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The map label for this gene is clpA [H]

Identifier: 94311824

GI number: 94311824

Start: 3147104

End: 3149401

Strand: Reverse

Name: clpA [H]

Synonym: Rmet_2892

Alternate gene names: 94311824

Gene position: 3149401-3147104 (Counterclockwise)

Preceding gene: 94311825

Following gene: 94311823

Centisome position: 80.18

GC content: 63.01

Gene sequence:

>2298_bases
ATGATTGCGCAAGAATTGGAAGTGAGCCTGCACATGGCCTTCGTCGAGGCTCGCCAGGCGCGCCACGAGTTCATCACCGT
GGAACACCTGCTGCTGGCGTTGCTCGACAACCCCACGGCGGCCGAGGTGCTGCGCGCGTGCGCAGCCAACATCGAGGACT
TGCGCACTAGTCTGAAGAACTTCATCGCCGACAACACGCCGGTCGTGCCCGGCACCGATGAAGTGGACACACAGCCGACA
CTCGGTTTCCAGCGAGTGATCCAGCGCGCCATCATGCATGTGCAGTCGACCTCCAACGGCAAGAAGGAGGTGACTGGCGC
AAACGTGCTGGTGGCGATCTTCGGCGAGAAGGATTCCCACGCGGTCTACTACCTGCAGCAGCAGGGCGTCACGCGCCTGG
ACGTGGTGAATTTCATCAGCCACGGCATCCGCAAGGATCAGGCCGAGCCCGCCAAGCATGGCGACGGCAACGCCGAAGGC
GAGGGCGGTGACGGCAAGGAAAGCCCGCTCGAGCAATACACCCAGAACCTGAACACGCTGGCCAAGGCCGGCAAGATCGA
TCCGCTGATCGGCCGCGAAAGCGAAGTCGAGCGCGTTGTCCAGGTGCTGTGCCGCCGCCGCAAGAACAACCCGCTGCTGA
CCGGCGAGGCCGGCGTGGGCAAGACGGCGATCGCCGAAGGTCTGGCCTGGCGCATCACCAAGGGCGAGGTGCCGGATATC
CTGGAAAAGGCCGTGGTGTACTCGCTCGACATGGGCGCGCTGCTGGCCGGCACCAAGTACCGTGGCGACTTCGAGCAGCG
CCTCAAGGGTGTGCTGAAGTCGCTCAAGGACAATCCGAACGCGATCCTGTTCATCGACGAGATCCACACGCTGATCGGCG
CGGGCGCCGCATCGGGCGGCACGCTGGACGCCAGCAACCTGCTGAAACCGGCGCTGTCGTCGGGGCAGCTCAAGTGCATC
GGCGCGACCACGTTCACCGAGTACCGTGGCATCTTCGAGAAGGATGCGGCGTTATCGCGTCGATTCCAGAAGATCGACGT
GGTCGAGCCTTCGGTAGACCAGACCGTGCAGATTCTGCGTGGCCTGAAGTCGCGCTTCGAGGAGCATCACGGCGTCAAAT
ACGCGGCCTCGGCGCTGACCGCGGCGGCCGAACTGTCGGCACGCTTCATCACGGACCGTCATCTGCCGGACAAGGCGATC
GATGTGATCGATGAAGCGGGTGCGGCACAGCGCATCCTGCCGAAGTCGAAGCAGAAGAAGACGATCGGCAAGGCCGAGAT
CGAGGACATCGTGTCGCGCATCGCGCGTATCCCGCCGCAAAGCGTGAACCAGGACGACCGCAGCAAGTTGCAGACGCTGG
AACGCGACCTGAAGTCGGTGGTGTTCGGTCAGGACCCGGCCATCGAGGCGCTGGCTTCGGCGATCAAGATGTCGCGTGCT
GGCCTGGGCAAGACCGACAAGCCGATCGGCTCGTTCCTGTTCTCGGGCCCGACCGGCGTCGGCAAGACCGAAGTGGCCAA
GCAGCTCGCGTTCATCATGGGCATTGAGTTGCTGCGCTTCGACATGTCCGAATACATGGAGCGCCACGCGGTGAGCCGCC
TGATCGGCGCGCCCCCGGGCTATGTCGGTTTCGACCAGGGCGGCCTGCTGACCGAGGCCGTCACGAAGAAGCCGCACTGC
GTGCTCCTGCTCGACGAGATCGAAAAGGCACATCCGGATATCTTCAACATCCTGCTGCAGGTCATGGACCACGGTTCGCT
CACCGACAACAACGGTCGCCGTGCCGACTTCCGCAACGTGATCATCATCATGACCACCAATGCGGGCGCCGAGACGATGA
ACCGTGCCACGATCGGCTTCACCACCGCCCGCGAGCAGGGCGACGAAATGGCCGATATCAAGCGGATGTTCACGCCCGAG
TTCCGTAACCGGCTCGATGCAATGATCAGCTTCCGCTCGCTGGATGAGGAAATCATTCTGCGCGTGGTGGACAAGTTCCT
GATGCAGCTGGAAGAGCAACTGCACGAGAAGAAGGTGGATGCCAGCTTCTCGGAGAAGCTGCGCAAGTATCTGGCGAAGA
AGGGCTTCGATCCACTGATGGGTGCCCGTCCGATGCAGCGTCTGATCCAGGACATGATCCGCAAGGCGCTGGCCGACGAG
CTGCTGTTTGGCAAGCTTGTCAGCGGCGGCAAGGTCGCGGTGGACCTGGACGATGACGACCAGATCAAGCTGACGTTCTC
CGAAGCGGATCCGGAGCCGCCCGAGGCGCCGGAAAGCGAGCAGCGCGCAGAAGTCTGA

Upstream 100 bases:

>100_bases
GTGGTATCTATACGCGTGATATCGCGGCGACCAAAGTCGAGCTTGTATCAACCCATGCGCGGCAGGCGGGGCACCCGCTG
CAGTGCGTGATGGAGGAAGC

Downstream 100 bases:

>100_bases
GCGTCTGACATATCAGCAAATTGGATAACGGCCGGGTCATTCCCGGCCGTTTTTCTTGGGCGATTGTTCCAGCTTCGTGG
GCTTTTGGGCGATCAGCGAA

Product: ATPase and specificity subunit of ClpA-ClpP ATP-dependent serine protease, chaperone activity

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 765; Mature: 765

Protein sequence:

>765_residues
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTSLKNFIADNTPVVPGTDEVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIRKDQAEPAKHGDGNAEG
EGGDGKESPLEQYTQNLNTLAKAGKIDPLIGRESEVERVVQVLCRRRKNNPLLTGEAGVGKTAIAEGLAWRITKGEVPDI
LEKAVVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLKCI
GATTFTEYRGIFEKDAALSRRFQKIDVVEPSVDQTVQILRGLKSRFEEHHGVKYAASALTAAAELSARFITDRHLPDKAI
DVIDEAGAAQRILPKSKQKKTIGKAEIEDIVSRIARIPPQSVNQDDRSKLQTLERDLKSVVFGQDPAIEALASAIKMSRA
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFIMGIELLRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKPHC
VLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRRADFRNVIIIMTTNAGAETMNRATIGFTTAREQGDEMADIKRMFTPE
FRNRLDAMISFRSLDEEIILRVVDKFLMQLEEQLHEKKVDASFSEKLRKYLAKKGFDPLMGARPMQRLIQDMIRKALADE
LLFGKLVSGGKVAVDLDDDDQIKLTFSEADPEPPEAPESEQRAEV

Sequences:

>Translated_765_residues
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTSLKNFIADNTPVVPGTDEVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIRKDQAEPAKHGDGNAEG
EGGDGKESPLEQYTQNLNTLAKAGKIDPLIGRESEVERVVQVLCRRRKNNPLLTGEAGVGKTAIAEGLAWRITKGEVPDI
LEKAVVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLKCI
GATTFTEYRGIFEKDAALSRRFQKIDVVEPSVDQTVQILRGLKSRFEEHHGVKYAASALTAAAELSARFITDRHLPDKAI
DVIDEAGAAQRILPKSKQKKTIGKAEIEDIVSRIARIPPQSVNQDDRSKLQTLERDLKSVVFGQDPAIEALASAIKMSRA
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFIMGIELLRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKPHC
VLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRRADFRNVIIIMTTNAGAETMNRATIGFTTAREQGDEMADIKRMFTPE
FRNRLDAMISFRSLDEEIILRVVDKFLMQLEEQLHEKKVDASFSEKLRKYLAKKGFDPLMGARPMQRLIQDMIRKALADE
LLFGKLVSGGKVAVDLDDDDQIKLTFSEADPEPPEAPESEQRAEV
>Mature_765_residues
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTSLKNFIADNTPVVPGTDEVDTQPT
LGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSHAVYYLQQQGVTRLDVVNFISHGIRKDQAEPAKHGDGNAEG
EGGDGKESPLEQYTQNLNTLAKAGKIDPLIGRESEVERVVQVLCRRRKNNPLLTGEAGVGKTAIAEGLAWRITKGEVPDI
LEKAVVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGGTLDASNLLKPALSSGQLKCI
GATTFTEYRGIFEKDAALSRRFQKIDVVEPSVDQTVQILRGLKSRFEEHHGVKYAASALTAAAELSARFITDRHLPDKAI
DVIDEAGAAQRILPKSKQKKTIGKAEIEDIVSRIARIPPQSVNQDDRSKLQTLERDLKSVVFGQDPAIEALASAIKMSRA
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFIMGIELLRFDMSEYMERHAVSRLIGAPPGYVGFDQGGLLTEAVTKKPHC
VLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRRADFRNVIIIMTTNAGAETMNRATIGFTTAREQGDEMADIKRMFTPE
FRNRLDAMISFRSLDEEIILRVVDKFLMQLEEQLHEKKVDASFSEKLRKYLAKKGFDPLMGARPMQRLIQDMIRKALADE
LLFGKLVSGGKVAVDLDDDDQIKLTFSEADPEPPEAPESEQRAEV

Specific function: ATP-dependent specificity component of the ClpP protease. It directs the protease to specific substrates. The primary function of the ClpA-ClpP complex appears to be the degradation of unfolded or abnormal proteins [H]

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the clpA/clpB family [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=345, Percent_Identity=30.4347826086957, Blast_Score=155, Evalue=2e-37,
Organism=Escherichia coli, GI1787109, Length=760, Percent_Identity=62.6315789473684, Blast_Score=981, Evalue=0.0,
Organism=Escherichia coli, GI1788943, Length=399, Percent_Identity=45.8646616541353, Blast_Score=310, Evalue=2e-85,
Organism=Saccharomyces cerevisiae, GI6320464, Length=253, Percent_Identity=57.3122529644269, Blast_Score=280, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6323002, Length=268, Percent_Identity=52.2388059701493, Blast_Score=266, Evalue=9e-72,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR013461
- InterPro:   IPR023150 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small [H]

EC number: NA

Molecular weight: Translated: 84100; Mature: 84100

Theoretical pI: Translated: 6.03; Mature: 6.03

Prosite motif: PS00870 CLPAB_1 ; PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTSLKN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIADNTPVVPGTDEVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIRKDQAEPAKHGDGNAEGEGGDGKESPLEQYTQNLNTL
EEEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AKAGKIDPLIGRESEVERVVQVLCRRRKNNPLLTGEAGVGKTAIAEGLAWRITKGEVPDI
HHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHCCCEEEECCCCCHHH
LEKAVVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGG
HHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
TLDASNLLKPALSSGQLKCIGATTFTEYRGIFEKDAALSRRFQKIDVVEPSVDQTVQILR
CCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSRFEEHHGVKYAASALTAAAELSARFITDRHLPDKAIDVIDEAGAAQRILPKSKQKK
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHHHH
TIGKAEIEDIVSRIARIPPQSVNQDDRSKLQTLERDLKSVVFGQDPAIEALASAIKMSRA
HCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFIMGIELLRFDMSEYMERHAVSRLIGAPPG
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRRADFRNV
CCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCE
IIIMTTNAGAETMNRATIGFTTAREQGDEMADIKRMFTPEFRNRLDAMISFRSLDEEIIL
EEEEECCCCHHHHCCCCEEEEHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHH
RVVDKFLMQLEEQLHEKKVDASFSEKLRKYLAKKGFDPLMGARPMQRLIQDMIRKALADE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLFGKLVSGGKVAVDLDDDDQIKLTFSEADPEPPEAPESEQRAEV
HHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCHHCCCC
>Mature Secondary Structure
MIAQELEVSLHMAFVEARQARHEFITVEHLLLALLDNPTAAEVLRACAANIEDLRTSLKN
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHH
FIADNTPVVPGTDEVDTQPTLGFQRVIQRAIMHVQSTSNGKKEVTGANVLVAIFGEKDSH
HHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEEEECCCCCC
AVYYLQQQGVTRLDVVNFISHGIRKDQAEPAKHGDGNAEGEGGDGKESPLEQYTQNLNTL
EEEEEHHCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHH
AKAGKIDPLIGRESEVERVVQVLCRRRKNNPLLTGEAGVGKTAIAEGLAWRITKGEVPDI
HHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCEEECCCCCCHHHHHCCCEEEECCCCCHHH
LEKAVVYSLDMGALLAGTKYRGDFEQRLKGVLKSLKDNPNAILFIDEIHTLIGAGAASGG
HHHHHHHHCCCHHHHCCCCCCCCHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCCCCCC
TLDASNLLKPALSSGQLKCIGATTFTEYRGIFEKDAALSRRFQKIDVVEPSVDQTVQILR
CCCHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHH
GLKSRFEEHHGVKYAASALTAAAELSARFITDRHLPDKAIDVIDEAGAAQRILPKSKQKK
HHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHCCCCHHHH
TIGKAEIEDIVSRIARIPPQSVNQDDRSKLQTLERDLKSVVFGQDPAIEALASAIKMSRA
HCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHC
GLGKTDKPIGSFLFSGPTGVGKTEVAKQLAFIMGIELLRFDMSEYMERHAVSRLIGAPPG
CCCCCCCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
YVGFDQGGLLTEAVTKKPHCVLLLDEIEKAHPDIFNILLQVMDHGSLTDNNGRRADFRNV
CCCCCCCCCHHHHHCCCCCEEEEHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCCCCCCCE
IIIMTTNAGAETMNRATIGFTTAREQGDEMADIKRMFTPEFRNRLDAMISFRSLDEEIIL
EEEEECCCCHHHHCCCCEEEEHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHHCCHHHHH
RVVDKFLMQLEEQLHEKKVDASFSEKLRKYLAKKGFDPLMGARPMQRLIQDMIRKALADE
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
LLFGKLVSGGKVAVDLDDDDQIKLTFSEADPEPPEAPESEQRAEV
HHHHHHCCCCEEEEECCCCCEEEEEECCCCCCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]