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The map label for this gene is phr [H]

Identifier: 94311677

GI number: 94311677

Start: 2979622

End: 2981163

Strand: Direct

Name: phr [H]

Synonym: Rmet_2745

Alternate gene names: 94311677

Gene position: 2979622-2981163 (Clockwise)

Preceding gene: 94311668

Following gene: 94311678

Centisome position: 75.85

GC content: 64.79

Gene sequence:

>1542_bases
ATGTCTGGATCGCCCTCCCCCGAATCTGAAGCCGACGCCGCGCGCCTGCCTTACCGGATCGACCGGAATTTTACCCGCGG
CCTGGTCTGGCTCCGGCGCGACTTGCGCACCGATGACAACGCGGCGCTGCATTATGCCCTCAAGCACTGCCGGCAGGTAT
GGTGCGTTTTCGTGTTCGACCGGGAAATCCTGGCGCCGCTGCTGGCGCGGGGGCTGCATGCCGATCGCCGCGTCGAGTTT
ATCCTGCGTTCGCTGGAGCCATTGCGCCGGGCGCTGGAAGATTCGGGCGGCGGCCTGATCGTGCTCGACGGCACCGCGCG
GCAGGCAATTCCGAGGCTGGCCGCAGAGCTTGAAGTGGAGGCCGTCTTCGCCAACCATGATTACGAGCCGGCCGCCAACG
ATCGCGACGAAGCCGTGCGCCGGACACTAGCCGCCGACAGCCGGGTGCTGCTCACGTTCAAGGACCAGGTCATCTTCGAA
CGCGACGAGATCCTGACTGGCCAAGGCCGCCCCTTCAGCGTATTCACGCCCTACAAGAACGCCTGGCTGCGCACGGTGCG
GCCGTTCGACCTGCGGCCATATCCGATCGAAAAGCACCAGGAAACGCTTGCACCTGTTCCGCAACGGTACCGGGGGCAAT
TGCCAACGCTGGCCGACCTCGGCTTCACTGCCACCAACCTGGCGGGGATCGCCATGCCCACGGGCAGTGACGGCGCTCAC
GCGCTGTTCGACGAATTCCTGTCCCGCATTGGCGACTACGGCCGTCGGCGCGATTTTCCGGCTGTGCGGGGACCAAGCTA
TCTCTCGGTCCACCTGCGCTTCGGCACGATCTCGATCCGCACACTCGCCCGCGCCGCGCATGACACCATGCTGCGCGGCG
GTGCCGCGAGCGAAGGCGCGACCGTCTGGCTCTCGGAACTGATCTGGCGCGACTTCTATTTCATGATCTTGCATCACCAT
CCGCGCGTGGCGGAAGGTAAGTCGTTTCACGCCGAATACGATGGGCTGCGGTGGATCGCGCCGGCCACCGGCGACCGGTA
CTTCGCAGCCTGGTGCGACGCGCGGACCGGCTATCCGCTGATCGACGCGGCGATGCTCCAGATCCGCCAGAGCGGCTACA
TGCACAACCGCCTGCGCATGGTGACCGCCAGCTTCCTGGTCAAGGACCTGGGCGTGGATTGGCGCCGTGGCGAACAGTAC
TTCGCCGACCAGCTCAACGATTTCGACCTTGCGGCCAACAACGGCGGCTGGCAGTGGGCGGCCTCGACGGGCTGCGACGC
GCAACCGTACTTCCGCATCTTCAATCCGGTCACGCAGTCGGAGAAATTCGATCCGCAGGGGCAGTTCATCCGGAGATACC
TGCCGATGCTGGCTGCGCTGCCCGACAGGTACATCCATGCGCCGTGGACGGCACCCAATGAGGTGCTACGGGCAGCGGGA
GTGACACTTGGAAAAGACTATCCACGCCCGATCGTTCAACACGATGTGGCGCGGAAGGAAACGCTTGAGCGGTACGGTGT
AGTGAAGAGCGCGAAAGCGTGA

Upstream 100 bases:

>100_bases
TGGGATTGCAGGATGCGGTCGAGTGTCGTGGCCATGGGAATATCTTTCTGCTGCTTGGATGGGACTGCTGGAGTTCCGGT
TGCTATGTTAGGTTACGGCG

Downstream 100 bases:

>100_bases
GCATATGAGCACTTCGGTCCCACCTCGACCAATGGCGCGGGAAAGGGCAGTGGCATAATCGCGCCTTTCCCCCCGACTGA
TCAAATGGACCTCTACTCGA

Product: deoxyribodipyrimidine photolyase, FAD-binding protein

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 513; Mature: 512

Protein sequence:

>513_residues
MSGSPSPESEADAARLPYRIDRNFTRGLVWLRRDLRTDDNAALHYALKHCRQVWCVFVFDREILAPLLARGLHADRRVEF
ILRSLEPLRRALEDSGGGLIVLDGTARQAIPRLAAELEVEAVFANHDYEPAANDRDEAVRRTLAADSRVLLTFKDQVIFE
RDEILTGQGRPFSVFTPYKNAWLRTVRPFDLRPYPIEKHQETLAPVPQRYRGQLPTLADLGFTATNLAGIAMPTGSDGAH
ALFDEFLSRIGDYGRRRDFPAVRGPSYLSVHLRFGTISIRTLARAAHDTMLRGGAASEGATVWLSELIWRDFYFMILHHH
PRVAEGKSFHAEYDGLRWIAPATGDRYFAAWCDARTGYPLIDAAMLQIRQSGYMHNRLRMVTASFLVKDLGVDWRRGEQY
FADQLNDFDLAANNGGWQWAASTGCDAQPYFRIFNPVTQSEKFDPQGQFIRRYLPMLAALPDRYIHAPWTAPNEVLRAAG
VTLGKDYPRPIVQHDVARKETLERYGVVKSAKA

Sequences:

>Translated_513_residues
MSGSPSPESEADAARLPYRIDRNFTRGLVWLRRDLRTDDNAALHYALKHCRQVWCVFVFDREILAPLLARGLHADRRVEF
ILRSLEPLRRALEDSGGGLIVLDGTARQAIPRLAAELEVEAVFANHDYEPAANDRDEAVRRTLAADSRVLLTFKDQVIFE
RDEILTGQGRPFSVFTPYKNAWLRTVRPFDLRPYPIEKHQETLAPVPQRYRGQLPTLADLGFTATNLAGIAMPTGSDGAH
ALFDEFLSRIGDYGRRRDFPAVRGPSYLSVHLRFGTISIRTLARAAHDTMLRGGAASEGATVWLSELIWRDFYFMILHHH
PRVAEGKSFHAEYDGLRWIAPATGDRYFAAWCDARTGYPLIDAAMLQIRQSGYMHNRLRMVTASFLVKDLGVDWRRGEQY
FADQLNDFDLAANNGGWQWAASTGCDAQPYFRIFNPVTQSEKFDPQGQFIRRYLPMLAALPDRYIHAPWTAPNEVLRAAG
VTLGKDYPRPIVQHDVARKETLERYGVVKSAKA
>Mature_512_residues
SGSPSPESEADAARLPYRIDRNFTRGLVWLRRDLRTDDNAALHYALKHCRQVWCVFVFDREILAPLLARGLHADRRVEFI
LRSLEPLRRALEDSGGGLIVLDGTARQAIPRLAAELEVEAVFANHDYEPAANDRDEAVRRTLAADSRVLLTFKDQVIFER
DEILTGQGRPFSVFTPYKNAWLRTVRPFDLRPYPIEKHQETLAPVPQRYRGQLPTLADLGFTATNLAGIAMPTGSDGAHA
LFDEFLSRIGDYGRRRDFPAVRGPSYLSVHLRFGTISIRTLARAAHDTMLRGGAASEGATVWLSELIWRDFYFMILHHHP
RVAEGKSFHAEYDGLRWIAPATGDRYFAAWCDARTGYPLIDAAMLQIRQSGYMHNRLRMVTASFLVKDLGVDWRRGEQYF
ADQLNDFDLAANNGGWQWAASTGCDAQPYFRIFNPVTQSEKFDPQGQFIRRYLPMLAALPDRYIHAPWTAPNEVLRAAGV
TLGKDYPRPIVQHDVARKETLERYGVVKSAKA

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Homo sapiens, GI188536100, Length=498, Percent_Identity=31.7269076305221, Blast_Score=218, Evalue=1e-56,
Organism=Homo sapiens, GI4758072, Length=490, Percent_Identity=28.3673469387755, Blast_Score=204, Evalue=1e-52,
Organism=Homo sapiens, GI188536103, Length=448, Percent_Identity=31.4732142857143, Blast_Score=198, Evalue=9e-51,
Organism=Escherichia coli, GI1786926, Length=501, Percent_Identity=41.5169660678643, Blast_Score=323, Evalue=2e-89,
Organism=Saccharomyces cerevisiae, GI6324962, Length=522, Percent_Identity=26.6283524904215, Blast_Score=181, Evalue=2e-46,
Organism=Drosophila melanogaster, GI17137248, Length=498, Percent_Identity=28.5140562248996, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24585455, Length=498, Percent_Identity=28.5140562248996, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI24648152, Length=523, Percent_Identity=28.6806883365201, Blast_Score=159, Evalue=5e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002081
- InterPro:   IPR018394
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 58186; Mature: 58054

Theoretical pI: Translated: 8.75; Mature: 8.75

Prosite motif: PS00691 DNA_PHOTOLYASES_1_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSGSPSPESEADAARLPYRIDRNFTRGLVWLRRDLRTDDNAALHYALKHCRQVWCVFVFD
CCCCCCCCCCCHHHHCCEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEC
REILAPLLARGLHADRRVEFILRSLEPLRRALEDSGGGLIVLDGTARQAIPRLAAELEVE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHEEE
AVFANHDYEPAANDRDEAVRRTLAADSRVLLTFKDQVIFERDEILTGQGRPFSVFTPYKN
EEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCHHEECCCEECCCCCCEEEECCCCH
AWLRTVRPFDLRPYPIEKHQETLAPVPQRYRGQLPTLADLGFTATNLAGIAMPTGSDGAH
HHHHCCCCCCCCCCCCCHHHHHHCCCCHHHCCCCCCHHHCCCCHHCCCEEEECCCCCCHH
ALFDEFLSRIGDYGRRRDFPAVRGPSYLSVHLRFGTISIRTLARAAHDTMLRGGAASEGA
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECEEHHHHHHHHHHHHHHCCCCCCCCH
TVWLSELIWRDFYFMILHHHPRVAEGKSFHAEYDGLRWIAPATGDRYFAAWCDARTGYPL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCH
IDAAMLQIRQSGYMHNRLRMVTASFLVKDLGVDWRRGEQYFADQLNDFDLAANNGGWQWA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHCCCCCEEEECCCCEEEE
ASTGCDAQPYFRIFNPVTQSEKFDPQGQFIRRYLPMLAALPDRYIHAPWTAPNEVLRAAG
CCCCCCCCCHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHC
VTLGKDYPRPIVQHDVARKETLERYGVVKSAKA
CCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCC
>Mature Secondary Structure 
SGSPSPESEADAARLPYRIDRNFTRGLVWLRRDLRTDDNAALHYALKHCRQVWCVFVFD
CCCCCCCCCCHHHHCCEEECCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHEEEC
REILAPLLARGLHADRRVEFILRSLEPLRRALEDSGGGLIVLDGTARQAIPRLAAELEVE
HHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCHHHHHHHHHHHHEEE
AVFANHDYEPAANDRDEAVRRTLAADSRVLLTFKDQVIFERDEILTGQGRPFSVFTPYKN
EEEECCCCCCCCCCHHHHHHHHHHCCCEEEEEECCCHHEECCCEECCCCCCEEEECCCCH
AWLRTVRPFDLRPYPIEKHQETLAPVPQRYRGQLPTLADLGFTATNLAGIAMPTGSDGAH
HHHHCCCCCCCCCCCCCHHHHHHCCCCHHHCCCCCCHHHCCCCHHCCCEEEECCCCCCHH
ALFDEFLSRIGDYGRRRDFPAVRGPSYLSVHLRFGTISIRTLARAAHDTMLRGGAASEGA
HHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEEEECEEHHHHHHHHHHHHHHCCCCCCCCH
TVWLSELIWRDFYFMILHHHPRVAEGKSFHAEYDGLRWIAPATGDRYFAAWCDARTGYPL
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCH
IDAAMLQIRQSGYMHNRLRMVTASFLVKDLGVDWRRGEQYFADQLNDFDLAANNGGWQWA
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCHHCCHHHHHHCCCCCEEEECCCCEEEE
ASTGCDAQPYFRIFNPVTQSEKFDPQGQFIRRYLPMLAALPDRYIHAPWTAPNEVLRAAG
CCCCCCCCCHHHHHCCHHCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCCHHHHHHHHC
VTLGKDYPRPIVQHDVARKETLERYGVVKSAKA
CCCCCCCCCHHHHHHHHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6325460; 8905232; 9278503; 2200511; 7604260 [H]