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The map label for this gene is panC

Identifier: 94311706

GI number: 94311706

Start: 3021450

End: 3022292

Strand: Direct

Name: panC

Synonym: Rmet_2774

Alternate gene names: 94311706

Gene position: 3021450-3022292 (Clockwise)

Preceding gene: 94311705

Following gene: 94311708

Centisome position: 76.92

GC content: 65.6

Gene sequence:

>843_bases
ATGAAAGTCATCTCCTCCATCCAGGCGCTGCGGGACCAGTTGCGCGGACAGAACCGCGTCGCTTTCGTCCCGACCATGGG
TAACCTGCACGAAGGCCACCTGTCGCTGATGCGGCTGGCCCGCCAGCATGGAGACCCCGTGGTGGCGTCGATCTTCGTCA
ACCGCCTGCAGTTCGGCCCGAACGAGGACTTCGACAAATACCCGCGCACGCTGCAGGACGACATCGAGAAGCTGCAGAGC
GAAGGCGTCTACGTACTGTTCGCGCCGACCGAGTCGGACATGTATCCGGTGCCGCAGGAGTACCGCGTGGACCCGCCGCA
TGACCTGGGTGACATCCTCGAAGGTGAATTCCGCCCGGGCTTCTTCAAAGGCGTCTGCACGGTGGTGATGAAGCTGTTCT
GCTGCGTGCAGCCGCGCGTGGCGGTGTTCGGCAAGAAGGACTACCAGCAGTTGATGATCGTGCGCCGCATGGCCAAGCAG
TTCGCGCTGCCGGTGGACATCATTCCGGCCGAAACCATCCGAGCCGAGGATGGGCTGGCCCTCTCGTCGCGCAACCGCTA
CCTCGGCGAGACCGAGCGCGCCGAGGCGCCGGTGCTCTACAAGACGCTGCACGAAGTGCGTGACACCGTGCTGGGCGGCG
ATGGCGTGGACCTGCTGGCCGTCGAGGCCGACGCGCTGGCCCGCCTGCAGGCCCGTGGCTGGAAGCCCGACTATGTGTCG
ATTCGCAAACAGGACAACCTGCAGCCCCCGACCCGCGAGGAATTCGCGGCCGGCGCCCCGCTGGTGGTGCTGACGGCGGC
CAAGCTCGGCGCTACCCGGTTGATCGACAACCTGGAGATCTGA

Upstream 100 bases:

>100_bases
TACAATCCGCCGACAGCCCGGCCGACGTCTGCCATGAGAGCCAGGCACGGGTGAAGTCCGACTTCGGGACGCTCCCCTAC
CACGACCGCACACGACATTC

Downstream 100 bases:

>100_bases
GCGCGAATCTGAACGCAAGAGCGATCCGACCCCGCAACAAAAAAAGCCTGCGCACTTGCCGCAGGCTTTTTGCTTCTTGA
ACTGCTTCTTGAACGGCTGA

Product: pantoate--beta-alanine ligase

Products: NA

Alternate protein names: PS; Pantoate--beta-alanine ligase; Pantoate-activating enzyme

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MKVISSIQALRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLQDDIEKLQS
EGVYVLFAPTESDMYPVPQEYRVDPPHDLGDILEGEFRPGFFKGVCTVVMKLFCCVQPRVAVFGKKDYQQLMIVRRMAKQ
FALPVDIIPAETIRAEDGLALSSRNRYLGETERAEAPVLYKTLHEVRDTVLGGDGVDLLAVEADALARLQARGWKPDYVS
IRKQDNLQPPTREEFAAGAPLVVLTAAKLGATRLIDNLEI

Sequences:

>Translated_280_residues
MKVISSIQALRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLQDDIEKLQS
EGVYVLFAPTESDMYPVPQEYRVDPPHDLGDILEGEFRPGFFKGVCTVVMKLFCCVQPRVAVFGKKDYQQLMIVRRMAKQ
FALPVDIIPAETIRAEDGLALSSRNRYLGETERAEAPVLYKTLHEVRDTVLGGDGVDLLAVEADALARLQARGWKPDYVS
IRKQDNLQPPTREEFAAGAPLVVLTAAKLGATRLIDNLEI
>Mature_280_residues
MKVISSIQALRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGPNEDFDKYPRTLQDDIEKLQS
EGVYVLFAPTESDMYPVPQEYRVDPPHDLGDILEGEFRPGFFKGVCTVVMKLFCCVQPRVAVFGKKDYQQLMIVRRMAKQ
FALPVDIIPAETIRAEDGLALSSRNRYLGETERAEAPVLYKTLHEVRDTVLGGDGVDLLAVEADALARLQARGWKPDYVS
IRKQDNLQPPTREEFAAGAPLVVLTAAKLGATRLIDNLEI

Specific function: Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate

COG id: COG0414

COG function: function code H; Panthothenate synthetase

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pantothenate synthetase family

Homologues:

Organism=Escherichia coli, GI1786325, Length=283, Percent_Identity=44.5229681978799, Blast_Score=214, Evalue=6e-57,
Organism=Saccharomyces cerevisiae, GI6322046, Length=295, Percent_Identity=36.9491525423729, Blast_Score=151, Evalue=1e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PANC_RALME (Q1LJM9)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_584916.1
- ProteinModelPortal:   Q1LJM9
- SMR:   Q1LJM9
- STRING:   Q1LJM9
- GeneID:   4039600
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_2774
- eggNOG:   COG0414
- HOGENOM:   HBG428839
- OMA:   RLIDNFT
- PhylomeDB:   Q1LJM9
- ProtClustDB:   PRK00380
- BioCyc:   RMET266264:RMET_2774-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00158
- InterPro:   IPR004821
- InterPro:   IPR003721
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PANTHER:   PTHR21299:SF1
- TIGRFAMs:   TIGR00125
- TIGRFAMs:   TIGR00018

Pfam domain/function: PF02569 Pantoate_ligase

EC number: =6.3.2.1

Molecular weight: Translated: 31388; Mature: 31388

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: ACT_SITE 33-33 BINDING 57-57 BINDING 57-57 BINDING 150-150 BINDING 173-173

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKVISSIQALRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGP
CHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
NEDFDKYPRTLQDDIEKLQSEGVYVLFAPTESDMYPVPQEYRVDPPHDLGDILEGEFRPG
CCCHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHCCCCCCCCHHHHHCCCCCCC
FFKGVCTVVMKLFCCVQPRVAVFGKKDYQQLMIVRRMAKQFALPVDIIPAETIRAEDGLA
HHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEECCHHHHCCCCCCE
LSSRNRYLGETERAEAPVLYKTLHEVRDTVLGGDGVDLLAVEADALARLQARGWKPDYVS
ECCCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCCEE
IRKQDNLQPPTREEFAAGAPLVVLTAAKLGATRLIDNLEI
EECCCCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHHCCCC
>Mature Secondary Structure
MKVISSIQALRDQLRGQNRVAFVPTMGNLHEGHLSLMRLARQHGDPVVASIFVNRLQFGP
CHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
NEDFDKYPRTLQDDIEKLQSEGVYVLFAPTESDMYPVPQEYRVDPPHDLGDILEGEFRPG
CCCHHHCCHHHHHHHHHHHHCCEEEEEECCCCCCCCCCHHCCCCCCCCHHHHHCCCCCCC
FFKGVCTVVMKLFCCVQPRVAVFGKKDYQQLMIVRRMAKQFALPVDIIPAETIRAEDGLA
HHHHHHHHHHHHHHHCCCHHHHHCCHHHHHHHHHHHHHHHHCCCCEECCHHHHCCCCCCE
LSSRNRYLGETERAEAPVLYKTLHEVRDTVLGGDGVDLLAVEADALARLQARGWKPDYVS
ECCCCCCCCCCHHCCCCHHHHHHHHHHHHHCCCCCCEEEEECHHHHHHHHHCCCCCCCEE
IRKQDNLQPPTREEFAAGAPLVVLTAAKLGATRLIDNLEI
EECCCCCCCCCHHHHHCCCCEEEEEHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA