Click here to switch to the map view.

The map label for this gene is polB [H]

Identifier: 94310587

GI number: 94310587

Start: 1777996

End: 1780365

Strand: Reverse

Name: polB [H]

Synonym: Rmet_1645

Alternate gene names: 94310587

Gene position: 1780365-1777996 (Counterclockwise)

Preceding gene: 94310589

Following gene: 94310586

Centisome position: 45.32

GC content: 65.74

Gene sequence:

>2370_bases
TTGGCACTACAGCAGGGTTTTCTCCTGACCCGTCACTGGCGCGACACGCCCGCAGGCACGGAAGTCGAGTTCTGGCTCGC
CACCGATGAGGGCCCGCGCCGACTGCGCCTGCCCCGGCAGCCATCCACGGCGTTCATACCGGCCGCGCAACGCGAGACGG
CCGAGGCGCTGCTGCGTGGCGAGCGCGATGTCGAGTTCCGCCCGCTGAACTTGCAGGACTTCCAGCGACGCCCGGTGACA
GGGATCTACTGCGACCAGCACCGTCAGCTCATGCGGATTGAAAAGGCGCTCCGCGACGCGGGCGTCAGCGTCTACGAGGC
CGACGTCCGCCCGCCAGAGCGCTATCTGATGGAGCGGTTCATCACCGCCCCGGTCTGGTTCGACGGCCAGCCCGGGGCGG
ACGGCGTGCTGCGCGACGCCCAGATGAAGCCGGCGGCCGGCTACCGGCCCAAGCTGCGCCTGGTCTCGCTCGACATCGAA
ACTAATGCGTTCGGCGAACTCTATTCCATCGCGCTGGAGGGCTGTGGCGAGCGGCAGGTCTACATGCTGGGCCCCACCCC
CGCGCAACCGGCGGCGGATATCGACTTCGCGCTCGAGTACCACGCAACCCGTCCTCTGCTGCTGGAGGCCCTCAACGACT
GGTTGGCCCGCCACGATCCCGACGCGATCATCGGCTGGAATCTGGTGCAATTCGACCTGCGTGTGCTGCGCGAACACGCG
CGCCAGCACCAGATTCCGCTGCGCCTGGGTCGTGGCGGCGCGGAACTGGAGTGGCGCGAGCACAACCAGCAGCAGCACTA
CTTCGCGGCAGCGGCGGGCCGGCTGATCATCGACGGCATCGAGGCCCTTCGCTCGGCCACCTGGAACTTCCCGTCGTTCA
GTCTCGAATCCGTGGCCCGGACGCTGCTGGGCGAAGGCAAGGCTATCGACAACCCGTACGACCGCATGGATGCGATCGAC
CGGATGTTCGCCGAAGACAAGCCGGCACTGGCCCGCTACAACCTCCGCGACTGCGAACTGGTCACGCGCATTTTCGAGAA
AGCGGAGCTGCTTCCCTTCCTGTTGGAACGCGCGACGGTGACCGGCCTGCCGGCGGATCGTAGTGGCGGTTCGGTCGCGG
CTTTCACGCATCTCTACATGCCGCTGATGCATCGGCAAGGCTACGTCGCGCCTAGTCTTGGCGAGAAGGCGCCGGAAGCC
AGCCCTGGTGGCTTTGTCATGGATTCCCGCCCCGGACTCTATGAATCGGTGCTCGTGCTCGACTACAAGAGCCTGTATCC
GTCGATCATCCGCACGTTCCTGATTGACCCGATCGGACTGGTCGAGGGCCTGGCCCACCCTGACGATGCCGAATCGGTGC
CCGGCTTCCGGGGCGCGCGGTTCTCACGCACGAAGCACTGCCTGCCGGCCATCGTCGCGCGCGTGTGGCAGGGCCGCGAA
GCCGCCAAGCGAGACAAGAACAAGCCGCTCTCGCAGGCGCTCAAGATCATCATGAACGCGTTCTACGGCGTGCTGGGTTC
CAGCGGCTGCCGCTTCTTCGACCCACGACTGGCGTCGTCGATCACGATGCGCGGCCACGAGATCATGCGCCAGACGCGCG
CGCTTATCGAGGCGCGGGGCTACGAGGTGATCTACGGCGACACCGATTCGACGTTCGTGTGGCTGCGTCGCGCGAGGTCT
GAGGCCGACGCCGCGCAGATCGGCCGCAGCCTGGTGGCGTACGTGAACGACTGGTGGCGAGATCATCTGTGGCAGACCTA
CGGCCTGGAGTCCGCGCTCGAGCTGCAGTTCGAGACCCATTTCCGGCGCTTCCTGATGCCGACCATCCGTGGCGCCGATC
TCGGCAGCAAGAAGCGCTACGCGGGCCAGGTGATGCGCGCCGACGGCACGGCCGAGATGGTGTTCAAGGGCCTGGAAACC
GTGCGCACCGACTGGTCACCGCTGGCGCAGCAGTTCCAGCAGACGCTCTACGCGAAGATCTTCAACCGCGAGCCCTATCG
GGACTATGTGCGCGACACCGTCCACCGCACGCTCGCCGGCGAACTCGACGAGCAGTTGATCTACCGTAAGCGCCTGCGCC
GCCAGCTCGACGAATACCAGCGCAACGTGCCACCGCACGTACGGGCGGCACGCATCGCCGACGAGTACAACGTACTGCAC
GGCAGGCCGCGCCAGTACCAGCGTGGCGGCTGGATCAGCTACCTGATGACGGTGGCCGGCCCCGAACCACTGGAAACACG
CGCATCGCCAATCGACTATGAGCACTACGTCACACGACAGTTGCAGCCGATTGCCGATGCGATCCTGCCGTTTCTGGACG
ACGATTTCGAGACATTGCTGACTGGGCAAATGACGCTGTTTCCCCAGTAA

Upstream 100 bases:

>100_bases
CGTTTGGCGCCTCAGGCAAGTGAAATCATTCGTGTTGTGATTTAAGTTCGGTCCGTCCGCTAGAATTCCCGCCAGATACA
GGCCCCCGAAGGTTTCGAAG

Downstream 100 bases:

>100_bases
CTTCCCTAGTTGCACGGTTTCGGGCACATTCGCTGAGGTATGCTTGGCGACTTAGAACAAGAATCCGCAGAGACTTCCCG
CGCAGTCCATCATGTCCACC

Product: DNA polymerase II

Products: NA

Alternate protein names: Pol II [H]

Number of amino acids: Translated: 789; Mature: 788

Protein sequence:

>789_residues
MALQQGFLLTRHWRDTPAGTEVEFWLATDEGPRRLRLPRQPSTAFIPAAQRETAEALLRGERDVEFRPLNLQDFQRRPVT
GIYCDQHRQLMRIEKALRDAGVSVYEADVRPPERYLMERFITAPVWFDGQPGADGVLRDAQMKPAAGYRPKLRLVSLDIE
TNAFGELYSIALEGCGERQVYMLGPTPAQPAADIDFALEYHATRPLLLEALNDWLARHDPDAIIGWNLVQFDLRVLREHA
RQHQIPLRLGRGGAELEWREHNQQQHYFAAAAGRLIIDGIEALRSATWNFPSFSLESVARTLLGEGKAIDNPYDRMDAID
RMFAEDKPALARYNLRDCELVTRIFEKAELLPFLLERATVTGLPADRSGGSVAAFTHLYMPLMHRQGYVAPSLGEKAPEA
SPGGFVMDSRPGLYESVLVLDYKSLYPSIIRTFLIDPIGLVEGLAHPDDAESVPGFRGARFSRTKHCLPAIVARVWQGRE
AAKRDKNKPLSQALKIIMNAFYGVLGSSGCRFFDPRLASSITMRGHEIMRQTRALIEARGYEVIYGDTDSTFVWLRRARS
EADAAQIGRSLVAYVNDWWRDHLWQTYGLESALELQFETHFRRFLMPTIRGADLGSKKRYAGQVMRADGTAEMVFKGLET
VRTDWSPLAQQFQQTLYAKIFNREPYRDYVRDTVHRTLAGELDEQLIYRKRLRRQLDEYQRNVPPHVRAARIADEYNVLH
GRPRQYQRGGWISYLMTVAGPEPLETRASPIDYEHYVTRQLQPIADAILPFLDDDFETLLTGQMTLFPQ

Sequences:

>Translated_789_residues
MALQQGFLLTRHWRDTPAGTEVEFWLATDEGPRRLRLPRQPSTAFIPAAQRETAEALLRGERDVEFRPLNLQDFQRRPVT
GIYCDQHRQLMRIEKALRDAGVSVYEADVRPPERYLMERFITAPVWFDGQPGADGVLRDAQMKPAAGYRPKLRLVSLDIE
TNAFGELYSIALEGCGERQVYMLGPTPAQPAADIDFALEYHATRPLLLEALNDWLARHDPDAIIGWNLVQFDLRVLREHA
RQHQIPLRLGRGGAELEWREHNQQQHYFAAAAGRLIIDGIEALRSATWNFPSFSLESVARTLLGEGKAIDNPYDRMDAID
RMFAEDKPALARYNLRDCELVTRIFEKAELLPFLLERATVTGLPADRSGGSVAAFTHLYMPLMHRQGYVAPSLGEKAPEA
SPGGFVMDSRPGLYESVLVLDYKSLYPSIIRTFLIDPIGLVEGLAHPDDAESVPGFRGARFSRTKHCLPAIVARVWQGRE
AAKRDKNKPLSQALKIIMNAFYGVLGSSGCRFFDPRLASSITMRGHEIMRQTRALIEARGYEVIYGDTDSTFVWLRRARS
EADAAQIGRSLVAYVNDWWRDHLWQTYGLESALELQFETHFRRFLMPTIRGADLGSKKRYAGQVMRADGTAEMVFKGLET
VRTDWSPLAQQFQQTLYAKIFNREPYRDYVRDTVHRTLAGELDEQLIYRKRLRRQLDEYQRNVPPHVRAARIADEYNVLH
GRPRQYQRGGWISYLMTVAGPEPLETRASPIDYEHYVTRQLQPIADAILPFLDDDFETLLTGQMTLFPQ
>Mature_788_residues
ALQQGFLLTRHWRDTPAGTEVEFWLATDEGPRRLRLPRQPSTAFIPAAQRETAEALLRGERDVEFRPLNLQDFQRRPVTG
IYCDQHRQLMRIEKALRDAGVSVYEADVRPPERYLMERFITAPVWFDGQPGADGVLRDAQMKPAAGYRPKLRLVSLDIET
NAFGELYSIALEGCGERQVYMLGPTPAQPAADIDFALEYHATRPLLLEALNDWLARHDPDAIIGWNLVQFDLRVLREHAR
QHQIPLRLGRGGAELEWREHNQQQHYFAAAAGRLIIDGIEALRSATWNFPSFSLESVARTLLGEGKAIDNPYDRMDAIDR
MFAEDKPALARYNLRDCELVTRIFEKAELLPFLLERATVTGLPADRSGGSVAAFTHLYMPLMHRQGYVAPSLGEKAPEAS
PGGFVMDSRPGLYESVLVLDYKSLYPSIIRTFLIDPIGLVEGLAHPDDAESVPGFRGARFSRTKHCLPAIVARVWQGREA
AKRDKNKPLSQALKIIMNAFYGVLGSSGCRFFDPRLASSITMRGHEIMRQTRALIEARGYEVIYGDTDSTFVWLRRARSE
ADAAQIGRSLVAYVNDWWRDHLWQTYGLESALELQFETHFRRFLMPTIRGADLGSKKRYAGQVMRADGTAEMVFKGLETV
RTDWSPLAQQFQQTLYAKIFNREPYRDYVRDTVHRTLAGELDEQLIYRKRLRRQLDEYQRNVPPHVRAARIADEYNVLHG
RPRQYQRGGWISYLMTVAGPEPLETRASPIDYEHYVTRQLQPIADAILPFLDDDFETLLTGQMTLFPQ

Specific function: Thought to be involved in DNA repair and/or mutagenesis [H]

COG id: COG0417

COG function: function code L; DNA polymerase elongation subunit (family B)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA polymerase type-B family [H]

Homologues:

Organism=Homo sapiens, GI156616275, Length=698, Percent_Identity=26.3610315186246, Blast_Score=140, Evalue=4e-33,
Organism=Homo sapiens, GI106507301, Length=664, Percent_Identity=23.9457831325301, Blast_Score=129, Evalue=1e-29,
Organism=Escherichia coli, GI1786246, Length=785, Percent_Identity=68.6624203821656, Blast_Score=1102, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17559488, Length=715, Percent_Identity=25.7342657342657, Blast_Score=141, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI32565317, Length=561, Percent_Identity=24.9554367201426, Blast_Score=119, Evalue=9e-27,
Organism=Caenorhabditis elegans, GI86563326, Length=381, Percent_Identity=26.509186351706, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6320101, Length=642, Percent_Identity=25.3894080996885, Blast_Score=128, Evalue=4e-30,
Organism=Saccharomyces cerevisiae, GI6324227, Length=636, Percent_Identity=26.5723270440252, Blast_Score=118, Evalue=4e-27,
Organism=Drosophila melanogaster, GI24648780, Length=647, Percent_Identity=23.8021638330757, Blast_Score=128, Evalue=2e-29,
Organism=Drosophila melanogaster, GI24664937, Length=676, Percent_Identity=24.5562130177515, Blast_Score=112, Evalue=8e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006172
- InterPro:   IPR017964
- InterPro:   IPR006133
- InterPro:   IPR006134
- InterPro:   IPR023211
- InterPro:   IPR012337 [H]

Pfam domain/function: PF00136 DNA_pol_B; PF03104 DNA_pol_B_exo [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 90120; Mature: 89989

Theoretical pI: Translated: 7.19; Mature: 7.19

Prosite motif: PS00116 DNA_POLYMERASE_B

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALQQGFLLTRHWRDTPAGTEVEFWLATDEGPRRLRLPRQPSTAFIPAAQRETAEALLRG
CCCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
ERDVEFRPLNLQDFQRRPVTGIYCDQHRQLMRIEKALRDAGVSVYEADVRPPERYLMERF
CCCCCEECCCHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHH
ITAPVWFDGQPGADGVLRDAQMKPAAGYRPKLRLVSLDIETNAFGELYSIALEGCGERQV
HHCCEEECCCCCCCCHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEE
YMLGPTPAQPAADIDFALEYHATRPLLLEALNDWLARHDPDAIIGWNLVQFDLRVLREHA
EEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHH
RQHQIPLRLGRGGAELEWREHNQQQHYFAAAAGRLIIDGIEALRSATWNFPSFSLESVAR
HHCCCCEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TLLGEGKAIDNPYDRMDAIDRMFAEDKPALARYNLRDCELVTRIFEKAELLPFLLERATV
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TGLPADRSGGSVAAFTHLYMPLMHRQGYVAPSLGEKAPEASPGGFVMDSRPGLYESVLVL
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHH
DYKSLYPSIIRTFLIDPIGLVEGLAHPDDAESVPGFRGARFSRTKHCLPAIVARVWQGRE
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHH
AAKRDKNKPLSQALKIIMNAFYGVLGSSGCRFFDPRLASSITMRGHEIMRQTRALIEARG
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCC
YEVIYGDTDSTFVWLRRARSEADAAQIGRSLVAYVNDWWRDHLWQTYGLESALELQFETH
CEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FRRFLMPTIRGADLGSKKRYAGQVMRADGTAEMVFKGLETVRTDWSPLAQQFQQTLYAKI
HHHHHHHHHCCCCCCCCHHHHCHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
FNREPYRDYVRDTVHRTLAGELDEQLIYRKRLRRQLDEYQRNVPPHVRAARIADEYNVLH
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GRPRQYQRGGWISYLMTVAGPEPLETRASPIDYEHYVTRQLQPIADAILPFLDDDFETLL
CCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TGQMTLFPQ
CCCEEECCC
>Mature Secondary Structure 
ALQQGFLLTRHWRDTPAGTEVEFWLATDEGPRRLRLPRQPSTAFIPAAQRETAEALLRG
CCCCCCEEEECCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHCC
ERDVEFRPLNLQDFQRRPVTGIYCDQHRQLMRIEKALRDAGVSVYEADVRPPERYLMERF
CCCCCEECCCHHHHCCCCCCCEEHHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHH
ITAPVWFDGQPGADGVLRDAQMKPAAGYRPKLRLVSLDIETNAFGELYSIALEGCGERQV
HHCCEEECCCCCCCCHHCCCCCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCCCEE
YMLGPTPAQPAADIDFALEYHATRPLLLEALNDWLARHDPDAIIGWNLVQFDLRVLREHA
EEECCCCCCCCCCCHHHHHHCCCCHHHHHHHHHHHHHCCCCCEECCHHHHHHHHHHHHHH
RQHQIPLRLGRGGAELEWREHNQQQHYFAAAAGRLIIDGIEALRSATWNFPSFSLESVAR
HHCCCCEEECCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHH
TLLGEGKAIDNPYDRMDAIDRMFAEDKPALARYNLRDCELVTRIFEKAELLPFLLERATV
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHH
TGLPADRSGGSVAAFTHLYMPLMHRQGYVAPSLGEKAPEASPGGFVMDSRPGLYESVLVL
CCCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEECCCCCHHHHHHHH
DYKSLYPSIIRTFLIDPIGLVEGLAHPDDAESVPGFRGARFSRTKHCLPAIVARVWQGRE
HHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCHH
AAKRDKNKPLSQALKIIMNAFYGVLGSSGCRFFDPRLASSITMRGHEIMRQTRALIEARG
HHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCEECCHHHHHHHHHHHHHHHHHHHHHHHCC
YEVIYGDTDSTFVWLRRARSEADAAQIGRSLVAYVNDWWRDHLWQTYGLESALELQFETH
CEEEECCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHH
FRRFLMPTIRGADLGSKKRYAGQVMRADGTAEMVFKGLETVRTDWSPLAQQFQQTLYAKI
HHHHHHHHHCCCCCCCCHHHHCHHHCCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
FNREPYRDYVRDTVHRTLAGELDEQLIYRKRLRRQLDEYQRNVPPHVRAARIADEYNVLH
HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHC
GRPRQYQRGGWISYLMTVAGPEPLETRASPIDYEHYVTRQLQPIADAILPFLDDDFETLL
CCCCHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCHHHHH
TGQMTLFPQ
CCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2034216; 2261080; 1630901; 9278503; 2217198; 9079692 [H]