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The map label for this gene is hyi1 [C]

Identifier: 94310777

GI number: 94310777

Start: 1993824

End: 1994606

Strand: Direct

Name: hyi1 [C]

Synonym: Rmet_1839

Alternate gene names: 94310777

Gene position: 1993824-1994606 (Clockwise)

Preceding gene: 94310776

Following gene: 94310778

Centisome position: 50.76

GC content: 65.13

Gene sequence:

>783_bases
ATGCCGCGCTTCGCCGCGAACCTTTCAATGATGTACACGGAGCACGACTTTCTGGACCGCTTTGCCGCCGCCGCAAAGGA
CGGGTTCCAGGCCGTGGAGTACCTGTTCCCGTACGACCATCCGGCCGCCGAGATCCGCAAGCGGCTCGACGACAACGGCC
TGACCCAGGCCCTGTTCAACGCGCCGCCCGGTGACTGGGGCGCGGGCGAGCGTGGCATCGCCGCCCTGCCCGGCCGCGAG
ACCGAGTTCCGCACTGAGTTCGCGAAGGCCCTCGAATACGCTGCCGTGCTCGGCAACGACCGCGTGCACGTGATGGCAGG
CATCGTGCCGGCCGACGCCGACCACGCCCGCTGCCGCTCCATCTATCTCGAGAACCTGGCCTATGCCTCTGCCTCGGCCG
CGTCGCATGGCATCACGGTGCTGATCGAGCCGATCAACACCCGCGACATGCCGGGCTATTTCCTGAACCGCCAGGACGAA
GGCCAGACCATTTGCCGCCAGGTGGGCGCGGCCAATCTCAAGGTCCAGTTCGATTGCTATCACTGCCAGATCGTCGAGGG
TGATATCGCGAAGAAACTCGAACGCGACTTCGCTGGGATTGGCCATATCCAGATCGCCGGCGTGCCCGAACGCCACGAAC
CCGATATCGGCGAACTGAACTACCCGTACCTCTTCGACGTCATCGACCGGCTCGGATACACGGGCTGGATCGGCTGCGAA
TACCGCCCGCGTGGCGGCACGTCGGAAGGTCTGGGCTGGATCAAGCCCTGGCTGAAGCGCTGA

Upstream 100 bases:

>100_bases
GCTGTCGGCGATCCTGGTCGTGGGCGCCCTGCTGGTCTGGCTGACCCCGGCGAAGCTCGTCAATCGCTGATATCGAATCT
GAGGCTCAAGGAGACCTGAC

Downstream 100 bases:

>100_bases
TCCGGGCCTGTCACGGCCGTTTCCGCTCCGTACCGACCACGCCAATGATGAACACTCCGCAACCATGAACGTACTGATTA
CCGGCGGCGCCGGCTTCCTG

Product: hydroxypyruvate isomerase

Products: 2-hydroxy-3-oxopropanoate

Alternate protein names: ORF4 [H]

Number of amino acids: Translated: 260; Mature: 259

Protein sequence:

>260_residues
MPRFAANLSMMYTEHDFLDRFAAAAKDGFQAVEYLFPYDHPAAEIRKRLDDNGLTQALFNAPPGDWGAGERGIAALPGRE
TEFRTEFAKALEYAAVLGNDRVHVMAGIVPADADHARCRSIYLENLAYASASAASHGITVLIEPINTRDMPGYFLNRQDE
GQTICRQVGAANLKVQFDCYHCQIVEGDIAKKLERDFAGIGHIQIAGVPERHEPDIGELNYPYLFDVIDRLGYTGWIGCE
YRPRGGTSEGLGWIKPWLKR

Sequences:

>Translated_260_residues
MPRFAANLSMMYTEHDFLDRFAAAAKDGFQAVEYLFPYDHPAAEIRKRLDDNGLTQALFNAPPGDWGAGERGIAALPGRE
TEFRTEFAKALEYAAVLGNDRVHVMAGIVPADADHARCRSIYLENLAYASASAASHGITVLIEPINTRDMPGYFLNRQDE
GQTICRQVGAANLKVQFDCYHCQIVEGDIAKKLERDFAGIGHIQIAGVPERHEPDIGELNYPYLFDVIDRLGYTGWIGCE
YRPRGGTSEGLGWIKPWLKR
>Mature_259_residues
PRFAANLSMMYTEHDFLDRFAAAAKDGFQAVEYLFPYDHPAAEIRKRLDDNGLTQALFNAPPGDWGAGERGIAALPGRET
EFRTEFAKALEYAAVLGNDRVHVMAGIVPADADHARCRSIYLENLAYASASAASHGITVLIEPINTRDMPGYFLNRQDEG
QTICRQVGAANLKVQFDCYHCQIVEGDIAKKLERDFAGIGHIQIAGVPERHEPDIGELNYPYLFDVIDRLGYTGWIGCEY
RPRGGTSEGLGWIKPWLKR

Specific function: Unknown

COG id: COG3622

COG function: function code G; Hydroxypyruvate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the hyi family [H]

Homologues:

Organism=Homo sapiens, GI300068962, Length=265, Percent_Identity=41.8867924528302, Blast_Score=209, Evalue=2e-54,
Organism=Homo sapiens, GI300068964, Length=243, Percent_Identity=40.7407407407407, Blast_Score=182, Evalue=4e-46,
Organism=Escherichia coli, GI1789095, Length=258, Percent_Identity=51.937984496124, Blast_Score=275, Evalue=2e-75,
Organism=Escherichia coli, GI1786718, Length=257, Percent_Identity=45.9143968871595, Blast_Score=246, Evalue=9e-67,
Organism=Caenorhabditis elegans, GI17552022, Length=240, Percent_Identity=40.8333333333333, Blast_Score=187, Evalue=6e-48,
Organism=Drosophila melanogaster, GI17530883, Length=256, Percent_Identity=35.15625, Blast_Score=167, Evalue=6e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013022
- InterPro:   IPR012307 [H]

Pfam domain/function: PF01261 AP_endonuc_2 [H]

EC number: 5.3.1.22

Molecular weight: Translated: 28967; Mature: 28836

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRFAANLSMMYTEHDFLDRFAAAAKDGFQAVEYLFPYDHPAAEIRKRLDDNGLTQALFN
CCCHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHC
APPGDWGAGERGIAALPGRETEFRTEFAKALEYAAVLGNDRVHVMAGIVPADADHARCRS
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHH
IYLENLAYASASAASHGITVLIEPINTRDMPGYFLNRQDEGQTICRQVGAANLKVQFDCY
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEE
HCQIVEGDIAKKLERDFAGIGHIQIAGVPERHEPDIGELNYPYLFDVIDRLGYTGWIGCE
EEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCE
YRPRGGTSEGLGWIKPWLKR
ECCCCCCCCCCHHHHHHHCC
>Mature Secondary Structure 
PRFAANLSMMYTEHDFLDRFAAAAKDGFQAVEYLFPYDHPAAEIRKRLDDNGLTQALFN
CCHHCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHHC
APPGDWGAGERGIAALPGRETEFRTEFAKALEYAAVLGNDRVHVMAGIVPADADHARCRS
CCCCCCCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCHHHHHH
IYLENLAYASASAASHGITVLIEPINTRDMPGYFLNRQDEGQTICRQVGAANLKVQFDCY
HHHHHHHHHHCCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEEE
HCQIVEGDIAKKLERDFAGIGHIQIAGVPERHEPDIGELNYPYLFDVIDRLGYTGWIGCE
EEEEECCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHCCCCEEECCE
YRPRGGTSEGLGWIKPWLKR
ECCCCCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxypyruvate

Specific reaction: hydroxypyruvate = 2-hydroxy-3-oxopropanoate; Other Name(s): hydroxypyruvate ketol-isomerase

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7851418 [H]