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The map label for this gene is shc [H]

Identifier: 94313328

GI number: 94313328

Start: 998718

End: 1000703

Strand: Reverse

Name: shc [H]

Synonym: Rmet_4403

Alternate gene names: 94313328

Gene position: 1000703-998718 (Counterclockwise)

Preceding gene: 94313329

Following gene: 94313327

Centisome position: 38.79

GC content: 65.71

Gene sequence:

>1986_bases
ATGACCAGAAAAACAATCCCCGCATCGGAACTCGATGCTGCGATCGTCCGCGCACGCGACGCATTGCTGGACCGCCAGCA
CCCCGACGGCCACTGGTGTTTCGAACTCGAATGCGATGCCACCATCACGGCCGAGTACATCCTGATGATGCACTTCGTCG
ACGAGATCGACACCGCGCTGCAGGCCCGCATGGCGAAGTACCTGCGCGCGGTGCAACGGCTCGACGGCCATGGCGCATGG
GACCTCTACTTCGGCGGCGATCTCGATATCTCCTGCAGCGTCAAGGCCTACTTCGCGTTGAAGGCGGCGGGCGATCCGCC
GGATGCGCCGCATATGGTCAGGGCGCGCGAAGCCATCCTGGCGCGCGGCGGCGCGGCGAAGTCGAACGTGTTCACGCGCA
TCCTGCTGGCGACCTTCGGCGAGATCCCTTGGCGCGGCACGCCGTTCATGCCGGTGGAATTCGTGCTGTTTCCGCGCTGG
GCGCCGATCCACATGGACAAGGTGGCCTACTGGGCGCGTACCACGATGGTGCCGCTGCTGGTGCTGTGCTCGATACGCGC
CGCCGCGAAGAATCCGCTTGGCGTGCATGTGCAGGAACTGTTCGTCACGCCGCCCGAACTGGAGCGCGAATACTTCCCGC
GCAAGCGTGGGCTGCAGCAAGCGTTTCTGGTCGCGGACCGCGTGGTTCGCCATCTCGAACCGCTGATTCCGCGTGCATTG
CGCCGCCGGGCCATCCAGCGCGCGGTGGAATGGTCCGAAGCCCGCATGAACGGTGAAGACGGCTTCGGCGGCATCTTCCC
GCCGATGGTGTACAGCTACGAGATGATGGTGCTGCTCGACTACCCGGAGGATCATCCGTTGCGGGTGGAGTGCAAGGCCG
CGCTGAAGAAGCTCGTGGTCCATCGCGACGATGGTTCGTCGTATTGTCAGCCCTGCCTGTCGCCGGTGTGGGACACAGCC
TGGAGCGTGATGGCGCTCGAACAGGCACCCTCTGACGCACGCACCGAAACCGCCATCGCCCGCGCCTACGACTGGCTCAC
CGATCGTCAGGTGCTGGACCTGCGCGGCGACTGGGAAAACAATGCTGCGCCCAGCACGCCGCCTGGCGGCTGGGCATTCC
AGTACGAGAACCCGTACTACCCGGACATCGACGATTCGGCCGTCGTCCTGGCGATGCTTCACGCGCGTGGCAAGCGCACC
GGCCAGCCCGGGCGCTACGAGATGCCCGTCGCGCGTTGTCTGGACTGGATCATCGGGCTGCAGTCGCGCAACGGCGGCTT
TGGCGCGTTCGATGCGAACTGCGATCGCGACTTTCTCAATGCGATCCCGTTCGCCGATCACGGCGCTCTGCTCGATCCTC
CAACCGAGGACGTCTCCGGCCGCGTGCTGCTGGCACTTGGCATCACCGAGCGTCCGCAGGACGCTACCGCACGCGAGCGC
TGCATCCAGTACCTGCGCGACACGCAACAGCCCGATGGCAGTTGGTGGGGACGCTGGGGCACCAACTACATCTACGGCAC
CTGGAGCGTGCTGGCGGGCCTGGGGCTCGCCGGTGTCGATCGCAAGCTGCCGATGGTGCGCAACGGCCTGCAATGGCTGC
GCGGCAAGCAGAACGCCGACGGCGGCTGGGGCGAGACGAACGACAGCTATGCCCGCCCGGAACTGGCCGGCAAGCACGAA
GACGGCAGCATGGCCGAGCAAACGGCGTGGGCCATGCTCGGACAGATGGCCGTCGGCGAAGGAGATGCGGATTCGGTGCA
TCGTGGCGCCGCGTATCTGCTCGATGCGCAGAACGAAGATGGCTTCTGGATGCACCCGTATCACAACGCACCGGGCTTCC
CGCGCATCTTCCACCTGAAGTACCACGGGTACACAGCGTACTTCCCGCTGTGGGCGCTTGGCCGATACCGGCGGCTTGCG
GCCGCGCGCGCGTCGGCTATGCAAACGGCGAAAGCCGAATCCGCCGAATCCATGACGGCGCACTGA

Upstream 100 bases:

>100_bases
GGCTGGCCGATCTTCTTGGCCATCGCGCCATTCCCCCGGCTCAACGGGCTGAGCTGGTTCGCCGGCTCGAGCAATTAACG
CACTGCCGTCCTCAACAAGC

Downstream 100 bases:

>100_bases
TCGGGAAAGCACGCTAGGCGGCGCGGGCTGGAAAGTGCTACTGTCGCCCCATCCCCCGCTCCCGCCAGCCAGGCATGTCA
GAACGCCCGACGTATGAGGT

Product: Squalene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 661; Mature: 660

Protein sequence:

>661_residues
MTRKTIPASELDAAIVRARDALLDRQHPDGHWCFELECDATITAEYILMMHFVDEIDTALQARMAKYLRAVQRLDGHGAW
DLYFGGDLDISCSVKAYFALKAAGDPPDAPHMVRAREAILARGGAAKSNVFTRILLATFGEIPWRGTPFMPVEFVLFPRW
APIHMDKVAYWARTTMVPLLVLCSIRAAAKNPLGVHVQELFVTPPELEREYFPRKRGLQQAFLVADRVVRHLEPLIPRAL
RRRAIQRAVEWSEARMNGEDGFGGIFPPMVYSYEMMVLLDYPEDHPLRVECKAALKKLVVHRDDGSSYCQPCLSPVWDTA
WSVMALEQAPSDARTETAIARAYDWLTDRQVLDLRGDWENNAAPSTPPGGWAFQYENPYYPDIDDSAVVLAMLHARGKRT
GQPGRYEMPVARCLDWIIGLQSRNGGFGAFDANCDRDFLNAIPFADHGALLDPPTEDVSGRVLLALGITERPQDATARER
CIQYLRDTQQPDGSWWGRWGTNYIYGTWSVLAGLGLAGVDRKLPMVRNGLQWLRGKQNADGGWGETNDSYARPELAGKHE
DGSMAEQTAWAMLGQMAVGEGDADSVHRGAAYLLDAQNEDGFWMHPYHNAPGFPRIFHLKYHGYTAYFPLWALGRYRRLA
AARASAMQTAKAESAESMTAH

Sequences:

>Translated_661_residues
MTRKTIPASELDAAIVRARDALLDRQHPDGHWCFELECDATITAEYILMMHFVDEIDTALQARMAKYLRAVQRLDGHGAW
DLYFGGDLDISCSVKAYFALKAAGDPPDAPHMVRAREAILARGGAAKSNVFTRILLATFGEIPWRGTPFMPVEFVLFPRW
APIHMDKVAYWARTTMVPLLVLCSIRAAAKNPLGVHVQELFVTPPELEREYFPRKRGLQQAFLVADRVVRHLEPLIPRAL
RRRAIQRAVEWSEARMNGEDGFGGIFPPMVYSYEMMVLLDYPEDHPLRVECKAALKKLVVHRDDGSSYCQPCLSPVWDTA
WSVMALEQAPSDARTETAIARAYDWLTDRQVLDLRGDWENNAAPSTPPGGWAFQYENPYYPDIDDSAVVLAMLHARGKRT
GQPGRYEMPVARCLDWIIGLQSRNGGFGAFDANCDRDFLNAIPFADHGALLDPPTEDVSGRVLLALGITERPQDATARER
CIQYLRDTQQPDGSWWGRWGTNYIYGTWSVLAGLGLAGVDRKLPMVRNGLQWLRGKQNADGGWGETNDSYARPELAGKHE
DGSMAEQTAWAMLGQMAVGEGDADSVHRGAAYLLDAQNEDGFWMHPYHNAPGFPRIFHLKYHGYTAYFPLWALGRYRRLA
AARASAMQTAKAESAESMTAH
>Mature_660_residues
TRKTIPASELDAAIVRARDALLDRQHPDGHWCFELECDATITAEYILMMHFVDEIDTALQARMAKYLRAVQRLDGHGAWD
LYFGGDLDISCSVKAYFALKAAGDPPDAPHMVRAREAILARGGAAKSNVFTRILLATFGEIPWRGTPFMPVEFVLFPRWA
PIHMDKVAYWARTTMVPLLVLCSIRAAAKNPLGVHVQELFVTPPELEREYFPRKRGLQQAFLVADRVVRHLEPLIPRALR
RRAIQRAVEWSEARMNGEDGFGGIFPPMVYSYEMMVLLDYPEDHPLRVECKAALKKLVVHRDDGSSYCQPCLSPVWDTAW
SVMALEQAPSDARTETAIARAYDWLTDRQVLDLRGDWENNAAPSTPPGGWAFQYENPYYPDIDDSAVVLAMLHARGKRTG
QPGRYEMPVARCLDWIIGLQSRNGGFGAFDANCDRDFLNAIPFADHGALLDPPTEDVSGRVLLALGITERPQDATARERC
IQYLRDTQQPDGSWWGRWGTNYIYGTWSVLAGLGLAGVDRKLPMVRNGLQWLRGKQNADGGWGETNDSYARPELAGKHED
GSMAEQTAWAMLGQMAVGEGDADSVHRGAAYLLDAQNEDGFWMHPYHNAPGFPRIFHLKYHGYTAYFPLWALGRYRRLAA
ARASAMQTAKAESAESMTAH

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 4 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI47933395, Length=663, Percent_Identity=25.6410256410256, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI47933397, Length=663, Percent_Identity=25.6410256410256, Blast_Score=162, Evalue=9e-40,
Organism=Homo sapiens, GI224177558, Length=663, Percent_Identity=25.6410256410256, Blast_Score=162, Evalue=1e-39,
Organism=Homo sapiens, GI224177556, Length=663, Percent_Identity=25.1885369532428, Blast_Score=150, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6321863, Length=599, Percent_Identity=23.0383973288815, Blast_Score=112, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 74128; Mature: 73997

Theoretical pI: Translated: 6.38; Mature: 6.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTRKTIPASELDAAIVRARDALLDRQHPDGHWCFELECDATITAEYILMMHFVDEIDTAL
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
QARMAKYLRAVQRLDGHGAWDLYFGGDLDISCSVKAYFALKAAGDPPDAPHMVRAREAIL
HHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEEEEEECCCCCCCCHHHHHHHHHH
ARGGAAKSNVFTRILLATFGEIPWRGTPFMPVEFVLFPRWAPIHMDKVAYWARTTMVPLL
HCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
VLCSIRAAAKNPLGVHVQELFVTPPELEREYFPRKRGLQQAFLVADRVVRHLEPLIPRAL
HHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRRAIQRAVEWSEARMNGEDGFGGIFPPMVYSYEMMVLLDYPEDHPLRVECKAALKKLVV
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCEEEEEEEECCCCCCEEEEHHHHHHHHHE
HRDDGSSYCQPCLSPVWDTAWSVMALEQAPSDARTETAIARAYDWLTDRQVLDLRGDWEN
ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCC
NAAPSTPPGGWAFQYENPYYPDIDDSAVVLAMLHARGKRTGQPGRYEMPVARCLDWIIGL
CCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
QSRNGGFGAFDANCDRDFLNAIPFADHGALLDPPTEDVSGRVLLALGITERPQDATARER
CCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHH
CIQYLRDTQQPDGSWWGRWGTNYIYGTWSVLAGLGLAGVDRKLPMVRNGLQWLRGKQNAD
HHHHHHHCCCCCCCCCCCCCCCEEEECHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCC
GGWGETNDSYARPELAGKHEDGSMAEQTAWAMLGQMAVGEGDADSVHRGAAYLLDAQNED
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEEECCCCC
GFWMHPYHNAPGFPRIFHLKYHGYTAYFPLWALGRYRRLAAARASAMQTAKAESAESMTA
CCEECCCCCCCCCCEEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
H
C
>Mature Secondary Structure 
TRKTIPASELDAAIVRARDALLDRQHPDGHWCFELECDATITAEYILMMHFVDEIDTAL
CCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHH
QARMAKYLRAVQRLDGHGAWDLYFGGDLDISCSVKAYFALKAAGDPPDAPHMVRAREAIL
HHHHHHHHHHHHHHCCCCCEEEEECCCCCEEEEEEEEEEEEECCCCCCCCHHHHHHHHHH
ARGGAAKSNVFTRILLATFGEIPWRGTPFMPVEFVLFPRWAPIHMDKVAYWARTTMVPLL
HCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHH
VLCSIRAAAKNPLGVHVQELFVTPPELEREYFPRKRGLQQAFLVADRVVRHLEPLIPRAL
HHHHHHHHHCCCCCCCHHHHCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RRRAIQRAVEWSEARMNGEDGFGGIFPPMVYSYEMMVLLDYPEDHPLRVECKAALKKLVV
HHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHCEEEEEEEECCCCCCEEEEHHHHHHHHHE
HRDDGSSYCQPCLSPVWDTAWSVMALEQAPSDARTETAIARAYDWLTDRQVLDLRGDWEN
ECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEECCCCCCC
NAAPSTPPGGWAFQYENPYYPDIDDSAVVLAMLHARGKRTGQPGRYEMPVARCLDWIIGL
CCCCCCCCCCEEEECCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
QSRNGGFGAFDANCDRDFLNAIPFADHGALLDPPTEDVSGRVLLALGITERPQDATARER
CCCCCCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCHHHHHH
CIQYLRDTQQPDGSWWGRWGTNYIYGTWSVLAGLGLAGVDRKLPMVRNGLQWLRGKQNAD
HHHHHHHCCCCCCCCCCCCCCCEEEECHHHHHCCCCCCCCCCCHHHHHHHHHHCCCCCCC
GGWGETNDSYARPELAGKHEDGSMAEQTAWAMLGQMAVGEGDADSVHRGAAYLLDAQNED
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHCCEEEEEECCCCC
GFWMHPYHNAPGFPRIFHLKYHGYTAYFPLWALGRYRRLAAARASAMQTAKAESAESMTA
CCEECCCCCCCCCCEEEEEEECCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHCC
H
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7894707 [H]