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The map label for this gene is mscS1 [H]

Identifier: 94311808

GI number: 94311808

Start: 3126602

End: 3127972

Strand: Reverse

Name: mscS1 [H]

Synonym: Rmet_2876

Alternate gene names: 94311808

Gene position: 3127972-3126602 (Counterclockwise)

Preceding gene: 94311809

Following gene: 94311807

Centisome position: 79.63

GC content: 60.76

Gene sequence:

>1371_bases
ATGGCGGATAGCACGCTGATGAACCCCGATACGCTCGCGGAGCTGAAACGATCGCACGCGATGTTCGGCAAGATGGTGCA
GGACCTGATCCACGATGCGGGCGGTCCGGGGTTTTTCTGGCAGATCGGGGTACTGGCCATTTGCCTGCTGATCGCGTGGC
CGCTGTCGCGGCGCGTGGTCAAGCGGCTGGAGGTTCGCCACCAGTCGGCAAGCTTCTCGTTGCGCATGGCCGCGGTCAGC
CTGGAGCGTGCGGTGTTCCCGCTCATCAGCTGGCTGCTGGTGTTGGTGGCGCTTTTCTCGCTGGAATCGCTGATCCCGAT
CAGCGTTCTGCGGCTCGCGCTGGTGCCGCTGTTCGGCATCACCTCGTTGTATGTGACGTTCTACATCCTCCGGCGAGTGA
TATCGGGACATGGCCAGCTTCACGGCATGCTTGTGCTGGTGGAGAAGGTACTGACGACCCTGACGTGGATCGCCATGGGT
TTGTACGTGCTTGGCGTGCTGCCGGACGTGGTCGCGTGGATGCGGGACGTGCGGTTCTCGATTGGCGGCAAGCAGCACAT
CAACCTGGCCGATTCGCTGATGGCAATGGTCTGGATTCTCCTGACCGTGCTGGTGGCGATGTGGTTTGGTTCGTGGCTGG
AAGAGCGCCTGATGCGTGCGACCACGCTCGATTCGAACCTGAAGGTCGTGCTGACGCGCATCACGAAGGCGCTGCTGTTA
CTGGTGTCGTTGCTGCTGAGCCTGTCGCTCGTGGGCATCGACCTGACCGTGCTCTCGGTGTTTGGCGGCGCACTGGGTGT
CGGCCTCGGTCTTGGCCTGCAGAAGATCGCGAGCAACTACATATCTGGCTTCATCATCCTGCTCGATCGCTCGGTCAAGC
TTGGCGACCAGATCACGGTCGACAAGTACACCGGCATCGTGTCGCAGATTCGCACGCGCTACACCGTTGTGCGCAATGGC
GACGGCGAGACGCTTGTGCCGAATGAGCAACTTGTGGCCCAGTCAGTGCAAAACCATTCGTTCTCTGGAACGAATGTGCG
CGTGGCTACCCGGGTGCAAGCGGACTATGCCGCCGATCCAGAAATGGTGATCGGATTGCTGCAGGATTGTGTGCGCAATT
TGCCACGTGTGCTCGAAGCGCCGGCACCCGCCGCATTCCTTGTGATGTTTGCTGACAGCGGCATCGAGTACGAAACTGCC
GTCTACATCGCGGATCCACAGAACGGCAAGCTTGGCGTGCAGTCGGCGATGAATCGGGCCATCTGGCGCGCGTTTCACGA
AAATGGCATTTCGATCCCATATCCGCAGCGCGAGGTGCGGATGCTGAATCCGGCGACGCCACTTGTCGTGGCGGATGCCG
CACAGGATTGA

Upstream 100 bases:

>100_bases
AGGTGCCGGAGTTGCCGGCGGAAGGCGGCATGTTGGCGCTCTATCCGCATATCCATCAGACCGATGGCTTCTTCGCCGCT
GTTCTGGAGCGCACGCGCTG

Downstream 100 bases:

>100_bases
ACGTTTCCCGCGCCAGCCGCTCAAAGTCGGGGAAAAAGCGGATGTCTGACCCGCGTCGATCCGGTAGAATATCGGGCTGA
ACGCGGGTTGCAGACCAACC

Product: Small-conductance mechano-sensitive channel

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MADSTLMNPDTLAELKRSHAMFGKMVQDLIHDAGGPGFFWQIGVLAICLLIAWPLSRRVVKRLEVRHQSASFSLRMAAVS
LERAVFPLISWLLVLVALFSLESLIPISVLRLALVPLFGITSLYVTFYILRRVISGHGQLHGMLVLVEKVLTTLTWIAMG
LYVLGVLPDVVAWMRDVRFSIGGKQHINLADSLMAMVWILLTVLVAMWFGSWLEERLMRATTLDSNLKVVLTRITKALLL
LVSLLLSLSLVGIDLTVLSVFGGALGVGLGLGLQKIASNYISGFIILLDRSVKLGDQITVDKYTGIVSQIRTRYTVVRNG
DGETLVPNEQLVAQSVQNHSFSGTNVRVATRVQADYAADPEMVIGLLQDCVRNLPRVLEAPAPAAFLVMFADSGIEYETA
VYIADPQNGKLGVQSAMNRAIWRAFHENGISIPYPQREVRMLNPATPLVVADAAQD

Sequences:

>Translated_456_residues
MADSTLMNPDTLAELKRSHAMFGKMVQDLIHDAGGPGFFWQIGVLAICLLIAWPLSRRVVKRLEVRHQSASFSLRMAAVS
LERAVFPLISWLLVLVALFSLESLIPISVLRLALVPLFGITSLYVTFYILRRVISGHGQLHGMLVLVEKVLTTLTWIAMG
LYVLGVLPDVVAWMRDVRFSIGGKQHINLADSLMAMVWILLTVLVAMWFGSWLEERLMRATTLDSNLKVVLTRITKALLL
LVSLLLSLSLVGIDLTVLSVFGGALGVGLGLGLQKIASNYISGFIILLDRSVKLGDQITVDKYTGIVSQIRTRYTVVRNG
DGETLVPNEQLVAQSVQNHSFSGTNVRVATRVQADYAADPEMVIGLLQDCVRNLPRVLEAPAPAAFLVMFADSGIEYETA
VYIADPQNGKLGVQSAMNRAIWRAFHENGISIPYPQREVRMLNPATPLVVADAAQD
>Mature_455_residues
ADSTLMNPDTLAELKRSHAMFGKMVQDLIHDAGGPGFFWQIGVLAICLLIAWPLSRRVVKRLEVRHQSASFSLRMAAVSL
ERAVFPLISWLLVLVALFSLESLIPISVLRLALVPLFGITSLYVTFYILRRVISGHGQLHGMLVLVEKVLTTLTWIAMGL
YVLGVLPDVVAWMRDVRFSIGGKQHINLADSLMAMVWILLTVLVAMWFGSWLEERLMRATTLDSNLKVVLTRITKALLLL
VSLLLSLSLVGIDLTVLSVFGGALGVGLGLGLQKIASNYISGFIILLDRSVKLGDQITVDKYTGIVSQIRTRYTVVRNGD
GETLVPNEQLVAQSVQNHSFSGTNVRVATRVQADYAADPEMVIGLLQDCVRNLPRVLEAPAPAAFLVMFADSGIEYETAV
YIADPQNGKLGVQSAMNRAIWRAFHENGISIPYPQREVRMLNPATPLVVADAAQD

Specific function: Unknown

COG id: COG3264

COG function: function code M; Small-conductance mechanosensitive channel

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mscS (TC 1.A.23) family [H]

Homologues:

Organism=Escherichia coli, GI2367355, Length=283, Percent_Identity=31.8021201413428, Blast_Score=134, Evalue=1e-32,
Organism=Escherichia coli, GI1786670, Length=214, Percent_Identity=32.7102803738318, Blast_Score=125, Evalue=8e-30,
Organism=Escherichia coli, GI1787591, Length=259, Percent_Identity=23.9382239382239, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789291, Length=228, Percent_Identity=25.8771929824561, Blast_Score=66, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010920
- InterPro:   IPR011066
- InterPro:   IPR006685
- InterPro:   IPR006686
- InterPro:   IPR011014 [H]

Pfam domain/function: PF00924 MS_channel [H]

EC number: NA

Molecular weight: Translated: 50113; Mature: 49982

Theoretical pI: Translated: 8.96; Mature: 8.96

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHCCCCCCCCCHHHEEECCCCCEEEECCCCC
>Mature Secondary Structure 
ADSTLMNPDTLAELKRSHAMFGKMVQDLIHDAGGPGFFWQIGVLAICLLIAWPLSRRVV
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHH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HHHHHHHCCCCCCCCCHHHEEECCCCCEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503; 3042771 [H]