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The map label for this gene is metR [H]

Identifier: 94311922

GI number: 94311922

Start: 3247285

End: 3247785

Strand: Reverse

Name: metR [H]

Synonym: Rmet_2990

Alternate gene names: 94311922

Gene position: 3247785-3247285 (Counterclockwise)

Preceding gene: 94311923

Following gene: 94311921

Centisome position: 82.68

GC content: 63.87

Gene sequence:

>501_bases
GTGGGTCACTTCTGGGTGGAAATCAACACGCTGTTCAAGCCGGGGCTGAAGTTCGAACCCGTGTTCGACTACGAGCAGGT
GCTGGTCGTGGCCAAAGACCACCCCCTGGCTTCTACGGCCTACGTGAAGCCCCAGCAGCTGACCCGGGAAGTGCTCATCA
GTTACCCCGTGGACATCGAACGCCTGGACATCTACAGCCAGTTCCTGTTGCCGGCCGGCGTGACGCCCAAGCGCCACAAA
GCCATCGAAACCACCGACATCATGGTGCAGATGGTGGCCAGCGGCCGCGGTGTCGCCGCGCTGCCGCGCTGGCTGGTCGA
GGAATATGCGGCCAGGATGGACGTGGTGCCTGTGCGGCTGGGCGCGCGCGGTATTGCCAAGCAGATCTTCCTGGGCGCAC
GCGAGGCGGATACCGCCATTGACTACGTGCGGGCCTTCGTCGAACTGGCCCGCCAGCCTGCAACTGCCACCACCGCTATT
GCCCAAGGAGCCAAGGGATGA

Upstream 100 bases:

>100_bases
GTATCTCTGGGACGTTTAAGTCCTGTGGAATACCGGCACAAACTTGGCCTAGCCGCATAAAACCAGTCCAAGTTTTTATC
CGCACCCCCACCGGGGGCTA

Downstream 100 bases:

>100_bases
ACACCACCGTCGAACGCAAAGCGCTTGCGCTGCCCGGAGGCCACGACAAGGTGCTGCTGCATTCGTGCTGCGCGCCGTGC
TCAGGCGAGGTCATGGAGGC

Product: DNA-binding protein transcriptional activator, homocysteine-binding protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MGHFWVEINTLFKPGLKFEPVFDYEQVLVVAKDHPLASTAYVKPQQLTREVLISYPVDIERLDIYSQFLLPAGVTPKRHK
AIETTDIMVQMVASGRGVAALPRWLVEEYAARMDVVPVRLGARGIAKQIFLGAREADTAIDYVRAFVELARQPATATTAI
AQGAKG

Sequences:

>Translated_166_residues
MGHFWVEINTLFKPGLKFEPVFDYEQVLVVAKDHPLASTAYVKPQQLTREVLISYPVDIERLDIYSQFLLPAGVTPKRHK
AIETTDIMVQMVASGRGVAALPRWLVEEYAARMDVVPVRLGARGIAKQIFLGAREADTAIDYVRAFVELARQPATATTAI
AQGAKG
>Mature_165_residues
GHFWVEINTLFKPGLKFEPVFDYEQVLVVAKDHPLASTAYVKPQQLTREVLISYPVDIERLDIYSQFLLPAGVTPKRHKA
IETTDIMVQMVASGRGVAALPRWLVEEYAARMDVVPVRLGARGIAKQIFLGAREADTAIDYVRAFVELARQPATATTAIA
QGAKG

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=147, Percent_Identity=39.4557823129252, Blast_Score=110, Evalue=5e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 18396; Mature: 18264

Theoretical pI: Translated: 8.82; Mature: 8.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGHFWVEINTLFKPGLKFEPVFDYEQVLVVAKDHPLASTAYVKPQQLTREVLISYPVDIE
CCEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHH
RLDIYSQFLLPAGVTPKRHKAIETTDIMVQMVASGRGVAALPRWLVEEYAARMDVVPVRL
HHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEC
GARGIAKQIFLGAREADTAIDYVRAFVELARQPATATTAIAQGAKG
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC
>Mature Secondary Structure 
GHFWVEINTLFKPGLKFEPVFDYEQVLVVAKDHPLASTAYVKPQQLTREVLISYPVDIE
CEEEEEEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHCCCCHH
RLDIYSQFLLPAGVTPKRHKAIETTDIMVQMVASGRGVAALPRWLVEEYAARMDVVPVRL
HHHHHHHHHHCCCCCCCHHCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCEEEEC
GARGIAKQIFLGAREADTAIDYVRAFVELARQPATATTAIAQGAKG
CCHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]