Click here to switch to the map view.

The map label for this gene is hisI [H]

Identifier: 94312172

GI number: 94312172

Start: 3514729

End: 3515136

Strand: Reverse

Name: hisI [H]

Synonym: Rmet_3241

Alternate gene names: 94312172

Gene position: 3515136-3514729 (Counterclockwise)

Preceding gene: 94312173

Following gene: 94312171

Centisome position: 89.49

GC content: 60.05

Gene sequence:

>408_bases
ATGGCGAAGAAGTGGTTGAACAAGGTGAAGTGGGACGACAACGGTCTGGTGCCGGTGATCGTCCAGGAAGTCGGTTCCAA
CGACGTCCTGATGTTCGCGTTCATGAATCGCGACGCGCTGCAACGCACGGTGGAACTGGGCGAGGCCGTGTTCTGGTCGC
GCTCGCGCAAGCGCCTGTGGCACAAGGGCGAAGAATCAGGCCACGTCCAGAAAGTGCATGAGATTCGTCTGGATTGTGAC
GAAGACGTGGTGTTGCTCAAGGTGACGCAGATCGACAGCATCGCCTGCCACACCGGCCGTCACTCATGCTTCTTCCAGAA
GTTCGAGGGCGATGTCGAGTCCGGGGACTGGCAGACCGTCGAGCCGGTGCTCAAGGACCCGTCCTCGATCTACGCGGCCA
AGCCATGA

Upstream 100 bases:

>100_bases
ACGCCGTACTGGCCGCCAGCATCTTCCACTATGGCGAGCACACCGTTGGTGAGGCAAAGGCTTTCATGGCCCGCGAGGGC
ATTCCCGTCCGGATGTGATC

Downstream 100 bases:

>100_bases
GCGATAACCTGTCTCAGGCCGATATCCTGGCCCGCGTGGCGGCCACGCTGGAATCGCGCAAGCCCGAAAACGGTGGTGAC
CCGGAGAAATCCTATGTCGC

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH [H]

Number of amino acids: Translated: 135; Mature: 134

Protein sequence:

>135_residues
MAKKWLNKVKWDDNGLVPVIVQEVGSNDVLMFAFMNRDALQRTVELGEAVFWSRSRKRLWHKGEESGHVQKVHEIRLDCD
EDVVLLKVTQIDSIACHTGRHSCFFQKFEGDVESGDWQTVEPVLKDPSSIYAAKP

Sequences:

>Translated_135_residues
MAKKWLNKVKWDDNGLVPVIVQEVGSNDVLMFAFMNRDALQRTVELGEAVFWSRSRKRLWHKGEESGHVQKVHEIRLDCD
EDVVLLKVTQIDSIACHTGRHSCFFQKFEGDVESGDWQTVEPVLKDPSSIYAAKP
>Mature_134_residues
AKKWLNKVKWDDNGLVPVIVQEVGSNDVLMFAFMNRDALQRTVELGEAVFWSRSRKRLWHKGEESGHVQKVHEIRLDCDE
DVVLLKVTQIDSIACHTGRHSCFFQKFEGDVESGDWQTVEPVLKDPSSIYAAKP

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family [H]

Homologues:

Organism=Escherichia coli, GI2367128, Length=91, Percent_Identity=47.2527472527472, Blast_Score=90, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6319819, Length=105, Percent_Identity=33.3333333333333, Blast_Score=65, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002496
- ProDom:   PD002610 [H]

Pfam domain/function: PF01502 PRA-CH [H]

EC number: =3.5.4.19 [H]

Molecular weight: Translated: 15484; Mature: 15353

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKKWLNKVKWDDNGLVPVIVQEVGSNDVLMFAFMNRDALQRTVELGEAVFWSRSRKRLW
CCCHHHHHCCCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
HKGEESGHVQKVHEIRLDCDEDVVLLKVTQIDSIACHTGRHSCFFQKFEGDVESGDWQTV
CCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCEEECCCCCCEEHHHHCCCCCCCCCEEE
EPVLKDPSSIYAAKP
CHHHCCCCCEEECCC
>Mature Secondary Structure 
AKKWLNKVKWDDNGLVPVIVQEVGSNDVLMFAFMNRDALQRTVELGEAVFWSRSRKRLW
CCHHHHHCCCCCCCCEEEEEEECCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHH
HKGEESGHVQKVHEIRLDCDEDVVLLKVTQIDSIACHTGRHSCFFQKFEGDVESGDWQTV
CCCCCCCCHHHHHHHCCCCCCCEEEEEEECCCCEEECCCCCCEEHHHHCCCCCCCCCEEE
EPVLKDPSSIYAAKP
CHHHCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA