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The map label for this gene is hoxU [H]

Identifier: 94310465

GI number: 94310465

Start: 1645822

End: 1646532

Strand: Direct

Name: hoxU [H]

Synonym: Rmet_1523

Alternate gene names: 94310465

Gene position: 1645822-1646532 (Clockwise)

Preceding gene: 94310464

Following gene: 94310466

Centisome position: 41.9

GC content: 60.2

Gene sequence:

>711_bases
ATGAGCATTCAGATCACGATCGACGGCATCACGGTCACGACGGAGGAAGGGCGAACGCTGGTGGACGTCGCCGCAGAAAA
CGGCGTGTATATCCCGACGCTGTGCTACCTCAAGGACAAGCCCTGTCTTGGCACCTGCCGGGTGTGTTCGGTAAAAGTGA
ATGGCAACGTGAACGCGGCGTGTACGGTGCGGGTCTCCAAGGGCTTGAATGTCGAGGTCAATAGCCCTGAAATGGTCGAT
ATGCGCAAGGCGCTGGTCGAATTCCTGTTCGCGGAGGGAAACCACAACTGCCCGAGCTGCGAAAAGAGTGGCCGTTGCCA
GCTGCAGGCGGTCGGCTACGAGGTGGACATGATGGTCTCGCGCTTCCCGTACCGTTTCCCGGTTCGCGTACAGGACCAGG
CTTCGGAGAAGATCTGGCTGGAGCGGGATCGCTGCATCTTCTGCCAGCGCTGTGTCGAGTTCATCCGCGACAAGGCGACC
GGCAGGAAGATCTTCAGCATCAGCCAGCGCGGTTCCGAGTCGCGCATCGAAATCGATGTCGAACTCGCGAACGCCATGCC
GCCGGAGCAAGTCAAGGAAGCGGTTGCGATCTGCCCGGTTGGCACCATTCTCGAGAAACGGGTCGGCTACGACGACCCCA
TCGGACAACGCAAGTACGAAATCCAGTCGGTGCGCGCACGCGCGCTGGGCCTGGAAGGAGTGGACAAATGA

Upstream 100 bases:

>100_bases
AGCTGGTGAGGCACGAGGGCCCGCTGCTGCCGTCGTTCGACCTCGATACCGCCTTGGGCGGGCATGAGAAGGCGCTGAAG
GAACTGGAGGAGGCAAAAAA

Downstream 100 bases:

>100_bases
GCACCGCCGCAAAGAACGAGCTTGCGTCGCACGAGTTGCCTGCGACGCCGATGGATCCGGCGCTGGCCGCAAACCGCGAG
GGCAAGATCAAGGTGTCCAT

Product: NAD-reducing hydrogenase diaphorase moiety small subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 236; Mature: 235

Protein sequence:

>236_residues
MSIQITIDGITVTTEEGRTLVDVAAENGVYIPTLCYLKDKPCLGTCRVCSVKVNGNVNAACTVRVSKGLNVEVNSPEMVD
MRKALVEFLFAEGNHNCPSCEKSGRCQLQAVGYEVDMMVSRFPYRFPVRVQDQASEKIWLERDRCIFCQRCVEFIRDKAT
GRKIFSISQRGSESRIEIDVELANAMPPEQVKEAVAICPVGTILEKRVGYDDPIGQRKYEIQSVRARALGLEGVDK

Sequences:

>Translated_236_residues
MSIQITIDGITVTTEEGRTLVDVAAENGVYIPTLCYLKDKPCLGTCRVCSVKVNGNVNAACTVRVSKGLNVEVNSPEMVD
MRKALVEFLFAEGNHNCPSCEKSGRCQLQAVGYEVDMMVSRFPYRFPVRVQDQASEKIWLERDRCIFCQRCVEFIRDKAT
GRKIFSISQRGSESRIEIDVELANAMPPEQVKEAVAICPVGTILEKRVGYDDPIGQRKYEIQSVRARALGLEGVDK
>Mature_235_residues
SIQITIDGITVTTEEGRTLVDVAAENGVYIPTLCYLKDKPCLGTCRVCSVKVNGNVNAACTVRVSKGLNVEVNSPEMVDM
RKALVEFLFAEGNHNCPSCEKSGRCQLQAVGYEVDMMVSRFPYRFPVRVQDQASEKIWLERDRCIFCQRCVEFIRDKATG
RKIFSISQRGSESRIEIDVELANAMPPEQVKEAVAICPVGTILEKRVGYDDPIGQRKYEIQSVRARALGLEGVDK

Specific function: Subunits alpha and gamma of hoxS constitute an NADH-- oxidoreductase [H]

COG id: COG1034

COG function: function code C; NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 2Fe-2S ferredoxin-type domain [H]

Homologues:

Organism=Homo sapiens, GI33519475, Length=225, Percent_Identity=30.2222222222222, Blast_Score=89, Evalue=3e-18,
Organism=Escherichia coli, GI145693161, Length=211, Percent_Identity=27.0142180094787, Blast_Score=84, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI193209088, Length=224, Percent_Identity=29.4642857142857, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI32566231, Length=224, Percent_Identity=29.4642857142857, Blast_Score=85, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17565758, Length=224, Percent_Identity=29.4642857142857, Blast_Score=84, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24640559, Length=230, Percent_Identity=30.4347826086957, Blast_Score=89, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24640557, Length=230, Percent_Identity=30.4347826086957, Blast_Score=89, Evalue=3e-18,

Paralogues:

None

Copy number: 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012675
- InterPro:   IPR001041
- InterPro:   IPR016214
- InterPro:   IPR000283
- InterPro:   IPR019574 [H]

Pfam domain/function: PF00111 Fer2; PF10588 NADH-G_4Fe-4S_3 [H]

EC number: =1.12.1.2 [H]

Molecular weight: Translated: 26333; Mature: 26201

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: PS00641 COMPLEX1_75K_1 ; PS00642 COMPLEX1_75K_2 ; PS00643 COMPLEX1_75K_3 ; PS51085 2FE2S_FER_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

5.1 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
7.6 %Cys+Met (Translated Protein)
5.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
7.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIQITIDGITVTTEEGRTLVDVAAENGVYIPTLCYLKDKPCLGTCRVCSVKVNGNVNAA
CEEEEEECCEEEECCCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEEEEEEECCCCCEE
CTVRVSKGLNVEVNSPEMVDMRKALVEFLFAEGNHNCPSCEKSGRCQLQAVGYEVDMMVS
EEEEEECCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECEEEEHHHH
RFPYRFPVRVQDQASEKIWLERDRCIFCQRCVEFIRDKATGRKIFSISQRGSESRIEIDV
HCCCCCCEEECCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEE
ELANAMPPEQVKEAVAICPVGTILEKRVGYDDPIGQRKYEIQSVRARALGLEGVDK
EECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SIQITIDGITVTTEEGRTLVDVAAENGVYIPTLCYLKDKPCLGTCRVCSVKVNGNVNAA
EEEEEECCEEEECCCCCEEEEEECCCCEEEEEEEEECCCCCCCEEEEEEEEECCCCCEE
CTVRVSKGLNVEVNSPEMVDMRKALVEFLFAEGNHNCPSCEKSGRCQLQAVGYEVDMMVS
EEEEEECCCEEEECCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECEEEEHHHH
RFPYRFPVRVQDQASEKIWLERDRCIFCQRCVEFIRDKATGRKIFSISQRGSESRIEIDV
HCCCCCCEEECCCCCCCEEEECCCHHHHHHHHHHHHCCCCCCEEEEECCCCCCCEEEEEE
ELANAMPPEQVKEAVAICPVGTILEKRVGYDDPIGQRKYEIQSVRARALGLEGVDK
EECCCCCHHHHHHHHHHCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2188945; 12948488; 2496982 [H]