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The map label for this gene is livH3 [H]

Identifier: 94313401

GI number: 94313401

Start: 1076466

End: 1077323

Strand: Direct

Name: livH3 [H]

Synonym: Rmet_4476

Alternate gene names: 94313401

Gene position: 1076466-1077323 (Clockwise)

Preceding gene: 94313400

Following gene: 94313402

Centisome position: 41.72

GC content: 62.94

Gene sequence:

>858_bases
ATGAACGTCTATCTGTTGCAGGTCATCAATGGCGTTGGCATCGGGATGCTCTACTTCCTGCTGGCAGTAGGCTTGTCGAT
CGTCTTCGGTCTCTTGCGTTTCGTGAATTTCGCCCACGGCGCGTTCTACGCGCTTGGCGCCTACCTGTGCTTCCAGGCGC
TCCAGTTCGGCCTGGACTTCTGGGCGGCGCTCATCCTGGCGCCCATCATCATCGGCGCGCTGGCATGGCTCACGGAAAAG
GTGATGCTTCGCTATGTCTACGCGCAGCCGCACGAATTCCACATCCTCATCACGGTCGGCCTGGCCCTGGCGGTCCAGGA
ACTCATCATTGTCGGGTGGGGCCCGCTAGGCGTCGACGTACCGCCTCCCGATGTGCTGCAAGGCGTGGTGATGTGGGGCG
ATTTCGTCTATCCGAAATACCGTCTCTTCGTGATCGGCTTCACGGCCCTCCTTGCCGTTGCGCTCTGGTGGCTGCTCGAA
GGCACCCGCATCGGCAGTGCCGTTCGCGCTGGCAGTGAATCCACGGAAATGGTCTCGCTGCTTGGCATCAATGTTTTCCG
ACTGTTCAGCCTGATGTTCGCGCTCGGCGCGGGGACTGCCGCCATCGCGGGCGTCCTGGCCGCGCCAATCCGGGGTGCCG
AGCCGTTCATGGGCGTGGAAGCCCTGGGGGTGGCCTTTATCGTGGTCGTGATCGGCGGCATGGGCAGCTTCACCGGCGCC
CTGGTGGGTGGCCTGCTTGTTGGCATTGTGCAAAGCCTGATGAGCACGCTCTGGCCGGAAGGTGCCCGGCTGATGATCTA
TGTGGCCATGGCCGCGGTGCTGTTGCTGCGTCCGCACGGCCTGCTTGGGAGGGGATGA

Upstream 100 bases:

>100_bases
GGCGAAGCCGCGGTCGTTCTGACCGCGGACATCTCAAGTCATATTCGATGCACCGGACCGCGCCGCCGCGGTCTGGCGGT
CTCCCTCATTCGCACGGTTT

Downstream 100 bases:

>100_bases
TGGCGTCAAGCAGACAATGGTTGTTTCGCTACCGCTACTGGTGGCTAGCGCTGGGCGTCACGCTGCTGCTCCCGTTGACG
ATGCGTTCGGGCACGCTGGC

Product: branched-chain amino acid ABC transporter permease

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein H [H]

Number of amino acids: Translated: 285; Mature: 285

Protein sequence:

>285_residues
MNVYLLQVINGVGIGMLYFLLAVGLSIVFGLLRFVNFAHGAFYALGAYLCFQALQFGLDFWAALILAPIIIGALAWLTEK
VMLRYVYAQPHEFHILITVGLALAVQELIIVGWGPLGVDVPPPDVLQGVVMWGDFVYPKYRLFVIGFTALLAVALWWLLE
GTRIGSAVRAGSESTEMVSLLGINVFRLFSLMFALGAGTAAIAGVLAAPIRGAEPFMGVEALGVAFIVVVIGGMGSFTGA
LVGGLLVGIVQSLMSTLWPEGARLMIYVAMAAVLLLRPHGLLGRG

Sequences:

>Translated_285_residues
MNVYLLQVINGVGIGMLYFLLAVGLSIVFGLLRFVNFAHGAFYALGAYLCFQALQFGLDFWAALILAPIIIGALAWLTEK
VMLRYVYAQPHEFHILITVGLALAVQELIIVGWGPLGVDVPPPDVLQGVVMWGDFVYPKYRLFVIGFTALLAVALWWLLE
GTRIGSAVRAGSESTEMVSLLGINVFRLFSLMFALGAGTAAIAGVLAAPIRGAEPFMGVEALGVAFIVVVIGGMGSFTGA
LVGGLLVGIVQSLMSTLWPEGARLMIYVAMAAVLLLRPHGLLGRG
>Mature_285_residues
MNVYLLQVINGVGIGMLYFLLAVGLSIVFGLLRFVNFAHGAFYALGAYLCFQALQFGLDFWAALILAPIIIGALAWLTEK
VMLRYVYAQPHEFHILITVGLALAVQELIIVGWGPLGVDVPPPDVLQGVVMWGDFVYPKYRLFVIGFTALLAVALWWLLE
GTRIGSAVRAGSESTEMVSLLGINVFRLFSLMFALGAGTAAIAGVLAAPIRGAEPFMGVEALGVAFIVVVIGGMGSFTGA
LVGGLLVGIVQSLMSTLWPEGARLMIYVAMAAVLLLRPHGLLGRG

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG0559

COG function: function code E; Branched-chain amino acid ABC-type transport system, permease components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789866, Length=299, Percent_Identity=33.1103678929766, Blast_Score=118, Evalue=3e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851 [H]

Pfam domain/function: PF02653 BPD_transp_2 [H]

EC number: NA

Molecular weight: Translated: 30370; Mature: 30370

Theoretical pI: Translated: 6.96; Mature: 6.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNVYLLQVINGVGIGMLYFLLAVGLSIVFGLLRFVNFAHGAFYALGAYLCFQALQFGLDF
CCEEHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WAALILAPIIIGALAWLTEKVMLRYVYAQPHEFHILITVGLALAVQELIIVGWGPLGVDV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCC
PPPDVLQGVVMWGDFVYPKYRLFVIGFTALLAVALWWLLEGTRIGSAVRAGSESTEMVSL
CCHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCHHHHHHH
LGINVFRLFSLMFALGAGTAAIAGVLAAPIRGAEPFMGVEALGVAFIVVVIGGMGSFTGA
HHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHH
LVGGLLVGIVQSLMSTLWPEGARLMIYVAMAAVLLLRPHGLLGRG
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]