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The map label for this gene is nrdJ [H]

Identifier: 94311068

GI number: 94311068

Start: 2312562

End: 2315060

Strand: Reverse

Name: nrdJ [H]

Synonym: Rmet_2130

Alternate gene names: 94311068

Gene position: 2315060-2312562 (Counterclockwise)

Preceding gene: 94311069

Following gene: 94311067

Centisome position: 58.94

GC content: 65.67

Gene sequence:

>2499_bases
ATGAACGCAAACGACCAGATCCTCCGCGGCGCGCTTGCGCCGCAAGACATCTCCATCGAAGTACTCCAGGAAAAATACGC
CAAGGGCGAGGAGCAGACCATTGACGATGTGCGTCGCCGTGTGGCGCGCGCGCTCGCGGAGGTGGAACCTGCCGACAAAC
GCGAGGCCTGGGCCTCGCGCTTTCTTTGGGCGCTGGAAGGCGGCTTCGTGCCGGCCGGGCGTATCAACTCGGCGGCTGGC
ACAGGCATTCAAGCTACGCTGATCAACTGCTTCGTCCAGCCTGTGGGCGACTCGGTTTCCCAGGTGCGTGGCGGTAAGCC
GAGCATCTATACCGCCGTGGCCCAGGCTGCGGAGACGATGCGGCGCGGCGGCGGTGTCGGCTATGACTTTTCCTCGATCA
GGCCGGGTGGCGCGCTGGTGCGTGCCACGCACTCGCGCGCATCGGGGCCGGTGTCGTTCATGAAGGTGTTCGATGCATCG
TGTGCCACCGTGGAATCGGCCGGCGCACGGCGCGGCGCGCAGATGGGCGTGCTGCGCTGCGACCACCCCGATATCGAGAG
CTTTATCCACGCCAAGGACCGTGGCGACCTGACCAACTTCAATATCTCGATTGGCGTCACCGACGAGTTCATGCAAGCGG
TGGCGGCTGATGGGGAAATCGAACTGATCCACGAGGCCGAGCCTGGCGCGGACGGTATCGCGGCGGGCGCCTATCGCCGC
GACGACGGCCAGTGGGTGTATCGGCGTGTGCCGGCCCGTCGGCTGTGGGACCAGGTCATGCAGGCCACCTATGACCACGC
AGAGCCTGGCATCCTGTTCCTGTCGCGCATCAACGCCGACAACAATCTCTATTACTGCGAGACGATCGAGGCCACCAACC
CGTGCGCCGAGCAGCCGTTGCCGTCGTATGGCTGCTGCTGCCTGGGCTCGATCAACCTGACGCGCTTCGTACGCCGCCCG
TTTACCGATCAGGCCAGCTTCGATTTCGAGGCGTTTGCCGAGGTCGTGCGCGTTTCGACGCGGATGCTCGACAACGTGCT
CGACATCACCTACTGGCCGTTGCCCGAGCAGCAGGCCGAGGCGCAAGCCAAGCGTCGTATCGGCCTGGGGTTCCTGGGGC
TTGGTAGCGCACTGGTGATGCTGGGTCATCGCTATGACACCGATGCGGCGCGCGCGCTTGCGGGGCGGATCTCCGAGACC
ATGCGCGATCACGCCTATCTGGCATCGGTCGAACTCGCCGAGGAGAAGGGCCGCTTCCCGTTGTTCGATGCCGACGCCTA
TCTGAGTGGCGGCTTCGTGAGCCGCCTGCCCGAGCCCATCCGCGATGCCATCCGCGAACACGGCCTGCGCAACTCGCACC
TGCTTTCGATCGCGCCAACTGGCACGATCACGCTTGCCTTTGCCGATAACGCGTCAAATGGGATCGAGCCGGCCTTCTCG
TGGACCTACAACCGGCGCAAGCGGATGCCCGACGACAGCTATCGCACGTTCGAGGTGGCCGACCATGCATGGCGGCTCTA
TCGCCATATGGGCGGCGACGTCGAGCAGTTGCCGGAGAGCTTCGTCACGGCGCTCCAGATGTCTGCCATTGACCATATGC
GGATGCTGGAGGCGGTCCAGCCCTATATCGACACGAGCATCAGCAAGACTGTGAACGTGCCGGAGGACTATCCGTACGAA
GCCTTCCGCAATCTCTACCTCGAAGCGTGGAAGGCCGGGCTCAAGGGGCTCGCCACGTATCGGCCGAACCAGGTGCTTGG
CGCGGTGCTGTCGGTCACCCCGGCCGCCACGGCCACCACGGCGCCGGCGCCCGCCACGCCGAGCGAGGACGATCCGCTGA
CGCGGCCGTTCGGTAGCCGGCCACTCGGCGATCTGGAAGGCGTGACGTCGAAGGTCGAGTATTTGACCTATGAGGGTCAC
AAGACGGTCTACCTGACCGTCAACTTCATGCAGGTGTCCGGCACGATCGGTGGCCAGCCGGTGACGATCGAGCGGCCAAT
CGAGTTCTTCATGCCCGCGGGGCAGCGTTCCGAGGGCCAGCAGTGGATCACGTCGACGATGCGGCTATTGTCGATGGTGG
CCCGCTCGGGCGGACCGATCGCCAAGGCGCTGGCCGATATGCGGAACGTGGTCTGGGACAAGGGCACGGTCCGCTACGGC
TCCCTGGCCCGCCAGGACGGCACCGAGGTGCCGCGCTTCCATGATTCGGAGGTGGCGGCGCTGAGTTACGCGATTCAACG
CATCCTGATCAAGCGTGGTTTCCTGGACGAGGAGGGCAGCCAGGTACCGGTGGTGGCGCTGGCTGCCCGTCTGGCCCGGC
GCGAAGGCGGCGAGGCGGCTGTGGCGCTGGCTTCGCCGGCCGAAGCGGCGCCCGCCGCCAAACTGGCTGCCGGGATTGGC
ACCGGCAAGCCGTGCCCCGAGTGTGGCGCTCACGCCCTGCACAAGGTGGACGGCTGCGCCAAGTGCGCCAATTGCGGTTA
TGTGGGCGAGTGTGGCTAG

Upstream 100 bases:

>100_bases
CTGGTTGTTTGATCTGAAGCGGGGTTGGCGTCCTGCCATGCTGGCAGCATGGCGGACGGCAAATTCGGGCCGGAAAGCTC
TCAACTGACAGGCTGGGGAC

Downstream 100 bases:

>100_bases
CCGGCGACCCTTCACGGATGGCGGCGGCGTGCGATAGCATCTGGCAACTCCAAATCCAGGTCTGACCCAGGTCCGCCTTT
TGCTACAATCGCCGCCATGA

Product: ribonucleotide reductase, coenzyme B12-dependent

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 832; Mature: 832

Protein sequence:

>832_residues
MNANDQILRGALAPQDISIEVLQEKYAKGEEQTIDDVRRRVARALAEVEPADKREAWASRFLWALEGGFVPAGRINSAAG
TGIQATLINCFVQPVGDSVSQVRGGKPSIYTAVAQAAETMRRGGGVGYDFSSIRPGGALVRATHSRASGPVSFMKVFDAS
CATVESAGARRGAQMGVLRCDHPDIESFIHAKDRGDLTNFNISIGVTDEFMQAVAADGEIELIHEAEPGADGIAAGAYRR
DDGQWVYRRVPARRLWDQVMQATYDHAEPGILFLSRINADNNLYYCETIEATNPCAEQPLPSYGCCCLGSINLTRFVRRP
FTDQASFDFEAFAEVVRVSTRMLDNVLDITYWPLPEQQAEAQAKRRIGLGFLGLGSALVMLGHRYDTDAARALAGRISET
MRDHAYLASVELAEEKGRFPLFDADAYLSGGFVSRLPEPIRDAIREHGLRNSHLLSIAPTGTITLAFADNASNGIEPAFS
WTYNRRKRMPDDSYRTFEVADHAWRLYRHMGGDVEQLPESFVTALQMSAIDHMRMLEAVQPYIDTSISKTVNVPEDYPYE
AFRNLYLEAWKAGLKGLATYRPNQVLGAVLSVTPAATATTAPAPATPSEDDPLTRPFGSRPLGDLEGVTSKVEYLTYEGH
KTVYLTVNFMQVSGTIGGQPVTIERPIEFFMPAGQRSEGQQWITSTMRLLSMVARSGGPIAKALADMRNVVWDKGTVRYG
SLARQDGTEVPRFHDSEVAALSYAIQRILIKRGFLDEEGSQVPVVALAARLARREGGEAAVALASPAEAAPAAKLAAGIG
TGKPCPECGAHALHKVDGCAKCANCGYVGECG

Sequences:

>Translated_832_residues
MNANDQILRGALAPQDISIEVLQEKYAKGEEQTIDDVRRRVARALAEVEPADKREAWASRFLWALEGGFVPAGRINSAAG
TGIQATLINCFVQPVGDSVSQVRGGKPSIYTAVAQAAETMRRGGGVGYDFSSIRPGGALVRATHSRASGPVSFMKVFDAS
CATVESAGARRGAQMGVLRCDHPDIESFIHAKDRGDLTNFNISIGVTDEFMQAVAADGEIELIHEAEPGADGIAAGAYRR
DDGQWVYRRVPARRLWDQVMQATYDHAEPGILFLSRINADNNLYYCETIEATNPCAEQPLPSYGCCCLGSINLTRFVRRP
FTDQASFDFEAFAEVVRVSTRMLDNVLDITYWPLPEQQAEAQAKRRIGLGFLGLGSALVMLGHRYDTDAARALAGRISET
MRDHAYLASVELAEEKGRFPLFDADAYLSGGFVSRLPEPIRDAIREHGLRNSHLLSIAPTGTITLAFADNASNGIEPAFS
WTYNRRKRMPDDSYRTFEVADHAWRLYRHMGGDVEQLPESFVTALQMSAIDHMRMLEAVQPYIDTSISKTVNVPEDYPYE
AFRNLYLEAWKAGLKGLATYRPNQVLGAVLSVTPAATATTAPAPATPSEDDPLTRPFGSRPLGDLEGVTSKVEYLTYEGH
KTVYLTVNFMQVSGTIGGQPVTIERPIEFFMPAGQRSEGQQWITSTMRLLSMVARSGGPIAKALADMRNVVWDKGTVRYG
SLARQDGTEVPRFHDSEVAALSYAIQRILIKRGFLDEEGSQVPVVALAARLARREGGEAAVALASPAEAAPAAKLAAGIG
TGKPCPECGAHALHKVDGCAKCANCGYVGECG
>Mature_832_residues
MNANDQILRGALAPQDISIEVLQEKYAKGEEQTIDDVRRRVARALAEVEPADKREAWASRFLWALEGGFVPAGRINSAAG
TGIQATLINCFVQPVGDSVSQVRGGKPSIYTAVAQAAETMRRGGGVGYDFSSIRPGGALVRATHSRASGPVSFMKVFDAS
CATVESAGARRGAQMGVLRCDHPDIESFIHAKDRGDLTNFNISIGVTDEFMQAVAADGEIELIHEAEPGADGIAAGAYRR
DDGQWVYRRVPARRLWDQVMQATYDHAEPGILFLSRINADNNLYYCETIEATNPCAEQPLPSYGCCCLGSINLTRFVRRP
FTDQASFDFEAFAEVVRVSTRMLDNVLDITYWPLPEQQAEAQAKRRIGLGFLGLGSALVMLGHRYDTDAARALAGRISET
MRDHAYLASVELAEEKGRFPLFDADAYLSGGFVSRLPEPIRDAIREHGLRNSHLLSIAPTGTITLAFADNASNGIEPAFS
WTYNRRKRMPDDSYRTFEVADHAWRLYRHMGGDVEQLPESFVTALQMSAIDHMRMLEAVQPYIDTSISKTVNVPEDYPYE
AFRNLYLEAWKAGLKGLATYRPNQVLGAVLSVTPAATATTAPAPATPSEDDPLTRPFGSRPLGDLEGVTSKVEYLTYEGH
KTVYLTVNFMQVSGTIGGQPVTIERPIEFFMPAGQRSEGQQWITSTMRLLSMVARSGGPIAKALADMRNVVWDKGTVRYG
SLARQDGTEVPRFHDSEVAALSYAIQRILIKRGFLDEEGSQVPVVALAARLARREGGEAAVALASPAEAAPAAKLAAGIG
TGKPCPECGAHALHKVDGCAKCANCGYVGECG

Specific function: Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides [H]

COG id: COG0209

COG function: function code F; Ribonucleotide reductase, alpha subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ATP-cone domain [H]

Homologues:

Organism=Homo sapiens, GI4506749, Length=545, Percent_Identity=24.7706422018349, Blast_Score=151, Evalue=2e-36,
Organism=Escherichia coli, GI2367133, Length=551, Percent_Identity=24.6823956442831, Blast_Score=113, Evalue=6e-26,
Organism=Escherichia coli, GI1789030, Length=473, Percent_Identity=23.4672304439746, Blast_Score=100, Evalue=6e-22,
Organism=Caenorhabditis elegans, GI17555242, Length=548, Percent_Identity=27.1897810218978, Blast_Score=164, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322123, Length=583, Percent_Identity=25.7289879931389, Blast_Score=149, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6320914, Length=406, Percent_Identity=25.615763546798, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI17352481, Length=541, Percent_Identity=25.8780036968577, Blast_Score=161, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005144
- InterPro:   IPR013344
- InterPro:   IPR013509
- InterPro:   IPR000788
- InterPro:   IPR008926 [H]

Pfam domain/function: PF03477 ATP-cone; PF02867 Ribonuc_red_lgC; PF00317 Ribonuc_red_lgN [H]

EC number: =1.17.4.1 [H]

Molecular weight: Translated: 90459; Mature: 90459

Theoretical pI: Translated: 5.79; Mature: 5.79

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNANDQILRGALAPQDISIEVLQEKYAKGEEQTIDDVRRRVARALAEVEPADKREAWASR
CCCCHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FLWALEGGFVPAGRINSAAGTGIQATLINCFVQPVGDSVSQVRGGKPSIYTAVAQAAETM
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHH
RRGGGVGYDFSSIRPGGALVRATHSRASGPVSFMKVFDASCATVESAGARRGAQMGVLRC
HHCCCCCCCHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
DHPDIESFIHAKDRGDLTNFNISIGVTDEFMQAVAADGEIELIHEAEPGADGIAAGAYRR
CCCCHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEC
DDGQWVYRRVPARRLWDQVMQATYDHAEPGILFLSRINADNNLYYCETIEATNPCAEQPL
CCCCCHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCHHHCCC
PSYGCCCLGSINLTRFVRRPFTDQASFDFEAFAEVVRVSTRMLDNVLDITYWPLPEQQAE
CCCCCEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEECCCCHHHHH
AQAKRRIGLGFLGLGSALVMLGHRYDTDAARALAGRISETMRDHAYLASVELAEEKGRFP
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LFDADAYLSGGFVSRLPEPIRDAIREHGLRNSHLLSIAPTGTITLAFADNASNGIEPAFS
EECCCHHHCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCHH
WTYNRRKRMPDDSYRTFEVADHAWRLYRHMGGDVEQLPESFVTALQMSAIDHMRMLEAVQ
CCHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PYIDTSISKTVNVPEDYPYEAFRNLYLEAWKAGLKGLATYRPNQVLGAVLSVTPAATATT
HHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
APAPATPSEDDPLTRPFGSRPLGDLEGVTSKVEYLTYEGHKTVYLTVNFMQVSGTIGGQP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEECCCEEEEEEEEEEEEECCCCCCC
VTIERPIEFFMPAGQRSEGQQWITSTMRLLSMVARSGGPIAKALADMRNVVWDKGTVRYG
EEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEC
SLARQDGTEVPRFHDSEVAALSYAIQRILIKRGFLDEEGSQVPVVALAARLARREGGEAA
CHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEE
VALASPAEAAPAAKLAAGIGTGKPCPECGAHALHKVDGCAKCANCGYVGECG
EEECCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure
MNANDQILRGALAPQDISIEVLQEKYAKGEEQTIDDVRRRVARALAEVEPADKREAWASR
CCCCHHHHHHCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FLWALEGGFVPAGRINSAAGTGIQATLINCFVQPVGDSVSQVRGGKPSIYTAVAQAAETM
HHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHCCCCCHHHHHHHHHHHHH
RRGGGVGYDFSSIRPGGALVRATHSRASGPVSFMKVFDASCATVESAGARRGAQMGVLRC
HHCCCCCCCHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCEEEC
DHPDIESFIHAKDRGDLTNFNISIGVTDEFMQAVAADGEIELIHEAEPGADGIAAGAYRR
CCCCHHHHHHHCCCCCCEEEEEEECCCHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEC
DDGQWVYRRVPARRLWDQVMQATYDHAEPGILFLSRINADNNLYYCETIEATNPCAEQPL
CCCCCHHHHCCHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCEEEEEEECCCCCHHHCCC
PSYGCCCLGSINLTRFVRRPFTDQASFDFEAFAEVVRVSTRMLDNVLDITYWPLPEQQAE
CCCCCEEECCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCEECCCCHHHHH
AQAKRRIGLGFLGLGSALVMLGHRYDTDAARALAGRISETMRDHAYLASVELAEEKGRFP
HHHHHHHCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
LFDADAYLSGGFVSRLPEPIRDAIREHGLRNSHLLSIAPTGTITLAFADNASNGIEPAFS
EECCCHHHCCCHHHHCCHHHHHHHHHCCCCCCEEEEEECCCEEEEEEECCCCCCCCCCHH
WTYNRRKRMPDDSYRTFEVADHAWRLYRHMGGDVEQLPESFVTALQMSAIDHMRMLEAVQ
CCHHHHCCCCCCCCCEEHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
PYIDTSISKTVNVPEDYPYEAFRNLYLEAWKAGLKGLATYRPNQVLGAVLSVTPAATATT
HHHHCCHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCCC
APAPATPSEDDPLTRPFGSRPLGDLEGVTSKVEYLTYEGHKTVYLTVNFMQVSGTIGGQP
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHEEEECCCEEEEEEEEEEEEECCCCCCC
VTIERPIEFFMPAGQRSEGQQWITSTMRLLSMVARSGGPIAKALADMRNVVWDKGTVRYG
EEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEC
SLARQDGTEVPRFHDSEVAALSYAIQRILIKRGFLDEEGSQVPVVALAARLARREGGEAA
CHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCEE
VALASPAEAAPAAKLAAGIGTGKPCPECGAHALHKVDGCAKCANCGYVGECG
EEECCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]