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The map label for this gene is icd [H]

Identifier: 94311827

GI number: 94311827

Start: 3150904

End: 3152154

Strand: Reverse

Name: icd [H]

Synonym: Rmet_2895

Alternate gene names: 94311827

Gene position: 3152154-3150904 (Counterclockwise)

Preceding gene: 94311831

Following gene: 94311825

Centisome position: 80.25

GC content: 59.95

Gene sequence:

>1251_bases
ATGTATCAGCACATCAAGGTGCCGGCAGGCGAGAAGATCAAGGTCAACGCCGATCTTTCGCTGAACGTGCCGGATAATCC
GATCATTCCCTACATCGAAGGTGACGGCACGGGTGTCGATATCACCCCGGTGATGCTGAAAGTGGTGGATGCCGCCGTGG
CCAAGGCGTATGGCGGCAAGCGCAAGATCTCGTGGATGGAGATCTACGCGGGCGAGAAGTCGACCAAGGTCTATGGCCCG
GATGTGTGGCTGCCGGAAGAGACCATGGAAGTGGTCAAGGAATACGTGGTGTCGATCAAGGGCCCGCTGACCACGCCGGT
CGGTGGTGGCATCCGCTCGCTGAACGTGGCACTGCGTCAGCAGCTCGATCTCTATGTCTGCTTGCGCCCGGTGCGTTATT
TCAAAGGCGTGCCGTCCCCGGTGCGCGAGCCCGAGAAGACCGACATGGTGATCTTCCGCGAGAACTCGGAAGACATCTAT
GCCGGCATCGAGTGGGAAGCCGAAAGCGAAGGCGCGAAGAAGCTGATCGCCTTCCTGCAGAACGAAATGGGCGTGAAGAA
GATCCGCTTCCCGGAAACGTCCGGCATCGGCATCAAGCCCGTCTCGAAGGAAGGCACGCAGCGCCTGGTGCGCAAGGCGC
TCCAGTACGCGATCGACAACGACAAGCCGTCGGTGACGCTCGTGCACAAGGGCAACATCATGAAGTTCACCGAAGGCGGC
TTCCGCGACTGGGGCTATGAACTCGCGCAGCAGGAATTTGGCGCGGAACTGGTCGATGGCGGCCCGTGGTGCAAGTTCAA
GAATCCGAAGACTGGCCGCGATATCGTCGTCAAGGACGCTATCGCCGACGCATTCCTGCAGCAGATTCTGCTGCGTCCAG
CTGAATATTCGGTGATCGCCACGCTGAACCTGAACGGTGACTACATCTCCGACGCCCTGGCCGCCCAGGTGGGTGGCATC
GGCATCGCACCGGGCGCGAACATGTCCGATTCGGTCGCCATGTTCGAAGCCACGCACGGCACCGCGCCGAAGTATGCAGG
CAAGGACTACGTGAATCCAGGTTCGGAAATCCTCTCCGCGGAAATGATGCTGCGCCACATGGGCTGGACCGAAGCGGCCG
ACCTGATCATCCGCTCGATGGAGAAGTCGATCCAGTCGAAGAAGGTCACGTACGACTTCGCCCGGCTGCTAGAAGGTGCG
ACGCAGGTGTCGTGCTCGGGGTTTGGTCAGGTGATGATCGACAATATGTAA

Upstream 100 bases:

>100_bases
AACCCGATTCGCCCGTTACAATGCCTTGCACGACACAATCGCATTGCCGGGCTCTGCGGCCTGGTGCTGTCCTTACCCCC
ATCCGCAGTTGGAGACAAAT

Downstream 100 bases:

>100_bases
GCGCGACGGCCACTCCGCCGGAGACAGAAAGCCCCGCAGATGCGGGGCTTTTTCACGTCTATTGGCTGACGGAGATCACC
CGATCGTCGCGGCGCTGGCC

Product: isocitrate dehydrogenase

Products: NA

Alternate protein names: IDH; IDP; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase [H]

Number of amino acids: Translated: 416; Mature: 416

Protein sequence:

>416_residues
MYQHIKVPAGEKIKVNADLSLNVPDNPIIPYIEGDGTGVDITPVMLKVVDAAVAKAYGGKRKISWMEIYAGEKSTKVYGP
DVWLPEETMEVVKEYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIY
AGIEWEAESEGAKKLIAFLQNEMGVKKIRFPETSGIGIKPVSKEGTQRLVRKALQYAIDNDKPSVTLVHKGNIMKFTEGG
FRDWGYELAQQEFGAELVDGGPWCKFKNPKTGRDIVVKDAIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAQVGGI
GIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIIRSMEKSIQSKKVTYDFARLLEGA
TQVSCSGFGQVMIDNM

Sequences:

>Translated_416_residues
MYQHIKVPAGEKIKVNADLSLNVPDNPIIPYIEGDGTGVDITPVMLKVVDAAVAKAYGGKRKISWMEIYAGEKSTKVYGP
DVWLPEETMEVVKEYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIY
AGIEWEAESEGAKKLIAFLQNEMGVKKIRFPETSGIGIKPVSKEGTQRLVRKALQYAIDNDKPSVTLVHKGNIMKFTEGG
FRDWGYELAQQEFGAELVDGGPWCKFKNPKTGRDIVVKDAIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAQVGGI
GIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIIRSMEKSIQSKKVTYDFARLLEGA
TQVSCSGFGQVMIDNM
>Mature_416_residues
MYQHIKVPAGEKIKVNADLSLNVPDNPIIPYIEGDGTGVDITPVMLKVVDAAVAKAYGGKRKISWMEIYAGEKSTKVYGP
DVWLPEETMEVVKEYVVSIKGPLTTPVGGGIRSLNVALRQQLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIY
AGIEWEAESEGAKKLIAFLQNEMGVKKIRFPETSGIGIKPVSKEGTQRLVRKALQYAIDNDKPSVTLVHKGNIMKFTEGG
FRDWGYELAQQEFGAELVDGGPWCKFKNPKTGRDIVVKDAIADAFLQQILLRPAEYSVIATLNLNGDYISDALAAQVGGI
GIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEILSAEMMLRHMGWTEAADLIIRSMEKSIQSKKVTYDFARLLEGA
TQVSCSGFGQVMIDNM

Specific function: Unknown

COG id: COG0538

COG function: function code C; Isocitrate dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the isocitrate and isopropylmalate dehydrogenases family [H]

Homologues:

Organism=Homo sapiens, GI5031777, Length=386, Percent_Identity=31.3471502590674, Blast_Score=171, Evalue=2e-42,
Organism=Homo sapiens, GI28178821, Length=352, Percent_Identity=27.5568181818182, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI28178816, Length=352, Percent_Identity=27.5568181818182, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI28178838, Length=281, Percent_Identity=28.4697508896797, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI4758582, Length=279, Percent_Identity=28.3154121863799, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI28178819, Length=181, Percent_Identity=31.4917127071823, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1787381, Length=417, Percent_Identity=74.8201438848921, Blast_Score=656, Evalue=0.0,
Organism=Escherichia coli, GI1788101, Length=377, Percent_Identity=27.0557029177719, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI87081683, Length=401, Percent_Identity=23.1920199501247, Blast_Score=76, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71986051, Length=358, Percent_Identity=31.8435754189944, Blast_Score=160, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI25144293, Length=305, Percent_Identity=29.8360655737705, Blast_Score=119, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI17505779, Length=312, Percent_Identity=28.8461538461538, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI17550882, Length=260, Percent_Identity=26.5384615384615, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324709, Length=363, Percent_Identity=29.2011019283747, Blast_Score=156, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6322097, Length=367, Percent_Identity=28.3378746594005, Blast_Score=130, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6324291, Length=370, Percent_Identity=28.9189189189189, Blast_Score=127, Evalue=3e-30,
Organism=Drosophila melanogaster, GI24643270, Length=362, Percent_Identity=34.2541436464088, Blast_Score=184, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24643268, Length=362, Percent_Identity=34.2541436464088, Blast_Score=184, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24661184, Length=389, Percent_Identity=30.0771208226221, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI161078635, Length=297, Percent_Identity=27.6094276094276, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI161078637, Length=297, Percent_Identity=27.6094276094276, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161078639, Length=297, Percent_Identity=27.6094276094276, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI161078633, Length=297, Percent_Identity=27.6094276094276, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24650122, Length=297, Percent_Identity=27.6094276094276, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI20130355, Length=330, Percent_Identity=23.6363636363636, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI281362242, Length=338, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24648872, Length=338, Percent_Identity=26.9230769230769, Blast_Score=86, Evalue=7e-17,

Paralogues:

None

Copy number: 8180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 240 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR019818
- InterPro:   IPR001804
- InterPro:   IPR004439 [H]

Pfam domain/function: PF00180 Iso_dh [H]

EC number: =1.1.1.42 [H]

Molecular weight: Translated: 45681; Mature: 45681

Theoretical pI: Translated: 5.58; Mature: 5.58

Prosite motif: PS00470 IDH_IMDH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQHIKVPAGEKIKVNADLSLNVPDNPIIPYIEGDGTGVDITPVMLKVVDAAVAKAYGGK
CCCEEECCCCCEEEEECCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
RKISWMEIYAGEKSTKVYGPDVWLPEETMEVVKEYVVSIKGPLTTPVGGGIRSLNVALRQ
CCEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
QLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIYAGIEWEAESEGAKKLIAFLQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHH
NEMGVKKIRFPETSGIGIKPVSKEGTQRLVRKALQYAIDNDKPSVTLVHKGNIMKFTEGG
HCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
FRDWGYELAQQEFGAELVDGGPWCKFKNPKTGRDIVVKDAIADAFLQQILLRPAEYSVIA
CHHHHHHHHHHHHCCEEECCCCCEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEE
TLNLNGDYISDALAAQVGGIGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEILSA
EEECCCHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHH
EMMLRHMGWTEAADLIIRSMEKSIQSKKVTYDFARLLEGATQVSCSGFGQVMIDNM
HHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEECCCCCCEEECCC
>Mature Secondary Structure
MYQHIKVPAGEKIKVNADLSLNVPDNPIIPYIEGDGTGVDITPVMLKVVDAAVAKAYGGK
CCCEEECCCCCEEEEECCEEEECCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHCCCC
RKISWMEIYAGEKSTKVYGPDVWLPEETMEVVKEYVVSIKGPLTTPVGGGIRSLNVALRQ
CCEEEEEEECCCCCCEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHH
QLDLYVCLRPVRYFKGVPSPVREPEKTDMVIFRENSEDIYAGIEWEAESEGAKKLIAFLQ
HHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCHHHHHHHHHHH
NEMGVKKIRFPETSGIGIKPVSKEGTQRLVRKALQYAIDNDKPSVTLVHKGNIMKFTEGG
HCCCCEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCEEEECCCC
FRDWGYELAQQEFGAELVDGGPWCKFKNPKTGRDIVVKDAIADAFLQQILLRPAEYSVIA
CHHHHHHHHHHHHCCEEECCCCCEEECCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEE
TLNLNGDYISDALAAQVGGIGIAPGANMSDSVAMFEATHGTAPKYAGKDYVNPGSEILSA
EEECCCHHHHHHHHHHHCCEEECCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHH
EMMLRHMGWTEAADLIIRSMEKSIQSKKVTYDFARLLEGATQVSCSGFGQVMIDNM
HHHHHHCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCEEECCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10361714; 10556719; 12704232 [H]