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The map label for this gene is argH [H]

Identifier: 94313577

GI number: 94313577

Start: 1286827

End: 1288353

Strand: Direct

Name: argH [H]

Synonym: Rmet_4655

Alternate gene names: 94313577

Gene position: 1286827-1288353 (Clockwise)

Preceding gene: 94313575

Following gene: 94313578

Centisome position: 49.88

GC content: 63.79

Gene sequence:

>1527_bases
ATGCCTACCCCCCGACTGCACAGCCGAGTCAAATCACTGGCCAGGCTGACCGCACTAGCCATGCTGATGATGTCGGTCGG
CCCCCAAGCCGCATTCGCGGCGGGCGGCGCTAACCACGATGCCTTTTTCTGGCTAGGGGAGATCAACAAGGCGTCGACGG
TCATCAATACCGACGAGGGATTGCTGGATCGCTCGCAGGCGCCGCGAGTGGCGGGCGGCATTGCCACGGTGCTGGCCAAT
GGCGACAAGCCCGGCGGCCAACGACCGTCGACGGTGATTACTTTCGAGCCGCTGATGATTCAGGCCGCAGGTCAGGAAGT
CACGCTGATCCATGCCGGCCGCTCGAGCCAGGACATGCTTGCGACGGTGCGCGCGGCGATGTTGCGCGACGAAGTCTTGT
CGCTGGCCGACCAGCTCAACAAGACCTCCGCCACCATCGTCAAGCTGGCGCGGCAGCATGCCGAAACCATCGTGCCGAAC
TACACGAACGGCGTTGCTGCGCAGCCCAATAGTTATGGCCACTACCTGCTCGGCATCAATGCGGGTCTGGAACGCGATGC
CCAGCGCCTGCGGGAAGCCTATCAGCGCATCGATCGCTCGCCGATGGGAACGACGGTGCTGAACGGCACGGGCTGGCCGC
TGAACCGCACGCGAATGGCGAGCTACCTCGGATTCTCCGCGCTGGTGGATAACGCTTATGATGCGTCGCAGATCAGCGCC
GTGGACCTGCCGGTGGAAGTGGGCGCGATCGTGACCAGCATCGCCCTGCACACCGGGAGCTTCATCGAGGATGTGATGAC
GCAGTATGCGCAGCCGCGCCCCTGGATCCTGCTGCAGGAGGGCGGCGGCAATACCTATGTGTCCAGTGCGATGCCGCAGA
AGCGCAATCCGGGGCTGCTCAACTCCACGCGCGAGAAGGCCTCCACAGCGATCACGTTGGCCATGGGGCCGGTGATTCGT
GCGCACAACCTGCCGCCGGGCATGTCTGATGCCAAGGATGCCGTTACCAATGGCCAGATGGTGCAGAGCGCGATCACGAC
ATTGAAGGGGCTGGACCGCATCATGACAGCCCTGGTGATCGATCGGCCGCGCGCGCTGGATGAACTGGACAGCGACTGGA
CGGCATCACAGGAACTGGCCGACGAATTGATGCGCAAGTACAAGCTGCCGTTCCGCGTCGGCCATCACTTCGCGTCGAAC
CTGGTGGACTATGCGAAGGCGCACGACATAAAGCCAAGCGCCTTCCCCTATGCCGAGGCGAAGCGCATCTATGCCGAAGC
CGTGCGCGACTACGGTGGTGGGGAGTTTCCGATGAGCGAGGCGGAGTTTCGCGCGGCGCTCGATCCGGTGGCCATCGTCA
AGCGTCGCGTGACGGTGGGCGGACCGCAGCCAGCAGAGATGGAACGCATGCTGAAGGCGTCCGAGGGACAACTGGCACAA
CAGGATGCGTGGATCCGCGCGCGGCGGGCGGCGATCGATGGCTCGCTGGGCCGACTCGACCGTGATTTCGAGAAGTTGCT
GAAGTAG

Upstream 100 bases:

>100_bases
AATGCGCACCACAGGCAGAATGTCACGTGTGCCACAACTCGGCGATTCCACCCTAGAATCCGGAGTCCTGTCCGAACAAG
CAAACACCTCTGGAGACTAC

Downstream 100 bases:

>100_bases
GCGCCGATGCCCGCTGCGGTTCTGTCGCGACAACGGCCGCGTGGTGAAGCCAGCGAGTGATCGACGAAGACACCACGCTC
GACCATCATTGGCTCAAGAT

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 508; Mature: 507

Protein sequence:

>508_residues
MPTPRLHSRVKSLARLTALAMLMMSVGPQAAFAAGGANHDAFFWLGEINKASTVINTDEGLLDRSQAPRVAGGIATVLAN
GDKPGGQRPSTVITFEPLMIQAAGQEVTLIHAGRSSQDMLATVRAAMLRDEVLSLADQLNKTSATIVKLARQHAETIVPN
YTNGVAAQPNSYGHYLLGINAGLERDAQRLREAYQRIDRSPMGTTVLNGTGWPLNRTRMASYLGFSALVDNAYDASQISA
VDLPVEVGAIVTSIALHTGSFIEDVMTQYAQPRPWILLQEGGGNTYVSSAMPQKRNPGLLNSTREKASTAITLAMGPVIR
AHNLPPGMSDAKDAVTNGQMVQSAITTLKGLDRIMTALVIDRPRALDELDSDWTASQELADELMRKYKLPFRVGHHFASN
LVDYAKAHDIKPSAFPYAEAKRIYAEAVRDYGGGEFPMSEAEFRAALDPVAIVKRRVTVGGPQPAEMERMLKASEGQLAQ
QDAWIRARRAAIDGSLGRLDRDFEKLLK

Sequences:

>Translated_508_residues
MPTPRLHSRVKSLARLTALAMLMMSVGPQAAFAAGGANHDAFFWLGEINKASTVINTDEGLLDRSQAPRVAGGIATVLAN
GDKPGGQRPSTVITFEPLMIQAAGQEVTLIHAGRSSQDMLATVRAAMLRDEVLSLADQLNKTSATIVKLARQHAETIVPN
YTNGVAAQPNSYGHYLLGINAGLERDAQRLREAYQRIDRSPMGTTVLNGTGWPLNRTRMASYLGFSALVDNAYDASQISA
VDLPVEVGAIVTSIALHTGSFIEDVMTQYAQPRPWILLQEGGGNTYVSSAMPQKRNPGLLNSTREKASTAITLAMGPVIR
AHNLPPGMSDAKDAVTNGQMVQSAITTLKGLDRIMTALVIDRPRALDELDSDWTASQELADELMRKYKLPFRVGHHFASN
LVDYAKAHDIKPSAFPYAEAKRIYAEAVRDYGGGEFPMSEAEFRAALDPVAIVKRRVTVGGPQPAEMERMLKASEGQLAQ
QDAWIRARRAAIDGSLGRLDRDFEKLLK
>Mature_507_residues
PTPRLHSRVKSLARLTALAMLMMSVGPQAAFAAGGANHDAFFWLGEINKASTVINTDEGLLDRSQAPRVAGGIATVLANG
DKPGGQRPSTVITFEPLMIQAAGQEVTLIHAGRSSQDMLATVRAAMLRDEVLSLADQLNKTSATIVKLARQHAETIVPNY
TNGVAAQPNSYGHYLLGINAGLERDAQRLREAYQRIDRSPMGTTVLNGTGWPLNRTRMASYLGFSALVDNAYDASQISAV
DLPVEVGAIVTSIALHTGSFIEDVMTQYAQPRPWILLQEGGGNTYVSSAMPQKRNPGLLNSTREKASTAITLAMGPVIRA
HNLPPGMSDAKDAVTNGQMVQSAITTLKGLDRIMTALVIDRPRALDELDSDWTASQELADELMRKYKLPFRVGHHFASNL
VDYAKAHDIKPSAFPYAEAKRIYAEAVRDYGGGEFPMSEAEFRAALDPVAIVKRRVTVGGPQPAEMERMLKASEGQLAQQ
DAWIRARRAAIDGSLGRLDRDFEKLLK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=340, Percent_Identity=25.8823529411765, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI68303542, Length=340, Percent_Identity=25.8823529411765, Blast_Score=94, Evalue=4e-19,
Organism=Homo sapiens, GI68303547, Length=336, Percent_Identity=26.4880952380952, Blast_Score=85, Evalue=1e-16,
Organism=Escherichia coli, GI1790398, Length=313, Percent_Identity=30.0319488817891, Blast_Score=121, Evalue=9e-29,
Organism=Saccharomyces cerevisiae, GI6321806, Length=298, Percent_Identity=27.5167785234899, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI221473854, Length=405, Percent_Identity=24.9382716049383, Blast_Score=102, Evalue=4e-22,
Organism=Drosophila melanogaster, GI78706858, Length=405, Percent_Identity=24.9382716049383, Blast_Score=102, Evalue=4e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 55085; Mature: 54953

Theoretical pI: Translated: 9.02; Mature: 9.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPRLHSRVKSLARLTALAMLMMSVGPQAAFAAGGANHDAFFWLGEINKASTVINTDEG
CCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEECCCCCCEEEECCCC
LLDRSQAPRVAGGIATVLANGDKPGGQRPSTVITFEPLMIQAAGQEVTLIHAGRSSQDML
HHCCCCCCCHHHHHHHEEECCCCCCCCCCCEEEEECCEEEEECCCEEEEEECCCCCHHHH
ATVRAAMLRDEVLSLADQLNKTSATIVKLARQHAETIVPNYTNGVAAQPNSYGHYLLGIN
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEC
AGLERDAQRLREAYQRIDRSPMGTTVLNGTGWPLNRTRMASYLGFSALVDNAYDASQISA
CCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCEE
VDLPVEVGAIVTSIALHTGSFIEDVMTQYAQPRPWILLQEGGGNTYVSSAMPQKRNPGLL
ECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCC
NSTREKASTAITLAMGPVIRAHNLPPGMSDAKDAVTNGQMVQSAITTLKGLDRIMTALVI
CHHHHHHHHEEEEECCCHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
DRPRALDELDSDWTASQELADELMRKYKLPFRVGHHFASNLVDYAKAHDIKPSAFPYAEA
CCCHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
KRIYAEAVRDYGGGEFPMSEAEFRAALDPVAIVKRRVTVGGPQPAEMERMLKASEGQLAQ
HHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHH
QDAWIRARRAAIDGSLGRLDRDFEKLLK
HHHHHHHHHHHHCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
PTPRLHSRVKSLARLTALAMLMMSVGPQAAFAAGGANHDAFFWLGEINKASTVINTDEG
CCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCEEEEEECCCCCCEEEECCCC
LLDRSQAPRVAGGIATVLANGDKPGGQRPSTVITFEPLMIQAAGQEVTLIHAGRSSQDML
HHCCCCCCCHHHHHHHEEECCCCCCCCCCCEEEEECCEEEEECCCEEEEEECCCCCHHHH
ATVRAAMLRDEVLSLADQLNKTSATIVKLARQHAETIVPNYTNGVAAQPNSYGHYLLGIN
HHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEC
AGLERDAQRLREAYQRIDRSPMGTTVLNGTGWPLNRTRMASYLGFSALVDNAYDASQISA
CCCHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHCCCCCCHHCEE
VDLPVEVGAIVTSIALHTGSFIEDVMTQYAQPRPWILLQEGGGNTYVSSAMPQKRNPGLL
ECCCHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCEEEEEECCCCEEECCCCCCCCCCCCC
NSTREKASTAITLAMGPVIRAHNLPPGMSDAKDAVTNGQMVQSAITTLKGLDRIMTALVI
CHHHHHHHHEEEEECCCHHHHCCCCCCCCHHHHHHHCHHHHHHHHHHHHHHHHHHHHHHH
DRPRALDELDSDWTASQELADELMRKYKLPFRVGHHFASNLVDYAKAHDIKPSAFPYAEA
CCCHHHHHCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHH
KRIYAEAVRDYGGGEFPMSEAEFRAALDPVAIVKRRVTVGGPQPAEMERMLKASEGQLAQ
HHHHHHHHHHCCCCCCCCCHHHHHHHCCHHHHHHHHHCCCCCCHHHHHHHHHHCCCCHHH
QDAWIRARRAAIDGSLGRLDRDFEKLLK
HHHHHHHHHHHHCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA