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The map label for this gene is dnaX [H]

Identifier: 94311067

GI number: 94311067

Start: 2310078

End: 2312465

Strand: Reverse

Name: dnaX [H]

Synonym: Rmet_2129

Alternate gene names: 94311067

Gene position: 2312465-2310078 (Counterclockwise)

Preceding gene: 94311068

Following gene: 94311066

Centisome position: 58.87

GC content: 69.01

Gene sequence:

>2388_bases
ATGAGTTATCAAGTTCTAGCGCGCAAATGGCGCCCCAGGGATTTCACCACGCTGGTCGGCCAGGAGCACGTGGTCCGCGC
GCTCACGCACGCGCTGGAACAGCAGCGGCTGCATCACGCCTACCTGTTCACCGGCACGCGCGGCGTCGGCAAGACCACGC
TGTCCCGGATTCTGGCCAAGGCCCTCAATTGCACCGGCCCTGACGGCAACGGCGGCATCACCGCCCAGCCTTGCGGCCAG
TGCAAGGCCTGCACGGAAATCGACAGCGGGCGTTTCGTCGACTACATCGAGATGGACGCGGCGTCGAACCGCGGCGTCGA
CGAGATGGCGCAGCTGCTCGACAAGGCGATCTACGCCCCGACGGCCGGCCGCTTCAAGGTCTACATGATCGACGAAGTGC
ACATGCTGACCAACCACGCCTTCAACGCCATGCTGAAGACGCTGGAGGAGCCGCCCGAGCACGTCAAGTTCATCCTGGCC
ACGACCGATCCGCAGAAGATTCCGGTCACCGTGCTGTCACGCTGCCTGCAGTTCAATCTGAAGCAGATGCCGCCGGGCCA
CATCGTCTCGCACCTCGACCACATCCTGGCCCAGGAAGGGATCAGCCATGACGGTAGCGCGCTGCGCCTGCTGGCGCAGG
CCGCCCACGGGTCGATGCGCGATGCGCTGTCGCTGACCGACCAGGCCATTGCCTACAGTGCCGGCCAGGTGTCGGAAGAG
GCAGTGCGCGGCATGTTGGGGGCAATCGACCAGAGCTACCTCGTGCAACTGCTCGATGCGCTGGCTGCCGAAGACGGCGC
CACGATGCTCGGCATCGCCGATTCGATGGCCGACCGCAGCCTGTCGTTTGCCGGGGCGCTGCAGGATCTTGGCTCGCTGC
TGCACAAGGTCGCGCTGGCACAGGCCGTGCCGGCTTCCGTGCAGGACGAATGGCCCGAAGCCGAGGACGTGCGCCGCCTG
GCCCGGCAGTTCGACGCGCAGGAAACCCAGCTTTTCTACCAGATTGCCAACCTTGGCCGCAGCGAACTGGCGCTGGCGCC
GGACGAATACGCCGGCTTCACGATGACGTTGCTGCGAATGCTGGCGTTCCGGCCGTCCACTGCTCCCGCTTCGTCGGTCG
GCGGACAGGGCGGTGGCGGACAGCAGGTGGTACGCCCGCGCCCGGCTGGCACGACGAGCGCCGCACCGTCGCCTCGGGCC
ATGGCATCGGCTGTTGCCGAGCCTGTGGCGGCCGAGCCGGTCAAGGTCGCGCCAGTGGTCGCGCCGGCAGCGCCGACAGC
GCCGATTACGGCCGCTGCTCCGGCCGCATCCGCAGCACCCGCCATGCCCGCTGTGCCAGCGAAGTCAGCCGAACCCGCGC
CGCCCCAGGCTGACGTGGATACGTCGATGTCGCCAGCCCGTGCGGCGTTGGCCGCCGCGCGTCAAGCTTCCGCCGGTCGT
GCTGGCCGACCGATGTCGGCTGCGCCAAACGCAGGTGCCGCCGCCGCGGCCAGTTCGCGCCCGGCTGCGCAGCCGCTGCG
TCCGCCTTCCGCCTCACGGCCGGCTACCACTGCCGCGCCGGCTCCGGCTCCGGCAGTTGCGCCTGCCGCTGCGCCGGTAG
TGACGCCGGTAGTGACGCAGGCTGTCGCTCCGAGCAAGGCTGCTGCCGCCCCTGTCGCGGCCGCGCGCCCGGCACCGGTC
GCCAAGCCTGCGCCGCAACCCGAAGCCAAGTCCGTCCCGCCGTGGGAAGCCGCGGGTGCAAGTGACGTGCCGCCGTGGGA
AGAGATGCCGCCCGATCTGCCTGTGATCGGTCCGTACGACAGCGATCCGGGCTATGACCCGAGCTTCGGTGGTTTCGACA
ACGGCTTTGATTCCGACAGCGCCGATCGCGCGCCGCGCGCGGCTCGTAAGCCCGCGCCGACGCAATCGGCAGCCAAGCCG
ATCAGCAAGCCCGAGCCGGAACCGGCAGCGCAACTGGCACCTGCCGTCCCGCAAGTGGCGCCAAGCGCAGGCGAGGATGG
CACGCCACCGGTTTTCACAGGCGACTGGCCCGAGTTCGCCGCCACCCTGCCGCTCAAGGGGCTGGCCCAGCAGCTTGCCC
ATCAAAGCGAGTTGCATCGCGTGGTCGGCCGCACGCTGCATCTGCGCGTGCCGGTTGCGGCGATTGCCGAGGCTAACGTC
GCGGAGCGGCTTCAGGCAGCGCTGGTCGAGCATTTCCGCGTCGATGTGCGTGTGCAATGCGTCGTTGGCGGCGTGACGCA
TACCGCGGCGGCTGTCGATGCCGCGGCGCGTGCCGAACGCCAGCGCGAAGCCGAAGCCGAGATCGACCGCGACCCGTTTG
TACAAGGTCTGTTGCGGGAGTTCGGTGGCCAGATCGTGCCAGGGTCGATCCAGCCGCGCGCAGCCTGA

Upstream 100 bases:

>100_bases
CTAGCCGGCGACCCTTCACGGATGGCGGCGGCGTGCGATAGCATCTGGCAACTCCAAATCCAGGTCTGACCCAGGTCCGC
CTTTTGCTACAATCGCCGCC

Downstream 100 bases:

>100_bases
ATTTCAAGTTTCAAGTGGCGGCCGCCTGACCAACGGTCGCGCCGCCCGCCCCCATCCACACGTATTCAAGGAGTGATCCC
ATGATGAAAGGTCAACTGGC

Product: DNA polymerase III subunits gamma and tau

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 795; Mature: 794

Protein sequence:

>795_residues
MSYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKALNCTGPDGNGGITAQPCGQ
CKACTEIDSGRFVDYIEMDAASNRGVDEMAQLLDKAIYAPTAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILA
TTDPQKIPVTVLSRCLQFNLKQMPPGHIVSHLDHILAQEGISHDGSALRLLAQAAHGSMRDALSLTDQAIAYSAGQVSEE
AVRGMLGAIDQSYLVQLLDALAAEDGATMLGIADSMADRSLSFAGALQDLGSLLHKVALAQAVPASVQDEWPEAEDVRRL
ARQFDAQETQLFYQIANLGRSELALAPDEYAGFTMTLLRMLAFRPSTAPASSVGGQGGGGQQVVRPRPAGTTSAAPSPRA
MASAVAEPVAAEPVKVAPVVAPAAPTAPITAAAPAASAAPAMPAVPAKSAEPAPPQADVDTSMSPARAALAAARQASAGR
AGRPMSAAPNAGAAAAASSRPAAQPLRPPSASRPATTAAPAPAPAVAPAAAPVVTPVVTQAVAPSKAAAAPVAAARPAPV
AKPAPQPEAKSVPPWEAAGASDVPPWEEMPPDLPVIGPYDSDPGYDPSFGGFDNGFDSDSADRAPRAARKPAPTQSAAKP
ISKPEPEPAAQLAPAVPQVAPSAGEDGTPPVFTGDWPEFAATLPLKGLAQQLAHQSELHRVVGRTLHLRVPVAAIAEANV
AERLQAALVEHFRVDVRVQCVVGGVTHTAAAVDAAARAERQREAEAEIDRDPFVQGLLREFGGQIVPGSIQPRAA

Sequences:

>Translated_795_residues
MSYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKALNCTGPDGNGGITAQPCGQ
CKACTEIDSGRFVDYIEMDAASNRGVDEMAQLLDKAIYAPTAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILA
TTDPQKIPVTVLSRCLQFNLKQMPPGHIVSHLDHILAQEGISHDGSALRLLAQAAHGSMRDALSLTDQAIAYSAGQVSEE
AVRGMLGAIDQSYLVQLLDALAAEDGATMLGIADSMADRSLSFAGALQDLGSLLHKVALAQAVPASVQDEWPEAEDVRRL
ARQFDAQETQLFYQIANLGRSELALAPDEYAGFTMTLLRMLAFRPSTAPASSVGGQGGGGQQVVRPRPAGTTSAAPSPRA
MASAVAEPVAAEPVKVAPVVAPAAPTAPITAAAPAASAAPAMPAVPAKSAEPAPPQADVDTSMSPARAALAAARQASAGR
AGRPMSAAPNAGAAAAASSRPAAQPLRPPSASRPATTAAPAPAPAVAPAAAPVVTPVVTQAVAPSKAAAAPVAAARPAPV
AKPAPQPEAKSVPPWEAAGASDVPPWEEMPPDLPVIGPYDSDPGYDPSFGGFDNGFDSDSADRAPRAARKPAPTQSAAKP
ISKPEPEPAAQLAPAVPQVAPSAGEDGTPPVFTGDWPEFAATLPLKGLAQQLAHQSELHRVVGRTLHLRVPVAAIAEANV
AERLQAALVEHFRVDVRVQCVVGGVTHTAAAVDAAARAERQREAEAEIDRDPFVQGLLREFGGQIVPGSIQPRAA
>Mature_794_residues
SYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAKALNCTGPDGNGGITAQPCGQC
KACTEIDSGRFVDYIEMDAASNRGVDEMAQLLDKAIYAPTAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILAT
TDPQKIPVTVLSRCLQFNLKQMPPGHIVSHLDHILAQEGISHDGSALRLLAQAAHGSMRDALSLTDQAIAYSAGQVSEEA
VRGMLGAIDQSYLVQLLDALAAEDGATMLGIADSMADRSLSFAGALQDLGSLLHKVALAQAVPASVQDEWPEAEDVRRLA
RQFDAQETQLFYQIANLGRSELALAPDEYAGFTMTLLRMLAFRPSTAPASSVGGQGGGGQQVVRPRPAGTTSAAPSPRAM
ASAVAEPVAAEPVKVAPVVAPAAPTAPITAAAPAASAAPAMPAVPAKSAEPAPPQADVDTSMSPARAALAAARQASAGRA
GRPMSAAPNAGAAAAASSRPAAQPLRPPSASRPATTAAPAPAPAVAPAAAPVVTPVVTQAVAPSKAAAAPVAAARPAPVA
KPAPQPEAKSVPPWEAAGASDVPPWEEMPPDLPVIGPYDSDPGYDPSFGGFDNGFDSDSADRAPRAARKPAPTQSAAKPI
SKPEPEPAAQLAPAVPQVAPSAGEDGTPPVFTGDWPEFAATLPLKGLAQQLAHQSELHRVVGRTLHLRVPVAAIAEANVA
ERLQAALVEHFRVDVRVQCVVGGVTHTAAAVDAAARAERQREAEAEIDRDPFVQGLLREFGGQIVPGSIQPRAA

Specific function: The gamma chain seems to interact with the delta subunit to transfer the beta subunit on the DNA [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=307, Percent_Identity=24.4299674267101, Blast_Score=82, Evalue=2e-15,
Organism=Homo sapiens, GI194306571, Length=310, Percent_Identity=24.1935483870968, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI194306567, Length=310, Percent_Identity=24.1935483870968, Blast_Score=80, Evalue=5e-15,
Organism=Homo sapiens, GI194306569, Length=215, Percent_Identity=25.1162790697674, Blast_Score=76, Evalue=2e-13,
Organism=Escherichia coli, GI1786676, Length=366, Percent_Identity=54.9180327868852, Blast_Score=410, Evalue=1e-115,
Organism=Escherichia coli, GI1787341, Length=173, Percent_Identity=31.7919075144509, Blast_Score=70, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI71986063, Length=313, Percent_Identity=24.2811501597444, Blast_Score=72, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6324039, Length=266, Percent_Identity=24.0601503759398, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI19921076, Length=309, Percent_Identity=25.2427184466019, Blast_Score=80, Evalue=6e-15,
Organism=Drosophila melanogaster, GI18859927, Length=226, Percent_Identity=25.2212389380531, Blast_Score=69, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022001
- InterPro:   IPR022754
- InterPro:   IPR012763
- InterPro:   IPR021029 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3; PF12168 DNA_pol3_tau_4; PF12170 DNA_pol3_tau_5 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 82556; Mature: 82425

Theoretical pI: Translated: 6.24; Mature: 6.24

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAK
CCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
ALNCTGPDGNGGITAQPCGQCKACTEIDSGRFVDYIEMDAASNRGVDEMAQLLDKAIYAP
HHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCC
TAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNL
CCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCH
KQMPPGHIVSHLDHILAQEGISHDGSALRLLAQAAHGSMRDALSLTDQAIAYSAGQVSEE
HCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHH
AVRGMLGAIDQSYLVQLLDALAAEDGATMLGIADSMADRSLSFAGALQDLGSLLHKVALA
HHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVPASVQDEWPEAEDVRRLARQFDAQETQLFYQIANLGRSELALAPDEYAGFTMTLLRM
HHCCCCHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHEECCCHHHCHHHHHHHHH
LAFRPSTAPASSVGGQGGGGQQVVRPRPAGTTSAAPSPRAMASAVAEPVAAEPVKVAPVV
HHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHCCCCEECEEE
APAAPTAPITAAAPAASAAPAMPAVPAKSAEPAPPQADVDTSMSPARAALAAARQASAGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
AGRPMSAAPNAGAAAAASSRPAAQPLRPPSASRPATTAAPAPAPAVAPAAAPVVTPVVTQ
CCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
AVAPSKAAAAPVAAARPAPVAKPAPQPEAKSVPPWEAAGASDVPPWEEMPPDLPVIGPYD
HHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEECCCC
SDPGYDPSFGGFDNGFDSDSADRAPRAARKPAPTQSAAKPISKPEPEPAAQLAPAVPQVA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHCCCCCCCCCCHHHHCCCCHHCC
PSAGEDGTPPVFTGDWPEFAATLPLKGLAQQLAHQSELHRVVGRTLHLRVPVAAIAEANV
CCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
AERLQAALVEHFRVDVRVQCVVGGVTHTAAAVDAAARAERQREAEAEIDRDPFVQGLLRE
HHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FGGQIVPGSIQPRAA
HCCEECCCCCCCCCC
>Mature Secondary Structure 
SYQVLARKWRPRDFTTLVGQEHVVRALTHALEQQRLHHAYLFTGTRGVGKTTLSRILAK
CHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCCHHHHHHHHHH
ALNCTGPDGNGGITAQPCGQCKACTEIDSGRFVDYIEMDAASNRGVDEMAQLLDKAIYAP
HHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCC
TAGRFKVYMIDEVHMLTNHAFNAMLKTLEEPPEHVKFILATTDPQKIPVTVLSRCLQFNL
CCCCEEEEEECHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCH
KQMPPGHIVSHLDHILAQEGISHDGSALRLLAQAAHGSMRDALSLTDQAIAYSAGQVSEE
HCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCHHHH
AVRGMLGAIDQSYLVQLLDALAAEDGATMLGIADSMADRSLSFAGALQDLGSLLHKVALA
HHHHHHHHCCHHHHHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QAVPASVQDEWPEAEDVRRLARQFDAQETQLFYQIANLGRSELALAPDEYAGFTMTLLRM
HHCCCCHHHCCCCHHHHHHHHHHHCHHHHHHHHHHHHCCCHHEECCCHHHCHHHHHHHHH
LAFRPSTAPASSVGGQGGGGQQVVRPRPAGTTSAAPSPRAMASAVAEPVAAEPVKVAPVV
HHCCCCCCCHHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCHHCCCCEECEEE
APAAPTAPITAAAPAASAAPAMPAVPAKSAEPAPPQADVDTSMSPARAALAAARQASAGR
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCC
AGRPMSAAPNAGAAAAASSRPAAQPLRPPSASRPATTAAPAPAPAVAPAAAPVVTPVVTQ
CCCCCCCCCCCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHH
AVAPSKAAAAPVAAARPAPVAKPAPQPEAKSVPPWEAAGASDVPPWEEMPPDLPVIGPYD
HHCCCHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCEECCCC
SDPGYDPSFGGFDNGFDSDSADRAPRAARKPAPTQSAAKPISKPEPEPAAQLAPAVPQVA
CCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCHHHHCCCCCCCCCCHHHHCCCCHHCC
PSAGEDGTPPVFTGDWPEFAATLPLKGLAQQLAHQSELHRVVGRTLHLRVPVAAIAEANV
CCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHCCCEEEECCHHHHHHHHH
AERLQAALVEHFRVDVRVQCVVGGVTHTAAAVDAAARAERQREAEAEIDRDPFVQGLLRE
HHHHHHHHHHHHHCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
FGGQIVPGSIQPRAA
HCCEECCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3534795; 3018672; 9278503; 2186364; 2187190; 2181440; 1575709 [H]