Click here to switch to the map view.

The map label for this gene is fabF [H]

Identifier: 94311362

GI number: 94311362

Start: 2636174

End: 2637406

Strand: Reverse

Name: fabF [H]

Synonym: Rmet_2426

Alternate gene names: 94311362

Gene position: 2637406-2636174 (Counterclockwise)

Preceding gene: 94311363

Following gene: 94311361

Centisome position: 67.14

GC content: 62.53

Gene sequence:

>1233_bases
GTGAGCCGTCGTCGCGTCGTCGTCACTGGGCTTGGCCTTGTGTCTCCCGTCGGAAACACGGTTGCCGAAGGCTGGGCCAA
TCTGGTTGCCGGCAAGTCCGGCATCGCCACCATCACCAAGTTCGATCACTCTCCCTTTGCTGTGCACTTTGCGGGCGAAG
TGAAGGGCTTCAATGCCGAGGATTACATCCCGGCCAAGGAAGCCCGGAACATGGATACCTTCATCCATTTCGGCATCGCC
GCCGGTTCGCAGGCGCTCAAGGACAGCGGCCTGGAAGTGACCGAGGCCAACGCCGAGCGCATCGGTGTGCTGGTGGGCTC
GGGTATTGGCGGGCTGCCGATGATCGAAGATACGCAGATGACGCTGGCCGAACGCGGCCCGCGCCGGATCTCGCCGTTCT
TCGTGCCAGGTTCGATCATCAACATGATCTCCGGCCACCTGTCGATTATCCACGGCCTCAAGGGCCCGAACCTGGCTGCG
GTGACGGCCTGCACGACCGGGCTGCACAGCATCGGCCTGGCGGCGCGTCTGATTCAGGCGGGCGACTGCGATGCGATGCT
GGCTGGCGGAGCGGAGTCGACGGTGTCGCCGCTCGGCATCGGCGGTTTTGCGGCAGCACGCGCGCTTTCCACTCGCAACG
ATGACCCTGCTGCGGCGTCGCGTCCGTGGGACAAGGACCGCGATGGCTTCGTGCTGGGCGAGGGTGCCGGCGTGATGATG
CTCGAGGAGTATGAGTCGGCCAAGGCGCGCGGCGCGCGAATCTATGCTGAACTCATCGGCTTCGGCATGAGCGGTGACGC
GTTCCACATGACGGCGCCGAACACCGACGGTCCGCGCCGCTGCATGGTCGCTGCGATCAAGGATGCCGGAATCAATCCGG
ACGAAGTGCAGTACCTCAACGCGCATGGCACCTCGACGCCGCTGGGTGACAAGAATGAGACCGATGCCGTCAAGCTGGCA
TTCGGTGATCACGCCTACAAGATGGTGGTCAACTCGACGAAGTCGATGACCGGTCACTTGCTGGGTGGCGCTGGGGGCCT
GGAGTCGGTGTTCACGGTTCTGGCGATTCACAATCAGATCTCGCCGCCGACCATCAACATCTTCAATCAAGATCCCGAGT
GTGATCTCGATTACGTCGCCAATACGGCACGTGACATGAAGATTGATGTCGCCGTGAAGAACAACTTCGGCTTCGGCGGT
ACCAACGGTACGCTTGTCTTCCGCCGCGTCTGA

Upstream 100 bases:

>100_bases
TCTCAGCCGCTTCCTCTCGCAAGGAATCACTTCCTATCGGCAGGAGCAGCGAGATCCTGAATCAATCCAATTCCGCTTCA
CGTACTCGTAGGAAAAAATA

Downstream 100 bases:

>100_bases
TATCGCGCGCGTTTCGCATGAAACGGGGCCGGCTGGTGACAGCGGCCCCCGTCCCATCCTGTACTCCCCGGCATTTCCCC
GAATCCTTGGGTTGCACGCA

Product: 3-oxoacyl-(acyl carrier protein) synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 410; Mature: 409

Protein sequence:

>410_residues
MSRRRVVVTGLGLVSPVGNTVAEGWANLVAGKSGIATITKFDHSPFAVHFAGEVKGFNAEDYIPAKEARNMDTFIHFGIA
AGSQALKDSGLEVTEANAERIGVLVGSGIGGLPMIEDTQMTLAERGPRRISPFFVPGSIINMISGHLSIIHGLKGPNLAA
VTACTTGLHSIGLAARLIQAGDCDAMLAGGAESTVSPLGIGGFAAARALSTRNDDPAAASRPWDKDRDGFVLGEGAGVMM
LEEYESAKARGARIYAELIGFGMSGDAFHMTAPNTDGPRRCMVAAIKDAGINPDEVQYLNAHGTSTPLGDKNETDAVKLA
FGDHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLAIHNQISPPTINIFNQDPECDLDYVANTARDMKIDVAVKNNFGFGG
TNGTLVFRRV

Sequences:

>Translated_410_residues
MSRRRVVVTGLGLVSPVGNTVAEGWANLVAGKSGIATITKFDHSPFAVHFAGEVKGFNAEDYIPAKEARNMDTFIHFGIA
AGSQALKDSGLEVTEANAERIGVLVGSGIGGLPMIEDTQMTLAERGPRRISPFFVPGSIINMISGHLSIIHGLKGPNLAA
VTACTTGLHSIGLAARLIQAGDCDAMLAGGAESTVSPLGIGGFAAARALSTRNDDPAAASRPWDKDRDGFVLGEGAGVMM
LEEYESAKARGARIYAELIGFGMSGDAFHMTAPNTDGPRRCMVAAIKDAGINPDEVQYLNAHGTSTPLGDKNETDAVKLA
FGDHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLAIHNQISPPTINIFNQDPECDLDYVANTARDMKIDVAVKNNFGFGG
TNGTLVFRRV
>Mature_409_residues
SRRRVVVTGLGLVSPVGNTVAEGWANLVAGKSGIATITKFDHSPFAVHFAGEVKGFNAEDYIPAKEARNMDTFIHFGIAA
GSQALKDSGLEVTEANAERIGVLVGSGIGGLPMIEDTQMTLAERGPRRISPFFVPGSIINMISGHLSIIHGLKGPNLAAV
TACTTGLHSIGLAARLIQAGDCDAMLAGGAESTVSPLGIGGFAAARALSTRNDDPAAASRPWDKDRDGFVLGEGAGVMML
EEYESAKARGARIYAELIGFGMSGDAFHMTAPNTDGPRRCMVAAIKDAGINPDEVQYLNAHGTSTPLGDKNETDAVKLAF
GDHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLAIHNQISPPTINIFNQDPECDLDYVANTARDMKIDVAVKNNFGFGGT
NGTLVFRRV

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthes

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=416, Percent_Identity=46.6346153846154, Blast_Score=375, Evalue=1e-104,
Organism=Homo sapiens, GI223972627, Length=167, Percent_Identity=49.1017964071856, Blast_Score=161, Evalue=9e-40,
Organism=Homo sapiens, GI41872631, Length=433, Percent_Identity=24.4803695150115, Blast_Score=113, Evalue=3e-25,
Organism=Escherichia coli, GI1787337, Length=413, Percent_Identity=60.2905569007264, Blast_Score=490, Evalue=1e-140,
Organism=Escherichia coli, GI1788663, Length=412, Percent_Identity=37.8640776699029, Blast_Score=240, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71983541, Length=412, Percent_Identity=35.9223300970874, Blast_Score=243, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI71983535, Length=264, Percent_Identity=38.6363636363636, Blast_Score=182, Evalue=4e-46,
Organism=Caenorhabditis elegans, GI212642053, Length=378, Percent_Identity=25.6613756613757, Blast_Score=124, Evalue=1e-28,
Organism=Caenorhabditis elegans, GI17550940, Length=411, Percent_Identity=24.330900243309, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6320904, Length=446, Percent_Identity=35.2017937219731, Blast_Score=258, Evalue=1e-69,
Organism=Drosophila melanogaster, GI24644341, Length=413, Percent_Identity=45.5205811138014, Blast_Score=342, Evalue=3e-94,
Organism=Drosophila melanogaster, GI19920632, Length=390, Percent_Identity=24.3589743589744, Blast_Score=105, Evalue=8e-23,
Organism=Drosophila melanogaster, GI221330659, Length=390, Percent_Identity=24.3589743589744, Blast_Score=104, Evalue=1e-22,
Organism=Drosophila melanogaster, GI24581345, Length=384, Percent_Identity=24.4791666666667, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 42930; Mature: 42799

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00606 B_KETOACYL_SYNTHASE ; PS00107 PROTEIN_KINASE_ATP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRRVVVTGLGLVSPVGNTVAEGWANLVAGKSGIATITKFDHSPFAVHFAGEVKGFNAE
CCCCEEEEEECCHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCC
DYIPAKEARNMDTFIHFGIAAGSQALKDSGLEVTEANAERIGVLVGSGIGGLPMIEDTQM
CCCCHHHHCCCCEEEEEEECCCCHHHHHCCCEEEECCCCEEEEEEECCCCCCCCCCCCHH
TLAERGPRRISPFFVPGSIINMISGHLSIIHGLKGPNLAAVTACTTGLHSIGLAARLIQA
HHHHCCCCCCCCEECCHHHHHHHHHHHHHEECCCCCCEEEEHHHHHHHHHHHHHHHHHHC
GDCDAMLAGGAESTVSPLGIGGFAAARALSTRNDDPAAASRPWDKDRDGFVLGEGAGVMM
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYESAKARGARIYAELIGFGMSGDAFHMTAPNTDGPRRCMVAAIKDAGINPDEVQYLN
EECHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHEEEEEHHHCCCCHHHEEEEE
AHGTSTPLGDKNETDAVKLAFGDHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLAIHNQI
CCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCHHCEEEECCCCCHHHHHHHHHHHCCC
SPPTINIFNQDPECDLDYVANTARDMKIDVAVKNNFGFGGTNGTLVFRRV
CCCEEEEECCCCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEEEC
>Mature Secondary Structure 
SRRRVVVTGLGLVSPVGNTVAEGWANLVAGKSGIATITKFDHSPFAVHFAGEVKGFNAE
CCCEEEEEECCHHCCCCHHHHHHHHHHHCCCCCCEEEEEECCCCEEEEEECCCCCCCCC
DYIPAKEARNMDTFIHFGIAAGSQALKDSGLEVTEANAERIGVLVGSGIGGLPMIEDTQM
CCCCHHHHCCCCEEEEEEECCCCHHHHHCCCEEEECCCCEEEEEEECCCCCCCCCCCCHH
TLAERGPRRISPFFVPGSIINMISGHLSIIHGLKGPNLAAVTACTTGLHSIGLAARLIQA
HHHHCCCCCCCCEECCHHHHHHHHHHHHHEECCCCCCEEEEHHHHHHHHHHHHHHHHHHC
GDCDAMLAGGAESTVSPLGIGGFAAARALSTRNDDPAAASRPWDKDRDGFVLGEGAGVMM
CCCCEEEECCCCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEEECCCCEEE
LEEYESAKARGARIYAELIGFGMSGDAFHMTAPNTDGPRRCMVAAIKDAGINPDEVQYLN
EECHHHHHHCCCEEEEHHHCCCCCCCEEEEECCCCCCCHHEEEEEHHHCCCCHHHEEEEE
AHGTSTPLGDKNETDAVKLAFGDHAYKMVVNSTKSMTGHLLGGAGGLESVFTVLAIHNQI
CCCCCCCCCCCCCCCEEEEEECCCEEEEEECCCCHHCEEEECCCCCHHHHHHHHHHHCCC
SPPTINIFNQDPECDLDYVANTARDMKIDVAVKNNFGFGGTNGTLVFRRV
CCCEEEEECCCCCCCHHHHHCCCCCEEEEEEEECCCCCCCCCCEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550484 [H]