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The map label for this gene is ilvG [H]

Identifier: 94310578

GI number: 94310578

Start: 1764891

End: 1766570

Strand: Direct

Name: ilvG [H]

Synonym: Rmet_1636

Alternate gene names: 94310578

Gene position: 1764891-1766570 (Clockwise)

Preceding gene: 94310572

Following gene: 335055538

Centisome position: 44.93

GC content: 67.02

Gene sequence:

>1680_bases
ATGACCGCTAACGCTTCTTCTCCCGTCGCCCGCACTGGCGGACGTGTCCTCGTCGATCAACTTCGCATCCACGGCACCGA
GCGCATTTTTTGCGTGCCGGGGGAGAGCTTTCTGGATGTTCTGGACGCGCTGCATGACCAGCCGGCGATCGACCTGATCG
TTACCAAGCACGAAGGGGCGGCCGCCAACATGGCGGAGGCGGACGGCAAGCTGACCGGGCGTCCCGGCATCTGCTTCGTG
ACGCGCGGACCGGGCGCCACGCACGCAAGCTGCGGCGTGCATATCGCCGCGCAGGATTCCACGCCGATGATCCTGTTCGT
TGGCCAGATCGCGCGCGAGCACAAGGGGCGGGAAGCGTTCCAGGAAGTGGATTACGCCGCGGTCTTCGGCTCGATGGCCA
AGTGGGCGGCCGAAATCGATGATCCCGCGCGGATTCCGGAGATGGTGGCCCGTGCCTTCCAGGTGGCTACGTCGGGCCGT
CCCGGCCCGGTGGTGCTGGCATTGCCGGAGGACGTACTCGACAACATGGTGGACTGCGTCGACGCGGCGCCGTATCGCGC
GGTGGCAGCGGCCCCGCGTGCCGAAGATGCCCAGGCGCTGGCCTCGGCCCTGCGCGCGGCGGAGCGTCCGCTCGTGATCG
CCGGTGGCGCCAACTGGACGGAAGCCACTGTGCGCGACTTCGCGGCCTTCGTGCACGCATGGGATTTGCCGGTGGCCTGC
GCCTTCCGCCGCCAGGACGTGCTCGACAATCGTGATCCGCATTACGTCGGGCACCTGAGCCTGGGCGTCAATCCGAAGCT
TGCTGAGCGCGTGGAAACCGCCGACCTGATCGTCGCATTCGGCACGCGCCTCGGGGACATCGCCACCGATGGCTACACAA
TGCTCGAGGTGCCGCGGCCGAAACAGAAGCTCGTGCATATCCATGCCGACAGCTTCGAGTTGGGCCGCGTCTACCAGGCC
GCGCTGCCGATCCATGCCGGGGTGGAACCCGGCGCGGCGATGCTCGCATCGCTGCAGCCGCCAGCGCAGGTACCGTGGAA
GTCGTGGACGGCGGGCGCGCGCGCGGATCACGAGGCCTTTGTCACACCGCCGAAGCCGCATTCGGAATTGAGCGGCGTGA
ATATGTCCGCCGCGATTTCGCACCTGAGCAGCGTGCTGCCCGAGGATTCGGTCGTGACCAACGGTGCAGGCAACTATGCC
GTCTGGCTGCACCGCTTCTACGCCTACAAGCGCCCCCGTACCGAACTGGCGCCGACCTGTGGCGCGATGGGCTATGGCCT
GCCGGCGGCGATCGCAGCCAAGTTGCGTCATCCGGAAAAGACCGTGGTCTGTCTGGCCGGCGACGGCTGCTTCCTGATGT
ACCCGCAGGAGATCGCCACCGCTGCGGCGCATGGCGTCAACCTGATCGTGGTGGTGGTCAACAACCGTATGTACGGCACG
ATCCGGATGCATCAGGAGCGCCGCTACCCGGGCCGTCAAAGCGGCACGACGATCGTCAATCCGGATTTCGTTGGCATGGC
GCGCGCCTGCGGCGCCTGGGCCGAGCGCGTGGAGAAAACCGAGGATTTCGCGGCGGCCTTCGAGCGGGCCCGCAATGCCG
GCAAGCCCGCCGTGCTGGAACTGCTGACCGACCCGCTTCAGATCACGCCCGCCATGCGGGTGACCGAAATGCCGACCTGA

Upstream 100 bases:

>100_bases
CGCTGACTTGCAGAATCTGCATAACAGAAATGCACGATAGACCGCGCGAGGGCGCGCGTCAAACGGAACAATCGCAGACA
TTCCATCGCAGGCTTTCGAT

Downstream 100 bases:

>100_bases
AATCGGATCGGCCATTAAGGTCGGAAACGTCGGAAAGGTTGGGTTGCTCCGACTGATCCTAGAAGAGCGTTGCCTGCGGC
CGGACTTCGTGTCCGGCCGT

Product: thiamine pyrophosphate protein

Products: NA

Alternate protein names: AHAS-II; ALS-II; Acetohydroxy-acid synthase II large subunit [H]

Number of amino acids: Translated: 559; Mature: 558

Protein sequence:

>559_residues
MTANASSPVARTGGRVLVDQLRIHGTERIFCVPGESFLDVLDALHDQPAIDLIVTKHEGAAANMAEADGKLTGRPGICFV
TRGPGATHASCGVHIAAQDSTPMILFVGQIAREHKGREAFQEVDYAAVFGSMAKWAAEIDDPARIPEMVARAFQVATSGR
PGPVVLALPEDVLDNMVDCVDAAPYRAVAAAPRAEDAQALASALRAAERPLVIAGGANWTEATVRDFAAFVHAWDLPVAC
AFRRQDVLDNRDPHYVGHLSLGVNPKLAERVETADLIVAFGTRLGDIATDGYTMLEVPRPKQKLVHIHADSFELGRVYQA
ALPIHAGVEPGAAMLASLQPPAQVPWKSWTAGARADHEAFVTPPKPHSELSGVNMSAAISHLSSVLPEDSVVTNGAGNYA
VWLHRFYAYKRPRTELAPTCGAMGYGLPAAIAAKLRHPEKTVVCLAGDGCFLMYPQEIATAAAHGVNLIVVVVNNRMYGT
IRMHQERRYPGRQSGTTIVNPDFVGMARACGAWAERVEKTEDFAAAFERARNAGKPAVLELLTDPLQITPAMRVTEMPT

Sequences:

>Translated_559_residues
MTANASSPVARTGGRVLVDQLRIHGTERIFCVPGESFLDVLDALHDQPAIDLIVTKHEGAAANMAEADGKLTGRPGICFV
TRGPGATHASCGVHIAAQDSTPMILFVGQIAREHKGREAFQEVDYAAVFGSMAKWAAEIDDPARIPEMVARAFQVATSGR
PGPVVLALPEDVLDNMVDCVDAAPYRAVAAAPRAEDAQALASALRAAERPLVIAGGANWTEATVRDFAAFVHAWDLPVAC
AFRRQDVLDNRDPHYVGHLSLGVNPKLAERVETADLIVAFGTRLGDIATDGYTMLEVPRPKQKLVHIHADSFELGRVYQA
ALPIHAGVEPGAAMLASLQPPAQVPWKSWTAGARADHEAFVTPPKPHSELSGVNMSAAISHLSSVLPEDSVVTNGAGNYA
VWLHRFYAYKRPRTELAPTCGAMGYGLPAAIAAKLRHPEKTVVCLAGDGCFLMYPQEIATAAAHGVNLIVVVVNNRMYGT
IRMHQERRYPGRQSGTTIVNPDFVGMARACGAWAERVEKTEDFAAAFERARNAGKPAVLELLTDPLQITPAMRVTEMPT
>Mature_558_residues
TANASSPVARTGGRVLVDQLRIHGTERIFCVPGESFLDVLDALHDQPAIDLIVTKHEGAAANMAEADGKLTGRPGICFVT
RGPGATHASCGVHIAAQDSTPMILFVGQIAREHKGREAFQEVDYAAVFGSMAKWAAEIDDPARIPEMVARAFQVATSGRP
GPVVLALPEDVLDNMVDCVDAAPYRAVAAAPRAEDAQALASALRAAERPLVIAGGANWTEATVRDFAAFVHAWDLPVACA
FRRQDVLDNRDPHYVGHLSLGVNPKLAERVETADLIVAFGTRLGDIATDGYTMLEVPRPKQKLVHIHADSFELGRVYQAA
LPIHAGVEPGAAMLASLQPPAQVPWKSWTAGARADHEAFVTPPKPHSELSGVNMSAAISHLSSVLPEDSVVTNGAGNYAV
WLHRFYAYKRPRTELAPTCGAMGYGLPAAIAAKLRHPEKTVVCLAGDGCFLMYPQEIATAAAHGVNLIVVVVNNRMYGTI
RMHQERRYPGRQSGTTIVNPDFVGMARACGAWAERVEKTEDFAAAFERARNAGKPAVLELLTDPLQITPAMRVTEMPT

Specific function: Catalyzes the first step in the biosynthesis of branched-chain amino acids [H]

COG id: COG0028

COG function: function code EH; Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase]

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the TPP enzyme family [H]

Homologues:

Organism=Homo sapiens, GI93004078, Length=564, Percent_Identity=25.886524822695, Blast_Score=144, Evalue=3e-34,
Organism=Homo sapiens, GI21361361, Length=528, Percent_Identity=24.6212121212121, Blast_Score=93, Evalue=6e-19,
Organism=Escherichia coli, GI87081685, Length=539, Percent_Identity=30.6122448979592, Blast_Score=239, Evalue=3e-64,
Organism=Escherichia coli, GI1790104, Length=543, Percent_Identity=29.8342541436464, Blast_Score=209, Evalue=4e-55,
Organism=Escherichia coli, GI1786717, Length=535, Percent_Identity=26.1682242990654, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787096, Length=552, Percent_Identity=25, Blast_Score=119, Evalue=5e-28,
Organism=Escherichia coli, GI1788716, Length=569, Percent_Identity=24.0773286467487, Blast_Score=95, Evalue=9e-21,
Organism=Caenorhabditis elegans, GI17542570, Length=564, Percent_Identity=23.0496453900709, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17531299, Length=484, Percent_Identity=26.0330578512397, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI17531301, Length=484, Percent_Identity=26.0330578512397, Blast_Score=96, Evalue=5e-20,
Organism=Saccharomyces cerevisiae, GI6323755, Length=560, Percent_Identity=27.5, Blast_Score=233, Evalue=9e-62,
Organism=Saccharomyces cerevisiae, GI6323163, Length=495, Percent_Identity=21.8181818181818, Blast_Score=74, Evalue=8e-14,
Organism=Saccharomyces cerevisiae, GI6323073, Length=506, Percent_Identity=22.1343873517787, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI19922626, Length=486, Percent_Identity=27.9835390946502, Blast_Score=147, Evalue=1e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012846
- InterPro:   IPR012000
- InterPro:   IPR012001
- InterPro:   IPR000399
- InterPro:   IPR011766 [H]

Pfam domain/function: PF02775 TPP_enzyme_C; PF00205 TPP_enzyme_M; PF02776 TPP_enzyme_N [H]

EC number: =2.2.1.6 [H]

Molecular weight: Translated: 59935; Mature: 59804

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: PS00187 TPP_ENZYMES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTANASSPVARTGGRVLVDQLRIHGTERIFCVPGESFLDVLDALHDQPAIDLIVTKHEGA
CCCCCCCCHHHCCCCEEEEHHHCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEECCCC
AANMAEADGKLTGRPGICFVTRGPGATHASCGVHIAAQDSTPMILFVGQIAREHKGREAF
CCCHHHCCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEEHHHHHHHCHHHHH
QEVDYAAVFGSMAKWAAEIDDPARIPEMVARAFQVATSGRPGPVVLALPEDVLDNMVDCV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
DAAPYRAVAAAPRAEDAQALASALRAAERPLVIAGGANWTEATVRDFAAFVHAWDLPVAC
CCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHH
AFRRQDVLDNRDPHYVGHLSLGVNPKLAERVETADLIVAFGTRLGDIATDGYTMLEVPRP
HHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEECCCC
KQKLVHIHADSFELGRVYQAALPIHAGVEPGAAMLASLQPPAQVPWKSWTAGARADHEAF
HHEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEE
VTPPKPHSELSGVNMSAAISHLSSVLPEDSVVTNGAGNYAVWLHRFYAYKRPRTELAPTC
ECCCCCCHHHCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCC
GAMGYGLPAAIAAKLRHPEKTVVCLAGDGCFLMYPQEIATAAAHGVNLIVVVVNNRMYGT
CCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEECHHHHHHHHHCCCEEEEEEECCCEEEE
IRMHQERRYPGRQSGTTIVNPDFVGMARACGAWAERVEKTEDFAAAFERARNAGKPAVLE
EEEEHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LLTDPLQITPAMRVTEMPT
HHCCCHHCCCCCCCCCCCC
>Mature Secondary Structure 
TANASSPVARTGGRVLVDQLRIHGTERIFCVPGESFLDVLDALHDQPAIDLIVTKHEGA
CCCCCCCHHHCCCCEEEEHHHCCCCCEEEEECCHHHHHHHHHHCCCCCEEEEEEECCCC
AANMAEADGKLTGRPGICFVTRGPGATHASCGVHIAAQDSTPMILFVGQIAREHKGREAF
CCCHHHCCCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCCCEEEEEHHHHHHHCHHHHH
QEVDYAAVFGSMAKWAAEIDDPARIPEMVARAFQVATSGRPGPVVLALPEDVLDNMVDCV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHH
DAAPYRAVAAAPRAEDAQALASALRAAERPLVIAGGANWTEATVRDFAAFVHAWDLPVAC
CCCCCHHHHCCCCCHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHCCCHHH
AFRRQDVLDNRDPHYVGHLSLGVNPKLAERVETADLIVAFGTRLGDIATDGYTMLEVPRP
HHHHHHHCCCCCCCEEEEEEECCCHHHHHHHHHHHHHHHHCCHHCCCCCCCEEEEECCCC
KQKLVHIHADSFELGRVYQAALPIHAGVEPGAAMLASLQPPAQVPWKSWTAGARADHEAF
HHEEEEEECCCCHHHHHHHHHCCCCCCCCCCHHHHHCCCCCCCCCCCCCCCCCCCCCCEE
VTPPKPHSELSGVNMSAAISHLSSVLPEDSVVTNGAGNYAVWLHRFYAYKRPRTELAPTC
ECCCCCCHHHCCCCHHHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHHHCCCCCCCCCCC
GAMGYGLPAAIAAKLRHPEKTVVCLAGDGCFLMYPQEIATAAAHGVNLIVVVVNNRMYGT
CCCCCCCHHHHHHHHCCCCCEEEEEECCCEEEECHHHHHHHHHCCCEEEEEEECCCEEEE
IRMHQERRYPGRQSGTTIVNPDFVGMARACGAWAERVEKTEDFAAAFERARNAGKPAVLE
EEEEHHHCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
LLTDPLQITPAMRVTEMPT
HHCCCHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3550695; 1379743; 9278503; 1995430; 6154938; 7015336; 3897211 [H]