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The map label for this gene is nadC [H]

Identifier: 94311805

GI number: 94311805

Start: 3122960

End: 3123823

Strand: Reverse

Name: nadC [H]

Synonym: Rmet_2873

Alternate gene names: 94311805

Gene position: 3123823-3122960 (Counterclockwise)

Preceding gene: 94311806

Following gene: 94311801

Centisome position: 79.53

GC content: 65.97

Gene sequence:

>864_bases
ATGAGCGTGAATTCCGTATTCGATAGCTACGGCCCCGCGCTGCGTGTGGCGCTGGCCGCCAACGTCAAGGCGGCGATTGC
CGAGGATGTGGGGGCTGGTGACCTGACCGGTCTGCTGGTGCCGGCCGACAAGCCCGTGCACGCCCGCGTGATTGTTCGCG
AAGCTGCCGTGCTGTGCGGTCGCCCGTGGTTCGACGCCTGCATGCAAGCCATCGACGAGAGGCTGCAGGTGACGTGGCAG
AAGGAAGAGGGCGCGCGCCTGGCGCCGGACGACGTGGTCTGCGAAATCACCGGGCCGGCACGCGCGTTGCTGACCGCCGA
GCGGCCATCGCTGAATTTCCTGCAACTGCTCTCCGGCGTGGCGTCGGCCACTCGCCGTTACGCCGATCTGATCGCCGATA
CGCGCGCACGCGTGCTCGATACGCGCAAGACGCTGCCGGGTCTGCGGCTTGCGCAGAAGTATGCGGTGAGGATCGGAGGC
GGAGAGAACCAGCGCCTGGCGCTATACGACGGCATCCTGATCAAGGAGAACCACATCGCGGCGGCCGGCGGTATCGCGGC
GGCGATGGAAGCGGCGCTGGCGCTTGGCACCGATGCTTCGATCCAGATCGAGGTTGAATCGATCGCCGAGCTGGAAGAGG
CGCTGGCGGCAGGCGCGACGTCCGTGCTGATCGACAACTTCTCGCTGGAAATGATGCGAGAGGCCGTGGCGATCAACCGT
GAGCGTGCACTTCTCGAGGTGTCGGGCGGAGTGAACTACGAAACGATTCGCCGTTTCGCCGAAACCGGCGTCGACCGGAT
CTCGGTCGGCGCCCTCACCAAGGATGTGCGCGCGACCGATTACTCGCTGCGCATCGTCGGCTGA

Upstream 100 bases:

>100_bases
TCAACCGGATGCTCGATTTCGCCGCGCAGCAGAAAGCCAATGTTCGCCCCGCAGCCGATCTCGCCAAGGAATCGGCACTG
TTCAGCGGAGTTGGCCCGGC

Downstream 100 bases:

>100_bases
ACCTGGTCCTGGGCTGTCGCCGGAGGCTCAGACCTTCCGGCGGCTTGCCGCGCGGCCCGTCAGCGGTTGCAGCACGGTAG
GCAGCGCCTTCGGCAGCGTT

Product: nicotinate-nucleotide pyrophosphorylase

Products: NA

Alternate protein names: Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase [H]

Number of amino acids: Translated: 287; Mature: 286

Protein sequence:

>287_residues
MSVNSVFDSYGPALRVALAANVKAAIAEDVGAGDLTGLLVPADKPVHARVIVREAAVLCGRPWFDACMQAIDERLQVTWQ
KEEGARLAPDDVVCEITGPARALLTAERPSLNFLQLLSGVASATRRYADLIADTRARVLDTRKTLPGLRLAQKYAVRIGG
GENQRLALYDGILIKENHIAAAGGIAAAMEAALALGTDASIQIEVESIAELEEALAAGATSVLIDNFSLEMMREAVAINR
ERALLEVSGGVNYETIRRFAETGVDRISVGALTKDVRATDYSLRIVG

Sequences:

>Translated_287_residues
MSVNSVFDSYGPALRVALAANVKAAIAEDVGAGDLTGLLVPADKPVHARVIVREAAVLCGRPWFDACMQAIDERLQVTWQ
KEEGARLAPDDVVCEITGPARALLTAERPSLNFLQLLSGVASATRRYADLIADTRARVLDTRKTLPGLRLAQKYAVRIGG
GENQRLALYDGILIKENHIAAAGGIAAAMEAALALGTDASIQIEVESIAELEEALAAGATSVLIDNFSLEMMREAVAINR
ERALLEVSGGVNYETIRRFAETGVDRISVGALTKDVRATDYSLRIVG
>Mature_286_residues
SVNSVFDSYGPALRVALAANVKAAIAEDVGAGDLTGLLVPADKPVHARVIVREAAVLCGRPWFDACMQAIDERLQVTWQK
EEGARLAPDDVVCEITGPARALLTAERPSLNFLQLLSGVASATRRYADLIADTRARVLDTRKTLPGLRLAQKYAVRIGGG
ENQRLALYDGILIKENHIAAAGGIAAAMEAALALGTDASIQIEVESIAELEEALAAGATSVLIDNFSLEMMREAVAINRE
RALLEVSGGVNYETIRRFAETGVDRISVGALTKDVRATDYSLRIVG

Specific function: Involved in the catabolism of quinolinic acid (QA) [H]

COG id: COG0157

COG function: function code H; Nicotinate-nucleotide pyrophosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the nadC/modD family [H]

Homologues:

Organism=Homo sapiens, GI45269149, Length=277, Percent_Identity=35.7400722021661, Blast_Score=142, Evalue=3e-34,
Organism=Escherichia coli, GI1786299, Length=270, Percent_Identity=49.6296296296296, Blast_Score=234, Evalue=4e-63,
Organism=Saccharomyces cerevisiae, GI6321162, Length=289, Percent_Identity=33.2179930795848, Blast_Score=145, Evalue=6e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR004393
- InterPro:   IPR002638
- InterPro:   IPR022412 [H]

Pfam domain/function: PF01729 QRPTase_C; PF02749 QRPTase_N [H]

EC number: =2.4.2.19 [H]

Molecular weight: Translated: 30596; Mature: 30465

Theoretical pI: Translated: 4.84; Mature: 4.84

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVNSVFDSYGPALRVALAANVKAAIAEDVGAGDLTGLLVPADKPVHARVIVREAAVLCG
CCCHHHHHHCCHHEEEHHHHCHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
RPWFDACMQAIDERLQVTWQKEEGARLAPDDVVCEITGPARALLTAERPSLNFLQLLSGV
CHHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHH
ASATRRYADLIADTRARVLDTRKTLPGLRLAQKYAVRIGGGENQRLALYDGILIKENHIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEEECCCEE
AAGGIAAAMEAALALGTDASIQIEVESIAELEEALAAGATSVLIDNFSLEMMREAVAINR
HHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCC
ERALLEVSGGVNYETIRRFAETGVDRISVGALTKDVRATDYSLRIVG
CCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEEEEEC
>Mature Secondary Structure 
SVNSVFDSYGPALRVALAANVKAAIAEDVGAGDLTGLLVPADKPVHARVIVREAAVLCG
CCHHHHHHCCHHEEEHHHHCHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHCC
RPWFDACMQAIDERLQVTWQKEEGARLAPDDVVCEITGPARALLTAERPSLNFLQLLSGV
CHHHHHHHHHHHHHHEEEEECCCCCCCCCCCEEEEECCCCEEEEECCCCCCHHHHHHHHH
ASATRRYADLIADTRARVLDTRKTLPGLRLAQKYAVRIGGGENQRLALYDGILIKENHIA
HHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHEEEECCCCCCEEEEECCEEEECCCEE
AAGGIAAAMEAALALGTDASIQIEVESIAELEEALAAGATSVLIDNFSLEMMREAVAINR
HHHHHHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHCC
ERALLEVSGGVNYETIRRFAETGVDRISVGALTKDVRATDYSLRIVG
CCEEEEECCCCCHHHHHHHHHCCCCEEEHHHHHHCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043; 2430961; 8419294 [H]