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The map label for this gene is hisE

Identifier: 94312171

GI number: 94312171

Start: 3514364

End: 3514732

Strand: Reverse

Name: hisE

Synonym: Rmet_3240

Alternate gene names: 94312171

Gene position: 3514732-3514364 (Counterclockwise)

Preceding gene: 94312172

Following gene: 94312170

Centisome position: 89.48

GC content: 61.79

Gene sequence:

>369_bases
ATGAGCGATAACCTGTCTCAGGCCGATATCCTGGCCCGCGTGGCGGCCACGCTGGAATCGCGCAAGCCCGAAAACGGTGG
TGACCCGGAGAAATCCTATGTCGCCAAGCTGTTCAAGAAGGGTGACGACGCGATTCTCAAGAAGATCGGCGAGGAAGCCA
CCGAAACGGTCATGGCCGCCAAGGATGCACGGGCTGCAGACTTGGCCGACGAGGCCGTTAGCAAGGTGGTCTACGAGGTG
GCCGACCTGTGGTTCCACACCATGGTGCTGCTGGCTCGCATCGGTCGGACCCCGGAAGACGTCGTCAATGAACTGGCGCG
CCGCGAAGGATTGTCCGGACTGGTCGAGAAGGCCAGCCGCAAGGAGTAG

Upstream 100 bases:

>100_bases
CATGCTTCTTCCAGAAGTTCGAGGGCGATGTCGAGTCCGGGGACTGGCAGACCGTCGAGCCGGTGCTCAAGGACCCGTCC
TCGATCTACGCGGCCAAGCC

Downstream 100 bases:

>100_bases
GATACGAGTCACGCGGCCCGAACCGGTTCGGGCGCGGCTTGATCCTGGAGGGCATGATGGCGACGGACTATACCTCGCAA
GTCACGACGACCGCGGATGC

Product: phosphoribosyl-ATP pyrophosphatase

Products: NA

Alternate protein names: PRA-PH

Number of amino acids: Translated: 122; Mature: 121

Protein sequence:

>122_residues
MSDNLSQADILARVAATLESRKPENGGDPEKSYVAKLFKKGDDAILKKIGEEATETVMAAKDARAADLADEAVSKVVYEV
ADLWFHTMVLLARIGRTPEDVVNELARREGLSGLVEKASRKE

Sequences:

>Translated_122_residues
MSDNLSQADILARVAATLESRKPENGGDPEKSYVAKLFKKGDDAILKKIGEEATETVMAAKDARAADLADEAVSKVVYEV
ADLWFHTMVLLARIGRTPEDVVNELARREGLSGLVEKASRKE
>Mature_121_residues
SDNLSQADILARVAATLESRKPENGGDPEKSYVAKLFKKGDDAILKKIGEEATETVMAAKDARAADLADEAVSKVVYEVA
DLWFHTMVLLARIGRTPEDVVNELARREGLSGLVEKASRKE

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0140

COG function: function code E; Phosphoribosyl-ATP pyrophosphohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-PH family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS2_RALME (Q1LIB4)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_585381.1
- ProteinModelPortal:   Q1LIB4
- SMR:   Q1LIB4
- STRING:   Q1LIB4
- GeneID:   4040075
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_3240
- eggNOG:   COG0140
- HOGENOM:   HBG646527
- OMA:   ETVMAAK
- ProtClustDB:   PRK00400
- BioCyc:   RMET266264:RMET_3240-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_01020
- InterPro:   IPR008179
- InterPro:   IPR021130
- TIGRFAMs:   TIGR03188

Pfam domain/function: PF01503 PRA-PH

EC number: =3.6.1.31

Molecular weight: Translated: 13301; Mature: 13170

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDNLSQADILARVAATLESRKPENGGDPEKSYVAKLFKKGDDAILKKIGEEATETVMAA
CCCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KDARAADLADEAVSKVVYEVADLWFHTMVLLARIGRTPEDVVNELARREGLSGLVEKASR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
KE
CC
>Mature Secondary Structure 
SDNLSQADILARVAATLESRKPENGGDPEKSYVAKLFKKGDDAILKKIGEEATETVMAA
CCCHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
KDARAADLADEAVSKVVYEVADLWFHTMVLLARIGRTPEDVVNELARREGLSGLVEKASR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHC
KE
CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA