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The map label for this gene is gloB [H]

Identifier: 94310586

GI number: 94310586

Start: 1776204

End: 1777904

Strand: Reverse

Name: gloB [H]

Synonym: Rmet_1644

Alternate gene names: 94310586

Gene position: 1777904-1776204 (Counterclockwise)

Preceding gene: 94310587

Following gene: 94310585

Centisome position: 45.26

GC content: 67.55

Gene sequence:

>1701_bases
ATGTCCACCACCCTCCCCGATCCCACTTCCCCGGTTGCCCGTTCCAAGGCCATGCGCGCCGCCGCCAGCATGCTCGTACT
GCGTGACGGAACACGCGGCATGGAGGTGCTGATGATGCGCCGCCCGCAGCGCGACGACGATCGCAGCGCCGGCGCCTTCG
TGTTTCCCGGCGGCACGCTCGACCCGCAGGACGCCACGTTGCACAGCCTGTGCAGCGGACTCGAGGACTCAGCCGCCAGC
GCGCGGCTCAGCGTCGCGGCGAACGGACTCGACTACTACCTATGCGCGGTGCGAGAAGCGTTCGAGGAAGCCAACCTGCT
GTTCGCCTACGACACACGCGGGCAGTTGGTGCAACTCGACAGTCTGGCGGAAAGCGTGCGCCGCCAGTTGCGCGAGGCGG
CCGGCTACGGTGGCAAGGGGCTGGCGCACGTTTGCGAGATGCTGGGGTTGCGGCTGGCCGTCGACCGACTGGCGTACAGC
GCCTACTGGCTCACGCCACCCGGACTGCCCAAGCGCTTCGACACGCGCTTCTTCATGGCCATGCTGCCCTCTGGCCAGAC
CGCTCTCCACGACGGTGTGGAAGCCGTGGAGCACCGCTGGCTGCGTCCGGCCGAGGCTATCGACCCGGCCAGCAATTTCA
CGCTGGTCAATGCCACGCGCAAGATCCTGCAGTCGATCGCGCATTTCCAGAACGCGCAGACTTGCTTCGATTTCGCGCAG
CAGCAGCGCAATATCCCTCTGGTCATGCCACGTCTGGCGAGCGGACCCAAGGGCCAGCGCCCGGTGATGCCGGAAGAGGC
ACCGTATGCGGAAATCTCCCGCATCGACCCCGATGGCGCCGGGCACGGCCGCTACGCGCTGGAGCCGGGCCATGCCGTAA
AACTGTCCGATCGCGTCTGGCGCGTAACGGCCAACAACGGCAGCGTCATGACCGGGCCGGGTACCAATACGTACTTCGTG
GCCGGAGCGGACAACACCTGGGCCGTGATCGACCCGGGTCCCGATGATCCTGCCCACTTCGACGCCGTCATGGCCGCCGC
GCCTGGTCCCGTCAAATGGATCTTCGCCACGCACACGCATATGGACCATTCGCCGGGCGCCGTGCGACTGCGCGCCGCCA
CGGGCGCGCCCGTCATCGGGCTGGTCACGGCAGTGACTGACCGGCAGGACCCGACCTTCGCGCCCGACCACATGCCGCGG
CACGGCGACCGTATCGCCCTTGGGCCCCAGACGACGCTGCGCGTGGTCCACACCCCAGGCCATGCGTCGAACCATCTCTG
CTATCTGCTCGAGGAAGAGAAGACGCTGTTCACGGGCGACCACGTGATGCAGGGCTCGACCGTCGTGATCAACCCGCCCG
ATGGCGATATGCGCGCATACCTGGGGTCCCTGCGGGCGCTGCTCGACGAGGACATCGAGTGGATTGCCCCCGGTCATGGC
TTCCTGATGGGCCGGCCGCATGACGCGATCCGCCTGCTGATCCGGCATCGCCAGCAACGTGAAGCCAAGGTCATGAACGC
GCTGCGCGCGCTGGCCCCGACGGATCTCGCCACGCTGCTCGCCAGCGTCTACGACGACGTGCCTCCGGGCAAGCACCCGA
TCGCCCAACGCTCGCTGCTGGCACATCTGCGCAAGCTGGAGGCCGACGGCTTGGCACGCGAGGTGGAAGGTATCTGGCAC
CTCTTGCCGGGCGGGCTGTAA

Upstream 100 bases:

>100_bases
CCCCAGTAACTTCCCTAGTTGCACGGTTTCGGGCACATTCGCTGAGGTATGCTTGGCGACTTAGAACAAGAATCCGCAGA
GACTTCCCGCGCAGTCCATC

Downstream 100 bases:

>100_bases
CGGCTCGGCAGGCATCTTGCTGCGGCGCCGCAAAACCGCCACCATCGCTTGAAATATCTGGATACCACGCCGGTCTTGGC
GGTACGCCGGCGCGCTGCCT

Product: Metallo-beta-lactamase-like protein

Products: NA

Alternate protein names: Glyoxalase II; Glx II [H]

Number of amino acids: Translated: 566; Mature: 565

Protein sequence:

>566_residues
MSTTLPDPTSPVARSKAMRAAASMLVLRDGTRGMEVLMMRRPQRDDDRSAGAFVFPGGTLDPQDATLHSLCSGLEDSAAS
ARLSVAANGLDYYLCAVREAFEEANLLFAYDTRGQLVQLDSLAESVRRQLREAAGYGGKGLAHVCEMLGLRLAVDRLAYS
AYWLTPPGLPKRFDTRFFMAMLPSGQTALHDGVEAVEHRWLRPAEAIDPASNFTLVNATRKILQSIAHFQNAQTCFDFAQ
QQRNIPLVMPRLASGPKGQRPVMPEEAPYAEISRIDPDGAGHGRYALEPGHAVKLSDRVWRVTANNGSVMTGPGTNTYFV
AGADNTWAVIDPGPDDPAHFDAVMAAAPGPVKWIFATHTHMDHSPGAVRLRAATGAPVIGLVTAVTDRQDPTFAPDHMPR
HGDRIALGPQTTLRVVHTPGHASNHLCYLLEEEKTLFTGDHVMQGSTVVINPPDGDMRAYLGSLRALLDEDIEWIAPGHG
FLMGRPHDAIRLLIRHRQQREAKVMNALRALAPTDLATLLASVYDDVPPGKHPIAQRSLLAHLRKLEADGLAREVEGIWH
LLPGGL

Sequences:

>Translated_566_residues
MSTTLPDPTSPVARSKAMRAAASMLVLRDGTRGMEVLMMRRPQRDDDRSAGAFVFPGGTLDPQDATLHSLCSGLEDSAAS
ARLSVAANGLDYYLCAVREAFEEANLLFAYDTRGQLVQLDSLAESVRRQLREAAGYGGKGLAHVCEMLGLRLAVDRLAYS
AYWLTPPGLPKRFDTRFFMAMLPSGQTALHDGVEAVEHRWLRPAEAIDPASNFTLVNATRKILQSIAHFQNAQTCFDFAQ
QQRNIPLVMPRLASGPKGQRPVMPEEAPYAEISRIDPDGAGHGRYALEPGHAVKLSDRVWRVTANNGSVMTGPGTNTYFV
AGADNTWAVIDPGPDDPAHFDAVMAAAPGPVKWIFATHTHMDHSPGAVRLRAATGAPVIGLVTAVTDRQDPTFAPDHMPR
HGDRIALGPQTTLRVVHTPGHASNHLCYLLEEEKTLFTGDHVMQGSTVVINPPDGDMRAYLGSLRALLDEDIEWIAPGHG
FLMGRPHDAIRLLIRHRQQREAKVMNALRALAPTDLATLLASVYDDVPPGKHPIAQRSLLAHLRKLEADGLAREVEGIWH
LLPGGL
>Mature_565_residues
STTLPDPTSPVARSKAMRAAASMLVLRDGTRGMEVLMMRRPQRDDDRSAGAFVFPGGTLDPQDATLHSLCSGLEDSAASA
RLSVAANGLDYYLCAVREAFEEANLLFAYDTRGQLVQLDSLAESVRRQLREAAGYGGKGLAHVCEMLGLRLAVDRLAYSA
YWLTPPGLPKRFDTRFFMAMLPSGQTALHDGVEAVEHRWLRPAEAIDPASNFTLVNATRKILQSIAHFQNAQTCFDFAQQ
QRNIPLVMPRLASGPKGQRPVMPEEAPYAEISRIDPDGAGHGRYALEPGHAVKLSDRVWRVTANNGSVMTGPGTNTYFVA
GADNTWAVIDPGPDDPAHFDAVMAAAPGPVKWIFATHTHMDHSPGAVRLRAATGAPVIGLVTAVTDRQDPTFAPDHMPRH
GDRIALGPQTTLRVVHTPGHASNHLCYLLEEEKTLFTGDHVMQGSTVVINPPDGDMRAYLGSLRALLDEDIEWIAPGHGF
LMGRPHDAIRLLIRHRQQREAKVMNALRALAPTDLATLLASVYDDVPPGKHPIAQRSLLAHLRKLEADGLAREVEGIWHL
LPGGL

Specific function: Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid [H]

COG id: COG0491

COG function: function code R; Zn-dependent hydrolases, including glyoxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family [H]

Homologues:

Organism=Homo sapiens, GI7705793, Length=266, Percent_Identity=30.8270676691729, Blast_Score=102, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI193205216, Length=264, Percent_Identity=26.8939393939394, Blast_Score=96, Evalue=6e-20,
Organism=Caenorhabditis elegans, GI17537503, Length=264, Percent_Identity=26.8939393939394, Blast_Score=96, Evalue=7e-20,
Organism=Drosophila melanogaster, GI20129357, Length=282, Percent_Identity=31.2056737588652, Blast_Score=110, Evalue=3e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR017782 [H]

Pfam domain/function: PF00753 Lactamase_B [H]

EC number: =3.1.2.6 [H]

Molecular weight: Translated: 61604; Mature: 61473

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00213 LIPOCALIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTTLPDPTSPVARSKAMRAAASMLVLRDGTRGMEVLMMRRPQRDDDRSAGAFVFPGGTL
CCCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHCCCCCCCCCCCCEEEECCCCC
DPQDATLHSLCSGLEDSAASARLSVAANGLDYYLCAVREAFEEANLLFAYDTRGQLVQLD
CCCHHHHHHHHCCCCHHHHHCEEEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCEEEHH
SLAESVRRQLREAAGYGGKGLAHVCEMLGLRLAVDRLAYSAYWLTPPGLPKRFDTRFFMA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHCCEEEEE
MLPSGQTALHDGVEAVEHRWLRPAEAIDPASNFTLVNATRKILQSIAHFQNAQTCFDFAQ
ECCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHH
QQRNIPLVMPRLASGPKGQRPVMPEEAPYAEISRIDPDGAGHGRYALEPGHAVKLSDRVW
HHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCEEECCCCEEEECCEEE
RVTANNGSVMTGPGTNTYFVAGADNTWAVIDPGPDDPAHFDAVMAAAPGPVKWIFATHTH
EEEECCCEEEECCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEECC
MDHSPGAVRLRAATGAPVIGLVTAVTDRQDPTFAPDHMPRHGDRIALGPQTTLRVVHTPG
CCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCC
HASNHLCYLLEEEKTLFTGDHVMQGSTVVINPPDGDMRAYLGSLRALLDEDIEWIAPGHG
CCCCCEEEEEECCCEEEECCEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCCEECCCCC
FLMGRPHDAIRLLIRHRQQREAKVMNALRALAPTDLATLLASVYDDVPPGKHPIAQRSLL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
AHLRKLEADGLAREVEGIWHLLPGGL
HHHHHHHHCCHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
STTLPDPTSPVARSKAMRAAASMLVLRDGTRGMEVLMMRRPQRDDDRSAGAFVFPGGTL
CCCCCCCCCHHHHHHHHHHHHHHHEEECCCCCHHHHHHCCCCCCCCCCCCEEEECCCCC
DPQDATLHSLCSGLEDSAASARLSVAANGLDYYLCAVREAFEEANLLFAYDTRGQLVQLD
CCCHHHHHHHHCCCCHHHHHCEEEEEECCHHHHHHHHHHHHHHCCEEEEECCCCCEEEHH
SLAESVRRQLREAAGYGGKGLAHVCEMLGLRLAVDRLAYSAYWLTPPGLPKRFDTRFFMA
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHEEEEECCCCCCCHHCCEEEEE
MLPSGQTALHDGVEAVEHRWLRPAEAIDPASNFTLVNATRKILQSIAHFQNAQTCFDFAQ
ECCCCCHHHHHHHHHHHHHCCCCHHHCCCCCCEEEHHHHHHHHHHHHHHCCHHHHHHHHH
QQRNIPLVMPRLASGPKGQRPVMPEEAPYAEISRIDPDGAGHGRYALEPGHAVKLSDRVW
HHCCCCEEECCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCEEECCCCEEEECCEEE
RVTANNGSVMTGPGTNTYFVAGADNTWAVIDPGPDDPAHFDAVMAAAPGPVKWIFATHTH
EEEECCCEEEECCCCCEEEEEECCCEEEEECCCCCCCHHHHHHHHCCCCCEEEEEEEECC
MDHSPGAVRLRAATGAPVIGLVTAVTDRQDPTFAPDHMPRHGDRIALGPQTTLRVVHTPG
CCCCCCEEEEEECCCCCHHHHHHHHCCCCCCCCCCCCCCCCCCEEEECCCCEEEEEECCC
HASNHLCYLLEEEKTLFTGDHVMQGSTVVINPPDGDMRAYLGSLRALLDEDIEWIAPGHG
CCCCCEEEEEECCCEEEECCEEECCCEEEEECCCCHHHHHHHHHHHHHHCCCCEECCCCC
FLMGRPHDAIRLLIRHRQQREAKVMNALRALAPTDLATLLASVYDDVPPGKHPIAQRSLL
EEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHHHHH
AHLRKLEADGLAREVEGIWHLLPGGL
HHHHHHHHCCHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA