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The map label for this gene is lysP [H]

Identifier: 94310794

GI number: 94310794

Start: 2011950

End: 2013431

Strand: Direct

Name: lysP [H]

Synonym: Rmet_1856

Alternate gene names: 94310794

Gene position: 2011950-2013431 (Clockwise)

Preceding gene: 94310782

Following gene: 94310802

Centisome position: 51.22

GC content: 61.88

Gene sequence:

>1482_bases
ATGTCCCATCCACACCCCCATCAACACCCGGTCGTCGAGCACGACGACCTGCACCGCAAGCTCAAGGCCCGCCACCTGAC
GATGATCGCCCTGGGTGGTGCCATCGGCACCGGACTGTTTGTCGCCTCGGGCGCATCCATCGCACAGTCCGGCCCCGGCG
GCGCCCTGCTGGCCTACTGCCTGATCGGCCTGATGGTGTACTGCCTGATGACCAGCCTTGGCGAGCTCGCGGTGCACATG
CCCGTGGCAGGATCATTCGTAACCTACAGCGCCCTCTACGTCGACGAGGGCTTTGGCTTCGCACTTGGCTGGAACTACTG
GTTCAGCCTGGCCGTGACAATTGCCGTCGAACTGACCGCAGCCCAGTTGGTCATGCAGTATTGGTTCCCGGAGGTACCGG
GCATCTACTGGAGCGCGGGCTTTCTGGCACTGATGTTCGCGCTCAATGCGTTCTCGGTGAAGGGCTTCGGCGAGGCCGAG
TACTGGTTCGCCATGATCAAGGTTGTAACCGTCGTCGTTTTCCTGTGCGTGGGCGTGCTGATGATCCTCGGCATCCTCAA
GGGTGGGCCACAATCGGGCTGGCACAACTTCACGACCGGCGAAGCCCCATTCGTCGGTGGCCTCCCCGGGCTGTTCGCGG
TGGCGATGATTGCCGGCTTCTCATTTCAAGGAACCGAGACGGTCGGCGTGGCGGCTGGTGAAGCCGCGGACCCCGGACGC
ACGATTCCGCGCGCGATCCGACAGACGTTCTGGCGCATCCTGCTGTTCTATGTCGTTGCCATCCTGATCATTGGCGTGCT
CATTCCGTATACCGACCCGAACCTGCTTCGCAATGACGTGACCGACGTTGGCGTCAGCCCGTTTGCACTGGTATTCCAGC
ACGCTGGCCTGGCTTTTGCCGCGGCGCTGATGAACGCCGTGGTGCTGACCGCGCTGCTCTCGGCGGGGACATCGAGCATG
TATGTTTCGACTCGGATTCTCTATGGCTTGGCGGTCAGCCAGCGCGCCCCAAGGGCTCTAGCCAAGCTCACCCCGAACGG
CGTGCCATTCAACGCGCTGCTGGTGACCACGGGCATCGGCGCGCTGTGCTTCTTCAGTTCGCTGTTCGGCGACAAGGCCG
TGTACCTGTGGCTGCTCAACACATCGGCAATGACCGGCTTCTTCGCGTGGCTCGGTATCGCCGTCAGCCACTATCGTTTC
CGCAAGGGTCTGCTGTACCAGGGCTACAAGGTCAGCGATCTTGCCTACCGCTCTCCGCTCTATCCGTTCGGCCCGATCTT
CGCTGGCGTGCTGTGTCTCGTCATCGTGGGCGGCCAGAACTATCAGGCATTCACTGACATCCCCGGCCGTTGGCAAGAGA
TCGTCTCGACCTACATTGGCGTGCCAGTCTTCCTGGCGCTATGGCTCGGCTACCGCATCGTACGCGGCACGCGCATGATC
GACTACGAAGACATGCCGTTTGAACTGGTAAAGAAGGACTGA

Upstream 100 bases:

>100_bases
ATAAGGCACGGTAGACTCGCGCCTTTCGTTTTTCCGGGGTGATCCGGCCGGTCCACAAGACCTAGTCCAACCACACCCCT
CCGACGATCCAGCGACCCTG

Downstream 100 bases:

>100_bases
TCGCCGACGCTTGCTGGCGTCACGGCACCAAAAGCGCTAGCGCCCGCATTGCGGGCGCTTTTGCCTGGGGAACGAGATCA
CTCACTGGCTTCGCTTCAGC

Product: lysine transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 493; Mature: 492

Protein sequence:

>493_residues
MSHPHPHQHPVVEHDDLHRKLKARHLTMIALGGAIGTGLFVASGASIAQSGPGGALLAYCLIGLMVYCLMTSLGELAVHM
PVAGSFVTYSALYVDEGFGFALGWNYWFSLAVTIAVELTAAQLVMQYWFPEVPGIYWSAGFLALMFALNAFSVKGFGEAE
YWFAMIKVVTVVVFLCVGVLMILGILKGGPQSGWHNFTTGEAPFVGGLPGLFAVAMIAGFSFQGTETVGVAAGEAADPGR
TIPRAIRQTFWRILLFYVVAILIIGVLIPYTDPNLLRNDVTDVGVSPFALVFQHAGLAFAAALMNAVVLTALLSAGTSSM
YVSTRILYGLAVSQRAPRALAKLTPNGVPFNALLVTTGIGALCFFSSLFGDKAVYLWLLNTSAMTGFFAWLGIAVSHYRF
RKGLLYQGYKVSDLAYRSPLYPFGPIFAGVLCLVIVGGQNYQAFTDIPGRWQEIVSTYIGVPVFLALWLGYRIVRGTRMI
DYEDMPFELVKKD

Sequences:

>Translated_493_residues
MSHPHPHQHPVVEHDDLHRKLKARHLTMIALGGAIGTGLFVASGASIAQSGPGGALLAYCLIGLMVYCLMTSLGELAVHM
PVAGSFVTYSALYVDEGFGFALGWNYWFSLAVTIAVELTAAQLVMQYWFPEVPGIYWSAGFLALMFALNAFSVKGFGEAE
YWFAMIKVVTVVVFLCVGVLMILGILKGGPQSGWHNFTTGEAPFVGGLPGLFAVAMIAGFSFQGTETVGVAAGEAADPGR
TIPRAIRQTFWRILLFYVVAILIIGVLIPYTDPNLLRNDVTDVGVSPFALVFQHAGLAFAAALMNAVVLTALLSAGTSSM
YVSTRILYGLAVSQRAPRALAKLTPNGVPFNALLVTTGIGALCFFSSLFGDKAVYLWLLNTSAMTGFFAWLGIAVSHYRF
RKGLLYQGYKVSDLAYRSPLYPFGPIFAGVLCLVIVGGQNYQAFTDIPGRWQEIVSTYIGVPVFLALWLGYRIVRGTRMI
DYEDMPFELVKKD
>Mature_492_residues
SHPHPHQHPVVEHDDLHRKLKARHLTMIALGGAIGTGLFVASGASIAQSGPGGALLAYCLIGLMVYCLMTSLGELAVHMP
VAGSFVTYSALYVDEGFGFALGWNYWFSLAVTIAVELTAAQLVMQYWFPEVPGIYWSAGFLALMFALNAFSVKGFGEAEY
WFAMIKVVTVVVFLCVGVLMILGILKGGPQSGWHNFTTGEAPFVGGLPGLFAVAMIAGFSFQGTETVGVAAGEAADPGRT
IPRAIRQTFWRILLFYVVAILIIGVLIPYTDPNLLRNDVTDVGVSPFALVFQHAGLAFAAALMNAVVLTALLSAGTSSMY
VSTRILYGLAVSQRAPRALAKLTPNGVPFNALLVTTGIGALCFFSSLFGDKAVYLWLLNTSAMTGFFAWLGIAVSHYRFR
KGLLYQGYKVSDLAYRSPLYPFGPIFAGVLCLVIVGGQNYQAFTDIPGRWQEIVSTYIGVPVFLALWLGYRIVRGTRMID
YEDMPFELVKKD

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Escherichia coli, GI1788480, Length=486, Percent_Identity=64.6090534979424, Blast_Score=651, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=475, Percent_Identity=38.5263157894737, Blast_Score=310, Evalue=1e-85,
Organism=Escherichia coli, GI1786302, Length=412, Percent_Identity=38.1067961165049, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI1786789, Length=425, Percent_Identity=35.0588235294118, Blast_Score=260, Evalue=1e-70,
Organism=Escherichia coli, GI48994972, Length=429, Percent_Identity=36.3636363636364, Blast_Score=242, Evalue=4e-65,
Organism=Escherichia coli, GI87081915, Length=416, Percent_Identity=35.3365384615385, Blast_Score=229, Evalue=3e-61,
Organism=Escherichia coli, GI1786602, Length=464, Percent_Identity=33.8362068965517, Blast_Score=218, Evalue=6e-58,
Organism=Escherichia coli, GI1790653, Length=396, Percent_Identity=34.5959595959596, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI1789017, Length=422, Percent_Identity=31.7535545023697, Blast_Score=213, Evalue=2e-56,
Organism=Escherichia coli, GI87081869, Length=397, Percent_Identity=25.6926952141058, Blast_Score=76, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6320772, Length=495, Percent_Identity=37.1717171717172, Blast_Score=329, Evalue=5e-91,
Organism=Saccharomyces cerevisiae, GI6324061, Length=494, Percent_Identity=35.4251012145749, Blast_Score=306, Evalue=3e-84,
Organism=Saccharomyces cerevisiae, GI6324990, Length=497, Percent_Identity=33.4004024144869, Blast_Score=288, Evalue=1e-78,
Organism=Saccharomyces cerevisiae, GI6324059, Length=486, Percent_Identity=36.8312757201646, Blast_Score=286, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6322892, Length=480, Percent_Identity=33.5416666666667, Blast_Score=279, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6324924, Length=500, Percent_Identity=33.6, Blast_Score=264, Evalue=2e-71,
Organism=Saccharomyces cerevisiae, GI6321629, Length=500, Percent_Identity=30, Blast_Score=254, Evalue=2e-68,
Organism=Saccharomyces cerevisiae, GI6324553, Length=508, Percent_Identity=31.1023622047244, Blast_Score=252, Evalue=8e-68,
Organism=Saccharomyces cerevisiae, GI6322967, Length=470, Percent_Identity=32.7659574468085, Blast_Score=251, Evalue=2e-67,
Organism=Saccharomyces cerevisiae, GI6320717, Length=478, Percent_Identity=28.8702928870293, Blast_Score=241, Evalue=2e-64,
Organism=Saccharomyces cerevisiae, GI6321053, Length=499, Percent_Identity=31.2625250501002, Blast_Score=234, Evalue=2e-62,
Organism=Saccharomyces cerevisiae, GI6319824, Length=505, Percent_Identity=28.3168316831683, Blast_Score=233, Evalue=8e-62,
Organism=Saccharomyces cerevisiae, GI6324981, Length=470, Percent_Identity=32.5531914893617, Blast_Score=231, Evalue=2e-61,
Organism=Saccharomyces cerevisiae, GI6319543, Length=470, Percent_Identity=28.5106382978723, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6319542, Length=479, Percent_Identity=26.9311064718163, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6320251, Length=473, Percent_Identity=24.7357293868922, Blast_Score=202, Evalue=7e-53,
Organism=Saccharomyces cerevisiae, GI6319608, Length=499, Percent_Identity=26.8537074148297, Blast_Score=201, Evalue=1e-52,
Organism=Saccharomyces cerevisiae, GI6320364, Length=544, Percent_Identity=25.5514705882353, Blast_Score=169, Evalue=6e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53372; Mature: 53241

Theoretical pI: Translated: 8.19; Mature: 8.19

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHPHPHQHPVVEHDDLHRKLKARHLTMIALGGAIGTGLFVASGASIAQSGPGGALLAYC
CCCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCHHHCCCCCHHHHHHH
LIGLMVYCLMTSLGELAVHMPVAGSFVTYSALYVDEGFGFALGWNYWFSLAVTIAVELTA
HHHHHHHHHHHHHHHHHEECCCCCCHHHEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHH
AQLVMQYWFPEVPGIYWSAGFLALMFALNAFSVKGFGEAEYWFAMIKVVTVVVFLCVGVL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MILGILKGGPQSGWHNFTTGEAPFVGGLPGLFAVAMIAGFSFQGTETVGVAAGEAADPGR
HHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
TIPRAIRQTFWRILLFYVVAILIIGVLIPYTDPNLLRNDVTDVGVSPFALVFQHAGLAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
AALMNAVVLTALLSAGTSSMYVSTRILYGLAVSQRAPRALAKLTPNGVPFNALLVTTGIG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHH
ALCFFSSLFGDKAVYLWLLNTSAMTGFFAWLGIAVSHYRFRKGLLYQGYKVSDLAYRSPL
HHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCHHCCCCEECHHHHCCCC
YPFGPIFAGVLCLVIVGGQNYQAFTDIPGRWQEIVSTYIGVPVFLALWLGYRIVRGTRMI
CCCHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
DYEDMPFELVKKD
CCCCCCHHHHCCC
>Mature Secondary Structure 
SHPHPHQHPVVEHDDLHRKLKARHLTMIALGGAIGTGLFVASGASIAQSGPGGALLAYC
CCCCCCCCCCCCCHHHHHHHHHHHHHHEEECCHHHHHHHHCCCCHHHCCCCCHHHHHHH
LIGLMVYCLMTSLGELAVHMPVAGSFVTYSALYVDEGFGFALGWNYWFSLAVTIAVELTA
HHHHHHHHHHHHHHHHHEECCCCCCHHHEEEEEEECCCCEEEHHHHHHHHHHHHHHHHHH
AQLVMQYWFPEVPGIYWSAGFLALMFALNAFSVKGFGEAEYWFAMIKVVTVVVFLCVGVL
HHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
MILGILKGGPQSGWHNFTTGEAPFVGGLPGLFAVAMIAGFSFQGTETVGVAAGEAADPGR
HHHHHHCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCC
TIPRAIRQTFWRILLFYVVAILIIGVLIPYTDPNLLRNDVTDVGVSPFALVFQHAGLAFA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
AALMNAVVLTALLSAGTSSMYVSTRILYGLAVSQRAPRALAKLTPNGVPFNALLVTTGIG
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCHHHHHHCCCCCCCHHHHHHHHHHH
ALCFFSSLFGDKAVYLWLLNTSAMTGFFAWLGIAVSHYRFRKGLLYQGYKVSDLAYRSPL
HHHHHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHCHHCCCCEECHHHHCCCC
YPFGPIFAGVLCLVIVGGQNYQAFTDIPGRWQEIVSTYIGVPVFLALWLGYRIVRGTRMI
CCCHHHHHHHHHHHHCCCCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCEEE
DYEDMPFELVKKD
CCCCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]