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The map label for this gene is msrA [H]

Identifier: 94311581

GI number: 94311581

Start: 2882831

End: 2883373

Strand: Reverse

Name: msrA [H]

Synonym: Rmet_2645

Alternate gene names: 94311581

Gene position: 2883373-2882831 (Counterclockwise)

Preceding gene: 94311583

Following gene: 94311575

Centisome position: 73.4

GC content: 61.88

Gene sequence:

>543_bases
ATGGACCATGGCCTTGAAATCGCCACGCTCGGTGGCGGCTGCTTCTGGTGTCTGGAGGCGGTCTACCAACAGGTCGCCGG
TGTGCGCGCGGTGGAATCGGGATACACGGGTGGGCACGTCAGCCAGCCCACCTATCACGAGGTTTGCGCGGGAGATACCG
GGCACGCCGAAGTGGTGCGGGTGACATTCGACCCGTCCGCGATCAACTATCGCGAGATCCTTGAAATCTTCTTTTCGATC
CACGATCCGACGCAACTGAACCGGCAGGGCAACGATGTCGGCACACAGTACCGTTCCAGCATCTTCACGCACTCGGAGGC
GCAGCGCGCGGTCGCCGAGTATGTGATTGGCAAGCTGGCTGCCGAGCATGTCTACGATGCGCCGATCGTGACACAGGTGG
AGCCGGAGCAACCCTACTGGCCCGCCGAGGCCAGCCACCAGAACTACTACCAGGAGCACCCGGCGCAAGGGTATTGCGCA
TTCGTGATTTCGCCGAAGCTGACGAAATTCAGGCGCGATTTCTCGCACCGGATGCGGCGCTAG

Upstream 100 bases:

>100_bases
GGGCGCTTTAAAGTCGGCAGCAAGCGCGCCAAGTGCTTATCCTAGACAGGACGCCTGCGCGAGCCAGCGTGGCGTCCGCG
ACTGGAAGGGGGACGAGCAA

Downstream 100 bases:

>100_bases
GTCGCCAGCTTCCCGGCGATTACCTCAGCGAGCCGCGCGATGCTCAACGGCGCGCAGCCTTCGGCGTTATTGCTGACGAT
GACATGGGCGGGCTGGCCGG

Product: methionine sulfoxide reductase A

Products: NA

Alternate protein names: Protein-methionine-S-oxide reductase; Peptide-methionine (S)-S-oxide reductase; Peptide Met(O) reductase [H]

Number of amino acids: Translated: 180; Mature: 180

Protein sequence:

>180_residues
MDHGLEIATLGGGCFWCLEAVYQQVAGVRAVESGYTGGHVSQPTYHEVCAGDTGHAEVVRVTFDPSAINYREILEIFFSI
HDPTQLNRQGNDVGTQYRSSIFTHSEAQRAVAEYVIGKLAAEHVYDAPIVTQVEPEQPYWPAEASHQNYYQEHPAQGYCA
FVISPKLTKFRRDFSHRMRR

Sequences:

>Translated_180_residues
MDHGLEIATLGGGCFWCLEAVYQQVAGVRAVESGYTGGHVSQPTYHEVCAGDTGHAEVVRVTFDPSAINYREILEIFFSI
HDPTQLNRQGNDVGTQYRSSIFTHSEAQRAVAEYVIGKLAAEHVYDAPIVTQVEPEQPYWPAEASHQNYYQEHPAQGYCA
FVISPKLTKFRRDFSHRMRR
>Mature_180_residues
MDHGLEIATLGGGCFWCLEAVYQQVAGVRAVESGYTGGHVSQPTYHEVCAGDTGHAEVVRVTFDPSAINYREILEIFFSI
HDPTQLNRQGNDVGTQYRSSIFTHSEAQRAVAEYVIGKLAAEHVYDAPIVTQVEPEQPYWPAEASHQNYYQEHPAQGYCA
FVISPKLTKFRRDFSHRMRR

Specific function: Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine [H]

COG id: COG0225

COG function: function code O; Peptide methionine sulfoxide reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the msrA Met sulfoxide reductase family [H]

Homologues:

Organism=Homo sapiens, GI6912516, Length=161, Percent_Identity=42.8571428571429, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI208609995, Length=161, Percent_Identity=42.8571428571429, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI208609993, Length=113, Percent_Identity=43.3628318584071, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI1790665, Length=154, Percent_Identity=44.8051948051948, Blast_Score=144, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17533973, Length=146, Percent_Identity=31.5068493150685, Blast_Score=80, Evalue=6e-16,
Organism=Saccharomyces cerevisiae, GI6320881, Length=161, Percent_Identity=39.7515527950311, Blast_Score=113, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24664627, Length=165, Percent_Identity=35.7575757575758, Blast_Score=89, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24664631, Length=165, Percent_Identity=35.1515151515151, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI45553131, Length=162, Percent_Identity=34.5679012345679, Blast_Score=84, Evalue=5e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002569 [H]

Pfam domain/function: PF01625 PMSR [H]

EC number: =1.8.4.11 [H]

Molecular weight: Translated: 20279; Mature: 20279

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDHGLEIATLGGGCFWCLEAVYQQVAGVRAVESGYTGGHVSQPTYHEVCAGDTGHAEVVR
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEE
VTFDPSAINYREILEIFFSIHDPTQLNRQGNDVGTQYRSSIFTHSEAQRAVAEYVIGKLA
EEECCCCCCHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEHVYDAPIVTQVEPEQPYWPAEASHQNYYQEHPAQGYCAFVISPKLTKFRRDFSHRMRR
HHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDHGLEIATLGGGCFWCLEAVYQQVAGVRAVESGYTGGHVSQPTYHEVCAGDTGHAEVVR
CCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHCCCCCCCEEEE
VTFDPSAINYREILEIFFSIHDPTQLNRQGNDVGTQYRSSIFTHSEAQRAVAEYVIGKLA
EEECCCCCCHHHHHHHHHHCCCCHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AEHVYDAPIVTQVEPEQPYWPAEASHQNYYQEHPAQGYCAFVISPKLTKFRRDFSHRMRR
HHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCEEEEEECCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]