BacMap

Definition	Cupriavidus metallidurans CH34 megaplasmid, complete sequence.
Accession	NC_007974
Length	2,580,084

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The map label for this gene is ccmA

Identifier: 94312988

GI number: 94312988

Start: 626106

End: 626741

Strand: Reverse

Name: ccmA

Synonym: Rmet_4060

Alternate gene names: 94312988

Gene position: 626741-626106 (Counterclockwise)

Preceding gene: 94312989

Following gene: 94312987

Centisome position: 24.29

GC content: 69.18

Gene sequence:

>636_bases
ATGGCCGACGCGGTACTGGAGGCCCGCGAGCTTGGCGTCCGGCGCGGCCATTGCGCTATCTTCCGTGGCCTCGGCATTTC
CCTGGCACCCGGCGACCTGTTGCAGGTGATGGGCCCGAACGGTGCTGGCAAGACCAGCCTGCTACGCGTGTTGTCCAGCC
TGATGCCACCCGCCGAGGGCGACCTGTACTGGCGAGGCCGCGCGGTGCGGGCCGGAGACCCCGACTATCTCGCGCAGGTT
GCCTACCTCGGCCACGTCAACGGCATCTACCCCGACCTGTCCGCTTTCGAGAATCTTCAGTTCGCCGCTCGCATGGCTGG
CCAGCAGCCCGATGCGGATGCCATGCACCATGCTCTTGCCCGGTTCGGTCTCGATCGTGTCGCCGATGCCCCGGCGCGCA
CGCTCTCGCAAGGACAGCGCCGCCGCGTGGCGCTGTCCCGGCTGGCGCTGACGCCACGCGCGCTATGGCTGCTCGATGAA
CCGCTGACTTCGCTCGACGACGCATCGACCGACTGCTTCCACACGCTGCTCGCCGAGCACCTGCAGCGGGGCGGCATCGC
CGTGGTCGCCACGCATCAGCGGCTGCCCGCCGAGGGTGCGGTGCTCGATCTCGCCACAGACGCGGGTTCGCCATGA

Upstream 100 bases:

>100_bases
CTCGACCTATCTGGCCAACAAGGAAAAGACCTGCATCGATTGCCACAAGGGGATCGCCCACCATCTGCCTGACATCTCCA
AGGCCGAGGAGCAATAGCCT

Downstream 100 bases:

>100_bases
TCCAGGCCATCGGCACGATCATCGCGCACGACCTGTCGATCGCATGGCGGCGGCGCACCGGGCTGCTTTCCAGCCTGGTC
TTCTTCGTCATCGCCACGAG

Product: cytochrome c biogenesis protein CcmA

Products: NA

Alternate protein names: Heme exporter protein A 2

Number of amino acids: Translated: 211; Mature: 210

Protein sequence:

>211_residues
MADAVLEARELGVRRGHCAIFRGLGISLAPGDLLQVMGPNGAGKTSLLRVLSSLMPPAEGDLYWRGRAVRAGDPDYLAQV
AYLGHVNGIYPDLSAFENLQFAARMAGQQPDADAMHHALARFGLDRVADAPARTLSQGQRRRVALSRLALTPRALWLLDE
PLTSLDDASTDCFHTLLAEHLQRGGIAVVATHQRLPAEGAVLDLATDAGSP

Sequences:

>Translated_211_residues
MADAVLEARELGVRRGHCAIFRGLGISLAPGDLLQVMGPNGAGKTSLLRVLSSLMPPAEGDLYWRGRAVRAGDPDYLAQV
AYLGHVNGIYPDLSAFENLQFAARMAGQQPDADAMHHALARFGLDRVADAPARTLSQGQRRRVALSRLALTPRALWLLDE
PLTSLDDASTDCFHTLLAEHLQRGGIAVVATHQRLPAEGAVLDLATDAGSP
>Mature_210_residues
ADAVLEARELGVRRGHCAIFRGLGISLAPGDLLQVMGPNGAGKTSLLRVLSSLMPPAEGDLYWRGRAVRAGDPDYLAQVA
YLGHVNGIYPDLSAFENLQFAARMAGQQPDADAMHHALARFGLDRVADAPARTLSQGQRRRVALSRLALTPRALWLLDEP
LTSLDDASTDCFHTLLAEHLQRGGIAVVATHQRLPAEGAVLDLATDAGSP

Specific function: Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system

COG id: COG4133

COG function: function code O; ABC-type transport system involved in cytochrome c biogenesis, ATPase component

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transporter domain

Homologues:

Organism=Homo sapiens, GI47078218, Length=184, Percent_Identity=26.6304347826087, Blast_Score=73, Evalue=1e-13,
Organism=Homo sapiens, GI45446740, Length=184, Percent_Identity=26.6304347826087, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI62526033, Length=178, Percent_Identity=29.2134831460674, Blast_Score=72, Evalue=3e-13,
Organism=Homo sapiens, GI46592971, Length=189, Percent_Identity=26.984126984127, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI46592964, Length=189, Percent_Identity=26.4550264550265, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI46592898, Length=189, Percent_Identity=26.4550264550265, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI46592915, Length=189, Percent_Identity=26.4550264550265, Blast_Score=69, Evalue=2e-12,
Organism=Homo sapiens, GI46592978, Length=189, Percent_Identity=26.4550264550265, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI46592956, Length=189, Percent_Identity=26.4550264550265, Blast_Score=69, Evalue=3e-12,
Organism=Homo sapiens, GI150417984, Length=204, Percent_Identity=27.9411764705882, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI153792144, Length=176, Percent_Identity=27.2727272727273, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI6005701, Length=187, Percent_Identity=27.807486631016, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI11967969, Length=186, Percent_Identity=26.8817204301075, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI27436953, Length=180, Percent_Identity=26.6666666666667, Blast_Score=66, Evalue=2e-11,
Organism=Homo sapiens, GI116734710, Length=176, Percent_Identity=27.2727272727273, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI9955968, Length=202, Percent_Identity=25.2475247524752, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI27881501, Length=185, Percent_Identity=23.7837837837838, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI30795238, Length=185, Percent_Identity=23.7837837837838, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI9955966, Length=202, Percent_Identity=25.2475247524752, Blast_Score=65, Evalue=6e-11,
Organism=Homo sapiens, GI45243524, Length=202, Percent_Identity=25.2475247524752, Blast_Score=65, Evalue=6e-11,
Organism=Escherichia coli, GI87082064, Length=193, Percent_Identity=41.9689119170984, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786698, Length=194, Percent_Identity=29.8969072164948, Blast_Score=95, Evalue=3e-21,
Organism=Escherichia coli, GI48994943, Length=201, Percent_Identity=26.865671641791, Blast_Score=86, Evalue=1e-18,
Organism=Escherichia coli, GI87082267, Length=153, Percent_Identity=31.3725490196078, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI87081709, Length=170, Percent_Identity=30.5882352941176, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1790467, Length=185, Percent_Identity=27.5675675675676, Blast_Score=78, Evalue=4e-16,
Organism=Escherichia coli, GI1787029, Length=204, Percent_Identity=27.4509803921569, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1786563, Length=173, Percent_Identity=31.7919075144509, Blast_Score=75, Evalue=2e-15,
Organism=Escherichia coli, GI1786803, Length=194, Percent_Identity=29.3814432989691, Blast_Score=75, Evalue=3e-15,
Organism=Escherichia coli, GI87081782, Length=195, Percent_Identity=24.1025641025641, Blast_Score=73, Evalue=1e-14,
Organism=Escherichia coli, GI87081834, Length=182, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI87081791, Length=174, Percent_Identity=29.3103448275862, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788053, Length=210, Percent_Identity=30.952380952381, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI1787105, Length=184, Percent_Identity=28.2608695652174, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1789593, Length=217, Percent_Identity=26.7281105990783, Blast_Score=67, Evalue=8e-13,
Organism=Escherichia coli, GI1786872, Length=163, Percent_Identity=31.2883435582822, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1787041, Length=177, Percent_Identity=28.8135593220339, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788897, Length=184, Percent_Identity=27.7173913043478, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1786253, Length=163, Percent_Identity=30.0613496932515, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1787792, Length=201, Percent_Identity=26.865671641791, Blast_Score=65, Evalue=3e-12,
Organism=Escherichia coli, GI1790162, Length=208, Percent_Identity=26.9230769230769, Blast_Score=65, Evalue=4e-12,
Organism=Escherichia coli, GI1789873, Length=179, Percent_Identity=26.8156424581006, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI1789586, Length=209, Percent_Identity=26.3157894736842, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1787712, Length=178, Percent_Identity=29.7752808988764, Blast_Score=64, Evalue=5e-12,
Organism=Escherichia coli, GI1787370, Length=178, Percent_Identity=28.6516853932584, Blast_Score=64, Evalue=6e-12,
Organism=Escherichia coli, GI1788165, Length=164, Percent_Identity=30.4878048780488, Blast_Score=64, Evalue=8e-12,
Organism=Escherichia coli, GI1788761, Length=186, Percent_Identity=27.9569892473118, Blast_Score=63, Evalue=1e-11,
Organism=Escherichia coli, GI1787089, Length=193, Percent_Identity=30.5699481865285, Blast_Score=62, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17565586, Length=169, Percent_Identity=26.6272189349112, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533608, Length=179, Percent_Identity=27.9329608938547, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19920532, Length=180, Percent_Identity=28.8888888888889, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24580930, Length=180, Percent_Identity=28.8888888888889, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI221500365, Length=184, Percent_Identity=26.6304347826087, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI116007184, Length=184, Percent_Identity=26.6304347826087, Blast_Score=71, Evalue=7e-13,
Organism=Drosophila melanogaster, GI28574533, Length=190, Percent_Identity=27.3684210526316, Blast_Score=65, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): CCMA2_RALME (Q1LFZ8)

Other databases:

- EMBL:   CP000353
- RefSeq:   YP_586197.1
- ProteinModelPortal:   Q1LFZ8
- SMR:   Q1LFZ8
- STRING:   Q1LFZ8
- GeneID:   4040918
- GenomeReviews:   CP000353_GR
- KEGG:   rme:Rmet_4060
- eggNOG:   COG4133
- HOGENOM:   HBG758042
- OMA:   SARRGED
- PhylomeDB:   Q1LFZ8
- ProtClustDB:   PRK13538
- BioCyc:   RMET266264:RMET_4060-MONOMER
- HAMAP:   MF_01707
- InterPro:   IPR003439
- InterPro:   IPR017871
- InterPro:   IPR005895
- InterPro:   IPR003593
- PANTHER:   PTHR19222:SF5
- SMART:   SM00382
- TIGRFAMs:   TIGR01189

Pfam domain/function: PF00005 ABC_tran

EC number: =3.6.3.41

Molecular weight: Translated: 22533; Mature: 22402

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00211 ABC_TRANSPORTER_1; PS50893 ABC_TRANSPORTER_2; PS51243 CCMA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADAVLEARELGVRRGHCAIFRGLGISLAPGDLLQVMGPNGAGKTSLLRVLSSLMPPAEG
CCCHHHHHHHHCCCCCCHHHHHCCCCEECCCHHHHEECCCCCCHHHHHHHHHHHCCCCCC
DLYWRGRAVRAGDPDYLAQVAYLGHVNGIYPDLSAFENLQFAARMAGQQPDADAMHHALA
CEEECCEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
RFGLDRVADAPARTLSQGQRRRVALSRLALTPRALWLLDEPLTSLDDASTDCFHTLLAEH
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHCCCCHHHHHHHHHHH
LQRGGIAVVATHQRLPAEGAVLDLATDAGSP
HHHCCEEEEEECCCCCCCCCEEEECCCCCCC
>Mature Secondary Structure 
ADAVLEARELGVRRGHCAIFRGLGISLAPGDLLQVMGPNGAGKTSLLRVLSSLMPPAEG
CCHHHHHHHHCCCCCCHHHHHCCCCEECCCHHHHEECCCCCCHHHHHHHHHHHCCCCCC
DLYWRGRAVRAGDPDYLAQVAYLGHVNGIYPDLSAFENLQFAARMAGQQPDADAMHHALA
CEEECCEEECCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHH
RFGLDRVADAPARTLSQGQRRRVALSRLALTPRALWLLDEPLTSLDDASTDCFHTLLAEH
HHHHHHHHCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCHHHHCCCCHHHHHHHHHHH
LQRGGIAVVATHQRLPAEGAVLDLATDAGSP
HHHCCEEEEEECCCCCCCCCEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA