Click here to switch to the map view.

The map label for this gene is ndk [H]

Identifier: 94311048

GI number: 94311048

Start: 2292036

End: 2292461

Strand: Reverse

Name: ndk [H]

Synonym: Rmet_2110

Alternate gene names: 94311048

Gene position: 2292461-2292036 (Counterclockwise)

Preceding gene: 94311050

Following gene: 94311047

Centisome position: 58.36

GC content: 60.09

Gene sequence:

>426_bases
ATGGCGATCGAACGCACCCTGTCGATTATCAAGCCGGATGCCGTGGCCAAGAACGTTATCGGCCAGATCTACGCCCGTTT
CGAGGCCGCTGGCCTGAAAGTCGTTGCAGCCAAGATGGTTCACCTGTCGCGCGGTGAAGCCGAGCAGTTCTACGCTGTTC
ACAAGGCGCGCCCGTTCTTCAAGGACCTGGTGGACTTCATGGTTTCGGGCCCGGTCATGATCCAGGCTCTGGAAGGCGAA
AGCGCTATCGCCAAGAACCGCGACCTGATGGGTGCCACCGACCCGAAGAAGGCTGAAAAGGGCACGATCCGCGCCGATTT
TGCCGACAGCATCGACGCTAACGCCGTGCACGGTTCGGACGCTCCGGAAACGGCTGCCGTGGAAGTGGCTTTCTTCTTCC
CGGGCATGAACGTTTACAGCCGCTGA

Upstream 100 bases:

>100_bases
CCCGGAAATGCATTGGCAGGCATGTTCGAAACCGTCATGCGGTCGTGCTAGAATTGCACGTTTAATCCATTTGTAACCCC
TTCATTTTTCGGAGTTTTTC

Downstream 100 bases:

>100_bases
TTGTCTCTGACATCACGACTGAACCTGTAGTCAAGTTGGAACTGCCGTCATGAATAATCTCGTCAACCTGCTCGATCTCG
ACGCGGACGCGCTCACTGCC

Product: mulitfunctional nucleoside diphosphate kinase/apyrimidinic endonuclease/3'-phosphodiesterase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 141; Mature: 140

Protein sequence:

>141_residues
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAAKMVHLSRGEAEQFYAVHKARPFFKDLVDFMVSGPVMIQALEGE
SAIAKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPGMNVYSR

Sequences:

>Translated_141_residues
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAAKMVHLSRGEAEQFYAVHKARPFFKDLVDFMVSGPVMIQALEGE
SAIAKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPGMNVYSR
>Mature_140_residues
AIERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAAKMVHLSRGEAEQFYAVHKARPFFKDLVDFMVSGPVMIQALEGES
AIAKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSDAPETAAVEVAFFFPGMNVYSR

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI37693993, Length=132, Percent_Identity=42.4242424242424, Blast_Score=115, Evalue=1e-26,
Organism=Homo sapiens, GI66392203, Length=131, Percent_Identity=39.6946564885496, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI66392227, Length=131, Percent_Identity=39.6946564885496, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI66392205, Length=131, Percent_Identity=39.6946564885496, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI4505409, Length=131, Percent_Identity=39.6946564885496, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI66392192, Length=131, Percent_Identity=39.6946564885496, Blast_Score=111, Evalue=2e-25,
Organism=Homo sapiens, GI38045913, Length=131, Percent_Identity=38.9312977099237, Blast_Score=109, Evalue=8e-25,
Organism=Homo sapiens, GI4557797, Length=131, Percent_Identity=38.9312977099237, Blast_Score=109, Evalue=1e-24,
Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=36.1538461538462, Blast_Score=99, Evalue=1e-21,
Organism=Homo sapiens, GI7019465, Length=139, Percent_Identity=37.410071942446, Blast_Score=92, Evalue=2e-19,
Organism=Homo sapiens, GI37574614, Length=139, Percent_Identity=37.410071942446, Blast_Score=91, Evalue=2e-19,
Organism=Homo sapiens, GI5031951, Length=137, Percent_Identity=34.3065693430657, Blast_Score=80, Evalue=5e-16,
Organism=Homo sapiens, GI30023828, Length=138, Percent_Identity=32.6086956521739, Blast_Score=75, Evalue=2e-14,
Organism=Homo sapiens, GI148839372, Length=129, Percent_Identity=34.8837209302326, Blast_Score=66, Evalue=8e-12,
Organism=Homo sapiens, GI4505413, Length=136, Percent_Identity=32.3529411764706, Blast_Score=66, Evalue=1e-11,
Organism=Escherichia coli, GI1788866, Length=133, Percent_Identity=60.9022556390977, Blast_Score=177, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17506807, Length=130, Percent_Identity=41.5384615384615, Blast_Score=110, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6322783, Length=130, Percent_Identity=40.7692307692308, Blast_Score=115, Evalue=3e-27,
Organism=Drosophila melanogaster, GI45549037, Length=130, Percent_Identity=43.8461538461538, Blast_Score=119, Evalue=4e-28,
Organism=Drosophila melanogaster, GI18860097, Length=135, Percent_Identity=33.3333333333333, Blast_Score=78, Evalue=2e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15247; Mature: 15115

Theoretical pI: Translated: 6.81; Mature: 6.81

Prosite motif: PS00469 NDP_KINASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAAKMVHLSRGEAEQFYAVHKARPFF
CCCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHH
KDLVDFMVSGPVMIQALEGESAIAKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
APETAAVEVAFFFPGMNVYSR
CCCCCEEEEEEEECCCHHCCC
>Mature Secondary Structure 
AIERTLSIIKPDAVAKNVIGQIYARFEAAGLKVVAAKMVHLSRGEAEQFYAVHKARPFF
CCHHHHHHHCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHCCHHH
KDLVDFMVSGPVMIQALEGESAIAKNRDLMGATDPKKAEKGTIRADFADSIDANAVHGSD
HHHHHHHHCCCEEEEEECCCCHHHCCCCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCC
APETAAVEVAFFFPGMNVYSR
CCCCCEEEEEEEECCCHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA