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The map label for this gene is fahA

Identifier: 94313300

GI number: 94313300

Start: 973929

End: 975191

Strand: Direct

Name: fahA

Synonym: Rmet_4375

Alternate gene names: NA

Gene position: 973929-975191 (Clockwise)

Preceding gene: 94313299

Following gene: 94313301

Centisome position: 37.75

GC content: 64.37

Gene sequence:

>1263_bases
ATGACTGCCCCCAAGACTAGCTGGGTCAATTCCGCGAACGACGGCCAGACCCATTTCCCGCTGCAGAACCTGCCGTATGG
CATCTTTTCGACCACGGGCGGCGCGGCACGCGTGGGCGTGGCGATCGGCAACCAGATCGTCGATCTGGCTGCGCTGGACG
ATGCCGGCCTGATGCCGACGGCGGCCAAGGGCGCGTTTGCAGCGTCGAGCCTCAACCGCTTTATCGCGCTGGGCAAGCCG
GTCTGGACCGACGTGCGCGCGCGCCTGACCGCGCTGCTGTCCGCCGATGACCAGCGGCTCTCCGGCAACGTGGCGCTGCG
CGACAAGGCACTCGTGCCGATGTCGGCCGCCACGCTGCATTTGCCGGTGGATATTCCCGGCTATACGGACTTCTATTCGT
CGCGCGAACACGCCACCAACGTTGGCCGCATGTTCCGCGATCCCGAAAACGCGCTGCTGCCAAACTGGCTCGAAATCCCG
ATCGGCTATAACGGCCGTGCGAGTTCGGTGGTCGTCAGCGGCACCGCGCTGCATCGTCCCAATGGCCAGATCAAGCTGCC
GAACGAGGCACGCCCGATCTTCAGCCCCTGCCGCAAGCTTGATTACGAGCTCGAGATGGCCTTTATCGTCGGCAAGCCGT
CGAACCTCGGCGAGCCGGTGAGCACAGGCGATGCCCCGGCCCATATGTTCGGTCTGGTGATCCTCAACGATTGGAGCGCC
CGCGATATCCAGCAGTGGGAGTACGTGCCGCTCGGTCCGTTCAACAGCAAGTCCTTCGGCACCTCAATTTCGCCGTGGGT
GGTGACGATGGACGCGCTGGAGCCGTTCCGCCGCGAAAACCCGGCGCAATCGCCGGAGCCGTTGCCGTATCTGCAGCAGC
AAGGGCAAAACGCCTACGACATCGACCTGGAAGTGGCGCTGCAACCAGCCGGCGCCACGGCGGCCAGCACGGTGTGCCGC
ACCAACTTCAAGGCGATGTACTGGACCATGGCGCAGCAACTGGCCCACCACACGGTATCGGGCTGCAATGTGCGCATTGG
CGACCTGATGGGCTCCGGCACGATCAGCGGCACTACGTCGGATTCGTGCGGCAGCCTGCTGGAAACCACGCGTAATGGTG
CGGAACCCGTCACCTTGGCTGATGGCGCGAAGCGCGGTTTCCTCGAGGATGGCGATACCGTGACCATGACGGGCTGGTGT
CAGGGCGAAGGGTATCGCGTCGGCTTCGGCGAGGTAACAGGTAAAATCCTGCCGGCGCGCTAA

Upstream 100 bases:

>100_bases
AGCACGATTACTACACCTGCTGGCAAGGCCTGAAGAAGCATTTCAACCCGAACGTGCGTTGATCTGACGCGACTCTCGCA
CCAATAGGAGTAACAAGATA

Downstream 100 bases:

>100_bases
GTACCGCGACGGCTGCTACGGCGGCCACGGCAAGTCAACAGGGCGGAGCGGCAAGAAAGTGCTGCATCCGCCCTGTTACA
TTTCCGAAATTCCGTTACTT

Product: fumarylacetoacetase

Products: acetoacetate; fumarate

Alternate protein names: Fumarylacetoacetate Hydrolase; Fumarylacetoacetate Hydrolase Family Protein; Hydroxylase; Fumarylacetoacetase Hydrolase; LOW QUALITY PROTEIN Fumarylacetoacetase

Number of amino acids: Translated: 420; Mature: 419

Protein sequence:

>420_residues
MTAPKTSWVNSANDGQTHFPLQNLPYGIFSTTGGAARVGVAIGNQIVDLAALDDAGLMPTAAKGAFAASSLNRFIALGKP
VWTDVRARLTALLSADDQRLSGNVALRDKALVPMSAATLHLPVDIPGYTDFYSSREHATNVGRMFRDPENALLPNWLEIP
IGYNGRASSVVVSGTALHRPNGQIKLPNEARPIFSPCRKLDYELEMAFIVGKPSNLGEPVSTGDAPAHMFGLVILNDWSA
RDIQQWEYVPLGPFNSKSFGTSISPWVVTMDALEPFRRENPAQSPEPLPYLQQQGQNAYDIDLEVALQPAGATAASTVCR
TNFKAMYWTMAQQLAHHTVSGCNVRIGDLMGSGTISGTTSDSCGSLLETTRNGAEPVTLADGAKRGFLEDGDTVTMTGWC
QGEGYRVGFGEVTGKILPAR

Sequences:

>Translated_420_residues
MTAPKTSWVNSANDGQTHFPLQNLPYGIFSTTGGAARVGVAIGNQIVDLAALDDAGLMPTAAKGAFAASSLNRFIALGKP
VWTDVRARLTALLSADDQRLSGNVALRDKALVPMSAATLHLPVDIPGYTDFYSSREHATNVGRMFRDPENALLPNWLEIP
IGYNGRASSVVVSGTALHRPNGQIKLPNEARPIFSPCRKLDYELEMAFIVGKPSNLGEPVSTGDAPAHMFGLVILNDWSA
RDIQQWEYVPLGPFNSKSFGTSISPWVVTMDALEPFRRENPAQSPEPLPYLQQQGQNAYDIDLEVALQPAGATAASTVCR
TNFKAMYWTMAQQLAHHTVSGCNVRIGDLMGSGTISGTTSDSCGSLLETTRNGAEPVTLADGAKRGFLEDGDTVTMTGWC
QGEGYRVGFGEVTGKILPAR
>Mature_419_residues
TAPKTSWVNSANDGQTHFPLQNLPYGIFSTTGGAARVGVAIGNQIVDLAALDDAGLMPTAAKGAFAASSLNRFIALGKPV
WTDVRARLTALLSADDQRLSGNVALRDKALVPMSAATLHLPVDIPGYTDFYSSREHATNVGRMFRDPENALLPNWLEIPI
GYNGRASSVVVSGTALHRPNGQIKLPNEARPIFSPCRKLDYELEMAFIVGKPSNLGEPVSTGDAPAHMFGLVILNDWSAR
DIQQWEYVPLGPFNSKSFGTSISPWVVTMDALEPFRRENPAQSPEPLPYLQQQGQNAYDIDLEVALQPAGATAASTVCRT
NFKAMYWTMAQQLAHHTVSGCNVRIGDLMGSGTISGTTSDSCGSLLETTRNGAEPVTLADGAKRGFLEDGDTVTMTGWCQ
GEGYRVGFGEVTGKILPAR

Specific function: Unknown

COG id: COG0179

COG function: function code Q; 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4557587, Length=416, Percent_Identity=54.0865384615385, Blast_Score=469, Evalue=1e-132,
Organism=Caenorhabditis elegans, GI17568863, Length=407, Percent_Identity=53.3169533169533, Blast_Score=437, Evalue=1e-123,
Organism=Drosophila melanogaster, GI24657182, Length=404, Percent_Identity=51.2376237623762, Blast_Score=412, Evalue=1e-115,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.7.1.2

Molecular weight: Translated: 45042; Mature: 44911

Theoretical pI: Translated: 5.65; Mature: 5.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAPKTSWVNSANDGQTHFPLQNLPYGIFSTTGGAARVGVAIGNQIVDLAALDDAGLMPT
CCCCCCCCCCCCCCCCEECCHHHCCCCEEECCCCCEEEEEECCCCEEEEEEECCCCCCCC
AAKGAFAASSLNRFIALGKPVWTDVRARLTALLSADDQRLSGNVALRDKALVPMSAATLH
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEE
LPVDIPGYTDFYSSREHATNVGRMFRDPENALLPNWLEIPIGYNGRASSVVVSGTALHRP
EEEECCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEECEEEECC
NGQIKLPNEARPIFSPCRKLDYELEMAFIVGKPSNLGEPVSTGDAPAHMFGLVILNDWSA
CCCEECCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCC
RDIQQWEYVPLGPFNSKSFGTSISPWVVTMDALEPFRRENPAQSPEPLPYLQQQGQNAYD
CCCCCCCEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEE
IDLEVALQPAGATAASTVCRTNFKAMYWTMAQQLAHHTVSGCNVRIGDLMGSGTISGTTS
EEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECEECCCEECCCCC
DSCGSLLETTRNGAEPVTLADGAKRGFLEDGDTVTMTGWCQGEGYRVGFGEVTGKILPAR
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEEEEEECCCCEEEEHHHCCCEEECCC
>Mature Secondary Structure 
TAPKTSWVNSANDGQTHFPLQNLPYGIFSTTGGAARVGVAIGNQIVDLAALDDAGLMPT
CCCCCCCCCCCCCCCEECCHHHCCCCEEECCCCCEEEEEECCCCEEEEEEECCCCCCCC
AAKGAFAASSLNRFIALGKPVWTDVRARLTALLSADDQRLSGNVALRDKALVPMSAATLH
CCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEE
LPVDIPGYTDFYSSREHATNVGRMFRDPENALLPNWLEIPIGYNGRASSVVVSGTALHRP
EEEECCCCHHHHCCHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCCEEEEECEEEECC
NGQIKLPNEARPIFSPCRKLDYELEMAFIVGKPSNLGEPVSTGDAPAHMFGLVILNDWSA
CCCEECCCCCCHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCCCCEEEEEEEECCCC
RDIQQWEYVPLGPFNSKSFGTSISPWVVTMDALEPFRRENPAQSPEPLPYLQQQGQNAYD
CCCCCCCEEECCCCCCCCCCCCCCCCEEEHHHHHHHHHCCCCCCCCCCCHHHHCCCCEEE
IDLEVALQPAGATAASTVCRTNFKAMYWTMAQQLAHHTVSGCNVRIGDLMGSGTISGTTS
EEEEEEEECCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCCEEEECEECCCEECCCCC
DSCGSLLETTRNGAEPVTLADGAKRGFLEDGDTVTMTGWCQGEGYRVGFGEVTGKILPAR
HHHHHHHHHHCCCCCCEEECCCCCCCCCCCCCEEEEEEEECCCCEEEEHHHCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: 4-fumarylacetoacetate; H2O

Specific reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA