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The map label for this gene is kynU [H]

Identifier: 94311584

GI number: 94311584

Start: 2885545

End: 2886801

Strand: Direct

Name: kynU [H]

Synonym: Rmet_2650

Alternate gene names: 94311584

Gene position: 2885545-2886801 (Clockwise)

Preceding gene: 335055618

Following gene: 94311585

Centisome position: 73.46

GC content: 67.78

Gene sequence:

>1257_bases
ATGACAACGCTGACCCGAGCACACTGCCAGACGCTGGACCGGGATGACCCGCTCCGCGCACTGCGCGAACAGTTCGCCCT
GCCCGAGGGCGTGATCTACCTCGATGGCAACTCGCTGGGCGCACGCCCGCGCGCCGCCGCCGCGCGCGCCGCGGAAGTCG
TGAGCGAGGAATGGGGCAATGGCCTGATCCGCAGCTGGAATACCGCGGGCTGGTTCGACCTGCCGCGCCGCCTGGGCAAC
CTGCTGGCTCCGCTGATCGGCGCCGGCAATGACGAGGTAGTGGTCACTGACACGACATCGATCAACCTGTTCAAGGTGCT
GGCGGCCGCGCTGCGCGTGCAGCGCCAGCGCGATCCGGCCCGGCGCGTGATCGTGTCGGAGGCCAGCAACTTCCCGACTG
ATCTCTATATCGCCCAAGGCCTGGCCGATCTGCTGCAGCAAGGCTATGAAGTCCGGCTGGTCAACAGCCCGGACGAGATC
GACGCCGCCGTAGGCGCTGACACCGCCGTGCTGATGCTCACGCACGTCAACTACAAGACTGGCGAGATGCTCGACATGGC
CGGCCTGACCGAACTGGCGCACGCACGCGGCGTGCTGACCGTTTGGGATCTGGCCCACTCGGCCGGCGCCGTGCCCGTGG
CGCTCAATGTGGCCAAGGCCGATTACGCGATCGGCTGCACTTACAAGTACCTGAACGGCGGCCCGGGCTCCCCGGCTTTC
GTCTGGGTAGCACCCGCGCTGCGCGACCAGTTCTGGCAGCCGCTGTCGGGCTGGTGGGGCCACGGCGCGCCGTTCGCGAT
GTCGCCGCAGTACGAACCGGCGCAGGGCATCGGCCGCTTCCTGTGTGGCACGCAGCCGATGACGTCGCTGGCCATGGTCG
AATGCGGCCTGGATATCTTCGCGCAGACCAGCATGACCGCGCTGCGCGCCAAGTCGCTGAAGCTGACCGATCTGTTTATC
GAACTGGTCGAGGCCCGCTGCGCCACGCACCCGCTCTCGCTGGTCACACCGCGCGACCACACGAAGCGCGGCAGCCAGGT
CAGCTTCGCGCACCCCGACGCCTACGCGCTGGTAGCCGCGCTGATCGAGCGTGGCGTCATTGGCGACTATCGCGAGCCGG
GCATCGCCCGCTTCGGCTTCACGCCGCTCTACACGAGCTTTACTGAAGTGTGGGACGCCGTCGAGATCATCCGCGACGTG
CTCGACAGCGGCGTCTATCGTGACGCGCGCTTTGCCGTGCGGACGGCGGTGACCTGA

Upstream 100 bases:

>100_bases
TGCCGCTGCGCCTGGCCACGCTTGATGCGAGCCCGGTGCGCGCCGTGCTGCGCGAGCTCCCCTGACATTCACGAACCGAT
TTCGAACGGACGAAGACCGC

Downstream 100 bases:

>100_bases
GCGGGAGTCGATCATGAGCGAATTCAAGGGATGCCCGATGGGGCACGGAGCCGCCCCGCAAAACGGTGATGGCGGTGATA
GCGGTGATACCGGCAATGGC

Product: Kynureninase, L-Kynurenine hydrolase

Products: NA

Alternate protein names: L-kynurenine hydrolase [H]

Number of amino acids: Translated: 418; Mature: 417

Protein sequence:

>418_residues
MTTLTRAHCQTLDRDDPLRALREQFALPEGVIYLDGNSLGARPRAAAARAAEVVSEEWGNGLIRSWNTAGWFDLPRRLGN
LLAPLIGAGNDEVVVTDTTSINLFKVLAAALRVQRQRDPARRVIVSEASNFPTDLYIAQGLADLLQQGYEVRLVNSPDEI
DAAVGADTAVLMLTHVNYKTGEMLDMAGLTELAHARGVLTVWDLAHSAGAVPVALNVAKADYAIGCTYKYLNGGPGSPAF
VWVAPALRDQFWQPLSGWWGHGAPFAMSPQYEPAQGIGRFLCGTQPMTSLAMVECGLDIFAQTSMTALRAKSLKLTDLFI
ELVEARCATHPLSLVTPRDHTKRGSQVSFAHPDAYALVAALIERGVIGDYREPGIARFGFTPLYTSFTEVWDAVEIIRDV
LDSGVYRDARFAVRTAVT

Sequences:

>Translated_418_residues
MTTLTRAHCQTLDRDDPLRALREQFALPEGVIYLDGNSLGARPRAAAARAAEVVSEEWGNGLIRSWNTAGWFDLPRRLGN
LLAPLIGAGNDEVVVTDTTSINLFKVLAAALRVQRQRDPARRVIVSEASNFPTDLYIAQGLADLLQQGYEVRLVNSPDEI
DAAVGADTAVLMLTHVNYKTGEMLDMAGLTELAHARGVLTVWDLAHSAGAVPVALNVAKADYAIGCTYKYLNGGPGSPAF
VWVAPALRDQFWQPLSGWWGHGAPFAMSPQYEPAQGIGRFLCGTQPMTSLAMVECGLDIFAQTSMTALRAKSLKLTDLFI
ELVEARCATHPLSLVTPRDHTKRGSQVSFAHPDAYALVAALIERGVIGDYREPGIARFGFTPLYTSFTEVWDAVEIIRDV
LDSGVYRDARFAVRTAVT
>Mature_417_residues
TTLTRAHCQTLDRDDPLRALREQFALPEGVIYLDGNSLGARPRAAAARAAEVVSEEWGNGLIRSWNTAGWFDLPRRLGNL
LAPLIGAGNDEVVVTDTTSINLFKVLAAALRVQRQRDPARRVIVSEASNFPTDLYIAQGLADLLQQGYEVRLVNSPDEID
AAVGADTAVLMLTHVNYKTGEMLDMAGLTELAHARGVLTVWDLAHSAGAVPVALNVAKADYAIGCTYKYLNGGPGSPAFV
WVAPALRDQFWQPLSGWWGHGAPFAMSPQYEPAQGIGRFLCGTQPMTSLAMVECGLDIFAQTSMTALRAKSLKLTDLFIE
LVEARCATHPLSLVTPRDHTKRGSQVSFAHPDAYALVAALIERGVIGDYREPGIARFGFTPLYTSFTEVWDAVEIIRDVL
DSGVYRDARFAVRTAVT

Specific function: Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively [H]

COG id: COG3844

COG function: function code E; Kynureninase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the kynureninase family [H]

Homologues:

Organism=Homo sapiens, GI4504937, Length=439, Percent_Identity=26.4236902050114, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI74101437, Length=252, Percent_Identity=25.3968253968254, Blast_Score=90, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17550466, Length=433, Percent_Identity=24.7113163972286, Blast_Score=138, Evalue=4e-33,
Organism=Saccharomyces cerevisiae, GI6323261, Length=453, Percent_Identity=27.8145695364238, Blast_Score=142, Evalue=1e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010111
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =3.7.1.3 [H]

Molecular weight: Translated: 45471; Mature: 45340

Theoretical pI: Translated: 5.64; Mature: 5.64

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLTRAHCQTLDRDDPLRALREQFALPEGVIYLDGNSLGARPRAAAARAAEVVSEEWGN
CCCCCHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
GLIRSWNTAGWFDLPRRLGNLLAPLIGAGNDEVVVTDTTSINLFKVLAAALRVQRQRDPA
CCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCHH
RRVIVSEASNFPTDLYIAQGLADLLQQGYEVRLVNSPDEIDAAVGADTAVLMLTHVNYKT
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCEEEEEEECCCCC
GEMLDMAGLTELAHARGVLTVWDLAHSAGAVPVALNVAKADYAIGCTYKYLNGGPGSPAF
CCHHHHHHHHHHHHHCCCEEEEHHHHCCCCCEEEEEEECCCEEEEEEEEECCCCCCCCEE
VWVAPALRDQFWQPLSGWWGHGAPFAMSPQYEPAQGIGRFLCGTQPMTSLAMVECGLDIF
EEECHHHHHHHHCHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCHHHH
AQTSMTALRAKSLKLTDLFIELVEARCATHPLSLVTPRDHTKRGSQVSFAHPDAYALVAA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEECCCHHHHHHHH
LIERGVIGDYREPGIARFGFTPLYTSFTEVWDAVEIIRDVLDSGVYRDARFAVRTAVT
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC
>Mature Secondary Structure 
TTLTRAHCQTLDRDDPLRALREQFALPEGVIYLDGNSLGARPRAAAARAAEVVSEEWGN
CCCCHHHHHHCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHCC
GLIRSWNTAGWFDLPRRLGNLLAPLIGAGNDEVVVTDTTSINLFKVLAAALRVQRQRDPA
CCEECCCCCCHHHHHHHHHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHCCHH
RRVIVSEASNFPTDLYIAQGLADLLQQGYEVRLVNSPDEIDAAVGADTAVLMLTHVNYKT
HHHHHHHCCCCCHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHCCCCEEEEEEECCCCC
GEMLDMAGLTELAHARGVLTVWDLAHSAGAVPVALNVAKADYAIGCTYKYLNGGPGSPAF
CCHHHHHHHHHHHHHCCCEEEEHHHHCCCCCEEEEEEECCCEEEEEEEEECCCCCCCCEE
VWVAPALRDQFWQPLSGWWGHGAPFAMSPQYEPAQGIGRFLCGTQPMTSLAMVECGLDIF
EEECHHHHHHHHCHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCHHHHHHHHHCHHHH
AQTSMTALRAKSLKLTDLFIELVEARCATHPLSLVTPRDHTKRGSQVSFAHPDAYALVAA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCEEEECCCHHHHHHHH
LIERGVIGDYREPGIARFGFTPLYTSFTEVWDAVEIIRDVLDSGVYRDARFAVRTAVT
HHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA