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The map label for this gene is yfcY [C]

Identifier: 94311538

GI number: 94311538

Start: 2829602

End: 2830750

Strand: Direct

Name: yfcY [C]

Synonym: Rmet_2602

Alternate gene names: 94311538

Gene position: 2829602-2830750 (Clockwise)

Preceding gene: 94311537

Following gene: 94311539

Centisome position: 72.04

GC content: 67.89

Gene sequence:

>1149_bases
ATGAACCGCCTGCTGCAGCAAACCTCGGTCTATGTCATCGGCGTCGGCCTGCATCCGTACCAGTTCGCGTCGGATACCCC
TTATGTCAGCCTCGGTCTGCGTGCGATGCGCGAGGCGCTGTCGGACGCCGGCATCGCCTGGCCCGAGGTGCAGAGCGCCT
ACGTGGGCACCTCGGCAATCGGCATGGCAACGGGACGCGTGATGTTCCGCCACCTGGGCTCTACCGGCCTGGCCGTGACA
CAGGTGGAAAGCGCCTCGGCATCGGGCTGCTCGGCGTTCCGCCAGGCGTGCCTGGAAGTGGCAAGCGGCGTCTCGGACGT
GGTGGTGGCAATCGGCGTCGACAAGTTCGGCGATGGCCGCAAGGCGGCCGACAAGGACGGCCTGCCGCACCTTGCGCCCA
CCGCGACCATGCCGCCCGTGAAGTTCGCGCTGATGGCGCATGAATACCTGCGCCAGCACGGGCTGAAGCCCGAAGCGATG
GCGCGCGTCGCGGTAAAGAACCATGGCAACGCTGCGCTCAACCCATATGCGCAGTTCCGCAAGGCTCGTACGCTCGAGCA
GGTCATGGCTTCGCCCAAGGTGGTGGGTGACCTGACGGTGCAGCAGTGCTGCCCGCGTGGCGATGGCGCCGCAGCCGTGA
TCGTGGTGTCCGAGGCCGCGATCAAGCGGCTCGGCCTGGACAAGCGCCGCGCCGTGCGCGTGCTGGCATCGGTGGCGAAC
AGCGAAGAACTGGAACACGGCGATTCGTCTGCAGCCGTCGACATGGTGCGCAAGTCCACCGCGATGGCGTACGAGCAGGC
CGGCGTCGGCCCCCGCGACCTGAACCTGGTGGAGTTGCACGAGGCCTTTTCGATCGAGGAATTGGTCTACACCGAAGCGA
TGGACCTGTGCGCGCCCGGAGAAGGCGCGGCATGGCTCGAACGCGGCGCTTCCGCCATTGGCGGCGAATGCGCGGTCAAT
GCTTCGGGTGGCCTGCTCGGCATGGGCCACCCGACCGGCCCGACCGGCATCGGGCAGATCGCCGAAATCACGCGCCAGAT
TCGCGGCGAGGCACACGGACGGCAGCACCCCGGCGCACGCCTGGGGCTCGCCCACATGATCGGGCTCGGCTCGGTGGCCT
TCGCGCACATCCTGGCAGCATCGCACTGA

Upstream 100 bases:

>100_bases
TGGCCCCGGGCATGACGGTTCAGGGCGTGATCCGCGCCGACGCTCCGTGCGGCGACCGCTATCCGCTGCGCTTCGTACCC
GCCAGCCAGGAGGTGCAACG

Downstream 100 bases:

>100_bases
CCGTGCGGATGCGCCTGCCGCGAGCACGGCTGGCGCATCCGTCGCGCACATCATTCCAGGCAAGGAGACAAGGATGCAAT
TCGAAACCCTGTTGTACGAA

Product: Thiolase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MNRLLQQTSVYVIGVGLHPYQFASDTPYVSLGLRAMREALSDAGIAWPEVQSAYVGTSAIGMATGRVMFRHLGSTGLAVT
QVESASASGCSAFRQACLEVASGVSDVVVAIGVDKFGDGRKAADKDGLPHLAPTATMPPVKFALMAHEYLRQHGLKPEAM
ARVAVKNHGNAALNPYAQFRKARTLEQVMASPKVVGDLTVQQCCPRGDGAAAVIVVSEAAIKRLGLDKRRAVRVLASVAN
SEELEHGDSSAAVDMVRKSTAMAYEQAGVGPRDLNLVELHEAFSIEELVYTEAMDLCAPGEGAAWLERGASAIGGECAVN
ASGGLLGMGHPTGPTGIGQIAEITRQIRGEAHGRQHPGARLGLAHMIGLGSVAFAHILAASH

Sequences:

>Translated_382_residues
MNRLLQQTSVYVIGVGLHPYQFASDTPYVSLGLRAMREALSDAGIAWPEVQSAYVGTSAIGMATGRVMFRHLGSTGLAVT
QVESASASGCSAFRQACLEVASGVSDVVVAIGVDKFGDGRKAADKDGLPHLAPTATMPPVKFALMAHEYLRQHGLKPEAM
ARVAVKNHGNAALNPYAQFRKARTLEQVMASPKVVGDLTVQQCCPRGDGAAAVIVVSEAAIKRLGLDKRRAVRVLASVAN
SEELEHGDSSAAVDMVRKSTAMAYEQAGVGPRDLNLVELHEAFSIEELVYTEAMDLCAPGEGAAWLERGASAIGGECAVN
ASGGLLGMGHPTGPTGIGQIAEITRQIRGEAHGRQHPGARLGLAHMIGLGSVAFAHILAASH
>Mature_382_residues
MNRLLQQTSVYVIGVGLHPYQFASDTPYVSLGLRAMREALSDAGIAWPEVQSAYVGTSAIGMATGRVMFRHLGSTGLAVT
QVESASASGCSAFRQACLEVASGVSDVVVAIGVDKFGDGRKAADKDGLPHLAPTATMPPVKFALMAHEYLRQHGLKPEAM
ARVAVKNHGNAALNPYAQFRKARTLEQVMASPKVVGDLTVQQCCPRGDGAAAVIVVSEAAIKRLGLDKRRAVRVLASVAN
SEELEHGDSSAAVDMVRKSTAMAYEQAGVGPRDLNLVELHEAFSIEELVYTEAMDLCAPGEGAAWLERGASAIGGECAVN
ASGGLLGMGHPTGPTGIGQIAEITRQIRGEAHGRQHPGARLGLAHMIGLGSVAFAHILAASH

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=385, Percent_Identity=36.1038961038961, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI302344760, Length=379, Percent_Identity=35.0923482849604, Blast_Score=206, Evalue=2e-53,
Organism=Homo sapiens, GI302344767, Length=314, Percent_Identity=37.2611464968153, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI302344762, Length=298, Percent_Identity=38.5906040268456, Blast_Score=195, Evalue=7e-50,
Organism=Homo sapiens, GI55956775, Length=264, Percent_Identity=37.1212121212121, Blast_Score=160, Evalue=3e-39,
Organism=Caenorhabditis elegans, GI17537653, Length=383, Percent_Identity=28.9817232375979, Blast_Score=182, Evalue=4e-46,
Organism=Drosophila melanogaster, GI19921506, Length=387, Percent_Identity=37.4677002583979, Blast_Score=238, Evalue=6e-63,
Organism=Drosophila melanogaster, GI24585051, Length=387, Percent_Identity=37.4677002583979, Blast_Score=238, Evalue=6e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 39918; Mature: 39918

Theoretical pI: Translated: 7.20; Mature: 7.20

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNRLLQQTSVYVIGVGLHPYQFASDTPYVSLGLRAMREALSDAGIAWPEVQSAYVGTSAI
CCCHHHHCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHH
GMATGRVMFRHLGSTGLAVTQVESASASGCSAFRQACLEVASGVSDVVVAIGVDKFGDGR
HHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCC
KAADKDGLPHLAPTATMPPVKFALMAHEYLRQHGLKPEAMARVAVKNHGNAALNPYAQFR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHH
KARTLEQVMASPKVVGDLTVQQCCPRGDGAAAVIVVSEAAIKRLGLDKRRAVRVLASVAN
HHHHHHHHHCCCCHHHCCCHHHHCCCCCCCEEEEEECHHHHHHHCCCHHHHHHHHHHHHC
SEELEHGDSSAAVDMVRKSTAMAYEQAGVGPRDLNLVELHEAFSIEELVYTEAMDLCAPG
CHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
EGAAWLERGASAIGGECAVNASGGLLGMGHPTGPTGIGQIAEITRQIRGEAHGRQHPGAR
CCHHHHHHCHHHCCCCEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHH
LGLAHMIGLGSVAFAHILAASH
HHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNRLLQQTSVYVIGVGLHPYQFASDTPYVSLGLRAMREALSDAGIAWPEVQSAYVGTSAI
CCCHHHHCCEEEEEECCCCEECCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCHHH
GMATGRVMFRHLGSTGLAVTQVESASASGCSAFRQACLEVASGVSDVVVAIGVDKFGDGR
HHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHHHHHHHHHCCHHHEEEEEECCCCCCCC
KAADKDGLPHLAPTATMPPVKFALMAHEYLRQHGLKPEAMARVAVKNHGNAALNPYAQFR
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCHHHHHH
KARTLEQVMASPKVVGDLTVQQCCPRGDGAAAVIVVSEAAIKRLGLDKRRAVRVLASVAN
HHHHHHHHHCCCCHHHCCCHHHHCCCCCCCEEEEEECHHHHHHHCCCHHHHHHHHHHHHC
SEELEHGDSSAAVDMVRKSTAMAYEQAGVGPRDLNLVELHEAFSIEELVYTEAMDLCAPG
CHHHHCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
EGAAWLERGASAIGGECAVNASGGLLGMGHPTGPTGIGQIAEITRQIRGEAHGRQHPGAR
CCHHHHHHCHHHCCCCEEEECCCCEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCHH
LGLAHMIGLGSVAFAHILAASH
HHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: Acyl group transfer; Claisen condensation [C]

Inhibitor: Tris (hydroxy methyl) aminomethane [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]