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The map label for this gene is panE [C]

Identifier: 94313281

GI number: 94313281

Start: 951157

End: 952164

Strand: Direct

Name: panE [C]

Synonym: Rmet_4356

Alternate gene names: 94313281

Gene position: 951157-952164 (Clockwise)

Preceding gene: 94313276

Following gene: 94313282

Centisome position: 36.87

GC content: 65.58

Gene sequence:

>1008_bases
ATGAAAATTTGTATCTACGGCGCGGGCGCCATCGGCGGCTATATGGGCGCGCAACTGGCGCTGGCCGGGGCGGACGTCAG
TTTCATCGCCCGTGGGCCCCATCTGGCGGCGATGCAGGCAAACGGCGTGCGGTTGCTGATCGAAGGCGAGGAACGGGTGG
CCAAGGTCCGTTGCGCCAGCGACCCGCACGAACTCGGCCCTCAGGACTATGTGTTCATCACGCTCAAGGCGCACCAGGTG
CCTGGGGTGGTGGACCTGATGCAGCCGCTGCTCGGGCCGGACACTGCGGTGGTGACCGGCGTCAACGGCATCCCGTATTG
GTACTTCCATCAGCACGGCGGCGAGTTCGCGGGGCGCACGCTGGAAAGCGTCGATCCTGGCGCCCGCCAATGGAATGGGC
TGGGCCCGGAGCGTGCCATCGGCTGTGTGCTGTATCCAGCCGCCGAAATCATCGCGCCGGGCGTGATCAAGCATGTCTAT
GGCAAGAAATTCCCGATCGGGGAGCCGGACGGCACCCGCTCCGAGCGCGTGACCCGTCTGGCAGAGATGATGGCGCGGGC
GGACATGGACGCCCCGGTGCGCGACAACATTCGCGACGAGATCTGGCTCAAGCTCTGGGGCAACCTCTGCTTCAACCCGA
TCAGCGCCTTGACGCATGCGACGCTCGACATCATTACGTCGGACCCGGCCACGCGGGCGCTGTCGCGCCAGATGATGCTC
GAAGCGAAGCACATCGCCGAGAGCTTCGGTGTGCATTTCCGGGTAGACGTCGAACGTCGGATCGACGGTGCCGGTGCGGT
TGGCGCCCACAAGACGTCGATGCTGCAGGATCTGGAGGCGGGCAGGGCGATGGAAATCGACCCGCTGCTGACGGTGGTGC
AGGAGATGGGCCGAATGATCGGGCAGCCGACACCGATGATCGACGCGGTGCTCGGACTGATCAAGCAACGTGACCGGATG
GCCCAGGCAGCGCCTTCAGGCGCGGCGCCAATGGCCAAGGCAGCCTGA

Upstream 100 bases:

>100_bases
AGCAAAGATTGAGGTTGTCGAATGGCGATTGTGAAATATAGTATGTGATATATCAAAATTAACCATCACTCAGCAATCAC
AACCATCGAGGAGACAACCG

Downstream 100 bases:

>100_bases
AACGCGGACGGTCTGCCGGAAATCGGCGACAATCGGCATTGTGGTCAATGTGATATACGATATACGAAAGGTCGGATTCG
TCCCTTTCCAGGCCAGAACT

Product: 2-dehydropantoate 2-reductase

Products: NA

Alternate protein names: Ketopantoate reductase; KPA reductase; KPR [H]

Number of amino acids: Translated: 335; Mature: 335

Protein sequence:

>335_residues
MKICIYGAGAIGGYMGAQLALAGADVSFIARGPHLAAMQANGVRLLIEGEERVAKVRCASDPHELGPQDYVFITLKAHQV
PGVVDLMQPLLGPDTAVVTGVNGIPYWYFHQHGGEFAGRTLESVDPGARQWNGLGPERAIGCVLYPAAEIIAPGVIKHVY
GKKFPIGEPDGTRSERVTRLAEMMARADMDAPVRDNIRDEIWLKLWGNLCFNPISALTHATLDIITSDPATRALSRQMML
EAKHIAESFGVHFRVDVERRIDGAGAVGAHKTSMLQDLEAGRAMEIDPLLTVVQEMGRMIGQPTPMIDAVLGLIKQRDRM
AQAAPSGAAPMAKAA

Sequences:

>Translated_335_residues
MKICIYGAGAIGGYMGAQLALAGADVSFIARGPHLAAMQANGVRLLIEGEERVAKVRCASDPHELGPQDYVFITLKAHQV
PGVVDLMQPLLGPDTAVVTGVNGIPYWYFHQHGGEFAGRTLESVDPGARQWNGLGPERAIGCVLYPAAEIIAPGVIKHVY
GKKFPIGEPDGTRSERVTRLAEMMARADMDAPVRDNIRDEIWLKLWGNLCFNPISALTHATLDIITSDPATRALSRQMML
EAKHIAESFGVHFRVDVERRIDGAGAVGAHKTSMLQDLEAGRAMEIDPLLTVVQEMGRMIGQPTPMIDAVLGLIKQRDRM
AQAAPSGAAPMAKAA
>Mature_335_residues
MKICIYGAGAIGGYMGAQLALAGADVSFIARGPHLAAMQANGVRLLIEGEERVAKVRCASDPHELGPQDYVFITLKAHQV
PGVVDLMQPLLGPDTAVVTGVNGIPYWYFHQHGGEFAGRTLESVDPGARQWNGLGPERAIGCVLYPAAEIIAPGVIKHVY
GKKFPIGEPDGTRSERVTRLAEMMARADMDAPVRDNIRDEIWLKLWGNLCFNPISALTHATLDIITSDPATRALSRQMML
EAKHIAESFGVHFRVDVERRIDGAGAVGAHKTSMLQDLEAGRAMEIDPLLTVVQEMGRMIGQPTPMIDAVLGLIKQRDRM
AQAAPSGAAPMAKAA

Specific function: Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid [H]

COG id: COG1893

COG function: function code H; Ketopantoate reductase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketopantoate reductase family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR003710
- InterPro:   IPR013752
- InterPro:   IPR013332
- InterPro:   IPR013328
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02558 ApbA; PF08546 ApbA_C [H]

EC number: =1.1.1.169 [H]

Molecular weight: Translated: 36059; Mature: 36059

Theoretical pI: Translated: 6.68; Mature: 6.68

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKICIYGAGAIGGYMGAQLALAGADVSFIARGPHLAAMQANGVRLLIEGEERVAKVRCAS
CEEEEEECCHHHHHHHHHEEEECCCEEEEECCCCEEEEECCCEEEEEECCHHHEEEECCC
DPHELGPQDYVFITLKAHQVPGVVDLMQPLLGPDTAVVTGVNGIPYWYFHQHGGEFAGRT
CHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCHHHCCC
LESVDPGARQWNGLGPERAIGCVLYPAAEIIAPGVIKHVYGKKFPIGEPDGTRSERVTRL
HHHCCCCHHHCCCCCHHHHHCEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
AEMMARADMDAPVRDNIRDEIWLKLWGNLCFNPISALTHATLDIITSDPATRALSRQMML
HHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHH
EAKHIAESFGVHFRVDVERRIDGAGAVGAHKTSMLQDLEAGRAMEIDPLLTVVQEMGRMI
HHHHHHHHCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GQPTPMIDAVLGLIKQRDRMAQAAPSGAAPMAKAA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MKICIYGAGAIGGYMGAQLALAGADVSFIARGPHLAAMQANGVRLLIEGEERVAKVRCAS
CEEEEEECCHHHHHHHHHEEEECCCEEEEECCCCEEEEECCCEEEEEECCHHHEEEECCC
DPHELGPQDYVFITLKAHQVPGVVDLMQPLLGPDTAVVTGVNGIPYWYFHQHGGEFAGRT
CHHHCCCCCEEEEEEECCCCCCHHHHHHHHCCCCCEEEECCCCCCEEEEECCCCHHHCCC
LESVDPGARQWNGLGPERAIGCVLYPAAEIIAPGVIKHVYGKKFPIGEPDGTRSERVTRL
HHHCCCCHHHCCCCCHHHHHCEEEECHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
AEMMARADMDAPVRDNIRDEIWLKLWGNLCFNPISALTHATLDIITSDPATRALSRQMML
HHHHHHCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCHHHHHHHHHHHH
EAKHIAESFGVHFRVDVERRIDGAGAVGAHKTSMLQDLEAGRAMEIDPLLTVVQEMGRMI
HHHHHHHHCCCEEEEEHHHCCCCCCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
GQPTPMIDAVLGLIKQRDRMAQAAPSGAAPMAKAA
CCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11214968 [H]