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The map label for this gene is sqhC [H]

Identifier: 94313075

GI number: 94313075

Start: 722723

End: 724732

Strand: Reverse

Name: sqhC [H]

Synonym: Rmet_4148

Alternate gene names: 94313075

Gene position: 724732-722723 (Counterclockwise)

Preceding gene: 94313076

Following gene: 94313074

Centisome position: 28.09

GC content: 67.91

Gene sequence:

>2010_bases
ATGAACCAGGCCGCAACAATAACCCGCCCCCAGGATGAAACGCTGACCACCAGCGCCCGTCGCCCTGCCCAGCCGGCCCT
GCCCGATCCGCTCGATGCCGGCATCGCCCATGTCGTCGAATCCCTGCTGGCGCAACAGCAGTCCGATGGCCACTGGGTCT
ACGAACTCGAAGCCGACGCCACGATTCCGGCCGAGTACATCCTGATGGTCCACTACCTCGGCGAGACGCCGGATCTGGTA
CTGGAAGGCAAGATCGCCAACTACCTGCGCCGCATCCAGAACGCCGATGGCGGCTGGCCGCTGTTCCACGCCGGCGCCTC
GGACATCAGTGCCAGCGTGAAGGGCTACTTCGCGCTGAAGATGGCCGGCGACAACCCGGAAGCCGAACACATGCGCCGCG
CGCGCGCCGCGATCCACGCGATGGGCGGCGCCGAGGCCAGCAACGTATTCACGCGCACGCTGCTCGCGCTGTACGGCGTG
ATGCCGTGGCAGGCGGTGCCGATGATGCCGGTGGAGATCATGCTGCTGCCCGAGTGGTTTCCGTTCCATCTGTCGAAGGT
GTCGTACTGGGCCCGCACGGTCATCGTGCCGCTGCTGGTGCTCAACAGCCTGCGTCCGCAGGCGCGCAATCCGCGCAAGA
TCGGCATCGACGAATTGTTCGTACGCCCGTGCCAGGCCACCCGCCTGCCGCGCCGCGCGCCGCACCAGAGCCCGCTATGG
GTCGGCGTGTTCCGCACGCTCGACGCCGTGGTGCGCATGGCCGAGCCACTGTTCCCGCGTGGCCTGCGCCAGCGGGCCAT
CGAGCGCGCGCGTGAATTCACGGTCGAACGGCTGAACGGCGAAGACGGCCTCGGCGCGATCTTCCCGGCGATGGTCAACT
CAGTGCTGATGTTCGACGTCCTCGGCGTGCCCGAGAGCGACCCGAACCGGGCCATCGCCCGCCGCTCGATCGACAAGCTG
CTCGTGATCAAGGATGACGAGGCTTACTGCCAGCCATGCCTGTCGCCGGTCTGGGATACGTCGCTGGCCGCCCATGCCTT
GCTGGAAGTCGGCGAGCCGCGCACGATCGCGGCTGCGGCACGCGGGCTGGACTGGCTGCTGCCGCTGCAGGAACTCGAAC
TGCGCGGCGACTGGACGGTGCGCCGTCCCAACGTCCGCCCGGGCGGCTGGGCTTTCCAGTACGCCAACCCTCACTACCCC
GACGTGGACGACACCGCCGTGGTGGCTGCCGCGATGGACCGGGTGGACAAGGGCGACCGCTCCAACCGTTATGACGAGGC
CGTATCCCGCGCCTGCGAGTGGATCGTCGGCATGCAAAGCAGCAACGGTGGCTGGGGCGCGTTCGAACCCGAGAACACGC
ACCTTTACCTGAACAACATCCCGTTCGCCGATCACGGCGCGCTGCTCGATCCGCCCACGGCCGACGTGTCCGCGCGTTGT
CTGGCGATGCTGTGCCAGCTAGGCCAGATGCCGGCCAACAGCGAGCCGGCCGCGCGCGCGCTGCGCTACCTGCTCGACGA
ACAGGAAGCCGACGGAAGCTGGTTCGGCCGCTGGGGCACCAACTATATCTATGGCACGTGGAGCGCGCTGTGCGGGCTGA
ACGCCGCCGGCATCGGCACGGACGCGCCCGAGATGAAGCGCGCGGCCCAATGGCTGCTGTCGATCCAGAACGAGGATGGC
GGCTGGGGCGAGTCGGGCGACAGCTACAAGCTCGAGTATCGGGGCTATGAAAAGGCGCCGAGCACGGCATCGCAAACCGC
CTGGGCCATGCTCGGCCTGATGGCCGCCGGCGCAGGCGACCACCCCGCCCTGGTGCGCGGCGTCGAGTACCTGCTGCGCA
CGCAGGCCAGCCATGGTTTCTGGGACGAGCCGTACTTCACGGCGGTGGGTTTCCCTCGCGTGTTCTATCTGCGCTACCAC
GGCTATTCGCGCTTCTTCCCGCTCTGGGCACTGGCGCGCTTCCGCAACCTGCTGCGCGATGGCAATCGCGCCATCTCCTG
GGGGCTCTGA

Upstream 100 bases:

>100_bases
TCTGCTCCGACATGCCATCGCATGATTTGCCCGCCTTGTATTTAGCCAAGGCACGCGGCCATTGCCGCGTGCCCAGAACA
GAGAAGTGCCCCCGATTTAG

Downstream 100 bases:

>100_bases
AGTCGTGGCGGTACTGGCAGTCAGCGGGATGGATTTCGAGGCGCGCATCGCGTCGGGAGCGGGCGTGGAAACGCTCTACG
GGCATCGCGATGCGGCACTG

Product: squalene-hopene cyclase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 669; Mature: 669

Protein sequence:

>669_residues
MNQAATITRPQDETLTTSARRPAQPALPDPLDAGIAHVVESLLAQQQSDGHWVYELEADATIPAEYILMVHYLGETPDLV
LEGKIANYLRRIQNADGGWPLFHAGASDISASVKGYFALKMAGDNPEAEHMRRARAAIHAMGGAEASNVFTRTLLALYGV
MPWQAVPMMPVEIMLLPEWFPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRKIGIDELFVRPCQATRLPRRAPHQSPLW
VGVFRTLDAVVRMAEPLFPRGLRQRAIERAREFTVERLNGEDGLGAIFPAMVNSVLMFDVLGVPESDPNRAIARRSIDKL
LVIKDDEAYCQPCLSPVWDTSLAAHALLEVGEPRTIAAAARGLDWLLPLQELELRGDWTVRRPNVRPGGWAFQYANPHYP
DVDDTAVVAAAMDRVDKGDRSNRYDEAVSRACEWIVGMQSSNGGWGAFEPENTHLYLNNIPFADHGALLDPPTADVSARC
LAMLCQLGQMPANSEPAARALRYLLDEQEADGSWFGRWGTNYIYGTWSALCGLNAAGIGTDAPEMKRAAQWLLSIQNEDG
GWGESGDSYKLEYRGYEKAPSTASQTAWAMLGLMAAGAGDHPALVRGVEYLLRTQASHGFWDEPYFTAVGFPRVFYLRYH
GYSRFFPLWALARFRNLLRDGNRAISWGL

Sequences:

>Translated_669_residues
MNQAATITRPQDETLTTSARRPAQPALPDPLDAGIAHVVESLLAQQQSDGHWVYELEADATIPAEYILMVHYLGETPDLV
LEGKIANYLRRIQNADGGWPLFHAGASDISASVKGYFALKMAGDNPEAEHMRRARAAIHAMGGAEASNVFTRTLLALYGV
MPWQAVPMMPVEIMLLPEWFPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRKIGIDELFVRPCQATRLPRRAPHQSPLW
VGVFRTLDAVVRMAEPLFPRGLRQRAIERAREFTVERLNGEDGLGAIFPAMVNSVLMFDVLGVPESDPNRAIARRSIDKL
LVIKDDEAYCQPCLSPVWDTSLAAHALLEVGEPRTIAAAARGLDWLLPLQELELRGDWTVRRPNVRPGGWAFQYANPHYP
DVDDTAVVAAAMDRVDKGDRSNRYDEAVSRACEWIVGMQSSNGGWGAFEPENTHLYLNNIPFADHGALLDPPTADVSARC
LAMLCQLGQMPANSEPAARALRYLLDEQEADGSWFGRWGTNYIYGTWSALCGLNAAGIGTDAPEMKRAAQWLLSIQNEDG
GWGESGDSYKLEYRGYEKAPSTASQTAWAMLGLMAAGAGDHPALVRGVEYLLRTQASHGFWDEPYFTAVGFPRVFYLRYH
GYSRFFPLWALARFRNLLRDGNRAISWGL
>Mature_669_residues
MNQAATITRPQDETLTTSARRPAQPALPDPLDAGIAHVVESLLAQQQSDGHWVYELEADATIPAEYILMVHYLGETPDLV
LEGKIANYLRRIQNADGGWPLFHAGASDISASVKGYFALKMAGDNPEAEHMRRARAAIHAMGGAEASNVFTRTLLALYGV
MPWQAVPMMPVEIMLLPEWFPFHLSKVSYWARTVIVPLLVLNSLRPQARNPRKIGIDELFVRPCQATRLPRRAPHQSPLW
VGVFRTLDAVVRMAEPLFPRGLRQRAIERAREFTVERLNGEDGLGAIFPAMVNSVLMFDVLGVPESDPNRAIARRSIDKL
LVIKDDEAYCQPCLSPVWDTSLAAHALLEVGEPRTIAAAARGLDWLLPLQELELRGDWTVRRPNVRPGGWAFQYANPHYP
DVDDTAVVAAAMDRVDKGDRSNRYDEAVSRACEWIVGMQSSNGGWGAFEPENTHLYLNNIPFADHGALLDPPTADVSARC
LAMLCQLGQMPANSEPAARALRYLLDEQEADGSWFGRWGTNYIYGTWSALCGLNAAGIGTDAPEMKRAAQWLLSIQNEDG
GWGESGDSYKLEYRGYEKAPSTASQTAWAMLGLMAAGAGDHPALVRGVEYLLRTQASHGFWDEPYFTAVGFPRVFYLRYH
GYSRFFPLWALARFRNLLRDGNRAISWGL

Specific function: Catalyzes the cyclization of squalene into hopene [H]

COG id: COG1657

COG function: function code I; Squalene cyclase

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 3 PFTB repeats [H]

Homologues:

Organism=Homo sapiens, GI224177558, Length=647, Percent_Identity=27.9752704791345, Blast_Score=185, Evalue=1e-46,
Organism=Homo sapiens, GI47933395, Length=647, Percent_Identity=27.9752704791345, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI47933397, Length=647, Percent_Identity=27.9752704791345, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI224177556, Length=647, Percent_Identity=27.2024729520866, Blast_Score=169, Evalue=7e-42,
Organism=Saccharomyces cerevisiae, GI6321863, Length=610, Percent_Identity=22.2950819672131, Blast_Score=100, Evalue=1e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006400
- InterPro:   IPR001330
- InterPro:   IPR018333
- InterPro:   IPR002365
- InterPro:   IPR008930 [H]

Pfam domain/function: PF00432 Prenyltrans [H]

EC number: =5.4.99.17 [H]

Molecular weight: Translated: 74337; Mature: 74337

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQAATITRPQDETLTTSARRPAQPALPDPLDAGIAHVVESLLAQQQSDGHWVYELEADA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
TIPAEYILMVHYLGETPDLVLEGKIANYLRRIQNADGGWPLFHAGASDISASVKGYFALK
CCCHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCCCCEEECCCHHHHHCCCEEEEEE
MAGDNPEAEHMRRARAAIHAMGGAEASNVFTRTLLALYGVMPWQAVPMMPVEIMLLPEWF
ECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCC
PFHLSKVSYWARTVIVPLLVLNSLRPQARNPRKIGIDELFVRPCQATRLPRRAPHQSPLW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCHH
VGVFRTLDAVVRMAEPLFPRGLRQRAIERAREFTVERLNGEDGLGAIFPAMVNSVLMFDV
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LGVPESDPNRAIARRSIDKLLVIKDDEAYCQPCLSPVWDTSLAAHALLEVGEPRTIAAAA
HCCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHH
RGLDWLLPLQELELRGDWTVRRPNVRPGGWAFQYANPHYPDVDDTAVVAAAMDRVDKGDR
CCCHHHCCHHHHHCCCCEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
SNRYDEAVSRACEWIVGMQSSNGGWGAFEPENTHLYLNNIPFADHGALLDPPTADVSARC
CCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHH
LAMLCQLGQMPANSEPAARALRYLLDEQEADGSWFGRWGTNYIYGTWSALCGLNAAGIGT
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCEEEECHHHHHCCCCCCCCC
DAPEMKRAAQWLLSIQNEDGGWGESGDSYKLEYRGYEKAPSTASQTAWAMLGLMAAGAGD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
HPALVRGVEYLLRTQASHGFWDEPYFTAVGFPRVFYLRYHGYSRFFPLWALARFRNLLRD
CHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHC
GNRAISWGL
CCCEEECCC
>Mature Secondary Structure
MNQAATITRPQDETLTTSARRPAQPALPDPLDAGIAHVVESLLAQQQSDGHWVYELEADA
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCC
TIPAEYILMVHYLGETPDLVLEGKIANYLRRIQNADGGWPLFHAGASDISASVKGYFALK
CCCHHHHHHHHHHCCCCCEEEECHHHHHHHHHHCCCCCCCEEECCCHHHHHCCCEEEEEE
MAGDNPEAEHMRRARAAIHAMGGAEASNVFTRTLLALYGVMPWQAVPMMPVEIMLLPEWF
ECCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEECCCC
PFHLSKVSYWARTVIVPLLVLNSLRPQARNPRKIGIDELFVRPCQATRLPRRAPHQSPLW
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCHHHHCCCCCCCCCCCHH
VGVFRTLDAVVRMAEPLFPRGLRQRAIERAREFTVERLNGEDGLGAIFPAMVNSVLMFDV
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHH
LGVPESDPNRAIARRSIDKLLVIKDDEAYCQPCLSPVWDTSLAAHALLEVGEPRTIAAAA
HCCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHCCHHHHHHHHHHHHHHCCCCCHHHHHH
RGLDWLLPLQELELRGDWTVRRPNVRPGGWAFQYANPHYPDVDDTAVVAAAMDRVDKGDR
CCCHHHCCHHHHHCCCCEEEECCCCCCCCEEEECCCCCCCCCCHHHHHHHHHHHHCCCCC
SNRYDEAVSRACEWIVGMQSSNGGWGAFEPENTHLYLNNIPFADHGALLDPPTADVSARC
CCHHHHHHHHHHHHHHEECCCCCCCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHH
LAMLCQLGQMPANSEPAARALRYLLDEQEADGSWFGRWGTNYIYGTWSALCGLNAAGIGT
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCEEECCCCCEEEECHHHHHCCCCCCCCC
DAPEMKRAAQWLLSIQNEDGGWGESGDSYKLEYRGYEKAPSTASQTAWAMLGLMAAGAGD
CCHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCC
HPALVRGVEYLLRTQASHGFWDEPYFTAVGFPRVFYLRYHGYSRFFPLWALARFRNLLRD
CHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCEEEEEEECCCCHHHHHHHHHHHHHHHHC
GNRAISWGL
CCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]