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The map label for this gene is coxN [H]

Identifier: 94312884

GI number: 94312884

Start: 515661

End: 517418

Strand: Direct

Name: coxN [H]

Synonym: Rmet_3956

Alternate gene names: 94312884

Gene position: 515661-517418 (Clockwise)

Preceding gene: 94312883

Following gene: 94312885

Centisome position: 19.99

GC content: 60.98

Gene sequence:

>1758_bases
ATGGCCTATGCCGATGATGCCGCCCACCACGGCCCACAGAGTTTCTGGACGCGCTACATCTGGAGCCAGGACCACAAGGT
GATCGCCGTGCAGTACACGCTGGTCGCCATCGTGGTCGGGTTGATCGGTGTGACGCTGTCGAATCTGATGCGGATGCAAC
TGGGTTTTCCGGGGAGGTTCGATTTCATCGACGCCAATCGCTATTACCAGTTCGTGACGATGCACGGGATGATCATGGTG
ATCTACCTGCTGACGGCACTGTTTCTTGGCGGTTTCGGCAATTACCTGATCCCGCTGATGGTTGGCGCGCGCGACATGGT
ATTCCCATTCCTGAACATGCTCAGCTTCTGGGTCTACTTCCTGTCGGTGCTCGTGCTGCTCGCCAGCTTCTTCGTGCCGG
GCGGACCCACCGGCGCGGGCTGGACGCTCTATCCACCGCAGGCAATCCTGCCCGGCACGCCAGGGCATGACTGGGGCATC
ATCCTGATGCTGGTGTCGCTGCTGATCTTCATCGTGGCGGCTACCATGGGTGGCCTGAATTACGTGACCACGGTGCTGCA
GGCGCGTACCGAGGGCATGACGATGCTGCGGATGCCGCTGGCCGTGTGGGGTATCTTCATGGCGACGATTCTCGCACTGC
TGGCGTTCCCGGCGCTGTTCGTCTCCGGTGTGATGATGCTGCTCGACAAGACGCTCAGTACCAGCTTCTTCATGCCCGCA
GTCGTCTCGATGGGGCAGCAGCTCAACTACAAGGGCGGCAGCCCTCTGCTGTTCCAGCACCTGTTCTGGTTCTTCGGTCA
TCCCGAGGTTTATATCGTCGCGCTGCCCGCGTTCGGGATCGTCTCCGATCTGATCAGCGTGCATTCGCGCAAGAGCATCT
TCGGCTATCGCACGATGGTGTGGGCGATTCTGGCCATCGGTGTGCTGTCGGTGGTGGTGTGGGCGCACCACATGTTCGTG
AGCGGCATGAATCCGTACTTCGGCTTCTTCTTCGCCACCACGACGCTGATCATCGCGGTACCCACCGCCATCAAGGTCTA
CAACTGGGTGATCACGCTGTGGCAGGGCGACATCCATTTCTCGGTGCCGATGCTGTTCGCCATCGCCTTCATCAGCACGT
TCGTGATTGGCGGCCTGACGGGCCTGTTCCTCGGCAATGTCAGCGTGGACATTCCGTTGTCGAACACCTACTTCGTCGTG
GCGCACTTTCATATGGTGATGGGCGTCTCGCCGATCCTGGTCGTCTTCGGCGGGATCTACCACTGGTATCCGAAAGTCAC
CGGACGCATGCTCAACGACACGCTTGGCCGCATTCATTTTTGGATCACGTTCGTCGGCACCTACGCCATCTTCTTTCCGA
TGCACTACCTCGGTATTCTGGGGATGCCGCGGCGCTACTACGCGTGGCAGGGCTATGACTTCATACCCGAGTCCGCGCAC
ACCCTGAACATGTACATCTCGATCGCAGCGTTCATCGTCGCGGCGGCGCAGTTGCTTTTCATCTTCAACCTCGCGTGGAG
CGTGCGGCGTGGACAGCCTGCAGGCGCCAACCCGTGGCGTGCCGCCTCGCTGGAGTGGCAGACGCCGCAGACGCCGCCGG
CGCACGGCAACTGGGGTGCGCATCTTCCCGTGGTCTATCGCTGGGCTTACGCGTACAGCGTGCCGGGTGCGAAGGAGGAC
TTCATTGCGCAGAATGCGCCGCCAGACGCAGGTGGGAGCGAACCCGAGCCACACGCGAGAAGGGGGGCCGTGGCATGA

Upstream 100 bases:

>100_bases
CTGTCGGCGTATATCCGTTCGCTGGGTGCTGGCGCAACGGGCACCCCGCAGGCCGGCAAATAGCGGCCCGGTGCACAGTC
AGAGATCGGAGAGCAAAAAG

Downstream 100 bases:

>100_bases
AAGCCGAATCGTTCGCGGTGGATACGGGTGGCGGCGTCTTCCGGGCTTCGCGTGAAGCACCCGGAGGCAGCCCCGCCGGT
GGCGACGCCTTGCATGGACA

Product: cytochrome c oxidase subunit I

Products: NA

Alternate protein names: Alternative cytochrome c oxidase polypeptide I; Cytochrome BB3 subunit 1; Oxidase BB(3) subunit 1 [H]

Number of amino acids: Translated: 585; Mature: 584

Protein sequence:

>585_residues
MAYADDAAHHGPQSFWTRYIWSQDHKVIAVQYTLVAIVVGLIGVTLSNLMRMQLGFPGRFDFIDANRYYQFVTMHGMIMV
IYLLTALFLGGFGNYLIPLMVGARDMVFPFLNMLSFWVYFLSVLVLLASFFVPGGPTGAGWTLYPPQAILPGTPGHDWGI
ILMLVSLLIFIVAATMGGLNYVTTVLQARTEGMTMLRMPLAVWGIFMATILALLAFPALFVSGVMMLLDKTLSTSFFMPA
VVSMGQQLNYKGGSPLLFQHLFWFFGHPEVYIVALPAFGIVSDLISVHSRKSIFGYRTMVWAILAIGVLSVVVWAHHMFV
SGMNPYFGFFFATTTLIIAVPTAIKVYNWVITLWQGDIHFSVPMLFAIAFISTFVIGGLTGLFLGNVSVDIPLSNTYFVV
AHFHMVMGVSPILVVFGGIYHWYPKVTGRMLNDTLGRIHFWITFVGTYAIFFPMHYLGILGMPRRYYAWQGYDFIPESAH
TLNMYISIAAFIVAAAQLLFIFNLAWSVRRGQPAGANPWRAASLEWQTPQTPPAHGNWGAHLPVVYRWAYAYSVPGAKED
FIAQNAPPDAGGSEPEPHARRGAVA

Sequences:

>Translated_585_residues
MAYADDAAHHGPQSFWTRYIWSQDHKVIAVQYTLVAIVVGLIGVTLSNLMRMQLGFPGRFDFIDANRYYQFVTMHGMIMV
IYLLTALFLGGFGNYLIPLMVGARDMVFPFLNMLSFWVYFLSVLVLLASFFVPGGPTGAGWTLYPPQAILPGTPGHDWGI
ILMLVSLLIFIVAATMGGLNYVTTVLQARTEGMTMLRMPLAVWGIFMATILALLAFPALFVSGVMMLLDKTLSTSFFMPA
VVSMGQQLNYKGGSPLLFQHLFWFFGHPEVYIVALPAFGIVSDLISVHSRKSIFGYRTMVWAILAIGVLSVVVWAHHMFV
SGMNPYFGFFFATTTLIIAVPTAIKVYNWVITLWQGDIHFSVPMLFAIAFISTFVIGGLTGLFLGNVSVDIPLSNTYFVV
AHFHMVMGVSPILVVFGGIYHWYPKVTGRMLNDTLGRIHFWITFVGTYAIFFPMHYLGILGMPRRYYAWQGYDFIPESAH
TLNMYISIAAFIVAAAQLLFIFNLAWSVRRGQPAGANPWRAASLEWQTPQTPPAHGNWGAHLPVVYRWAYAYSVPGAKED
FIAQNAPPDAGGSEPEPHARRGAVA
>Mature_584_residues
AYADDAAHHGPQSFWTRYIWSQDHKVIAVQYTLVAIVVGLIGVTLSNLMRMQLGFPGRFDFIDANRYYQFVTMHGMIMVI
YLLTALFLGGFGNYLIPLMVGARDMVFPFLNMLSFWVYFLSVLVLLASFFVPGGPTGAGWTLYPPQAILPGTPGHDWGII
LMLVSLLIFIVAATMGGLNYVTTVLQARTEGMTMLRMPLAVWGIFMATILALLAFPALFVSGVMMLLDKTLSTSFFMPAV
VSMGQQLNYKGGSPLLFQHLFWFFGHPEVYIVALPAFGIVSDLISVHSRKSIFGYRTMVWAILAIGVLSVVVWAHHMFVS
GMNPYFGFFFATTTLIIAVPTAIKVYNWVITLWQGDIHFSVPMLFAIAFISTFVIGGLTGLFLGNVSVDIPLSNTYFVVA
HFHMVMGVSPILVVFGGIYHWYPKVTGRMLNDTLGRIHFWITFVGTYAIFFPMHYLGILGMPRRYYAWQGYDFIPESAHT
LNMYISIAAFIVAAAQLLFIFNLAWSVRRGQPAGANPWRAASLEWQTPQTPPAHGNWGAHLPVVYRWAYAYSVPGAKEDF
IAQNAPPDAGGSEPEPHARRGAVA

Specific function: Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. Co I is the catalytic subunit of the enzyme. Electrons originating in cytochrome

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=524, Percent_Identity=41.2213740458015, Blast_Score=360, Evalue=2e-99,
Organism=Escherichia coli, GI1786634, Length=523, Percent_Identity=37.2848948374761, Blast_Score=332, Evalue=3e-92,
Organism=Saccharomyces cerevisiae, GI6226519, Length=501, Percent_Identity=39.7205588822355, Blast_Score=366, Evalue=1e-102,
Organism=Saccharomyces cerevisiae, GI6226524, Length=336, Percent_Identity=38.9880952380952, Blast_Score=245, Evalue=1e-65,
Organism=Saccharomyces cerevisiae, GI6226523, Length=258, Percent_Identity=36.4341085271318, Blast_Score=153, Evalue=7e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014241 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: =1.9.3.1 [H]

Molecular weight: Translated: 65083; Mature: 64951

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCHHHHHHHHHEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
AYADDAAHHGPQSFWTRYIWSQDHKVIAVQYTLVAIVVGLIGVTLSNLMRMQLGFPGRF
CCCCCCCCCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC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CCHHHHHHHHHEECCCCCHHHHCCCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1444719; 12597275 [H]