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The map label for this gene is parC [H]

Identifier: 94311455

GI number: 94311455

Start: 2735047

End: 2737377

Strand: Reverse

Name: parC [H]

Synonym: Rmet_2519

Alternate gene names: 94311455

Gene position: 2737377-2735047 (Counterclockwise)

Preceding gene: 94311456

Following gene: 94311454

Centisome position: 69.69

GC content: 66.15

Gene sequence:

>2331_bases
ATGGATCAACCAGACATTACGTTTCAGGCCGACGAGCCTGCCGATTCGCTGACGCTTGCTCGCTACGCCGAGCGCGCCTA
TCTCGACTACGCCGTGAGCGTGGTCAAGGGCCGCGCGCTGCCCGAAGTGGCCGACGGCCAGAAGCCCGTGCAGCGCCGCA
TCCTCTTCGCCATGCAGGCGATGGGCCTGCGTGCCGATGCCAAGCCCGTGAAGTCGGCCCGTGTGGTCGGCGAGGTGCTC
GGTAAATTCCACCCGCACGGCGACCAGTCCGCCTATGACGCCCTGGTGCGCCTGGCGCAGGACTTCTCGCTGCGCTATCC
GCTGATCGACGGCCAGGGCAACTTCGGCTCGCGCGATGGCGATGGCGCGGCGGCCATGCGTTACACGGAAGCCCGCCTGA
CGCCGATCTCGCGCCTGCTGCTCGATGAGATCGACATGGGCACGGTGGACTTCCTGCCGAACTACGACGGTTCGGAAGAA
GAGCCGAAGCTGTTGCCCGCGCGACTGCCGTTCGTGCTGCTGAACGGCGCATCGGGCATCGCGGTGGGTATGGCCACGGA
AATTCCGCCGCACAATCTGCGCGAAGTGGCAGGTGCCACGGTGGCGATGATCCGCAACCCGAATATCTCGCTAGCGGACC
TGCTGGCCCTGATGCCGGGGCCGGACTACCCGGGCGGCGGCCAGATCATTTCGCCGGCGTCGGAGATCGCCCAGATCTAC
GAAAGCGGCCGTGGCAGCCTGAAGGTGCGCGCGCGCTGGACCATCGAGGAAATGGCGCGGGGCCAGTGGCAGATGGTGGT
GACCGAACTGCCGCCGGGCACGTCGGCGCAGAAGGTGCTCGAGGAAATCGAGGAAATCACCAACCCGAAGATCCGCACCG
GCAAGAAGGCGCTGACGCCCGAGCAGACCCAGCTCAAGACGACGATGCTGTCCGTGCTCGACGCGGTGCGCGACGAGTCG
GGCAAGGATGCGCCGGTTCGCCTGGTGTTCGAGCCCAAGAGCAAGAACACCGAGCAGCAGGACTTCATCCAGACGCTGCT
CGCGCATACGAGCCTGGAATCGGGTGCGCCGATCAACCTGGTGATGATCGGCACCGATGGCCGTCCGCGTCAGAAGGGGC
TGCAGGAAATCCTGCGCGAGTGGATCGAGTTCCGCTTTGCCACGGTGACGCGCCGCACGCGCTTCCAGCTGACCAAGGTA
GAGGACCGCATCCACATCCTGGAAGGCCGGATGCTGGTGCTGCTGAACATCGACGAGGTGATCCGCATCATCCGCGAAAG
CGACGAGCCGAAGCCCGCGCTGATCGAGGCGTTCCGCCTGAGCGACCGCCAGGCAGAGGACATCCTGGAAATCCGCCTGC
GCCAGCTGGCGCGCCTGGAAGCGATCAAGATCGAACAGGAACTGGCGAAGCTGCGCGACGAGCAGGCCGAACTGGACGTG
CTGCTGAAGTCCGAGACGATGATGCGCCGTCGCATCATCAAGGAAATCGAGCAGGACGCGAAGCAGTACAGCCCGGAAGA
CAAGGATCCGCGCCGCACGCTGATCCAGGAGGCCAGCCGCGCCGCCGCCGAGGTGAAGGTGATCGACGAGCCGGTGACGG
TCATCGTGTCGGGCAAGGGCTGGGTGCGCACGCGCCAGGGCCACGGCCACGATGCGTCGCAGTTCACGTTCAAGGCGGGC
GACAACCTCTACGGCACCTTCGAATGCCGCACCATCGACACGTTGCTGGCTTTCGGCAGCAATGGCCGCGTGTACTCGGT
GGCCGTGTCGGGCCTGCCGGGCGGGCGAGGCGATGGCGTGCCTGTGACGACGCTGATCGACCTGGCCGCCGGCACGCAGA
TCGCGCATACGTTCGCCGGTGCCGCCGAGCAACGGATGCTGATCGCCACGGCGGGTGGCAATGGCTTTGTGACCAAGGTT
GGCGACATGATCGGCCGCCAGAAGGCAGGCAAGGCCTTCGTGACGCTGGACGAGGGTGACACGCTGCTGGCCCCGACGCC
GATTGGTGAGGAGTGCACGCATGTGGCCTGCTTCTCGGCCAATGGCCGCCTGCTGCTGGCGGGGCTGGACGAGGTCAAGG
TGCTGTCGGCCGGTGGCCGCGGCGTGATCCTGATGGAGCTGGAACCGAAGGAAACGCTGATGCAGGCGGTGGCCGTGGGC
GCGCCGGGCCTGATGATCTCCGGCATCGGCGTTCGTGGCGGCAAGGTGCCGCCGCAGAAGCTGGCCGGCAAGACGCTGAT
CCCTTACGTGGGCAAGCGCGCCCGCAAAGGCAAGGCGATCGAGCCGCGCCTCAAGGAAGTGAAGATCGAGCCGGTAAAGG
TTGGGGAGTAA

Upstream 100 bases:

>100_bases
TGCGGCGGTATCGCCATCTACTTCCTTTAGAATCCCACGCTGACTGCAACAGCCGGCTGCCGGGCGCGCAGGTGCCTGCC
GGGCCGAAATCTTGCCAAAC

Downstream 100 bases:

>100_bases
AGGGGAACGGCGTCGGTGATTCCGGCGCTGGTCCTCTGATTCTCTGATCCGGCCCTTCTCCTGCTGGGCGGGAGAGGGGA
GCGAACCCTCGGCATGTGAG

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 776; Mature: 776

Protein sequence:

>776_residues
MDQPDITFQADEPADSLTLARYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMQAMGLRADAKPVKSARVVGEVL
GKFHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLDEIDMGTVDFLPNYDGSEE
EPKLLPARLPFVLLNGASGIAVGMATEIPPHNLREVAGATVAMIRNPNISLADLLALMPGPDYPGGGQIISPASEIAQIY
ESGRGSLKVRARWTIEEMARGQWQMVVTELPPGTSAQKVLEEIEEITNPKIRTGKKALTPEQTQLKTTMLSVLDAVRDES
GKDAPVRLVFEPKSKNTEQQDFIQTLLAHTSLESGAPINLVMIGTDGRPRQKGLQEILREWIEFRFATVTRRTRFQLTKV
EDRIHILEGRMLVLLNIDEVIRIIRESDEPKPALIEAFRLSDRQAEDILEIRLRQLARLEAIKIEQELAKLRDEQAELDV
LLKSETMMRRRIIKEIEQDAKQYSPEDKDPRRTLIQEASRAAAEVKVIDEPVTVIVSGKGWVRTRQGHGHDASQFTFKAG
DNLYGTFECRTIDTLLAFGSNGRVYSVAVSGLPGGRGDGVPVTTLIDLAAGTQIAHTFAGAAEQRMLIATAGGNGFVTKV
GDMIGRQKAGKAFVTLDEGDTLLAPTPIGEECTHVACFSANGRLLLAGLDEVKVLSAGGRGVILMELEPKETLMQAVAVG
APGLMISGIGVRGGKVPPQKLAGKTLIPYVGKRARKGKAIEPRLKEVKIEPVKVGE

Sequences:

>Translated_776_residues
MDQPDITFQADEPADSLTLARYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMQAMGLRADAKPVKSARVVGEVL
GKFHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLDEIDMGTVDFLPNYDGSEE
EPKLLPARLPFVLLNGASGIAVGMATEIPPHNLREVAGATVAMIRNPNISLADLLALMPGPDYPGGGQIISPASEIAQIY
ESGRGSLKVRARWTIEEMARGQWQMVVTELPPGTSAQKVLEEIEEITNPKIRTGKKALTPEQTQLKTTMLSVLDAVRDES
GKDAPVRLVFEPKSKNTEQQDFIQTLLAHTSLESGAPINLVMIGTDGRPRQKGLQEILREWIEFRFATVTRRTRFQLTKV
EDRIHILEGRMLVLLNIDEVIRIIRESDEPKPALIEAFRLSDRQAEDILEIRLRQLARLEAIKIEQELAKLRDEQAELDV
LLKSETMMRRRIIKEIEQDAKQYSPEDKDPRRTLIQEASRAAAEVKVIDEPVTVIVSGKGWVRTRQGHGHDASQFTFKAG
DNLYGTFECRTIDTLLAFGSNGRVYSVAVSGLPGGRGDGVPVTTLIDLAAGTQIAHTFAGAAEQRMLIATAGGNGFVTKV
GDMIGRQKAGKAFVTLDEGDTLLAPTPIGEECTHVACFSANGRLLLAGLDEVKVLSAGGRGVILMELEPKETLMQAVAVG
APGLMISGIGVRGGKVPPQKLAGKTLIPYVGKRARKGKAIEPRLKEVKIEPVKVGE
>Mature_776_residues
MDQPDITFQADEPADSLTLARYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMQAMGLRADAKPVKSARVVGEVL
GKFHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISRLLLDEIDMGTVDFLPNYDGSEE
EPKLLPARLPFVLLNGASGIAVGMATEIPPHNLREVAGATVAMIRNPNISLADLLALMPGPDYPGGGQIISPASEIAQIY
ESGRGSLKVRARWTIEEMARGQWQMVVTELPPGTSAQKVLEEIEEITNPKIRTGKKALTPEQTQLKTTMLSVLDAVRDES
GKDAPVRLVFEPKSKNTEQQDFIQTLLAHTSLESGAPINLVMIGTDGRPRQKGLQEILREWIEFRFATVTRRTRFQLTKV
EDRIHILEGRMLVLLNIDEVIRIIRESDEPKPALIEAFRLSDRQAEDILEIRLRQLARLEAIKIEQELAKLRDEQAELDV
LLKSETMMRRRIIKEIEQDAKQYSPEDKDPRRTLIQEASRAAAEVKVIDEPVTVIVSGKGWVRTRQGHGHDASQFTFKAG
DNLYGTFECRTIDTLLAFGSNGRVYSVAVSGLPGGRGDGVPVTTLIDLAAGTQIAHTFAGAAEQRMLIATAGGNGFVTKV
GDMIGRQKAGKAFVTLDEGDTLLAPTPIGEECTHVACFSANGRLLLAGLDEVKVLSAGGRGVILMELEPKETLMQAVAVG
APGLMISGIGVRGGKVPPQKLAGKTLIPYVGKRARKGKAIEPRLKEVKIEPVKVGE

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=255, Percent_Identity=32.156862745098, Blast_Score=101, Evalue=3e-21,
Organism=Homo sapiens, GI19913406, Length=168, Percent_Identity=35.7142857142857, Blast_Score=92, Evalue=2e-18,
Organism=Escherichia coli, GI1789396, Length=754, Percent_Identity=42.7055702917772, Blast_Score=582, Evalue=1e-167,
Organism=Escherichia coli, GI1788562, Length=736, Percent_Identity=36.1413043478261, Blast_Score=390, Evalue=1e-109,
Organism=Caenorhabditis elegans, GI17535065, Length=166, Percent_Identity=38.5542168674699, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI212645845, Length=384, Percent_Identity=25.2604166666667, Blast_Score=94, Evalue=3e-19,
Organism=Caenorhabditis elegans, GI212645657, Length=180, Percent_Identity=33.8888888888889, Blast_Score=87, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI115534553, Length=162, Percent_Identity=34.5679012345679, Blast_Score=82, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6324241, Length=163, Percent_Identity=34.9693251533742, Blast_Score=86, Evalue=3e-17,
Organism=Drosophila melanogaster, GI17136538, Length=173, Percent_Identity=34.1040462427746, Blast_Score=91, Evalue=4e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84764; Mature: 84764

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDQPDITFQADEPADSLTLARYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMQA
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MGLRADAKPVKSARVVGEVLGKFHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDG
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCCCCC
DGAAAMRYTEARLTPISRLLLDEIDMGTVDFLPNYDGSEEEPKLLPARLPFVLLNGASGI
CCCHHEEEHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEECCCCE
AVGMATEIPPHNLREVAGATVAMIRNPNISLADLLALMPGPDYPGGGQIISPASEIAQIY
EEEEECCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCEECCHHHHHHHH
ESGRGSLKVRARWTIEEMARGQWQMVVTELPPGTSAQKVLEEIEEITNPKIRTGKKALTP
HCCCCCEEEEEEECHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
EQTQLKTTMLSVLDAVRDESGKDAPVRLVFEPKSKNTEQQDFIQTLLAHTSLESGAPINL
CHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCEEE
VMIGTDGRPRQKGLQEILREWIEFRFATVTRRTRFQLTKVEDRIHILEGRMLVLLNIDEV
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHEEEECCCEEEEEEHHHH
IRIIRESDEPKPALIEAFRLSDRQAEDILEIRLRQLARLEAIKIEQELAKLRDEQAELDV
HHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LLKSETMMRRRIIKEIEQDAKQYSPEDKDPRRTLIQEASRAAAEVKVIDEPVTVIVSGKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEECCCEEEEECCCC
WVRTRQGHGHDASQFTFKAGDNLYGTFECRTIDTLLAFGSNGRVYSVAVSGLPGGRGDGV
EEEECCCCCCCCCCEEEECCCCEEEEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
PVTTLIDLAAGTQIAHTFAGAAEQRMLIATAGGNGFVTKVGDMIGRQKAGKAFVTLDEGD
CHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCHHCCCCEEEEECCCC
TLLAPTPIGEECTHVACFSANGRLLLAGLDEVKVLSAGGRGVILMELEPKETLMQAVAVG
EEECCCCCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCEEEEEEECCHHHHHHHHHCC
APGLMISGIGVRGGKVPPQKLAGKTLIPYVGKRARKGKAIEPRLKEVKIEPVKVGE
CCCEEEEECCCCCCCCCHHHHCCCCHHHHHCCHHCCCCCCCCHHHHEEECEEECCC
>Mature Secondary Structure
MDQPDITFQADEPADSLTLARYAERAYLDYAVSVVKGRALPEVADGQKPVQRRILFAMQA
CCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
MGLRADAKPVKSARVVGEVLGKFHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDG
HCCCCCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCCCCC
DGAAAMRYTEARLTPISRLLLDEIDMGTVDFLPNYDGSEEEPKLLPARLPFVLLNGASGI
CCCHHEEEHHHHHHHHHHHHHHHCCCCCEECCCCCCCCCCCCCCCCCCCCEEEEECCCCE
AVGMATEIPPHNLREVAGATVAMIRNPNISLADLLALMPGPDYPGGGQIISPASEIAQIY
EEEEECCCCCHHHHHHCCCEEEEEECCCCCHHHHHHHCCCCCCCCCCCEECCHHHHHHHH
ESGRGSLKVRARWTIEEMARGQWQMVVTELPPGTSAQKVLEEIEEITNPKIRTGKKALTP
HCCCCCEEEEEEECHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
EQTQLKTTMLSVLDAVRDESGKDAPVRLVFEPKSKNTEQQDFIQTLLAHTSLESGAPINL
CHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCEEE
VMIGTDGRPRQKGLQEILREWIEFRFATVTRRTRFQLTKVEDRIHILEGRMLVLLNIDEV
EEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEHHHHEEEECCCEEEEEEHHHH
IRIIRESDEPKPALIEAFRLSDRQAEDILEIRLRQLARLEAIKIEQELAKLRDEQAELDV
HHHHHCCCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHH
LLKSETMMRRRIIKEIEQDAKQYSPEDKDPRRTLIQEASRAAAEVKVIDEPVTVIVSGKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHEEEEECCCEEEEECCCC
WVRTRQGHGHDASQFTFKAGDNLYGTFECRTIDTLLAFGSNGRVYSVAVSGLPGGRGDGV
EEEECCCCCCCCCCEEEECCCCEEEEEEHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCC
PVTTLIDLAAGTQIAHTFAGAAEQRMLIATAGGNGFVTKVGDMIGRQKAGKAFVTLDEGD
CHHHHHHHHCCCHHHHHHHCCCCCEEEEEEECCCCCHHHHHHHHCHHCCCCEEEEECCCC
TLLAPTPIGEECTHVACFSANGRLLLAGLDEVKVLSAGGRGVILMELEPKETLMQAVAVG
EEECCCCCCCCCCEEEEECCCCEEEEEECCCEEEEECCCCEEEEEEECCHHHHHHHHHCC
APGLMISGIGVRGGKVPPQKLAGKTLIPYVGKRARKGKAIEPRLKEVKIEPVKVGE
CCCEEEEECCCCCCCCCHHHHCCCCHHHHHCCHHCCCCCCCCHHHHEEECEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]