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The map label for this gene is lysR [H]

Identifier: 94313367

GI number: 94313367

Start: 1038346

End: 1039350

Strand: Reverse

Name: lysR [H]

Synonym: Rmet_4442

Alternate gene names: 94313367

Gene position: 1039350-1038346 (Counterclockwise)

Preceding gene: 94313368

Following gene: 94313366

Centisome position: 40.28

GC content: 69.05

Gene sequence:

>1005_bases
TTGCCCAAAACGGGGGTAACGGCGGTAACGGGGGTATTTCGGCCACTTGTCCGCTACACTGCGGCGCAATGCCGTCGATC
CAGCCCCCGCGCCATGCGCCTGCGTCACCTTGAAATCTTCCATGCGGTCATGCGTACCGGCTCGCTGAGCCGGGCCGCCG
AACTGCTCTTCATCTCCCAGCCCGCGGCCAGCAAGGTGCTGGCCCACGCGGAACGCGACCTCGGCTTCAAGCTGTTCACC
CGCGCGCACGGCCGGCTGCTGCCCACGCGCGAGGCGCAACTGCTGCACGCCGAAACGGTGCATCTGTTCGCTAACCTGGA
GAACGTGCGCCAGCTCGCGCGCAACCTGCGACGCCATCCCGAGGGCCATCTGCGCATTGGCTGCCTGCCGAGCCTGGGCC
TGAGCCTGATCCCGCAGGCGGTGCGAGAGTTTCGCCAGCGCTGCCCCGGCGTCTCGCTGGAAATCGAGACACGGCATGGC
GACGAACTGCAAGGCCTGGTGATGTCGCGCGAACTCGACATCGCCGTGGTCTTCGACCCGGCCCCGCGCCCGGGCGTGAC
ATCGAGCGCTCTCGGGCAAGCGGAAGTCGTCTACCTCGGCCCCGCCTCGAACGCACCGCCGCATGGGCCGGTGCAACTGG
CCGCGCTCGACGATCAGCACTGGATCGGCATCGGCAACAGCGACCCGCTGGGTGGCCTGATCGCCCAGGCCTTCCGCGAT
CTCGGGCTGGAGGAGCGCACGCCGATGATCGAGGCGCGTACCTATTACGTGGCCGCCGCGCTGGCGGAGTGCGGCGTCGG
CTACGCTCTGGTCGACCATTTCACGGCACAGTTCTCGCAGCGCGCTAGCGGCGAGGAACTGCTGATCCGCCCGCTGGAGC
CCGCCCTGTCGGTGGGCGTGGCCGCGATCTACGCGGACGGCGCGGCGTCCTCGCACGCCCACGACACCCTGCTGGCGATC
CTCGGATCCCAGTTCGAGGCGGCGCTGCCGGGCCGGCCTGAATAA

Upstream 100 bases:

>100_bases
AAGCGCGTGTGCATTGACTCGATCCACGACGGCAACCGGCAGATGTATGCGCTGGATGTCGCCTCGCTGGTCGATCCCGC
GTAAGCATCGGCCGAAAGCA

Downstream 100 bases:

>100_bases
CCTCAGGTTATAGGGTATGCGCTAAAGGTCATTTGAACCCTACCCCGCTCTCGTCAACACTGTCGCCTTGCCCGCAGTTG
CGGGCGGCAGGTCATTTTCA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 334; Mature: 333

Protein sequence:

>334_residues
MPKTGVTAVTGVFRPLVRYTAAQCRRSSPRAMRLRHLEIFHAVMRTGSLSRAAELLFISQPAASKVLAHAERDLGFKLFT
RAHGRLLPTREAQLLHAETVHLFANLENVRQLARNLRRHPEGHLRIGCLPSLGLSLIPQAVREFRQRCPGVSLEIETRHG
DELQGLVMSRELDIAVVFDPAPRPGVTSSALGQAEVVYLGPASNAPPHGPVQLAALDDQHWIGIGNSDPLGGLIAQAFRD
LGLEERTPMIEARTYYVAAALAECGVGYALVDHFTAQFSQRASGEELLIRPLEPALSVGVAAIYADGAASSHAHDTLLAI
LGSQFEAALPGRPE

Sequences:

>Translated_334_residues
MPKTGVTAVTGVFRPLVRYTAAQCRRSSPRAMRLRHLEIFHAVMRTGSLSRAAELLFISQPAASKVLAHAERDLGFKLFT
RAHGRLLPTREAQLLHAETVHLFANLENVRQLARNLRRHPEGHLRIGCLPSLGLSLIPQAVREFRQRCPGVSLEIETRHG
DELQGLVMSRELDIAVVFDPAPRPGVTSSALGQAEVVYLGPASNAPPHGPVQLAALDDQHWIGIGNSDPLGGLIAQAFRD
LGLEERTPMIEARTYYVAAALAECGVGYALVDHFTAQFSQRASGEELLIRPLEPALSVGVAAIYADGAASSHAHDTLLAI
LGSQFEAALPGRPE
>Mature_333_residues
PKTGVTAVTGVFRPLVRYTAAQCRRSSPRAMRLRHLEIFHAVMRTGSLSRAAELLFISQPAASKVLAHAERDLGFKLFTR
AHGRLLPTREAQLLHAETVHLFANLENVRQLARNLRRHPEGHLRIGCLPSLGLSLIPQAVREFRQRCPGVSLEIETRHGD
ELQGLVMSRELDIAVVFDPAPRPGVTSSALGQAEVVYLGPASNAPPHGPVQLAALDDQHWIGIGNSDPLGGLIAQAFRDL
GLEERTPMIEARTYYVAAALAECGVGYALVDHFTAQFSQRASGEELLIRPLEPALSVGVAAIYADGAASSHAHDTLLAIL
GSQFEAALPGRPE

Specific function: This protein activates the transcription of the lysA gene encoding diaminopimelate decarboxylase. LysR is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789204, Length=279, Percent_Identity=32.258064516129, Blast_Score=119, Evalue=3e-28,
Organism=Escherichia coli, GI1788481, Length=191, Percent_Identity=26.7015706806283, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788297, Length=174, Percent_Identity=29.8850574712644, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI87081904, Length=168, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1788887, Length=255, Percent_Identity=25.8823529411765, Blast_Score=68, Evalue=1e-12,
Organism=Escherichia coli, GI1789173, Length=161, Percent_Identity=31.055900621118, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI157672245, Length=193, Percent_Identity=26.4248704663212, Blast_Score=64, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 36143; Mature: 36012

Theoretical pI: Translated: 7.75; Mature: 7.75

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPKTGVTAVTGVFRPLVRYTAAQCRRSSPRAMRLRHLEIFHAVMRTGSLSRAAELLFISQ
CCCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHEEEECC
PAASKVLAHAERDLGFKLFTRAHGRLLPTREAQLLHAETVHLFANLENVRQLARNLRRHP
CHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EGHLRIGCLPSLGLSLIPQAVREFRQRCPGVSLEIETRHGDELQGLVMSRELDIAVVFDP
CCCEEEECCHHCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHEECCCCEEEEECC
APRPGVTSSALGQAEVVYLGPASNAPPHGPVQLAALDDQHWIGIGNSDPLGGLIAQAFRD
CCCCCCCHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHH
LGLEERTPMIEARTYYVAAALAECGVGYALVDHFTAQFSQRASGEELLIRPLEPALSVGV
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHCC
AAIYADGAASSHAHDTLLAILGSQFEAALPGRPE
CEEEECCCCCCHHHHHHHHHHHCCHHHCCCCCCC
>Mature Secondary Structure 
PKTGVTAVTGVFRPLVRYTAAQCRRSSPRAMRLRHLEIFHAVMRTGSLSRAAELLFISQ
CCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHHEEEECC
PAASKVLAHAERDLGFKLFTRAHGRLLPTREAQLLHAETVHLFANLENVRQLARNLRRHP
CHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
EGHLRIGCLPSLGLSLIPQAVREFRQRCPGVSLEIETRHGDELQGLVMSRELDIAVVFDP
CCCEEEECCHHCHHHHHHHHHHHHHHHCCCCEEEEECCCCCHHHHHHEECCCCEEEEECC
APRPGVTSSALGQAEVVYLGPASNAPPHGPVQLAALDDQHWIGIGNSDPLGGLIAQAFRD
CCCCCCCHHCCCCEEEEEECCCCCCCCCCCEEEEEECCCCEEECCCCCCHHHHHHHHHHH
LGLEERTPMIEARTYYVAAALAECGVGYALVDHFTAQFSQRASGEELLIRPLEPALSVGV
CCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCEEEECCCHHHHHCC
AAIYADGAASSHAHDTLLAILGSQFEAALPGRPE
CEEEECCCCCCHHHHHHHHHHHCCHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6350602; 9278503; 2836407 [H]