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The map label for this gene is cupR [H]

Identifier: 94312454

GI number: 94312454

Start: 3815131

End: 3815550

Strand: Reverse

Name: cupR [H]

Synonym: Rmet_3523

Alternate gene names: 94312454

Gene position: 3815550-3815131 (Counterclockwise)

Preceding gene: 94312455

Following gene: 94312453

Centisome position: 97.14

GC content: 66.43

Gene sequence:

>420_bases
ATGAACATCGGAGAAGCCGCGGAAGCCTCGGGCGTTTCCGCAAAGATGATTCGCCACTACGAGTCGATCGGACTGGTCGA
TGCGCCGCCGCGCAGCGAGGGCGGGTATCGGCGGTATGACGAACGCGCGGTGCACACCTTGCGCTTCGTGCGACGGGCCC
GTAATCTCGGATTCTCGCTCGACGAGATTCGCGGTCTGTTGTCGCTCTGGCATGACCGGGCGCGCGCCAGCGCGGATGTG
AAGGCGCTGACGCTCAAGCACGTGGCCGACCTGGAGGTCCGCATCGCCGAACTCGCTGCGATGCGCGACACACTGCGGTC
GCTGGCCGAAGCGTGCACGGGGGATGACCGGCCCGACTGCCCGATCCTGTCGGATATGGCCCGTGCCGACAGCGAGGATC
GCCCGGCCTGCCATCACTAA

Upstream 100 bases:

>100_bases
GCGCCGCCATGGCATTTTCAAGTGTCAGCGTGGTCAGCAACGCACTGCTGCTGCGCCGCTGGCATCCGCTCGCAGGCAGT
GGCCACAAGGAGGTAACGCA

Downstream 100 bases:

>100_bases
GTGCTGGCGGCCCGGGGCCGGGGGAGCGCAGGCGTCAGCGGGACTGAAGGATCCAGATCCAGATCACTAACAACAAGCAG
GCGTACCCGACGAGGAGACG

Product: DNA-binding transcriptional activator of copper-responsive regulon genes

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 139; Mature: 139

Protein sequence:

>139_residues
MNIGEAAEASGVSAKMIRHYESIGLVDAPPRSEGGYRRYDERAVHTLRFVRRARNLGFSLDEIRGLLSLWHDRARASADV
KALTLKHVADLEVRIAELAAMRDTLRSLAEACTGDDRPDCPILSDMARADSEDRPACHH

Sequences:

>Translated_139_residues
MNIGEAAEASGVSAKMIRHYESIGLVDAPPRSEGGYRRYDERAVHTLRFVRRARNLGFSLDEIRGLLSLWHDRARASADV
KALTLKHVADLEVRIAELAAMRDTLRSLAEACTGDDRPDCPILSDMARADSEDRPACHH
>Mature_139_residues
MNIGEAAEASGVSAKMIRHYESIGLVDAPPRSEGGYRRYDERAVHTLRFVRRARNLGFSLDEIRGLLSLWHDRARASADV
KALTLKHVADLEVRIAELAAMRDTLRSLAEACTGDDRPDCPILSDMARADSEDRPACHH

Specific function: Transcriptional regulator involved in acid tolerance. Binds copper [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=139, Percent_Identity=46.0431654676259, Blast_Score=127, Evalue=2e-31,
Organism=Escherichia coli, GI1789687, Length=138, Percent_Identity=36.231884057971, Blast_Score=89, Evalue=1e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15453; Mature: 15453

Theoretical pI: Translated: 6.79; Mature: 6.79

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGEAAEASGVSAKMIRHYESIGLVDAPPRSEGGYRRYDERAVHTLRFVRRARNLGFSL
CCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
DEIRGLLSLWHDRARASADVKALTLKHVADLEVRIAELAAMRDTLRSLAEACTGDDRPDC
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PILSDMARADSEDRPACHH
CHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MNIGEAAEASGVSAKMIRHYESIGLVDAPPRSEGGYRRYDERAVHTLRFVRRARNLGFSL
CCCCCCHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCH
DEIRGLLSLWHDRARASADVKALTLKHVADLEVRIAELAAMRDTLRSLAEACTGDDRPDC
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PILSDMARADSEDRPACHH
CHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11481431 [H]