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The map label for this gene is pcaR [H]

Identifier: 94311586

GI number: 94311586

Start: 2887777

End: 2888601

Strand: Reverse

Name: pcaR [H]

Synonym: Rmet_2652

Alternate gene names: 94311586

Gene position: 2888601-2887777 (Counterclockwise)

Preceding gene: 94311588

Following gene: 94311583

Centisome position: 73.54

GC content: 67.76

Gene sequence:

>825_bases
TTGGACATTTCATCCGAATCCGTCGCGCCAGCCGCGGAGCCGGCCCCGCGTGAACGCGAAAGCGATCCGAACTTCGTTAC
TGCGCTGGCGCGCGGACTGGAGTTGCTGCGCTGTTTCCGCACGGGGGAGACCATGCTCGGCAATCAGGATTTCGTGCGCC
GCACCGGCTTCCCGAAGGCGACGGTCAGCCGCCTGGCCGGCACGCTGGTGCAGCTTGGCTACCTTCGCTATGACGACAGC
CTGGGCAAGTATGCGCTCGATGCCGGCGTGCTGGCACTCGGGTTCTCGTACCTGTCGGCCTCCGGCGTGGTGGCGCTGGC
GCGTCCGCACATGCTGGCATTCGCGCAGCAGCACGGCGTGTCTGTGTCGCTGGGCAAGCGCGAGCGGCTGGAAGTCATCT
ACCTGGAGTCGATCCGGAACGACGCGGGCGCGATGCTCGGCCTGGGCGTGGGATCGCGCCTGTCGCTGGTATCGAGTTCG
ATGGGGCGGGCTTATCTGGCTGCGCTGCCGCAGGCCCGGCGCGATCGCGTGCTGGCCGAGTTCGCGCAGGCGTTCCCGGA
ACAATGGAAGGCACAGGAAGCACTGACGCGCGCGGCATTGGCGACGGCGGAGCGCGACGGCTATGCGGCGTCGTTCCGTG
ACTGGCATCCCGCCATTCACGCGTGCGCGGTGGCGTTTCGTCCGGTGGGGGAGAAGGATTTGCACATGCTCAGCTGCAGC
GCATCGTATGGCGCCGTCGGCGAGGAGGTGTTTCGGGAGAAGCTGGCGCCTGCGTTGCAGGCGTTGGCCACGCGGCTGTC
GGACCCGGCCGGGCGACAAGTCTGA

Upstream 100 bases:

>100_bases
TGAGCTAGTATAGCCGAACCGATCCGCGGCGCAACAGGGGAAATCTCGCGCCCCGGAGATTTGCGTTCGGCAATCGACCA
ACCCCATCTGGAGTTTCGCC

Downstream 100 bases:

>100_bases
GTGCCGCAGCTATGCGCTCCCCTCGCCCATGAATTGGGGGGAGGGGAGCAAACCAGCAGGTACTACAGGTCTGTCCGCAG
TTTCCACAGTTCCGGAAACA

Product: IclR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 274; Mature: 274

Protein sequence:

>274_residues
MDISSESVAPAAEPAPRERESDPNFVTALARGLELLRCFRTGETMLGNQDFVRRTGFPKATVSRLAGTLVQLGYLRYDDS
LGKYALDAGVLALGFSYLSASGVVALARPHMLAFAQQHGVSVSLGKRERLEVIYLESIRNDAGAMLGLGVGSRLSLVSSS
MGRAYLAALPQARRDRVLAEFAQAFPEQWKAQEALTRAALATAERDGYAASFRDWHPAIHACAVAFRPVGEKDLHMLSCS
ASYGAVGEEVFREKLAPALQALATRLSDPAGRQV

Sequences:

>Translated_274_residues
MDISSESVAPAAEPAPRERESDPNFVTALARGLELLRCFRTGETMLGNQDFVRRTGFPKATVSRLAGTLVQLGYLRYDDS
LGKYALDAGVLALGFSYLSASGVVALARPHMLAFAQQHGVSVSLGKRERLEVIYLESIRNDAGAMLGLGVGSRLSLVSSS
MGRAYLAALPQARRDRVLAEFAQAFPEQWKAQEALTRAALATAERDGYAASFRDWHPAIHACAVAFRPVGEKDLHMLSCS
ASYGAVGEEVFREKLAPALQALATRLSDPAGRQV
>Mature_274_residues
MDISSESVAPAAEPAPRERESDPNFVTALARGLELLRCFRTGETMLGNQDFVRRTGFPKATVSRLAGTLVQLGYLRYDDS
LGKYALDAGVLALGFSYLSASGVVALARPHMLAFAQQHGVSVSLGKRERLEVIYLESIRNDAGAMLGLGVGSRLSLVSSS
MGRAYLAALPQARRDRVLAEFAQAFPEQWKAQEALTRAALATAERDGYAASFRDWHPAIHACAVAFRPVGEKDLHMLSCS
ASYGAVGEEVFREKLAPALQALATRLSDPAGRQV

Specific function: Positive regulator of all genes within the pca regulon, pcaBDC, pcaIJ and pcaF. Also required for the chemotactic response to aromatic compounds [H]

COG id: COG1414

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 iclR-ED (iclR effector binding) domain [H]

Homologues:

Organism=Escherichia coli, GI87082359, Length=175, Percent_Identity=24.5714285714286, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1786468, Length=251, Percent_Identity=25.0996015936255, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012794
- InterPro:   IPR014757
- InterPro:   IPR005471
- InterPro:   IPR011991 [H]

Pfam domain/function: PF09339 HTH_IclR; PF01614 IclR [H]

EC number: NA

Molecular weight: Translated: 29528; Mature: 29528

Theoretical pI: Translated: 8.46; Mature: 8.46

Prosite motif: PS51077 HTH_ICLR ; PS51078 ICLR_ED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDISSESVAPAAEPAPRERESDPNFVTALARGLELLRCFRTGETMLGNQDFVRRTGFPKA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHCCCCHH
TVSRLAGTLVQLGYLRYDDSLGKYALDAGVLALGFSYLSASGVVALARPHMLAFAQQHGV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEEHHCHHHHHHHHHCCC
SVSLGKRERLEVIYLESIRNDAGAMLGLGVGSRLSLVSSSMGRAYLAALPQARRDRVLAE
EEECCCCCCCCEEEHHHHCCCHHHEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
FAQAFPEQWKAQEALTRAALATAERDGYAASFRDWHPAIHACAVAFRPVGEKDLHMLSCS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHEEECC
ASYGAVGEEVFREKLAPALQALATRLSDPAGRQV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MDISSESVAPAAEPAPRERESDPNFVTALARGLELLRCFRTGETMLGNQDFVRRTGFPKA
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHCCCHHHHHHCCCCHH
TVSRLAGTLVQLGYLRYDDSLGKYALDAGVLALGFSYLSASGVVALARPHMLAFAQQHGV
HHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCEEEHHCHHHHHHHHHCCC
SVSLGKRERLEVIYLESIRNDAGAMLGLGVGSRLSLVSSSMGRAYLAALPQARRDRVLAE
EEECCCCCCCCEEEHHHHCCCHHHEEECCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHH
FAQAFPEQWKAQEALTRAALATAERDGYAASFRDWHPAIHACAVAFRPVGEKDLHMLSCS
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCHHEEECC
ASYGAVGEEVFREKLAPALQALATRLSDPAGRQV
CCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8083169 [H]