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The map label for this gene is folP [H]

Identifier: 94311125

GI number: 94311125

Start: 2395138

End: 2396007

Strand: Reverse

Name: folP [H]

Synonym: Rmet_2187

Alternate gene names: 94311125

Gene position: 2396007-2395138 (Counterclockwise)

Preceding gene: 94311126

Following gene: 94311124

Centisome position: 61.0

GC content: 60.0

Gene sequence:

>870_bases
TTGTCGACTGAGTTCTTCCAGTGCGGGCGCTATCGTTTTTCCCGCCGCCGCCGCCCACTCGTGATGGGTATTCTCAATGT
GACCCCTGATTCGTTCTCAGATGGCGGGCAGCACGCCACCCGTGACGCCGCGCTGCGCCATGCGGAGCAATTGATTGCGG
AGGGTGTCGACATCATCGATATCGGTGGGGAGTCCAGCCGACCTGGGTCGGCCGCGCTGCCGCTCGATCAGGAACTAGAT
CGCGTGATGCCGATCGTCGAGTCGCTGGCCGATTGCGGTAAGCCGCTTTCGATCGACACCTACAAGCCGGAGGTTATGCG
TGCAGCGCTGGCGGGCGGAGCAGATCTGATCAATGATATCTGGGGCTTCCGAATGCCGGGTGCGGTTGAGGCAGTTGCCG
CAGGGCAGTTCGGACTATGCGTCATGCATATGCAGCGTGATCCCCAGACGATGCAGGAAGATCCGCACTACACCGATGTG
GTTGCCGAGGTGGCATCTTTCCTGGAAGAACGGGTGTCAACCCTGCGTGCGGCGGGCATCGACACGGCACGTATTTCCCT
TGATCCAGGTTTTGGATTTGGCAAGACTCCAGATCATAATCTGAGGTTGCTCGGACAATTACCTAGCCTTGCTGTTGATG
GCCTGCCGATCCTGGTGGGTCTGTCGCGCAAATCGACGCTGGGTGCAATCATCGGCGGCAAACCTCCACAGGCGCGCGTA
GCTGCCAGTGTGGCGGCAGCCGTGTGCGCAGCTGAGCGCGGCGCATATATCGTCCGGGTACATGATGTTGAACAAACAGT
GGACGCCCTCAAGGTGTGGTGGGCCGTCCGCCAAGAATCAGTTGCCCCCGATGGGCAACACGGAGAATGA

Upstream 100 bases:

>100_bases
ATGAGGTGACACGCAGAGACCAGCTCGCAAGGGCTGGTTTCTGATAGCCTCTCAGGCCGGTGCCTTGCGCGCCGGCTTTT
TTGTTTTCAGGACGCGAATC

Downstream 100 bases:

>100_bases
GAAACATGACACGCAAGTATTTCGGGACAGACGGCGTGCGGGGTCGGGTCGGCGACGCGCCGATCACGCCGGATTTTGTG
ATGCGACTTGGCCATGCGGC

Product: 7,8-dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 289; Mature: 288

Protein sequence:

>289_residues
MSTEFFQCGRYRFSRRRRPLVMGILNVTPDSFSDGGQHATRDAALRHAEQLIAEGVDIIDIGGESSRPGSAALPLDQELD
RVMPIVESLADCGKPLSIDTYKPEVMRAALAGGADLINDIWGFRMPGAVEAVAAGQFGLCVMHMQRDPQTMQEDPHYTDV
VAEVASFLEERVSTLRAAGIDTARISLDPGFGFGKTPDHNLRLLGQLPSLAVDGLPILVGLSRKSTLGAIIGGKPPQARV
AASVAAAVCAAERGAYIVRVHDVEQTVDALKVWWAVRQESVAPDGQHGE

Sequences:

>Translated_289_residues
MSTEFFQCGRYRFSRRRRPLVMGILNVTPDSFSDGGQHATRDAALRHAEQLIAEGVDIIDIGGESSRPGSAALPLDQELD
RVMPIVESLADCGKPLSIDTYKPEVMRAALAGGADLINDIWGFRMPGAVEAVAAGQFGLCVMHMQRDPQTMQEDPHYTDV
VAEVASFLEERVSTLRAAGIDTARISLDPGFGFGKTPDHNLRLLGQLPSLAVDGLPILVGLSRKSTLGAIIGGKPPQARV
AASVAAAVCAAERGAYIVRVHDVEQTVDALKVWWAVRQESVAPDGQHGE
>Mature_288_residues
STEFFQCGRYRFSRRRRPLVMGILNVTPDSFSDGGQHATRDAALRHAEQLIAEGVDIIDIGGESSRPGSAALPLDQELDR
VMPIVESLADCGKPLSIDTYKPEVMRAALAGGADLINDIWGFRMPGAVEAVAAGQFGLCVMHMQRDPQTMQEDPHYTDVV
AEVASFLEERVSTLRAAGIDTARISLDPGFGFGKTPDHNLRLLGQLPSLAVDGLPILVGLSRKSTLGAIIGGKPPQARVA
ASVAAAVCAAERGAYIVRVHDVEQTVDALKVWWAVRQESVAPDGQHGE

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=259, Percent_Identity=49.4208494208494, Blast_Score=251, Evalue=4e-68,
Organism=Saccharomyces cerevisiae, GI6324073, Length=316, Percent_Identity=29.1139240506329, Blast_Score=116, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 31006; Mature: 30874

Theoretical pI: Translated: 5.18; Mature: 5.18

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTEFFQCGRYRFSRRRRPLVMGILNVTPDSFSDGGQHATRDAALRHAEQLIAEGVDIID
CCCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
IGGESSRPGSAALPLDQELDRVMPIVESLADCGKPLSIDTYKPEVMRAALAGGADLINDI
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
WGFRMPGAVEAVAAGQFGLCVMHMQRDPQTMQEDPHYTDVVAEVASFLEERVSTLRAAGI
HCCCCCCHHHHHHCCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DTARISLDPGFGFGKTPDHNLRLLGQLPSLAVDGLPILVGLSRKSTLGAIIGGKPPQARV
CEEEEEECCCCCCCCCCCCCCEEECCCCHHHHCCCEEEEECCCCCHHHHEECCCCCHHHH
AASVAAAVCAAERGAYIVRVHDVEQTVDALKVWWAVRQESVAPDGQHGE
HHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
STEFFQCGRYRFSRRRRPLVMGILNVTPDSFSDGGQHATRDAALRHAEQLIAEGVDIID
CCCHHHHHHHHHHHCCCCEEEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCEEE
IGGESSRPGSAALPLDQELDRVMPIVESLADCGKPLSIDTYKPEVMRAALAGGADLINDI
ECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCHHHHHHH
WGFRMPGAVEAVAAGQFGLCVMHMQRDPQTMQEDPHYTDVVAEVASFLEERVSTLRAAGI
HCCCCCCHHHHHHCCCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DTARISLDPGFGFGKTPDHNLRLLGQLPSLAVDGLPILVGLSRKSTLGAIIGGKPPQARV
CEEEEEECCCCCCCCCCCCCCEEECCCCHHHHCCCEEEEECCCCCHHHHEECCCCCHHHH
AASVAAAVCAAERGAYIVRVHDVEQTVDALKVWWAVRQESVAPDGQHGE
HHHHHHHHHHHHCCEEEEEEECHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]