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The map label for this gene is msrA [H]

Identifier: 94313479

GI number: 94313479

Start: 1168049

End: 1168555

Strand: Reverse

Name: msrA [H]

Synonym: Rmet_4557

Alternate gene names: 94313479

Gene position: 1168555-1168049 (Counterclockwise)

Preceding gene: 94313481

Following gene: 94313474

Centisome position: 45.29

GC content: 62.33

Gene sequence:

>507_bases
ATGACGACGCAAATCGAAACCGCAATCCTCGCCGGCGGCTGCTTCTGGGGGATGCAGGACCTGCTGCGGCGGTACCCCGG
CGTGCTGTCGACCCGGGTGGGCTACACCGGCGGCGACGTGCCGAATGCCACTTATCGCCACCACGGCACACACGCCGAGG
GCATCGAGATCGCCTTCGATCCGAGCCAGATCAGCTATCGCCAGATCCTGGAGTTCTTCTTCCAGATCCACGACCCAACC
ACCAAGAATCGCCAGGGCAACGATGTGGGGACGAGCTATCGCTCGGCGATCTTTTACCTGAACGACGAACAAAAGCAGAC
GGCGGAAGACACCGTGGCCGACGTGAATGCGTCCGGACTATGGCCTGGCAAGGTCGTGACTGAAATCGCACCGGCCGGAC
CGTTCTGGGATGCCGAGCCGGAACACCAGGACTACCTGGAGCGGTATCCGAACGGCTATACCTGCCACTTCATCCGGCCG
GGCTGGAAGCTGCCGAAGCGAGGTTGA

Upstream 100 bases:

>100_bases
TAGCCTGCGCGCGCTGTGGGGACTTTGTGGCCATGAGCGGATTCGACGCGGTGTGCGTATATTACTGGCCTCTACGCCAC
GCGATGCAAAGGACCAGAGT

Downstream 100 bases:

>100_bases
GGCAGGGCTGGAGGTCTGCCTGCGGCCGGTGAGGTTTTCGACAATCTTGTCCGTATCCTGTCAGGATGACTGTACGTTTA
TACAGTATAGTTATGCCGAC

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase 1; Peptide-methionine (S)-S-oxide reductase 1; Peptide Met(O) reductase 1 [H]

Number of amino acids: Translated: 168; Mature: 167

Protein sequence:

>168_residues
MTTQIETAILAGGCFWGMQDLLRRYPGVLSTRVGYTGGDVPNATYRHHGTHAEGIEIAFDPSQISYRQILEFFFQIHDPT
TKNRQGNDVGTSYRSAIFYLNDEQKQTAEDTVADVNASGLWPGKVVTEIAPAGPFWDAEPEHQDYLERYPNGYTCHFIRP
GWKLPKRG

Sequences:

>Translated_168_residues
MTTQIETAILAGGCFWGMQDLLRRYPGVLSTRVGYTGGDVPNATYRHHGTHAEGIEIAFDPSQISYRQILEFFFQIHDPT
TKNRQGNDVGTSYRSAIFYLNDEQKQTAEDTVADVNASGLWPGKVVTEIAPAGPFWDAEPEHQDYLERYPNGYTCHFIRP
GWKLPKRG
>Mature_167_residues
TTQIETAILAGGCFWGMQDLLRRYPGVLSTRVGYTGGDVPNATYRHHGTHAEGIEIAFDPSQISYRQILEFFFQIHDPTT
KNRQGNDVGTSYRSAIFYLNDEQKQTAEDTVADVNASGLWPGKVVTEIAPAGPFWDAEPEHQDYLERYPNGYTCHFIRPG
WKLPKRG

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI208609995, Length=156, Percent_Identity=37.1794871794872, Blast_Score=104, Evalue=3e-23,
Organism=Homo sapiens, GI6912516, Length=156, Percent_Identity=37.1794871794872, Blast_Score=104, Evalue=4e-23,
Organism=Homo sapiens, GI208609993, Length=107, Percent_Identity=38.3177570093458, Blast_Score=77, Evalue=7e-15,
Organism=Escherichia coli, GI1790665, Length=153, Percent_Identity=47.7124183006536, Blast_Score=134, Evalue=5e-33,
Organism=Caenorhabditis elegans, GI17533973, Length=141, Percent_Identity=38.2978723404255, Blast_Score=99, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320881, Length=164, Percent_Identity=36.5853658536585, Blast_Score=108, Evalue=5e-25,
Organism=Drosophila melanogaster, GI24664627, Length=142, Percent_Identity=38.7323943661972, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45553131, Length=136, Percent_Identity=38.9705882352941, Blast_Score=86, Evalue=9e-18,
Organism=Drosophila melanogaster, GI24664631, Length=144, Percent_Identity=37.5, Blast_Score=80, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 18955; Mature: 18824

Theoretical pI: Translated: 5.92; Mature: 5.92

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTQIETAILAGGCFWGMQDLLRRYPGVLSTRVGYTGGDVPNATYRHHGTHAEGIEIAFD
CCCCCCHHHHHCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
PSQISYRQILEFFFQIHDPTTKNRQGNDVGTSYRSAIFYLNDEQKQTAEDTVADVNASGL
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCC
WPGKVVTEIAPAGPFWDAEPEHQDYLERYPNGYTCHFIRPGWKLPKRG
CCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCC
>Mature Secondary Structure 
TTQIETAILAGGCFWGMQDLLRRYPGVLSTRVGYTGGDVPNATYRHHGTHAEGIEIAFD
CCCCCHHHHHCHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEC
PSQISYRQILEFFFQIHDPTTKNRQGNDVGTSYRSAIFYLNDEQKQTAEDTVADVNASGL
CCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHCCCCCC
WPGKVVTEIAPAGPFWDAEPEHQDYLERYPNGYTCHFIRPGWKLPKRG
CCHHHHHHHCCCCCCCCCCCCHHHHHHHCCCCCEEEEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]