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The map label for this gene is ggt [H]

Identifier: 94310895

GI number: 94310895

Start: 2129989

End: 2131839

Strand: Reverse

Name: ggt [H]

Synonym: Rmet_1957

Alternate gene names: 94310895

Gene position: 2131839-2129989 (Counterclockwise)

Preceding gene: 94310896

Following gene: 94310892

Centisome position: 54.27

GC content: 67.37

Gene sequence:

>1851_bases
GTGCTTGCCGATGATGGCGGCACCGTGGTGGTCGGCTCGAACTTGCCGGGCGATCCTGCCGCGCCGGAGCCCGCCAGCGG
CTACCGCAAGGGAATGCGGCCGATCCATGCCCGGTCGTATATGGTGTCGACCTCGAACGCGTACGCCAGTGCGGCGGGTT
GCGCGGTGCTCAGTCGGGGCGGCACCGCTGCGGACGCCGCCGTCGCGGTGCAGGCGGTGCTGGGGCTCACGGTGCCGGAG
GCCACTGGACTGGGTTCGGGCGGCTTCCTGCTCTATTACGACGCCACCACGCGGACCGTGCAGGCCTACGATGGCCGGGA
GACTGCGCCGGCGTCGGCTGGTGCGAACTATCTGGTTCACATCGACGATGCCAGGGACCGGCGTTCGCCAAAGCCCGATC
TTCGATCCAGCGGCCGCTCCATTGGCACACCCGGCGTGCCCCGATTGATCGAGCGCGTACAGCGGGAGCATGGCAAGCTG
CCCTGGCCGGGGCTGTTCGACGACGCCGTGACACTGGCGACGAACGGCTTCCCGATCGGCGGCAGATTGGCGCAGGCGAT
TGCCACGAACGCCAATGGTCTCAAGCGCGATGCCGAGGCGCGCGCGTACTTTCTCGATCCCGACGGCAAGCCGAAGGCAA
TCGGTACGGTTCTCAGGAATCCCGCCTACGCGCGGACGCTGCAGGCCCTGGCCAGCCAGGGTGCCGATGCGTTCTATACG
GGGCCGATCGCGGAAGGCATCGTGGTGTCGATCGCGGCCACGACGGGTGCCGATGGCCGGCCCATCACGCCAGGCAAGAC
GACGTTGGCCGATCTGGCGGCTTACACGGTGAAGCGGCACGAACCGGTCTGCATGGCCTACCGCGCGTTCTGGATCTGCG
GTGCGCCGCCACCCGCCGGCGGTATCACGGTGGCATCCGTGATGGGGATTCTGGAGAACTTCGACCTGGCCGAACTTGGA
CCGACCGCCGTCGACGGGGAGGGCGGCAAGCCATCCGTACACGGTGTGCACCTCGTCAGCGAGGCCGAGCGGCTGGCCTA
TGCAGATCGTGACAAGTACGTGGCCGATCCCGATTTCGTGCCGCTGCCGGGTGGTAGCGCGGATGCGCTGCTGGGCAAAC
GATACCTGCGCGGACGAGCGGCGCTGATCGATCGGCATCGCTCCATGGGCACCGCCATGGCCGGCAGCCTGGGCGGCGCG
CTGCTGGGCGTTGTGCCGCAGGCGGAACATGGAACGAACCACTTTTCGATCGTCGATGCGCAGGGGAGTGCGGTCAGCGC
CACCACATCGGTGGAAGCCAGCATGGGGTCGTTTCATATGACCCACGGATTCCTGCTCAACAACCAGTTGACCGATTTCA
GCGCGACGCCGGTGGACGCCAGAGGCCAGCCCGTCGCCAATCGCGTGGAGCCGGGCAAGCGTCCGCGCAGTTCGATGGCG
CCGACGCTGGTATTCCGCAAGGGTGCGGATGGCTCGATCGGAGATTTCCTGATGGCGACGGGTTCGCCGGGCGGCGGGGC
GATACCGCAGTACGTGATAAAGACGCTGGTCGGGGTGCTCGACTGGGGGCTCAACGCGCAGCAGTCGGCCGGTCTGGTCG
ACTTCGGCGCCAGCAACAGCCCAGTCACGACGCTCGGTGGCGAGCATCCGCATATCAACACGACGAACGACGGCGCCAGC
GACCCGCTGGTCCAGGGACTCAAGGCACTTGGCCACCGCATCTCGCTACGGGCCCAGCCAAGTGGCGTGAACACGATACT
GCGTACCCGGACGGGGGATGACGACCTGCTGGAAGGCGGTACCGATCCACGGCGCGAGGGTGTGGTGCTGGGCGACACTA
TCCGGCCTTGA

Upstream 100 bases:

>100_bases
TCTCGCAGGCGCGCTGCTCGTCGGGGGCTGTTCTAGCGTTGCGCCGCCATCGGCGCCACCTACGCCACCTACGTCGACAC
ACGCCGAAGGCGTCTGCCAG

Downstream 100 bases:

>100_bases
AGCGGGCGGGAAGGAGGGGGATTGTACTAATCTGTGACACCAGCTTCGCCATTGTCTGGCGCTTGACTTGTGTCAAGCCG
AGGGGGCGATTCGGTGGCTA

Product: gamma-glutamyltransferase 1

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 616; Mature: 616

Protein sequence:

>616_residues
MLADDGGTVVVGSNLPGDPAAPEPASGYRKGMRPIHARSYMVSTSNAYASAAGCAVLSRGGTAADAAVAVQAVLGLTVPE
ATGLGSGGFLLYYDATTRTVQAYDGRETAPASAGANYLVHIDDARDRRSPKPDLRSSGRSIGTPGVPRLIERVQREHGKL
PWPGLFDDAVTLATNGFPIGGRLAQAIATNANGLKRDAEARAYFLDPDGKPKAIGTVLRNPAYARTLQALASQGADAFYT
GPIAEGIVVSIAATTGADGRPITPGKTTLADLAAYTVKRHEPVCMAYRAFWICGAPPPAGGITVASVMGILENFDLAELG
PTAVDGEGGKPSVHGVHLVSEAERLAYADRDKYVADPDFVPLPGGSADALLGKRYLRGRAALIDRHRSMGTAMAGSLGGA
LLGVVPQAEHGTNHFSIVDAQGSAVSATTSVEASMGSFHMTHGFLLNNQLTDFSATPVDARGQPVANRVEPGKRPRSSMA
PTLVFRKGADGSIGDFLMATGSPGGGAIPQYVIKTLVGVLDWGLNAQQSAGLVDFGASNSPVTTLGGEHPHINTTNDGAS
DPLVQGLKALGHRISLRAQPSGVNTILRTRTGDDDLLEGGTDPRREGVVLGDTIRP

Sequences:

>Translated_616_residues
MLADDGGTVVVGSNLPGDPAAPEPASGYRKGMRPIHARSYMVSTSNAYASAAGCAVLSRGGTAADAAVAVQAVLGLTVPE
ATGLGSGGFLLYYDATTRTVQAYDGRETAPASAGANYLVHIDDARDRRSPKPDLRSSGRSIGTPGVPRLIERVQREHGKL
PWPGLFDDAVTLATNGFPIGGRLAQAIATNANGLKRDAEARAYFLDPDGKPKAIGTVLRNPAYARTLQALASQGADAFYT
GPIAEGIVVSIAATTGADGRPITPGKTTLADLAAYTVKRHEPVCMAYRAFWICGAPPPAGGITVASVMGILENFDLAELG
PTAVDGEGGKPSVHGVHLVSEAERLAYADRDKYVADPDFVPLPGGSADALLGKRYLRGRAALIDRHRSMGTAMAGSLGGA
LLGVVPQAEHGTNHFSIVDAQGSAVSATTSVEASMGSFHMTHGFLLNNQLTDFSATPVDARGQPVANRVEPGKRPRSSMA
PTLVFRKGADGSIGDFLMATGSPGGGAIPQYVIKTLVGVLDWGLNAQQSAGLVDFGASNSPVTTLGGEHPHINTTNDGAS
DPLVQGLKALGHRISLRAQPSGVNTILRTRTGDDDLLEGGTDPRREGVVLGDTIRP
>Mature_616_residues
MLADDGGTVVVGSNLPGDPAAPEPASGYRKGMRPIHARSYMVSTSNAYASAAGCAVLSRGGTAADAAVAVQAVLGLTVPE
ATGLGSGGFLLYYDATTRTVQAYDGRETAPASAGANYLVHIDDARDRRSPKPDLRSSGRSIGTPGVPRLIERVQREHGKL
PWPGLFDDAVTLATNGFPIGGRLAQAIATNANGLKRDAEARAYFLDPDGKPKAIGTVLRNPAYARTLQALASQGADAFYT
GPIAEGIVVSIAATTGADGRPITPGKTTLADLAAYTVKRHEPVCMAYRAFWICGAPPPAGGITVASVMGILENFDLAELG
PTAVDGEGGKPSVHGVHLVSEAERLAYADRDKYVADPDFVPLPGGSADALLGKRYLRGRAALIDRHRSMGTAMAGSLGGA
LLGVVPQAEHGTNHFSIVDAQGSAVSATTSVEASMGSFHMTHGFLLNNQLTDFSATPVDARGQPVANRVEPGKRPRSSMA
PTLVFRKGADGSIGDFLMATGSPGGGAIPQYVIKTLVGVLDWGLNAQQSAGLVDFGASNSPVTTLGGEHPHINTTNDGAS
DPLVQGLKALGHRISLRAQPSGVNTILRTRTGDDDLLEGGTDPRREGVVLGDTIRP

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Secreted [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=492, Percent_Identity=29.0650406504065, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI73915090, Length=492, Percent_Identity=29.0650406504065, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI73915096, Length=492, Percent_Identity=29.0650406504065, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI73915094, Length=492, Percent_Identity=29.0650406504065, Blast_Score=150, Evalue=3e-36,
Organism=Homo sapiens, GI113429324, Length=472, Percent_Identity=29.0254237288136, Blast_Score=131, Evalue=2e-30,
Organism=Homo sapiens, GI109148539, Length=496, Percent_Identity=30.4435483870968, Blast_Score=127, Evalue=3e-29,
Organism=Homo sapiens, GI153266885, Length=500, Percent_Identity=27, Blast_Score=126, Evalue=7e-29,
Organism=Homo sapiens, GI113429326, Length=502, Percent_Identity=28.2868525896414, Blast_Score=125, Evalue=2e-28,
Organism=Homo sapiens, GI153266901, Length=501, Percent_Identity=26.3473053892216, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI153266907, Length=497, Percent_Identity=24.9496981891348, Blast_Score=101, Evalue=2e-21,
Organism=Escherichia coli, GI1789856, Length=589, Percent_Identity=32.597623089983, Blast_Score=241, Evalue=7e-65,
Organism=Caenorhabditis elegans, GI193208247, Length=507, Percent_Identity=29.585798816568, Blast_Score=162, Evalue=7e-40,
Organism=Caenorhabditis elegans, GI193208245, Length=507, Percent_Identity=29.585798816568, Blast_Score=161, Evalue=8e-40,
Organism=Caenorhabditis elegans, GI17542894, Length=586, Percent_Identity=26.962457337884, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17506189, Length=489, Percent_Identity=27.8118609406953, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI212646519, Length=561, Percent_Identity=27.2727272727273, Blast_Score=145, Evalue=9e-35,
Organism=Caenorhabditis elegans, GI72000294, Length=561, Percent_Identity=27.2727272727273, Blast_Score=144, Evalue=9e-35,
Organism=Saccharomyces cerevisiae, GI6323330, Length=490, Percent_Identity=26.1224489795918, Blast_Score=97, Evalue=6e-21,
Organism=Drosophila melanogaster, GI18859893, Length=492, Percent_Identity=27.4390243902439, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24642670, Length=583, Percent_Identity=25.557461406518, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24642666, Length=583, Percent_Identity=25.557461406518, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI45551474, Length=583, Percent_Identity=25.557461406518, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI161077878, Length=583, Percent_Identity=25.557461406518, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI161077880, Length=583, Percent_Identity=25.557461406518, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI18859741, Length=551, Percent_Identity=25.9528130671506, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI161077496, Length=490, Percent_Identity=24.8979591836735, Blast_Score=116, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 63613; Mature: 63613

Theoretical pI: Translated: 7.05; Mature: 7.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLADDGGTVVVGSNLPGDPAAPEPASGYRKGMRPIHARSYMVSTSNAYASAAGCAVLSRG
CCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEECCCCHHHHHHHHEEECC
GTAADAAVAVQAVLGLTVPEATGLGSGGFLLYYDATTRTVQAYDGRETAPASAGANYLVH
CCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCEEEE
IDDARDRRSPKPDLRSSGRSIGTPGVPRLIERVQREHGKLPWPGLFDDAVTLATNGFPIG
ECCCHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCCH
GRLAQAIATNANGLKRDAEARAYFLDPDGKPKAIGTVLRNPAYARTLQALASQGADAFYT
HHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEE
GPIAEGIVVSIAATTGADGRPITPGKTTLADLAAYTVKRHEPVCMAYRAFWICGAPPPAG
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCC
GITVASVMGILENFDLAELGPTAVDGEGGKPSVHGVHLVSEAERLAYADRDKYVADPDFV
CHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCEE
PLPGGSADALLGKRYLRGRAALIDRHRSMGTAMAGSLGGALLGVVPQAEHGTNHFSIVDA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCCEEEEEEC
QGSAVSATTSVEASMGSFHMTHGFLLNNQLTDFSATPVDARGQPVANRVEPGKRPRSSMA
CCCEEEEECCHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHCC
PTLVFRKGADGSIGDFLMATGSPGGGAIPQYVIKTLVGVLDWGLNAQQSAGLVDFGASNS
CEEEEECCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCC
PVTTLGGEHPHINTTNDGASDPLVQGLKALGHRISLRAQPSGVNTILRTRTGDDDLLEGG
CEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCEEEEECCCCHHHHCCC
TDPRREGVVLGDTIRP
CCCCCCCEEECCCCCC
>Mature Secondary Structure
MLADDGGTVVVGSNLPGDPAAPEPASGYRKGMRPIHARSYMVSTSNAYASAAGCAVLSRG
CCCCCCCEEEECCCCCCCCCCCCCCHHHHHCCCCCCCCEEEEECCCCHHHHHHHHEEECC
GTAADAAVAVQAVLGLTVPEATGLGSGGFLLYYDATTRTVQAYDGRETAPASAGANYLVH
CCHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCCEEEEECCCCCCCCCCCCCCEEEE
IDDARDRRSPKPDLRSSGRSIGTPGVPRLIERVQREHGKLPWPGLFDDAVTLATNGFPIG
ECCCHHCCCCCCHHHHCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCHHEEECCCCCCH
GRLAQAIATNANGLKRDAEARAYFLDPDGKPKAIGTVLRNPAYARTLQALASQGADAFYT
HHHHHHHHCCCCCCCCCCCCEEEEECCCCCCHHHHHHHCCCHHHHHHHHHHHCCCCEEEE
GPIAEGIVVSIAATTGADGRPITPGKTTLADLAAYTVKRHEPVCMAYRAFWICGAPPPAG
CCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEEEECCCCCCC
GITVASVMGILENFDLAELGPTAVDGEGGKPSVHGVHLVSEAERLAYADRDKYVADPDFV
CHHHHHHHHHHHCCCHHHCCCCCCCCCCCCCCCCEEEHHHHHHHHHHCCCCCCCCCCCEE
PLPGGSADALLGKRYLRGRAALIDRHRSMGTAMAGSLGGALLGVVPQAEHGTNHFSIVDA
ECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHEEECCCCCCCCCEEEEEEC
QGSAVSATTSVEASMGSFHMTHGFLLNNQLTDFSATPVDARGQPVANRVEPGKRPRSSMA
CCCEEEEECCHHHCCCCEEEEEEEEECCCCCCCCCCCCCCCCCCCHHCCCCCCCCCHHCC
PTLVFRKGADGSIGDFLMATGSPGGGAIPQYVIKTLVGVLDWGLNAQQSAGLVDFGASNS
CEEEEECCCCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCC
PVTTLGGEHPHINTTNDGASDPLVQGLKALGHRISLRAQPSGVNTILRTRTGDDDLLEGG
CEEECCCCCCCCCCCCCCCCCHHHHHHHHHCCEEEEEECCCCCCEEEEECCCCHHHHCCC
TDPRREGVVLGDTIRP
CCCCCCCEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA