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The map label for this gene is hoxF [H]

Identifier: 94310464

GI number: 94310464

Start: 1644017

End: 1645825

Strand: Direct

Name: hoxF [H]

Synonym: Rmet_1522

Alternate gene names: 94310464

Gene position: 1644017-1645825 (Clockwise)

Preceding gene: 94310463

Following gene: 94310465

Centisome position: 41.85

GC content: 60.36

Gene sequence:

>1809_bases
ATGAGCAAAGACATCCGGACAATACTTGAGCGTTACCGCTCAGACAGAGCCCGTCTGATGGACATACTTTGGGATGTTCA
GCATCTGTACGGGCACATTCCCGATGAGGTGCTGCCGCAACTAGCGGCCGAGTTGAACCTGTCCCCACTCGACATTCGGG
AAACAGCGTCGTTCTACCATCTTTTCCATGACAAACCGTCGGGAAAGCATCGGATTTACCTGTGCAATTCCGTGATTGCC
AAGATGAACGGCTATCAGGCGGTGCACGATGCCCTCGAGCGCGAGACTGGAGTCCGTTTCGGCGAAACCGACCCGAATGG
AATGTTCGGCCTGTTCGAAACGCCCTGTATCGGACTCAGCGATCAGGAGCCGGCGATGCTGATCGACAAGGTGGTATTCA
CCCGCCTGAGGCCCGGAAAGATCGCAGACATCATCGCCCAGCTGAAACAGGGGCGGTCCCCGGCCGAGATCGCGAACCCG
GCCGGGTTGCCCAGCGACGATATCGCCTATGTCGATGCCCTGGTGGAATCCAATGTGCGCACGAAGGGGCCGGTATTCTT
CCGTGGCAGGACGGATTTCAAGGCCGTGCTCGACCACTGCCTGACGCTCAGGCCCGAACAGGTGATCGACGAGATCATCG
AATCCAAGCTGCGCGGACGCGGGGGCGCCGGGTTCACGACCGGGCTGAAGTGGCAGCTTTGCCGGCGTGCTTTGAGCGAC
ACGAAGTACGTCATCTGCAATGCCGACGAAGGCGAGCCCGGGACCTTCAAGGACAGGGCCCTGCTGACACGCTCGCCCAA
GGAGGTATTCATCGGAATGGCGATCGCCGCCCATGCCATCGGCTGCCGCCATGGCATCGTTTACCTCCGCGCGGAGTACT
TTTATCTCAAGGATTATCTGGAACGACAGCTTCAGCAGCTCAGGGATGACGGGTTGCTGGGACGCGCTATTGGCGTCCGG
CGGGACTTTGATTTCGATATCCGTATTCAGATGGGGGCCGGCGCTTATATCTGCGGTGACGAGTCGGCCCTCATCGAGTC
CTGCGAGGGAAAACGCGGCACGCCACGGGTGAAACCTCCCTTTCCGGTGCAGCAGGGGTATCTGGGAAAACCCACCTGCG
TCAACAACGTCGAGACCTTTGCCGCCGTCTCCCGAATCATGGAGGAAGGCGCCGACTGGTTCAGTGCGATGGGAACGCCG
GACTCCGCCGGCACCCGACTGCTGAGTGTTGCCGGCGATTGCAGCAAGCCGGGGATCTACGAGGTGGAATGGGGCGTGAC
GCTCAACGAGGTACTGGCGATGGTCGGAGCGAAGGAGGCGCGGGCCGTTCAGATCAGCGGGCCCTCGGGTGAGTGCGTGT
CGGTGGAGAAGGATGGCGAACGCAGGCTCGCGTACGAGGATCTTTCCTGCAATGGTGCGTTCACGATCTTCAACCGGAAC
CGTGACCTGCTGGACATCGTCAAGGACTACATGCAGTTCTTCGTCGATGAGTCCTGCGGCATTTGCGTGCCGTGCCGGGC
CGGCAACGTCGACCTGCACAGGAAGGTCGAATGGGTGATCGCCGGCAAGGCGTGCCAGAAGGATCTGGACGACATGGTCA
GTTGGGGAGCGCTGGTGCGCAAGACCAGTCGATGTGGTCTTGGCGCCACCTCTCCCAAACCCATCCTGACGACGCTGGAG
AAGTTTCCCGAGATCTATCAGGACAAGCTGGTGAGGCACGAGGGCCCGCTGCTGCCGTCGTTCGACCTCGATACCGCCTT
GGGCGGGCATGAGAAGGCGCTGAAGGAACTGGAGGAGGCAAAAAAATGA

Upstream 100 bases:

>100_bases
TGCTCACGATTCGCTCATTGCAAGATCAGCGAAAAAGGGGCGACAATGCTAGCAGCGGGCGCCAGACCCTGAATCGCTTC
GACCACCAAGGAGGAGACAC

Downstream 100 bases:

>100_bases
GCATTCAGATCACGATCGACGGCATCACGGTCACGACGGAGGAAGGGCGAACGCTGGTGGACGTCGCCGCAGAAAACGGC
GTGTATATCCCGACGCTGTG

Product: NAD-reducing hydrogenase diaphorase moiety large subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 602; Mature: 601

Protein sequence:

>602_residues
MSKDIRTILERYRSDRARLMDILWDVQHLYGHIPDEVLPQLAAELNLSPLDIRETASFYHLFHDKPSGKHRIYLCNSVIA
KMNGYQAVHDALERETGVRFGETDPNGMFGLFETPCIGLSDQEPAMLIDKVVFTRLRPGKIADIIAQLKQGRSPAEIANP
AGLPSDDIAYVDALVESNVRTKGPVFFRGRTDFKAVLDHCLTLRPEQVIDEIIESKLRGRGGAGFTTGLKWQLCRRALSD
TKYVICNADEGEPGTFKDRALLTRSPKEVFIGMAIAAHAIGCRHGIVYLRAEYFYLKDYLERQLQQLRDDGLLGRAIGVR
RDFDFDIRIQMGAGAYICGDESALIESCEGKRGTPRVKPPFPVQQGYLGKPTCVNNVETFAAVSRIMEEGADWFSAMGTP
DSAGTRLLSVAGDCSKPGIYEVEWGVTLNEVLAMVGAKEARAVQISGPSGECVSVEKDGERRLAYEDLSCNGAFTIFNRN
RDLLDIVKDYMQFFVDESCGICVPCRAGNVDLHRKVEWVIAGKACQKDLDDMVSWGALVRKTSRCGLGATSPKPILTTLE
KFPEIYQDKLVRHEGPLLPSFDLDTALGGHEKALKELEEAKK

Sequences:

>Translated_602_residues
MSKDIRTILERYRSDRARLMDILWDVQHLYGHIPDEVLPQLAAELNLSPLDIRETASFYHLFHDKPSGKHRIYLCNSVIA
KMNGYQAVHDALERETGVRFGETDPNGMFGLFETPCIGLSDQEPAMLIDKVVFTRLRPGKIADIIAQLKQGRSPAEIANP
AGLPSDDIAYVDALVESNVRTKGPVFFRGRTDFKAVLDHCLTLRPEQVIDEIIESKLRGRGGAGFTTGLKWQLCRRALSD
TKYVICNADEGEPGTFKDRALLTRSPKEVFIGMAIAAHAIGCRHGIVYLRAEYFYLKDYLERQLQQLRDDGLLGRAIGVR
RDFDFDIRIQMGAGAYICGDESALIESCEGKRGTPRVKPPFPVQQGYLGKPTCVNNVETFAAVSRIMEEGADWFSAMGTP
DSAGTRLLSVAGDCSKPGIYEVEWGVTLNEVLAMVGAKEARAVQISGPSGECVSVEKDGERRLAYEDLSCNGAFTIFNRN
RDLLDIVKDYMQFFVDESCGICVPCRAGNVDLHRKVEWVIAGKACQKDLDDMVSWGALVRKTSRCGLGATSPKPILTTLE
KFPEIYQDKLVRHEGPLLPSFDLDTALGGHEKALKELEEAKK
>Mature_601_residues
SKDIRTILERYRSDRARLMDILWDVQHLYGHIPDEVLPQLAAELNLSPLDIRETASFYHLFHDKPSGKHRIYLCNSVIAK
MNGYQAVHDALERETGVRFGETDPNGMFGLFETPCIGLSDQEPAMLIDKVVFTRLRPGKIADIIAQLKQGRSPAEIANPA
GLPSDDIAYVDALVESNVRTKGPVFFRGRTDFKAVLDHCLTLRPEQVIDEIIESKLRGRGGAGFTTGLKWQLCRRALSDT
KYVICNADEGEPGTFKDRALLTRSPKEVFIGMAIAAHAIGCRHGIVYLRAEYFYLKDYLERQLQQLRDDGLLGRAIGVRR
DFDFDIRIQMGAGAYICGDESALIESCEGKRGTPRVKPPFPVQQGYLGKPTCVNNVETFAAVSRIMEEGADWFSAMGTPD
SAGTRLLSVAGDCSKPGIYEVEWGVTLNEVLAMVGAKEARAVQISGPSGECVSVEKDGERRLAYEDLSCNGAFTIFNRNR
DLLDIVKDYMQFFVDESCGICVPCRAGNVDLHRKVEWVIAGKACQKDLDDMVSWGALVRKTSRCGLGATSPKPILTTLEK
FPEIYQDKLVRHEGPLLPSFDLDTALGGHEKALKELEEAKK

Specific function: Subunits alpha and gamma of hoxS constitute an NADH-- oxidoreductase [H]

COG id: COG1894

COG function: function code C; NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 51 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI260656005, Length=382, Percent_Identity=33.7696335078534, Blast_Score=226, Evalue=3e-59,
Organism=Homo sapiens, GI20149568, Length=382, Percent_Identity=33.7696335078534, Blast_Score=226, Evalue=4e-59,
Organism=Homo sapiens, GI222080062, Length=154, Percent_Identity=27.9220779220779, Blast_Score=83, Evalue=6e-16,
Organism=Escherichia coli, GI1788620, Length=354, Percent_Identity=36.4406779661017, Blast_Score=238, Evalue=8e-64,
Organism=Escherichia coli, GI1788621, Length=141, Percent_Identity=32.6241134751773, Blast_Score=90, Evalue=5e-19,
Organism=Caenorhabditis elegans, GI17531727, Length=434, Percent_Identity=32.258064516129, Blast_Score=224, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI17561328, Length=175, Percent_Identity=26.2857142857143, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19920794, Length=375, Percent_Identity=33.6, Blast_Score=221, Evalue=1e-57,
Organism=Drosophila melanogaster, GI45550452, Length=382, Percent_Identity=32.9842931937173, Blast_Score=220, Evalue=2e-57,
Organism=Drosophila melanogaster, GI24653819, Length=385, Percent_Identity=29.6103896103896, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24653817, Length=360, Percent_Identity=27.5, Blast_Score=145, Evalue=1e-34,
Organism=Drosophila melanogaster, GI18859877, Length=152, Percent_Identity=25.6578947368421, Blast_Score=67, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21355353, Length=147, Percent_Identity=25.8503401360544, Blast_Score=67, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001949
- InterPro:   IPR019575
- InterPro:   IPR002023
- InterPro:   IPR011538
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa; PF01512 Complex1_51K; PF10589 NADH_4Fe-4S [H]

EC number: =1.12.1.2 [H]

Molecular weight: Translated: 66888; Mature: 66757

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00644 COMPLEX1_51K_1 ; PS00645 COMPLEX1_51K_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKDIRTILERYRSDRARLMDILWDVQHLYGHIPDEVLPQLAAELNLSPLDIRETASFYH
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
LFHDKPSGKHRIYLCNSVIAKMNGYQAVHDALERETGVRFGETDPNGMFGLFETPCIGLS
HHCCCCCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCC
DQEPAMLIDKVVFTRLRPGKIADIIAQLKQGRSPAEIANPAGLPSDDIAYVDALVESNVR
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCC
TKGPVFFRGRTDFKAVLDHCLTLRPEQVIDEIIESKLRGRGGAGFTTGLKWQLCRRALSD
CCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
TKYVICNADEGEPGTFKDRALLTRSPKEVFIGMAIAAHAIGCRHGIVYLRAEYFYLKDYL
CCEEEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHH
ERQLQQLRDDGLLGRAIGVRRDFDFDIRIQMGAGAYICGDESALIESCEGKRGTPRVKPP
HHHHHHHHHCCCEEHHHCCCCCCCEEEEEEECCCEEEECCCHHHHHHCCCCCCCCCCCCC
FPVQQGYLGKPTCVNNVETFAAVSRIMEEGADWFSAMGTPDSAGTRLLSVAGDCSKPGIY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEE
EVEWGVTLNEVLAMVGAKEARAVQISGPSGECVSVEKDGERRLAYEDLSCNGAFTIFNRN
EEECCCCHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCEEEEECCCCCCEEEEEECC
RDLLDIVKDYMQFFVDESCGICVPCRAGNVDLHRKVEWVIAGKACQKDLDDMVSWGALVR
CHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHEEEEEEEECHHHHHHHHHHHHHHHHHH
KTSRCGLGATSPKPILTTLEKFPEIYQDKLVRHEGPLLPSFDLDTALGGHEKALKELEEA
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHH
KK
CC
>Mature Secondary Structure 
SKDIRTILERYRSDRARLMDILWDVQHLYGHIPDEVLPQLAAELNLSPLDIRETASFYH
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCHHHHHHHHH
LFHDKPSGKHRIYLCNSVIAKMNGYQAVHDALERETGVRFGETDPNGMFGLFETPCIGLS
HHCCCCCCCEEEEEHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCEECCCCCCCCCC
DQEPAMLIDKVVFTRLRPGKIADIIAQLKQGRSPAEIANPAGLPSDDIAYVDALVESNVR
CCCHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCHHHCCCCCCCCCHHHHHHHHHHCCCC
TKGPVFFRGRTDFKAVLDHCLTLRPEQVIDEIIESKLRGRGGAGFTTGLKWQLCRRALSD
CCCCEEEECCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHCC
TKYVICNADEGEPGTFKDRALLTRSPKEVFIGMAIAAHAIGCRHGIVYLRAEYFYLKDYL
CCEEEEECCCCCCCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHHHHH
ERQLQQLRDDGLLGRAIGVRRDFDFDIRIQMGAGAYICGDESALIESCEGKRGTPRVKPP
HHHHHHHHHCCCEEHHHCCCCCCCEEEEEEECCCEEEECCCHHHHHHCCCCCCCCCCCCC
FPVQQGYLGKPTCVNNVETFAAVSRIMEEGADWFSAMGTPDSAGTRLLSVAGDCSKPGIY
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCCEE
EVEWGVTLNEVLAMVGAKEARAVQISGPSGECVSVEKDGERRLAYEDLSCNGAFTIFNRN
EEECCCCHHHHHHHHCCCCCCEEEEECCCCCEEEECCCCCCEEEEECCCCCCEEEEEECC
RDLLDIVKDYMQFFVDESCGICVPCRAGNVDLHRKVEWVIAGKACQKDLDDMVSWGALVR
CHHHHHHHHHHHHHHCCCCCEEEECCCCCCCHHEEEEEEEECHHHHHHHHHHHHHHHHHH
KTSRCGLGATSPKPILTTLEKFPEIYQDKLVRHEGPLLPSFDLDTALGGHEKALKELEEA
HHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCHHHHHHHHHHH
KK
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2188945; 12948488; 2496982 [H]