Click here to switch to the map view.

The map label for this gene is kefC [H]

Identifier: 94310572

GI number: 94310572

Start: 1758600

End: 1759814

Strand: Direct

Name: kefC [H]

Synonym: Rmet_1630

Alternate gene names: 94310572

Gene position: 1758600-1759814 (Clockwise)

Preceding gene: 94310570

Following gene: 94310578

Centisome position: 44.77

GC content: 62.3

Gene sequence:

>1215_bases
ATGGAATTGTTACTCCAGGCAGTGCTATTCCTCGCATCGGCCCTTGTGGTGGTGCCGCTCTCCATCAGGCTCGGGTTCGG
TTCCGTCCTCGGCTATCTGGTCGCCGGGATGCTCATCGGTCCCTCCGCGCTCGGGTTCGTCACGGATGTCAATGCCGTGC
TGCACATTGCCGAGCTCGGCATCATGCTGATGATGTTCATCATCGGCATCGAGATGGATGTTCGAAAACTCTGGAACCTG
CGGCGATCGATCTTTGGCCACGGCGGTGCCCAGGTCCTGCTTTGCGCGGTACTGCTGGCTCTCGCATTCACCGCCTTCGG
GGTGAACTGGCGTGTAGGGGTTGCCGCTGGCTTTGCACTGTCCCTGTCGTCGACGGCGATGGTGATCGCGATTCTGGAGC
AGCGCGGGCTGATGCAGGCGCCGATTGGCCGGGCGAGCTTTGGCATCCTGTTGTTCCAGGACATGGCCGCCATCCCGATG
ATTGCGCTGTTGCCGCTGCTTTCCCCCGCACCGGCCACTACCAACACGATCGCGGGGTGGATCGTCGCGCTCGAGGCGCT
GGGCATGCTGGCTGCCGTAGTGTTTGGCGGAACCATTCTGCTGCGGTATCTGTTGCCGATCATCCGGCGCAGCGGCACGC
GGGACATGGTGACCGTATTCGCGTTGCTCTGGGTGATCGGCATCGCGTTGCTGATGCAAAGCGTGCATCTGTCGATGTCT
TTGGGCGCGTTCGTGGCGGGGGTGTTGCTGGCGGGCTCCGACTGCCGCGAGGAAATCGAGGCGGACATCAGCCCCATCAA
GGGCGTATTGCTCGGCCTTTTCTTCATGGCCGTGGGCATGTCGATCAAGTTCGATGTCCTGGCAAGCAAGCCGTTCCTCG
TTGCCGTACTGCTCCTGGTGCTGCTGGTCGCCAAGATATCAGGCCTGCTTTTCCTCGCAAGGCAGATTCAGTTGCCGCGG
GGTGACCGAGTTTACTTTGCGGTGCTTCTTTCACAGGGTGGTGAGTTCGCGTTCGTCGTGATGGCCGTGGCCGAGGCGGC
ACGCCTGTTGAATGGCGAGCAGGCGTCCATCGTGACCGCCGTGGTGGCGCTATCCATGGCCGCAACGCCGTTGTTGCTGA
TGGCATTGCGCACGAAGGAGGTCGCGAGGGACGTGGAGCGTCCGCTGCCGGCCGCCAACCGCCACGCTGACGCACCGGAT
GCCGATCTGCATTGA

Upstream 100 bases:

>100_bases
ATGTAACGACGCGGCTCCAGTGGTGCGCCGACCGGGTGACTATTTCTTCCACTGAAATGATCAGACCCGGCCGATTGACC
TGACATGGAAGACGGCAACC

Downstream 100 bases:

>100_bases
CACTGCATGAACGCGGGATATCCGCACGATGATGGCCCGAGGGGGCTCGGATCTTGCTTAGATGAGCCGCGCCCCCGGCC
AGGCCCCCGACATCACGATA

Product: potassium-efflux system protein

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 404; Mature: 404

Protein sequence:

>404_residues
MELLLQAVLFLASALVVVPLSIRLGFGSVLGYLVAGMLIGPSALGFVTDVNAVLHIAELGIMLMMFIIGIEMDVRKLWNL
RRSIFGHGGAQVLLCAVLLALAFTAFGVNWRVGVAAGFALSLSSTAMVIAILEQRGLMQAPIGRASFGILLFQDMAAIPM
IALLPLLSPAPATTNTIAGWIVALEALGMLAAVVFGGTILLRYLLPIIRRSGTRDMVTVFALLWVIGIALLMQSVHLSMS
LGAFVAGVLLAGSDCREEIEADISPIKGVLLGLFFMAVGMSIKFDVLASKPFLVAVLLLVLLVAKISGLLFLARQIQLPR
GDRVYFAVLLSQGGEFAFVVMAVAEAARLLNGEQASIVTAVVALSMAATPLLLMALRTKEVARDVERPLPAANRHADAPD
ADLH

Sequences:

>Translated_404_residues
MELLLQAVLFLASALVVVPLSIRLGFGSVLGYLVAGMLIGPSALGFVTDVNAVLHIAELGIMLMMFIIGIEMDVRKLWNL
RRSIFGHGGAQVLLCAVLLALAFTAFGVNWRVGVAAGFALSLSSTAMVIAILEQRGLMQAPIGRASFGILLFQDMAAIPM
IALLPLLSPAPATTNTIAGWIVALEALGMLAAVVFGGTILLRYLLPIIRRSGTRDMVTVFALLWVIGIALLMQSVHLSMS
LGAFVAGVLLAGSDCREEIEADISPIKGVLLGLFFMAVGMSIKFDVLASKPFLVAVLLLVLLVAKISGLLFLARQIQLPR
GDRVYFAVLLSQGGEFAFVVMAVAEAARLLNGEQASIVTAVVALSMAATPLLLMALRTKEVARDVERPLPAANRHADAPD
ADLH
>Mature_404_residues
MELLLQAVLFLASALVVVPLSIRLGFGSVLGYLVAGMLIGPSALGFVTDVNAVLHIAELGIMLMMFIIGIEMDVRKLWNL
RRSIFGHGGAQVLLCAVLLALAFTAFGVNWRVGVAAGFALSLSSTAMVIAILEQRGLMQAPIGRASFGILLFQDMAAIPM
IALLPLLSPAPATTNTIAGWIVALEALGMLAAVVFGGTILLRYLLPIIRRSGTRDMVTVFALLWVIGIALLMQSVHLSMS
LGAFVAGVLLAGSDCREEIEADISPIKGVLLGLFFMAVGMSIKFDVLASKPFLVAVLLLVLLVAKISGLLFLARQIQLPR
GDRVYFAVLLSQGGEFAFVVMAVAEAARLLNGEQASIVTAVVALSMAATPLLLMALRTKEVARDVERPLPAANRHADAPD
ADLH

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=401, Percent_Identity=27.6807980049875, Blast_Score=83, Evalue=4e-16,
Organism=Escherichia coli, GI1786232, Length=399, Percent_Identity=46.8671679197995, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1789749, Length=403, Percent_Identity=44.4168734491315, Blast_Score=281, Evalue=4e-77,
Organism=Escherichia coli, GI1786685, Length=381, Percent_Identity=29.9212598425197, Blast_Score=111, Evalue=8e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 42774; Mature: 42774

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.7 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.7 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MELLLQAVLFLASALVVVPLSIRLGFGSVLGYLVAGMLIGPSALGFVTDVNAVLHIAELG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
IMLMMFIIGIEMDVRKLWNLRRSIFGHGGAQVLLCAVLLALAFTAFGVNWRVGVAAGFAL
HHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
SLSSTAMVIAILEQRGLMQAPIGRASFGILLFQDMAAIPMIALLPLLSPAPATTNTIAGW
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IVALEALGMLAAVVFGGTILLRYLLPIIRRSGTRDMVTVFALLWVIGIALLMQSVHLSMS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAFVAGVLLAGSDCREEIEADISPIKGVLLGLFFMAVGMSIKFDVLASKPFLVAVLLLV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHHH
LLVAKISGLLFLARQIQLPRGDRVYFAVLLSQGGEFAFVVMAVAEAARLLNGEQASIVTA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
VVALSMAATPLLLMALRTKEVARDVERPLPAANRHADAPDADLH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MELLLQAVLFLASALVVVPLSIRLGFGSVLGYLVAGMLIGPSALGFVTDVNAVLHIAELG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHH
IMLMMFIIGIEMDVRKLWNLRRSIFGHGGAQVLLCAVLLALAFTAFGVNWRVGVAAGFAL
HHHHHHHHCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHH
SLSSTAMVIAILEQRGLMQAPIGRASFGILLFQDMAAIPMIALLPLLSPAPATTNTIAGW
HHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHH
IVALEALGMLAAVVFGGTILLRYLLPIIRRSGTRDMVTVFALLWVIGIALLMQSVHLSMS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
LGAFVAGVLLAGSDCREEIEADISPIKGVLLGLFFMAVGMSIKFDVLASKPFLVAVLLLV
HHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEHHCCCHHHHHHHHHH
LLVAKISGLLFLARQIQLPRGDRVYFAVLLSQGGEFAFVVMAVAEAARLLNGEQASIVTA
HHHHHHHHHHHHHHHHCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHHH
VVALSMAATPLLLMALRTKEVARDVERPLPAANRHADAPDADLH
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA