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The map label for this gene is acdA [H]

Identifier: 94311535

GI number: 94311535

Start: 2826961

End: 2828109

Strand: Reverse

Name: acdA [H]

Synonym: Rmet_2599

Alternate gene names: 94311535

Gene position: 2828109-2826961 (Counterclockwise)

Preceding gene: 94311536

Following gene: 94311534

Centisome position: 72.0

GC content: 64.4

Gene sequence:

>1149_bases
ATGTTTTTCGAAGCCACGCCAGAGCAGCGACTGCTGCGCGACAACATTCGCCGATTCATGCAGGCGGAGGTTGCTCCGCT
GATCAGCCGGCATGATCAGGAGAAGACCTTTCCGTTCGAGATCTTGAAGGGGCTGGCGCAGTTCGGCTACATCGGCGGGC
GCCTGTCAGAGGAACAGGGCGGGATGGGGCTGGACCAGCTCACTTGGGCGATGATGATGGAAGAGGCCGGCTATGCCTGG
CTTTCGCTGCGCACCATCCTGAACATCACTAACGGCCCGATCGCCAAGCTTGCCGCAGTCGGCACGCCGGACCAGAAGAC
CCGTTTCCTCGATCCGTTGCTGGCCTGCGAGCGCAAGGTGTTCACAGCGATCAGCGAGCCTGGCACCGGTTCCAATATCG
CGCAGATCCAGACGCGCGCCGACCTGAAGGGCGACCACTACGTGCTCAACGGCCGCAAGCTCTGGATCACCAACGGCGCG
TTTGCCGACTTCGGCATCGTGGTGGCGCGCACCTATAGCGACAACTGCGAAGGCCAGCTGTCGACGTTCCTGGTGGAGCG
CGAGGTCAGCCCCTACGAGGTGCGTCGCGTGGACACCATGGTGCTGCGCAGTACCGGCACCGCCGAGCTCGGTTTCGACA
ACGTGCGTGTGCCGCGCGAGAACCTGCTCGGCGAGGAAGGCGGCGCGCTCAAGCGTATGCTGCAGGGCCTGGATGGCGCG
CGCGTCAATATCGCGATGGGCGCTGTGGGCGCGGCGCAGTGCGCGCTCGATCTGGCTACGGACTACGCCAAGACGCGCAC
GCAGTTCGGTCGTGCCATCGGCAGCTTTCAGCTCGTGCAGAAGATGATCGTGGACATGACGATCCGGGTGGAAGCCGCTC
GCGCGCTCGGGTATCGCGCCGCGATGGCACTCGACCGTGGCGAGGACACGCGTGTCTCAGCGTCGATCGCCAAGCTGTAT
GCGACCGAGGCCGCGCACGAAGTAGCCAGCATGGCGCTGCAGGTGCATGGCGGTCTGGGTTACGCCACCGATTATCCGAT
CGAACGCATCTTCCGCGACACGCGCGGCGGCACCATTCCCGAGGGGACCACGGAGGTGCAGACCTTGATCGTCGGTCGCG
AGATTCTGGGCATGTCGGCGATTGCCTGA

Upstream 100 bases:

>100_bases
ATGGGACCGCTCCTGTGGCCGGCTTTGTTTCGACGGTGCCTGGCGATGATGCCGCTGGCGCCGGATGCATTTCCCAACCG
GACTATTACAGGAGACATCC

Downstream 100 bases:

>100_bases
TCGGCACAGCTGTCACCTTTTCCGCCCGGCGTAGCGGTGAACCAGTGCGTCAGCACATCGGCGCTTCATCGGGCTCCACA
GACTTCCGCATCGAGAGAAC

Product: acyl-CoA dehydrogenase

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 382; Mature: 382

Protein sequence:

>382_residues
MFFEATPEQRLLRDNIRRFMQAEVAPLISRHDQEKTFPFEILKGLAQFGYIGGRLSEEQGGMGLDQLTWAMMMEEAGYAW
LSLRTILNITNGPIAKLAAVGTPDQKTRFLDPLLACERKVFTAISEPGTGSNIAQIQTRADLKGDHYVLNGRKLWITNGA
FADFGIVVARTYSDNCEGQLSTFLVEREVSPYEVRRVDTMVLRSTGTAELGFDNVRVPRENLLGEEGGALKRMLQGLDGA
RVNIAMGAVGAAQCALDLATDYAKTRTQFGRAIGSFQLVQKMIVDMTIRVEAARALGYRAAMALDRGEDTRVSASIAKLY
ATEAAHEVASMALQVHGGLGYATDYPIERIFRDTRGGTIPEGTTEVQTLIVGREILGMSAIA

Sequences:

>Translated_382_residues
MFFEATPEQRLLRDNIRRFMQAEVAPLISRHDQEKTFPFEILKGLAQFGYIGGRLSEEQGGMGLDQLTWAMMMEEAGYAW
LSLRTILNITNGPIAKLAAVGTPDQKTRFLDPLLACERKVFTAISEPGTGSNIAQIQTRADLKGDHYVLNGRKLWITNGA
FADFGIVVARTYSDNCEGQLSTFLVEREVSPYEVRRVDTMVLRSTGTAELGFDNVRVPRENLLGEEGGALKRMLQGLDGA
RVNIAMGAVGAAQCALDLATDYAKTRTQFGRAIGSFQLVQKMIVDMTIRVEAARALGYRAAMALDRGEDTRVSASIAKLY
ATEAAHEVASMALQVHGGLGYATDYPIERIFRDTRGGTIPEGTTEVQTLIVGREILGMSAIA
>Mature_382_residues
MFFEATPEQRLLRDNIRRFMQAEVAPLISRHDQEKTFPFEILKGLAQFGYIGGRLSEEQGGMGLDQLTWAMMMEEAGYAW
LSLRTILNITNGPIAKLAAVGTPDQKTRFLDPLLACERKVFTAISEPGTGSNIAQIQTRADLKGDHYVLNGRKLWITNGA
FADFGIVVARTYSDNCEGQLSTFLVEREVSPYEVRRVDTMVLRSTGTAELGFDNVRVPRENLLGEEGGALKRMLQGLDGA
RVNIAMGAVGAAQCALDLATDYAKTRTQFGRAIGSFQLVQKMIVDMTIRVEAARALGYRAAMALDRGEDTRVSASIAKLY
ATEAAHEVASMALQVHGGLGYATDYPIERIFRDTRGGTIPEGTTEVQTLIVGREILGMSAIA

Specific function: Catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA. [C]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=376, Percent_Identity=36.7021276595745, Blast_Score=234, Evalue=7e-62,
Organism=Homo sapiens, GI4501859, Length=372, Percent_Identity=34.4086021505376, Blast_Score=224, Evalue=9e-59,
Organism=Homo sapiens, GI187960098, Length=381, Percent_Identity=33.3333333333333, Blast_Score=222, Evalue=6e-58,
Organism=Homo sapiens, GI4557231, Length=381, Percent_Identity=33.3333333333333, Blast_Score=221, Evalue=6e-58,
Organism=Homo sapiens, GI226958412, Length=377, Percent_Identity=34.7480106100796, Blast_Score=212, Evalue=4e-55,
Organism=Homo sapiens, GI7656849, Length=371, Percent_Identity=32.3450134770889, Blast_Score=204, Evalue=8e-53,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=35.1906158357771, Blast_Score=196, Evalue=2e-50,
Organism=Homo sapiens, GI21361497, Length=365, Percent_Identity=32.3287671232877, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4501857, Length=375, Percent_Identity=30.1333333333333, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI76496475, Length=406, Percent_Identity=31.2807881773399, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI4557235, Length=406, Percent_Identity=31.2807881773399, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4503943, Length=387, Percent_Identity=28.6821705426357, Blast_Score=142, Evalue=5e-34,
Organism=Homo sapiens, GI7669494, Length=355, Percent_Identity=28.4507042253521, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI38505218, Length=320, Percent_Identity=27.8125, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI48976061, Length=394, Percent_Identity=26.3959390862944, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI211971008, Length=394, Percent_Identity=26.3959390862944, Blast_Score=97, Evalue=3e-20,
Organism=Homo sapiens, GI218563752, Length=201, Percent_Identity=29.8507462686567, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1786223, Length=377, Percent_Identity=29.4429708222812, Blast_Score=174, Evalue=1e-44,
Organism=Escherichia coli, GI87081958, Length=380, Percent_Identity=28.9473684210526, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI87082384, Length=263, Percent_Identity=27.3764258555133, Blast_Score=74, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17570075, Length=380, Percent_Identity=33.4210526315789, Blast_Score=229, Evalue=2e-60,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=33.7696335078534, Blast_Score=219, Evalue=1e-57,
Organism=Caenorhabditis elegans, GI17538396, Length=383, Percent_Identity=34.7258485639687, Blast_Score=217, Evalue=8e-57,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=31.1345646437995, Blast_Score=210, Evalue=8e-55,
Organism=Caenorhabditis elegans, GI17508101, Length=364, Percent_Identity=31.3186813186813, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17506239, Length=372, Percent_Identity=30.3763440860215, Blast_Score=187, Evalue=1e-47,
Organism=Caenorhabditis elegans, GI71985184, Length=366, Percent_Identity=33.3333333333333, Blast_Score=181, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI17533517, Length=365, Percent_Identity=29.8630136986301, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17505929, Length=369, Percent_Identity=28.9972899728997, Blast_Score=152, Evalue=3e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=314, Percent_Identity=32.1656050955414, Blast_Score=146, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17551932, Length=368, Percent_Identity=28.804347826087, Blast_Score=145, Evalue=4e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=389, Percent_Identity=29.8200514138817, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI71990804, Length=284, Percent_Identity=31.3380281690141, Blast_Score=135, Evalue=4e-32,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=31.1688311688312, Blast_Score=119, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI71982178, Length=271, Percent_Identity=27.6752767527675, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531909, Length=241, Percent_Identity=27.3858921161826, Blast_Score=99, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17562446, Length=327, Percent_Identity=29.0519877675841, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17531913, Length=178, Percent_Identity=26.9662921348315, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI86563383, Length=258, Percent_Identity=30.2325581395349, Blast_Score=69, Evalue=3e-12,
Organism=Caenorhabditis elegans, GI86563381, Length=258, Percent_Identity=30.2325581395349, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24646207, Length=369, Percent_Identity=36.5853658536585, Blast_Score=247, Evalue=1e-65,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=36.7292225201072, Blast_Score=240, Evalue=1e-63,
Organism=Drosophila melanogaster, GI24660351, Length=378, Percent_Identity=35.978835978836, Blast_Score=232, Evalue=3e-61,
Organism=Drosophila melanogaster, GI21355753, Length=384, Percent_Identity=35.9375, Blast_Score=216, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24666513, Length=372, Percent_Identity=33.3333333333333, Blast_Score=212, Evalue=3e-55,
Organism=Drosophila melanogaster, GI281363737, Length=357, Percent_Identity=29.9719887955182, Blast_Score=167, Evalue=2e-41,
Organism=Drosophila melanogaster, GI19920834, Length=390, Percent_Identity=30.2564102564103, Blast_Score=152, Evalue=5e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 41839; Mature: 41839

Theoretical pI: Translated: 5.83; Mature: 5.83

Prosite motif: PS00464 RIBOSOMAL_L22 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFFEATPEQRLLRDNIRRFMQAEVAPLISRHDQEKTFPFEILKGLAQFGYIGGRLSEEQG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
GMGLDQLTWAMMMEEAGYAWLSLRTILNITNGPIAKLAAVGTPDQKTRFLDPLLACERKV
CCCHHHHHHHHHHHHCCCHHEEHHHHHHCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHH
FTAISEPGTGSNIAQIQTRADLKGDHYVLNGRKLWITNGAFADFGIVVARTYSDNCEGQL
HHHHCCCCCCCCHHEEEHHCCCCCCEEEECCEEEEEECCCCCCCCEEEEEECCCCCCCHH
STFLVEREVSPYEVRRVDTMVLRSTGTAELGFDNVRVPRENLLGEEGGALKRMLQGLDGA
HHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCC
RVNIAMGAVGAAQCALDLATDYAKTRTQFGRAIGSFQLVQKMIVDMTIRVEAARALGYRA
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHH
AMALDRGEDTRVSASIAKLYATEAAHEVASMALQVHGGLGYATDYPIERIFRDTRGGTIP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCC
EGTTEVQTLIVGREILGMSAIA
CCCHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MFFEATPEQRLLRDNIRRFMQAEVAPLISRHDQEKTFPFEILKGLAQFGYIGGRLSEEQG
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCC
GMGLDQLTWAMMMEEAGYAWLSLRTILNITNGPIAKLAAVGTPDQKTRFLDPLLACERKV
CCCHHHHHHHHHHHHCCCHHEEHHHHHHCCCCCHHHHEECCCCCHHHHHHHHHHHHHHHH
FTAISEPGTGSNIAQIQTRADLKGDHYVLNGRKLWITNGAFADFGIVVARTYSDNCEGQL
HHHHCCCCCCCCHHEEEHHCCCCCCEEEECCEEEEEECCCCCCCCEEEEEECCCCCCCHH
STFLVEREVSPYEVRRVDTMVLRSTGTAELGFDNVRVPRENLLGEEGGALKRMLQGLDGA
HHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHCCCCC
RVNIAMGAVGAAQCALDLATDYAKTRTQFGRAIGSFQLVQKMIVDMTIRVEAARALGYRA
EEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEHHHHHHHHHH
AMALDRGEDTRVSASIAKLYATEAAHEVASMALQVHGGLGYATDYPIERIFRDTRGGTIP
HHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHCCCCCCC
EGTTEVQTLIVGREILGMSAIA
CCCHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]