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The map label for this gene is ivd1 [H]

Identifier: 94311467

GI number: 94311467

Start: 2753206

End: 2754345

Strand: Direct

Name: ivd1 [H]

Synonym: Rmet_2531

Alternate gene names: 94311467

Gene position: 2753206-2754345 (Clockwise)

Preceding gene: 335055603

Following gene: 94311468

Centisome position: 70.09

GC content: 65.79

Gene sequence:

>1140_bases
GTGGACATCACCCGTACCGTGTTCCGCGAGGACCATGAGATGCTGCGCGACAGCGCGCGGCGCTTCTTCGAGCGCGAATG
CGCGCCACACCAGGAGGCGTGGGACCAGGCCGGCCGCGTCGACCGCGAAACCTGGCTCAAGGCCGGCCGTGAAGGCCTGT
TGTGCGTCGCGATCCCGACCGAGTACGGCGGTGGCGGCGGCGACTTCGGGCACTCCGCGGTGGTGCTGGAGGAAATGCAC
CGCGCCGGCATCTCGGGGGCCGGCTTCTCTCTGCACTCTGACATCGTCGCGCCGTACATCAACCGCCTGGGTACCGAGGA
ACAGAAGCAGCGCTGGCTGCCCGACATCTGCGCAGGCAAGACCATCCTGGCGGTGGGCATTACCGAGCCGGGAGGCGGCT
CGGACGTCAAGGCCTGCCGGACTACGGCGGTGCGCGACGGCGACGAATGGGTCATCAACGGCAGCAAGACCTTCATCTCC
AACGGCATGAGCGCCGACCTGATCATGCTGGTCTGCAAGACCGACCCCGCAGCCGGCGCCAGGGGCGTGAGCCTGATCCT
GGTCGAGACCAACCGAGAGGGTTTCCGCTGCGGCCGCAAGCTGCACAAGGTCGGCCAGCCGGCTGCCGACACCGCCGAAC
TGTTCTTCGACAACGTGCGCGTGCCGGCGGGCAACCTGCTGGGCGAGCCAAACCAGGGCTTTGGCTACCTGATGCAGGAG
CTGGCGCAGGAGCGCCTGATCATCGCGCTGTACGCCGCCACGGCACTGGAGCGCCTGCTCCGCATCACGCTGGAATATGT
GAAGGACCGCAAGGCTTTCGGCGGCACCGTCTGGGACTTCCAGAACACCAAGTTCAAGCTGGCCGATGTCAAGGCCAATG
CCGTGGCGCTGCGCACCATGGTGGACTACTACCTGGGCGAACACATGCGCCGCAAGCTCACCGTCAATGAAGCGGCCATT
GCCAAGCTGTATTCGACCGAAACGCTGTGGAAGTGCATCGACGACATGGTCCAGCTGCACGGCGGTTACGGCTACATGCT
CGAGTACCCGATCGCGCGGGCCTTTACGGACTACCGCGTGTCCCGCGTGGTGGGCGGCGCCAACGAAGTGATGCGCGAAC
TGATCGCACGCAAGCTCTGA

Upstream 100 bases:

>100_bases
CGTTCGCCTACAGGCTGGCCGCCATCATTTCCCGCAATGGCAGCGAGTGCGGTGACCACCGCCCTGCCCTCAGGTAACCA
GGACCAGCAAGGAGATCACT

Downstream 100 bases:

>100_bases
GCGCGACGCGAACGATCACGGTGCTACCTGCCCGCAAGCCGCGGGCCAATTATCTGGAGAAGACAAGATGAGTGAAAAAG
TACTGGTTGGCGGCGTGGGG

Product: isovaleryl-CoA dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 379; Mature: 379

Protein sequence:

>379_residues
MDITRTVFREDHEMLRDSARRFFERECAPHQEAWDQAGRVDRETWLKAGREGLLCVAIPTEYGGGGGDFGHSAVVLEEMH
RAGISGAGFSLHSDIVAPYINRLGTEEQKQRWLPDICAGKTILAVGITEPGGGSDVKACRTTAVRDGDEWVINGSKTFIS
NGMSADLIMLVCKTDPAAGARGVSLILVETNREGFRCGRKLHKVGQPAADTAELFFDNVRVPAGNLLGEPNQGFGYLMQE
LAQERLIIALYAATALERLLRITLEYVKDRKAFGGTVWDFQNTKFKLADVKANAVALRTMVDYYLGEHMRRKLTVNEAAI
AKLYSTETLWKCIDDMVQLHGGYGYMLEYPIARAFTDYRVSRVVGGANEVMRELIARKL

Sequences:

>Translated_379_residues
MDITRTVFREDHEMLRDSARRFFERECAPHQEAWDQAGRVDRETWLKAGREGLLCVAIPTEYGGGGGDFGHSAVVLEEMH
RAGISGAGFSLHSDIVAPYINRLGTEEQKQRWLPDICAGKTILAVGITEPGGGSDVKACRTTAVRDGDEWVINGSKTFIS
NGMSADLIMLVCKTDPAAGARGVSLILVETNREGFRCGRKLHKVGQPAADTAELFFDNVRVPAGNLLGEPNQGFGYLMQE
LAQERLIIALYAATALERLLRITLEYVKDRKAFGGTVWDFQNTKFKLADVKANAVALRTMVDYYLGEHMRRKLTVNEAAI
AKLYSTETLWKCIDDMVQLHGGYGYMLEYPIARAFTDYRVSRVVGGANEVMRELIARKL
>Mature_379_residues
MDITRTVFREDHEMLRDSARRFFERECAPHQEAWDQAGRVDRETWLKAGREGLLCVAIPTEYGGGGGDFGHSAVVLEEMH
RAGISGAGFSLHSDIVAPYINRLGTEEQKQRWLPDICAGKTILAVGITEPGGGSDVKACRTTAVRDGDEWVINGSKTFIS
NGMSADLIMLVCKTDPAAGARGVSLILVETNREGFRCGRKLHKVGQPAADTAELFFDNVRVPAGNLLGEPNQGFGYLMQE
LAQERLIIALYAATALERLLRITLEYVKDRKAFGGTVWDFQNTKFKLADVKANAVALRTMVDYYLGEHMRRKLTVNEAAI
AKLYSTETLWKCIDDMVQLHGGYGYMLEYPIARAFTDYRVSRVVGGANEVMRELIARKL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=48.5411140583554, Blast_Score=366, Evalue=1e-101,
Organism=Homo sapiens, GI226958412, Length=375, Percent_Identity=32.5333333333333, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4557233, Length=377, Percent_Identity=33.9522546419098, Blast_Score=206, Evalue=3e-53,
Organism=Homo sapiens, GI7656849, Length=373, Percent_Identity=32.171581769437, Blast_Score=201, Evalue=6e-52,
Organism=Homo sapiens, GI226958414, Length=339, Percent_Identity=33.6283185840708, Blast_Score=201, Evalue=7e-52,
Organism=Homo sapiens, GI4501859, Length=375, Percent_Identity=29.3333333333333, Blast_Score=197, Evalue=1e-50,
Organism=Homo sapiens, GI4557235, Length=381, Percent_Identity=32.8083989501312, Blast_Score=181, Evalue=7e-46,
Organism=Homo sapiens, GI76496475, Length=381, Percent_Identity=32.8083989501312, Blast_Score=181, Evalue=9e-46,
Organism=Homo sapiens, GI21361497, Length=366, Percent_Identity=31.1475409836066, Blast_Score=172, Evalue=4e-43,
Organism=Homo sapiens, GI187960098, Length=376, Percent_Identity=28.4574468085106, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4557231, Length=376, Percent_Identity=28.4574468085106, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI48976061, Length=352, Percent_Identity=29.5454545454545, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI211971008, Length=352, Percent_Identity=29.5454545454545, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI38505218, Length=341, Percent_Identity=25.8064516129032, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI7669494, Length=287, Percent_Identity=29.2682926829268, Blast_Score=84, Evalue=2e-16,
Organism=Homo sapiens, GI4503943, Length=284, Percent_Identity=28.5211267605634, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI87081958, Length=383, Percent_Identity=29.5039164490862, Blast_Score=145, Evalue=4e-36,
Organism=Escherichia coli, GI1786223, Length=323, Percent_Identity=27.2445820433437, Blast_Score=114, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17538396, Length=374, Percent_Identity=32.8877005347594, Blast_Score=210, Evalue=1e-54,
Organism=Caenorhabditis elegans, GI17533517, Length=373, Percent_Identity=32.171581769437, Blast_Score=206, Evalue=1e-53,
Organism=Caenorhabditis elegans, GI17508101, Length=373, Percent_Identity=30.8310991957105, Blast_Score=195, Evalue=3e-50,
Organism=Caenorhabditis elegans, GI17551932, Length=379, Percent_Identity=30.0791556728232, Blast_Score=190, Evalue=9e-49,
Organism=Caenorhabditis elegans, GI17505929, Length=375, Percent_Identity=30.9333333333333, Blast_Score=185, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17570075, Length=374, Percent_Identity=30.7486631016043, Blast_Score=184, Evalue=4e-47,
Organism=Caenorhabditis elegans, GI17569725, Length=379, Percent_Identity=30.8707124010554, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17506239, Length=374, Percent_Identity=28.3422459893048, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI17534899, Length=376, Percent_Identity=29.5212765957447, Blast_Score=174, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71990804, Length=278, Percent_Identity=34.8920863309352, Blast_Score=173, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71985184, Length=355, Percent_Identity=32.9577464788732, Blast_Score=172, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71982178, Length=274, Percent_Identity=29.5620437956204, Blast_Score=142, Evalue=3e-34,
Organism=Caenorhabditis elegans, GI32563615, Length=227, Percent_Identity=33.0396475770925, Blast_Score=138, Evalue=6e-33,
Organism=Caenorhabditis elegans, GI71985192, Length=302, Percent_Identity=31.7880794701987, Blast_Score=125, Evalue=3e-29,
Organism=Caenorhabditis elegans, GI17534353, Length=383, Percent_Identity=26.3707571801567, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17562446, Length=285, Percent_Identity=27.719298245614, Blast_Score=93, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17531909, Length=240, Percent_Identity=26.25, Blast_Score=88, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21355753, Length=375, Percent_Identity=32.5333333333333, Blast_Score=208, Evalue=6e-54,
Organism=Drosophila melanogaster, GI21356377, Length=373, Percent_Identity=29.7587131367292, Blast_Score=185, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24666513, Length=375, Percent_Identity=28.8, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24646207, Length=370, Percent_Identity=30.2702702702703, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24660351, Length=381, Percent_Identity=30.4461942257218, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI281363737, Length=388, Percent_Identity=29.1237113402062, Blast_Score=162, Evalue=3e-40,
Organism=Drosophila melanogaster, GI19920834, Length=375, Percent_Identity=28, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24652780, Length=289, Percent_Identity=24.2214532871972, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 42089; Mature: 42089

Theoretical pI: Translated: 6.93; Mature: 6.93

Prosite motif: PS00072 ACYL_COA_DH_1 ; PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDITRTVFREDHEMLRDSARRFFERECAPHQEAWDQAGRVDRETWLKAGREGLLCVAIPT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCCCCEEEEEECC
EYGGGGGDFGHSAVVLEEMHRAGISGAGFSLHSDIVAPYINRLGTEEQKQRWLPDICAGK
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHCCC
TILAVGITEPGGGSDVKACRTTAVRDGDEWVINGSKTFISNGMSADLIMLVCKTDPAAGA
EEEEEEECCCCCCCCHHHHHHHHCCCCCCEEECCCHHHHCCCCCCEEEEEEEECCCCCCC
RGVSLILVETNREGFRCGRKLHKVGQPAADTAELFFDNVRVPAGNLLGEPNQGFGYLMQE
CCEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHH
LAQERLIIALYAATALERLLRITLEYVKDRKAFGGTVWDFQNTKFKLADVKANAVALRTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCHHHHHHHH
VDYYLGEHMRRKLTVNEAAIAKLYSTETLWKCIDDMVQLHGGYGYMLEYPIARAFTDYRV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHH
SRVVGGANEVMRELIARKL
HHHHCCHHHHHHHHHHHCC
>Mature Secondary Structure
MDITRTVFREDHEMLRDSARRFFERECAPHQEAWDQAGRVDRETWLKAGREGLLCVAIPT
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHCCCCHHHHHHCCCCCEEEEEECC
EYGGGGGDFGHSAVVLEEMHRAGISGAGFSLHSDIVAPYINRLGTEEQKQRWLPDICAGK
CCCCCCCCCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHCCCHHHCCC
TILAVGITEPGGGSDVKACRTTAVRDGDEWVINGSKTFISNGMSADLIMLVCKTDPAAGA
EEEEEEECCCCCCCCHHHHHHHHCCCCCCEEECCCHHHHCCCCCCEEEEEEEECCCCCCC
RGVSLILVETNREGFRCGRKLHKVGQPAADTAELFFDNVRVPAGNLLGEPNQGFGYLMQE
CCEEEEEEECCCCHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCHHHCCCCCCCHHHHHHH
LAQERLIIALYAATALERLLRITLEYVKDRKAFGGTVWDFQNTKFKLADVKANAVALRTM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCHHHHHHHH
VDYYLGEHMRRKLTVNEAAIAKLYSTETLWKCIDDMVQLHGGYGYMLEYPIARAFTDYRV
HHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCHHHHHHHHHHH
SRVVGGANEVMRELIARKL
HHHHCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]