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The map label for this gene is dsbD [H]

Identifier: 94312219

GI number: 94312219

Start: 3564383

End: 3566257

Strand: Reverse

Name: dsbD [H]

Synonym: Rmet_3288

Alternate gene names: 94312219

Gene position: 3566257-3564383 (Counterclockwise)

Preceding gene: 94312220

Following gene: 94312215

Centisome position: 90.79

GC content: 64.8

Gene sequence:

>1875_bases
GTGCGACATATCGCCGCACTTTGGCTGACTGTATTCGCCTGCCTCTTCTTCTGGAACGTTGCACATGCGGCGACCGAAGA
CGATTTCCTGCCGCCGGAGCAGGCCTTTCGATTTGCCGCCAGACAGGTCGACCAGAAGACCGTCGAGGTTCGCTTCGACG
TGGCAGATGGCTACTACCTGTACCGTGAGCGCTTTTCCTTCGCTGCTCAGCCGGCTGACGTAAAACTCGGCAAGCCGGAG
ATGCCTGCCGGAAAGGTCCATTTCGATGAGACCTTCGGCAAGGACATGGAGACGTATCGTGGCGCCGTTGTGATCAAGGT
GCCGGTTGAGCAGGCGCCCGCAGATGGCCGCTGGTCGCTCGTGGTGACGTCGCAGGGTTGTGCGGACAAGGGGCTTTGCT
ATCCGCCGATGGAAAGCGTCTACAAGGTCGGTGGCTCCGCACTTGGCAACTTGTTCGGCGATCGTGGTGCGGCGGCTCAG
TCGACGCCGGAGGCGCAGGCTCCTGCCGCAGTGCAACCTGCACCGGATCGCGCGGCGCCGACGCGTCCAAGCAAGGTGGT
CGACGACACCGATAGGATCGCCAATGCACTCGCCAGCCGCAATCTCGCGCTGATCGGGGCCCTGTTCTTCGGCCTCGGCA
TTCTTCTGACATTCACGCCGTGCGTGCTGCCGATGGTGCCGATTCTTTCGTCGATCGTCGTCGGCGAGCATGTCACGCGC
GGGCGTGCGTTCCTGGTGTCGCTCTCCTACGTGCTTGGCATGGCCGTGGTCTACACCACGGTGGGCGTAGCGGCCGGTCT
GGCTGGCGAAGGCCTGGCCGCGGCGCTCCAGACGCCCTGGGTGCTTGGCGCTTTCGCAGCCTTGATGGTCGCGCTCGCGA
TGTCCATGTTCGGCATGTACGAACTGCAGATGCCGCAGCGCTGGCAAGCCCGACTGACCGAATCCTCGAATCGCCGACAG
AGCGGGCAGTTTGTCGGTGCGGCCCTGATGGGGGCGATTTCTGCGCTGATCGTGGGGCCCTGTGTCACGGCACCGCTCGC
GGGCGCGCTGGCGTATATCGCGCAAACCGGCGATGCCATCACCGGCGGAGCGGCCCTGATGGCTATGGCTCTCGGCATGG
GCGTGCCGCTGATGCTGGTTGGGATGGGCGCCGGCAATCTGCTGCCACGAGCGGGCAAGTGGATGGAGGCTACCAAGCGC
TTCTTCGGCTTCCTGCTTCTGGGCGTGGCGATCTGGATGGTGACGCCCGTACTGCCAGCGTGGGTCGTGATGCTGGCATG
GGCAGCGCTGCTGCTTGTGGCGGCCGTCTATCTCGGCGCGTTCGATGCGCTGGGCCCGGACCCACGGGGCGTGATGCGAC
TGGGCAAGGGGCTTGGCCTGCTGGCGGCATTGGTGGGCGCGATTCAGATCGTTGGTGTGGCGTCGGGCGGACGAAATCCC
TTGCAGCCGCTTTCCCATCTGAGTCTGTCGGCGGCCACGCTGCCACCGCATGCCGCCGAGATTCGCTTCGAGCGCGTGCG
GAACATCGCCGAACTCGATGCGCGGATCGCACAGGCCTCCGCTGCCGGGCGTCCGGTGCTGCTGGATTTCTATGCCGACT
GGTGCGTCAGTTGCAAGGAGATGGAGAAGCTGACGTTCCCGGACGCGAAAGTCAGGGCGCAACTCGCGGACGTCGTCCTG
TTGCAGGCTGACGTGACGGCCAACAATGCCGACGATCGCGCGTTACTGAAGCGTTTCGGTCTGTTCGGCCCGCCGGGCAT
CATCCTTTTCGGCAAGGATGGACAGGAGCGCCCGGTGCGGGTGATCGGCTATCAATCGGCATCGCGCTTCCTCGAAAGCC
TTGAGCGCGCGCTGGGGCCGCGGTCGCAGACCTGA

Upstream 100 bases:

>100_bases
AAGGTCTGAAGCTTCTCAAGTATCGGAATATCAACACATGGTAATGACGGGTAGCAGCATCGGAACAATGTGGAAAGCCG
GTGCAACGCGCGGGAATCTG

Downstream 100 bases:

>100_bases
CCCGGCCCGGTCCGCGTCCTAGCGATCCAGCCAGCGGCCCAGGCCCCAGACGCCACCGATCACGGCGACCACGGCTCCCA
TCAACCCGATCGACCACCAG

Product: Thiol:disulfide interchange protein (Protein-disulfide reductase)

Products: NA

Alternate protein names: Protein-disulfide reductase; Disulfide reductase [H]

Number of amino acids: Translated: 624; Mature: 624

Protein sequence:

>624_residues
MRHIAALWLTVFACLFFWNVAHAATEDDFLPPEQAFRFAARQVDQKTVEVRFDVADGYYLYRERFSFAAQPADVKLGKPE
MPAGKVHFDETFGKDMETYRGAVVIKVPVEQAPADGRWSLVVTSQGCADKGLCYPPMESVYKVGGSALGNLFGDRGAAAQ
STPEAQAPAAVQPAPDRAAPTRPSKVVDDTDRIANALASRNLALIGALFFGLGILLTFTPCVLPMVPILSSIVVGEHVTR
GRAFLVSLSYVLGMAVVYTTVGVAAGLAGEGLAAALQTPWVLGAFAALMVALAMSMFGMYELQMPQRWQARLTESSNRRQ
SGQFVGAALMGAISALIVGPCVTAPLAGALAYIAQTGDAITGGAALMAMALGMGVPLMLVGMGAGNLLPRAGKWMEATKR
FFGFLLLGVAIWMVTPVLPAWVVMLAWAALLLVAAVYLGAFDALGPDPRGVMRLGKGLGLLAALVGAIQIVGVASGGRNP
LQPLSHLSLSAATLPPHAAEIRFERVRNIAELDARIAQASAAGRPVLLDFYADWCVSCKEMEKLTFPDAKVRAQLADVVL
LQADVTANNADDRALLKRFGLFGPPGIILFGKDGQERPVRVIGYQSASRFLESLERALGPRSQT

Sequences:

>Translated_624_residues
MRHIAALWLTVFACLFFWNVAHAATEDDFLPPEQAFRFAARQVDQKTVEVRFDVADGYYLYRERFSFAAQPADVKLGKPE
MPAGKVHFDETFGKDMETYRGAVVIKVPVEQAPADGRWSLVVTSQGCADKGLCYPPMESVYKVGGSALGNLFGDRGAAAQ
STPEAQAPAAVQPAPDRAAPTRPSKVVDDTDRIANALASRNLALIGALFFGLGILLTFTPCVLPMVPILSSIVVGEHVTR
GRAFLVSLSYVLGMAVVYTTVGVAAGLAGEGLAAALQTPWVLGAFAALMVALAMSMFGMYELQMPQRWQARLTESSNRRQ
SGQFVGAALMGAISALIVGPCVTAPLAGALAYIAQTGDAITGGAALMAMALGMGVPLMLVGMGAGNLLPRAGKWMEATKR
FFGFLLLGVAIWMVTPVLPAWVVMLAWAALLLVAAVYLGAFDALGPDPRGVMRLGKGLGLLAALVGAIQIVGVASGGRNP
LQPLSHLSLSAATLPPHAAEIRFERVRNIAELDARIAQASAAGRPVLLDFYADWCVSCKEMEKLTFPDAKVRAQLADVVL
LQADVTANNADDRALLKRFGLFGPPGIILFGKDGQERPVRVIGYQSASRFLESLERALGPRSQT
>Mature_624_residues
MRHIAALWLTVFACLFFWNVAHAATEDDFLPPEQAFRFAARQVDQKTVEVRFDVADGYYLYRERFSFAAQPADVKLGKPE
MPAGKVHFDETFGKDMETYRGAVVIKVPVEQAPADGRWSLVVTSQGCADKGLCYPPMESVYKVGGSALGNLFGDRGAAAQ
STPEAQAPAAVQPAPDRAAPTRPSKVVDDTDRIANALASRNLALIGALFFGLGILLTFTPCVLPMVPILSSIVVGEHVTR
GRAFLVSLSYVLGMAVVYTTVGVAAGLAGEGLAAALQTPWVLGAFAALMVALAMSMFGMYELQMPQRWQARLTESSNRRQ
SGQFVGAALMGAISALIVGPCVTAPLAGALAYIAQTGDAITGGAALMAMALGMGVPLMLVGMGAGNLLPRAGKWMEATKR
FFGFLLLGVAIWMVTPVLPAWVVMLAWAALLLVAAVYLGAFDALGPDPRGVMRLGKGLGLLAALVGAIQIVGVASGGRNP
LQPLSHLSLSAATLPPHAAEIRFERVRNIAELDARIAQASAAGRPVLLDFYADWCVSCKEMEKLTFPDAKVRAQLADVVL
LQADVTANNADDRALLKRFGLFGPPGIILFGKDGQERPVRVIGYQSASRFLESLERALGPRSQT

Specific function: Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a

COG id: COG4232

COG function: function code OC; Thiol:disulfide interchange protein

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1790578, Length=607, Percent_Identity=39.2092257001647, Blast_Score=371, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003834
- InterPro:   IPR022910
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF02683 DsbD; PF00085 Thioredoxin [H]

EC number: =1.8.1.8 [H]

Molecular weight: Translated: 66288; Mature: 66288

Theoretical pI: Translated: 8.45; Mature: 8.45

Prosite motif: PS00962 RIBOSOMAL_S2_1 ; PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRHIAALWLTVFACLFFWNVAHAATEDDFLPPEQAFRFAARQVDQKTVEVRFDVADGYYL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHH
YRERFSFAAQPADVKLGKPEMPAGKVHFDETFGKDMETYRGAVVIKVPVEQAPADGRWSL
HHHHHHHCCCCCCCCCCCCCCCCCCEECHHHHCCCHHHHCCEEEEEEECCCCCCCCCEEE
VVTSQGCADKGLCYPPMESVYKVGGSALGNLFGDRGAAAQSTPEAQAPAAVQPAPDRAAP
EEECCCCCCCCCCCCCHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TRPSKVVDDTDRIANALASRNLALIGALFFGLGILLTFTPCVLPMVPILSSIVVGEHVTR
CCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRAFLVSLSYVLGMAVVYTTVGVAAGLAGEGLAAALQTPWVLGAFAALMVALAMSMFGMY
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ELQMPQRWQARLTESSNRRQSGQFVGAALMGAISALIVGPCVTAPLAGALAYIAQTGDAI
HCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TGGAALMAMALGMGVPLMLVGMGAGNLLPRAGKWMEATKRFFGFLLLGVAIWMVTPVLPA
CCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVVMLAWAALLLVAAVYLGAFDALGPDPRGVMRLGKGLGLLAALVGAIQIVGVASGGRNP
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHEEEECCCCCCC
LQPLSHLSLSAATLPPHAAEIRFERVRNIAELDARIAQASAAGRPVLLDFYADWCVSCKE
CHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCHHH
MEKLTFPDAKVRAQLADVVLLQADVTANNADDRALLKRFGLFGPPGIILFGKDGQERPVR
HHHCCCCCHHHHHHHHHHHHEEECCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCEE
VIGYQSASRFLESLERALGPRSQT
EEEHHHHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MRHIAALWLTVFACLFFWNVAHAATEDDFLPPEQAFRFAARQVDQKTVEVRFDVADGYYL
CHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEEEEEECCCCHH
YRERFSFAAQPADVKLGKPEMPAGKVHFDETFGKDMETYRGAVVIKVPVEQAPADGRWSL
HHHHHHHCCCCCCCCCCCCCCCCCCEECHHHHCCCHHHHCCEEEEEEECCCCCCCCCEEE
VVTSQGCADKGLCYPPMESVYKVGGSALGNLFGDRGAAAQSTPEAQAPAAVQPAPDRAAP
EEECCCCCCCCCCCCCHHHHHHHCHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCC
TRPSKVVDDTDRIANALASRNLALIGALFFGLGILLTFTPCVLPMVPILSSIVVGEHVTR
CCCCHHCCHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
GRAFLVSLSYVLGMAVVYTTVGVAAGLAGEGLAAALQTPWVLGAFAALMVALAMSMFGMY
CHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHH
ELQMPQRWQARLTESSNRRQSGQFVGAALMGAISALIVGPCVTAPLAGALAYIAQTGDAI
HCCCCHHHHHHHHHCCCCHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
TGGAALMAMALGMGVPLMLVGMGAGNLLPRAGKWMEATKRFFGFLLLGVAIWMVTPVLPA
CCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WVVMLAWAALLLVAAVYLGAFDALGPDPRGVMRLGKGLGLLAALVGAIQIVGVASGGRNP
HHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHCHHHHHHHHHHHHHEEEECCCCCCC
LQPLSHLSLSAATLPPHAAEIRFERVRNIAELDARIAQASAAGRPVLLDFYADWCVSCKE
CHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEHHHHHHHHCHHH
MEKLTFPDAKVRAQLADVVLLQADVTANNADDRALLKRFGLFGPPGIILFGKDGQERPVR
HHHCCCCCHHHHHHHHHHHHEEECCCCCCCHHHHHHHHCCCCCCCCEEEECCCCCCCCEE
VIGYQSASRFLESLERALGPRSQT
EEEHHHHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]