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The map label for this gene is hmgA [H]

Identifier: 94313299

GI number: 94313299

Start: 972562

End: 973890

Strand: Direct

Name: hmgA [H]

Synonym: Rmet_4374

Alternate gene names: 94313299

Gene position: 972562-973890 (Clockwise)

Preceding gene: 291481528

Following gene: 94313300

Centisome position: 37.69

GC content: 64.03

Gene sequence:

>1329_bases
ATGACCCAGACCCAACTCAATGTGGCCGACACCGCCGTGGCGGAGTACATGTCCGGTTTTGCCAATGAGTTCGCCACGGA
GGCGTTGCCCGGCGCGTTGCCGGTAGGACGCAACTCGCCGCAGCGCGCGCCGTATGGCCTGTATGCCGAACAGCTATCGG
GCACCGCGTTCACCGCGCCGCGCGCCCACAATCGCCGTTCGTGGCTGTATCGCATTCGCCCGGCAGCCATGCACAAGCCG
TTCACGTTGATCGAGCAGGATCGTTGGCTGAGCCGCTTCGACGAAGTGGCGCCATCGCCCAATCAGATGCGCTGGAGTGC
GCCGGCCATGCCGACCGTTCCCACCGACTTTGTCGATGGCATCGTCACGATGGCTGGTAACGGCGGTCCGGAAGCGCTGT
CCGGGTGCGGGATCCATCTGTATCTGGCCAACGCGTCGATGCGGGACCGCTTCTTCTACAACGCCGATGGCGAAATGCTG
ATCGTGCCGCAGGAGGGCCGTCTGCTGATCGTCACCGAGATGGGGCGCCTGGCGGTGGAGCCGCAGGAGATCGTGGTGAT
CCCGCGCGGCGTGCGTTTCCGCGTGGAACTGCCCGACGGCGCGGCGCGTGGCTATATCTGCGAAAACTACGGCGCGATGT
TCAAGCTGCCCGACCTCGGCGTAATCGGCTCCAACGGGCTGGCCAACCCGCGTGATTTCCTGACGCCGGTCGCCAGCTAC
GAGGATCGCGAAGGCGACTTCGAACTGGTCGCCCGTTTCCAGGGCAATCTGTGGCGTGCCGACATTGGCCACTCGCCGCT
CGATGTGGTGGCGTGGCACGGCAACTATGTGCCGTACAAGTACGATCTGCGCCTCTTCAACACGATCGGCTCGATCAGCT
ACGACCATCCGGACCCGTCGATTTTCCTGGTGCTGCAATCGCCGTCGGATACGCCGGGCGTGGACACGATCGACTTCGTG
ATCTTCGGCCCGCGCTGGCTGGCTGCGGAAGACACGTTCCGTCCGCCCTGGTTCCACCGCAATATCGCCAGCGAATTCAT
GGGTTTGATCGCGGGCGAGTATGACGCCAAGGCCGAAGGCTTTGTGCCGGGCGGGGCGAGCCTGCACAACTGCATGAGCG
GTCACGGCCCCGATGCGGAGACCTTCGAGCGTGCGTCCGCCTCTGACACCAGCAAGCCGCACCACATCACGGACACGATG
GCATTCATGTTCGAAACCCCGGGCGTGATCCGTCCGACGCGGCACGCTGCCGAGTCGGCGCTGCTCCAGCACGATTACTA
CACCTGCTGGCAAGGCCTGAAGAAGCATTTCAACCCGAACGTGCGTTGA

Upstream 100 bases:

>100_bases
ATCGTCACAGGACGGGCCTGGCGTTCGCCAGCAGCCAGTCTCCTTGCCGCCCAGGATGCTCGCCGCGTCGCAGGTACGAG
CAAAGTGAGAGGAAGACTTC

Downstream 100 bases:

>100_bases
TCTGACGCGACTCTCGCACCAATAGGAGTAACAAGATAATGACTGCCCCCAAGACTAGCTGGGTCAATTCCGCGAACGAC
GGCCAGACCCATTTCCCGCT

Product: homogentisate 1,2-dioxygenase

Products: NA

Alternate protein names: Homogentisate oxygenase; Homogentisic acid oxidase; Homogentisicase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTQTQLNVADTAVAEYMSGFANEFATEALPGALPVGRNSPQRAPYGLYAEQLSGTAFTAPRAHNRRSWLYRIRPAAMHKP
FTLIEQDRWLSRFDEVAPSPNQMRWSAPAMPTVPTDFVDGIVTMAGNGGPEALSGCGIHLYLANASMRDRFFYNADGEML
IVPQEGRLLIVTEMGRLAVEPQEIVVIPRGVRFRVELPDGAARGYICENYGAMFKLPDLGVIGSNGLANPRDFLTPVASY
EDREGDFELVARFQGNLWRADIGHSPLDVVAWHGNYVPYKYDLRLFNTIGSISYDHPDPSIFLVLQSPSDTPGVDTIDFV
IFGPRWLAAEDTFRPPWFHRNIASEFMGLIAGEYDAKAEGFVPGGASLHNCMSGHGPDAETFERASASDTSKPHHITDTM
AFMFETPGVIRPTRHAAESALLQHDYYTCWQGLKKHFNPNVR

Sequences:

>Translated_442_residues
MTQTQLNVADTAVAEYMSGFANEFATEALPGALPVGRNSPQRAPYGLYAEQLSGTAFTAPRAHNRRSWLYRIRPAAMHKP
FTLIEQDRWLSRFDEVAPSPNQMRWSAPAMPTVPTDFVDGIVTMAGNGGPEALSGCGIHLYLANASMRDRFFYNADGEML
IVPQEGRLLIVTEMGRLAVEPQEIVVIPRGVRFRVELPDGAARGYICENYGAMFKLPDLGVIGSNGLANPRDFLTPVASY
EDREGDFELVARFQGNLWRADIGHSPLDVVAWHGNYVPYKYDLRLFNTIGSISYDHPDPSIFLVLQSPSDTPGVDTIDFV
IFGPRWLAAEDTFRPPWFHRNIASEFMGLIAGEYDAKAEGFVPGGASLHNCMSGHGPDAETFERASASDTSKPHHITDTM
AFMFETPGVIRPTRHAAESALLQHDYYTCWQGLKKHFNPNVR
>Mature_441_residues
TQTQLNVADTAVAEYMSGFANEFATEALPGALPVGRNSPQRAPYGLYAEQLSGTAFTAPRAHNRRSWLYRIRPAAMHKPF
TLIEQDRWLSRFDEVAPSPNQMRWSAPAMPTVPTDFVDGIVTMAGNGGPEALSGCGIHLYLANASMRDRFFYNADGEMLI
VPQEGRLLIVTEMGRLAVEPQEIVVIPRGVRFRVELPDGAARGYICENYGAMFKLPDLGVIGSNGLANPRDFLTPVASYE
DREGDFELVARFQGNLWRADIGHSPLDVVAWHGNYVPYKYDLRLFNTIGSISYDHPDPSIFLVLQSPSDTPGVDTIDFVI
FGPRWLAAEDTFRPPWFHRNIASEFMGLIAGEYDAKAEGFVPGGASLHNCMSGHGPDAETFERASASDTSKPHHITDTMA
FMFETPGVIRPTRHAAESALLQHDYYTCWQGLKKHFNPNVR

Specific function: Unknown

COG id: COG3508

COG function: function code Q; Homogentisate 1,2-dioxygenase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the homogentisate dioxygenase family [H]

Homologues:

Organism=Homo sapiens, GI115527117, Length=440, Percent_Identity=52.9545454545455, Blast_Score=466, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI17507969, Length=429, Percent_Identity=53.8461538461538, Blast_Score=456, Evalue=1e-128,
Organism=Drosophila melanogaster, GI24583650, Length=434, Percent_Identity=52.073732718894, Blast_Score=437, Evalue=1e-123,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011051
- InterPro:   IPR005708
- InterPro:   IPR022950 [H]

Pfam domain/function: PF04209 HgmA [H]

EC number: =1.13.11.5 [H]

Molecular weight: Translated: 49061; Mature: 48930

Theoretical pI: Translated: 5.55; Mature: 5.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTQLNVADTAVAEYMSGFANEFATEALPGALPVGRNSPQRAPYGLYAEQLSGTAFTAP
CCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCEEECC
RAHNRRSWLYRIRPAAMHKPFTLIEQDRWLSRFDEVAPSPNQMRWSAPAMPTVPTDFVDG
CCCCCCCEEEEECHHHHCCCCEEEHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHCC
IVTMAGNGGPEALSGCGIHLYLANASMRDRFFYNADGEMLIVPQEGRLLIVTEMGRLAVE
EEEECCCCCHHHHCCCEEEEEEECCCCCCCEEECCCCCEEEEECCCCEEEEEECCCEEEC
PQEIVVIPRGVRFRVELPDGAARGYICENYGAMFKLPDLGVIGSNGLANPRDFLTPVASY
CCEEEEEECCEEEEEECCCCCCCCCEECCCCCEEECCCCCEECCCCCCCCHHHHCHHHCC
EDREGDFELVARFQGNLWRADIGHSPLDVVAWHGNYVPYKYDLRLFNTIGSISYDHPDPS
CCCCCCCEEHEECCCCEEEECCCCCCCEEEEECCCCCCEEEEEEEEEHHCCCCCCCCCCE
IFLVLQSPSDTPGVDTIDFVIFGPRWLAAEDTFRPPWFHRNIASEFMGLIAGEYDAKAEG
EEEEEECCCCCCCCCEEEEEEECCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
FVPGGASLHNCMSGHGPDAETFERASASDTSKPHHITDTMAFMFETPGVIRPTRHAAESA
CCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
LLQHDYYTCWQGLKKHFNPNVR
HHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
TQTQLNVADTAVAEYMSGFANEFATEALPGALPVGRNSPQRAPYGLYAEQLSGTAFTAP
CCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHCCCEEECC
RAHNRRSWLYRIRPAAMHKPFTLIEQDRWLSRFDEVAPSPNQMRWSAPAMPTVPTDFVDG
CCCCCCCEEEEECHHHHCCCCEEEHHHHHHHHHHHHCCCCCCEEECCCCCCCCCHHHHCC
IVTMAGNGGPEALSGCGIHLYLANASMRDRFFYNADGEMLIVPQEGRLLIVTEMGRLAVE
EEEECCCCCHHHHCCCEEEEEEECCCCCCCEEECCCCCEEEEECCCCEEEEEECCCEEEC
PQEIVVIPRGVRFRVELPDGAARGYICENYGAMFKLPDLGVIGSNGLANPRDFLTPVASY
CCEEEEEECCEEEEEECCCCCCCCCEECCCCCEEECCCCCEECCCCCCCCHHHHCHHHCC
EDREGDFELVARFQGNLWRADIGHSPLDVVAWHGNYVPYKYDLRLFNTIGSISYDHPDPS
CCCCCCCEEHEECCCCEEEECCCCCCCEEEEECCCCCCEEEEEEEEEHHCCCCCCCCCCE
IFLVLQSPSDTPGVDTIDFVIFGPRWLAAEDTFRPPWFHRNIASEFMGLIAGEYDAKAEG
EEEEEECCCCCCCCCEEEEEEECCEEECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCC
FVPGGASLHNCMSGHGPDAETFERASASDTSKPHHITDTMAFMFETPGVIRPTRHAAESA
CCCCCCHHHHHHCCCCCCHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHH
LLQHDYYTCWQGLKKHFNPNVR
HHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA