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The map label for this gene is fucA [C]

Identifier: 94313139

GI number: 94313139

Start: 796268

End: 797056

Strand: Direct

Name: fucA [C]

Synonym: Rmet_4212

Alternate gene names: 94313139

Gene position: 796268-797056 (Clockwise)

Preceding gene: 94313138

Following gene: 94313140

Centisome position: 30.86

GC content: 63.24

Gene sequence:

>789_bases
ATGACGAAACCGGGTGTGCTTAACATTCCCTCGATGCGCGGCCAGTGTAGCGACACGGAGTGGCAGGCGCGCGTCGATCT
CGCCGCGTGCTACAGGCTGGTCGAGCTCTATGGCATGGCCGACATGATGGCCAACCACATCTCGGTGCGCGTGCCGGATG
AAGAGGATGCGTTTCTGATCAACCCGTACGGCATGATGTACGAGGAGATCACAGCATCGTGCCTGATCAAGGTGGACCAC
GCGGGCAACATCTTGTCGAAGCCTGACTTCGGTTCGCTGAACTACGGCATCAACAAGGCCGGCTACGTGATTCACAGCGC
GGTGCATCACGCGCGGCCCGAGGTGGCGTGTGTGATCCATACCCATAGCTGGGCGTCGATGGCGGTGTCGTCCCTGGCGT
GCGGCCTGCTGCCGGTCACGCAGACGGCGATGCGCTTCCTGAAGATCGGCTATCACGACTATCAGGGCGTGGTGCTCGAT
ACCGCCGAACAGGCGTCGCTACTCGAAGACCTGGGCAAGGGCGAGGCGCTGATCCTGCGCAATCATGGCGCCCTGACCGT
TGGCAATACCGTGGGCGAGGCGTTCAACTGGATGCATCGGCTTGAACTGGCCTGCCGCTCGCAAGTGGCGGCGATGTCGT
GCAACACGCCGCTGCAGCAGGTGCCGGCGGACGTGCTGGAAGCCACGTGGAACAACTATCAGCCGGGCACGCGCCGTCCG
TACGGCGTCATGGAGTGGCCGGCGCTGCTGCGCAAGCTTGATCGCCTGGACCCCAGCTTCCGCGACTAG

Upstream 100 bases:

>100_bases
ACTGAAGTACAACATCGAAAAGCGCCGGCCGAGCGATCTCGCGCTGGGCGCCGACTAAGACATCGAATCGAATCAAGAAA
CCGAAAAGGGAGACAGGATC

Downstream 100 bases:

>100_bases
GAAGCCGAAGCAACGCATTCCCGTTGCATCTGAAGAAGAAAGCCTGAACGCCATCCAACGCCCGCAGAGGCGTGGATGGC
TTGCGGCGAACCGGCGGGAT

Product: class II aldolase/adducin-like protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 262; Mature: 261

Protein sequence:

>262_residues
MTKPGVLNIPSMRGQCSDTEWQARVDLAACYRLVELYGMADMMANHISVRVPDEEDAFLINPYGMMYEEITASCLIKVDH
AGNILSKPDFGSLNYGINKAGYVIHSAVHHARPEVACVIHTHSWASMAVSSLACGLLPVTQTAMRFLKIGYHDYQGVVLD
TAEQASLLEDLGKGEALILRNHGALTVGNTVGEAFNWMHRLELACRSQVAAMSCNTPLQQVPADVLEATWNNYQPGTRRP
YGVMEWPALLRKLDRLDPSFRD

Sequences:

>Translated_262_residues
MTKPGVLNIPSMRGQCSDTEWQARVDLAACYRLVELYGMADMMANHISVRVPDEEDAFLINPYGMMYEEITASCLIKVDH
AGNILSKPDFGSLNYGINKAGYVIHSAVHHARPEVACVIHTHSWASMAVSSLACGLLPVTQTAMRFLKIGYHDYQGVVLD
TAEQASLLEDLGKGEALILRNHGALTVGNTVGEAFNWMHRLELACRSQVAAMSCNTPLQQVPADVLEATWNNYQPGTRRP
YGVMEWPALLRKLDRLDPSFRD
>Mature_261_residues
TKPGVLNIPSMRGQCSDTEWQARVDLAACYRLVELYGMADMMANHISVRVPDEEDAFLINPYGMMYEEITASCLIKVDHA
GNILSKPDFGSLNYGINKAGYVIHSAVHHARPEVACVIHTHSWASMAVSSLACGLLPVTQTAMRFLKIGYHDYQGVVLDT
AEQASLLEDLGKGEALILRNHGALTVGNTVGEAFNWMHRLELACRSQVAAMSCNTPLQQVPADVLEATWNNYQPGTRRPY
GVMEWPALLRKLDRLDPSFRD

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI29826319, Length=249, Percent_Identity=39.7590361445783, Blast_Score=195, Evalue=3e-50,
Organism=Homo sapiens, GI29826323, Length=249, Percent_Identity=39.7590361445783, Blast_Score=195, Evalue=4e-50,
Organism=Homo sapiens, GI29826321, Length=249, Percent_Identity=39.7590361445783, Blast_Score=194, Evalue=5e-50,
Organism=Homo sapiens, GI29826325, Length=249, Percent_Identity=39.7590361445783, Blast_Score=194, Evalue=5e-50,
Organism=Homo sapiens, GI9943848, Length=195, Percent_Identity=41.025641025641, Blast_Score=164, Evalue=8e-41,
Organism=Homo sapiens, GI9951927, Length=195, Percent_Identity=41.025641025641, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI62912453, Length=195, Percent_Identity=41.025641025641, Blast_Score=164, Evalue=9e-41,
Organism=Homo sapiens, GI9257190, Length=245, Percent_Identity=36.3265306122449, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI89276787, Length=245, Percent_Identity=36.3265306122449, Blast_Score=159, Evalue=2e-39,
Organism=Homo sapiens, GI297307158, Length=245, Percent_Identity=36.3265306122449, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI9257192, Length=245, Percent_Identity=36.3265306122449, Blast_Score=159, Evalue=3e-39,
Organism=Homo sapiens, GI297307160, Length=245, Percent_Identity=36.3265306122449, Blast_Score=159, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI115533216, Length=250, Percent_Identity=39.2, Blast_Score=191, Evalue=3e-49,
Organism=Caenorhabditis elegans, GI115533218, Length=250, Percent_Identity=39.2, Blast_Score=189, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI71989560, Length=261, Percent_Identity=34.0996168582375, Blast_Score=160, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71989555, Length=242, Percent_Identity=35.1239669421488, Blast_Score=160, Evalue=4e-40,
Organism=Caenorhabditis elegans, GI71989550, Length=246, Percent_Identity=34.5528455284553, Blast_Score=160, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71989544, Length=246, Percent_Identity=34.5528455284553, Blast_Score=160, Evalue=5e-40,
Organism=Caenorhabditis elegans, GI71989541, Length=246, Percent_Identity=34.5528455284553, Blast_Score=160, Evalue=6e-40,
Organism=Drosophila melanogaster, GI281363755, Length=219, Percent_Identity=37.8995433789954, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI281363751, Length=219, Percent_Identity=37.8995433789954, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24655690, Length=219, Percent_Identity=37.8995433789954, Blast_Score=144, Evalue=6e-35,
Organism=Drosophila melanogaster, GI24655685, Length=219, Percent_Identity=37.8995433789954, Blast_Score=144, Evalue=7e-35,
Organism=Drosophila melanogaster, GI281363761, Length=219, Percent_Identity=37.8995433789954, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI281363759, Length=219, Percent_Identity=37.8995433789954, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI281363753, Length=219, Percent_Identity=37.8995433789954, Blast_Score=144, Evalue=8e-35,
Organism=Drosophila melanogaster, GI281363763, Length=219, Percent_Identity=37.8995433789954, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI281363757, Length=219, Percent_Identity=37.8995433789954, Blast_Score=143, Evalue=1e-34,
Organism=Drosophila melanogaster, GI17136738, Length=219, Percent_Identity=37.8995433789954, Blast_Score=143, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 29021; Mature: 28889

Theoretical pI: Translated: 6.17; Mature: 6.17

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
7.3 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKPGVLNIPSMRGQCSDTEWQARVDLAACYRLVELYGMADMMANHISVRVPDEEDAFLI
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEE
NPYGMMYEEITASCLIKVDHAGNILSKPDFGSLNYGINKAGYVIHSAVHHARPEVACVIH
CCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
THSWASMAVSSLACGLLPVTQTAMRFLKIGYHDYQGVVLDTAEQASLLEDLGKGEALILR
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCCCEEEEE
NHGALTVGNTVGEAFNWMHRLELACRSQVAAMSCNTPLQQVPADVLEATWNNYQPGTRRP
CCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHCCCCCCCCCCC
YGVMEWPALLRKLDRLDPSFRD
CCCHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure 
TKPGVLNIPSMRGQCSDTEWQARVDLAACYRLVELYGMADMMANHISVRVPDEEDAFLI
CCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCEEE
NPYGMMYEEITASCLIKVDHAGNILSKPDFGSLNYGINKAGYVIHSAVHHARPEVACVIH
CCHHHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEEEEEE
THSWASMAVSSLACGLLPVTQTAMRFLKIGYHDYQGVVLDTAEQASLLEDLGKGEALILR
ECCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECHHHHHHHHHHCCCCEEEEE
NHGALTVGNTVGEAFNWMHRLELACRSQVAAMSCNTPLQQVPADVLEATWNNYQPGTRRP
CCCCEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHHHHCCCCCCCCCCC
YGVMEWPALLRKLDRLDPSFRD
CCCHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]