCCEEEEECCCCCCCCHHHHHCCCCEEEECCCCHHHCCHHHHH
LGQYTFSIIKRDVTDILTATDAQLVEAMRFYAERMKMIVEPTGCLGLAAVMQMKDALKGK
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCC
RVGVVISGGNVDLERFCSLLSA
EEEEEEECCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA