Click here to switch to the map view.

The map label for this gene is dxr

Identifier: 94310383

GI number: 94310383

Start: 1561512

End: 1562690

Strand: Direct

Name: dxr

Synonym: Rmet_1441

Alternate gene names: 94310383

Gene position: 1561512-1562690 (Clockwise)

Preceding gene: 94310382

Following gene: 94310384

Centisome position: 39.75

GC content: 65.39

Gene sequence:

>1179_bases
ATGCAACGCATCACCATCCTCGGCGCTACGGGTTCCATCGGCGAGAGCACGCTTGACGTGGTTCGGCGCCATCCGGATCG
CTACTCTGTCCACGCACTCAGCGCGCATCGGCAAGTCGACAAGCTGGCGGCCGCCTGCGTGGAGTTTCGTCCCGCGCGGG
CCGTGGTAGGGTCGGCCGAGGCGGCGCGTGAACTCGAAGCCAAGCTGCGTGCCGCCGGTGTTCCCACCGAGGTGAGCTAT
GGCGAGACCGCGCTTGAATCCATCGCCGAGGACGCTGGCACGGATGCAGTGATGGCCGCCATCGTCGGTGCGGCAGGCTT
GCGATCCTCGCTGGCGGCTGCTCGGGCCGGCAAACGTGTGCTGCTGGCCAACAAGGAATCGCTCGTGATGTCCGGCGGCA
TCTTCATGGATGCCGTGCGTGAGCATGGCGCCACGCTGCTGCCCATCGACAGCGAACACAACGCCATCTTCCAGTGCCTG
CCGACCAGTGATCCGCGCTATGGCGCCGGGGTATCGAAGGTGCTGCTTACCGCCTCGGGTGGCCCGTTCCGCACGCGTGA
TCCGTCCACGCTGCACGACATCACGCCCGACCAGGCCTGCGCGCATCCGAAGTGGGTGATGGGGCGGAAGATATCGGTCG
ATTCCGCGACGATGATGAACAAGGGTCTCGAGGTCATCGAGGCGCACTGGCTGTTTGGCGCGCCGGCCGAGAAAATCGAG
GTGCTGATCCATCCGCAAAGCATTGTCCACTCGATGGTGGCCTACGCGGACGGCTCCGTGCTGGCGCAACTGGGCAACCC
CGACATGCGGACACCCATCGCCTACGGTATGGCCTATCCGGAGCGGATCGACTCCGGTGTAACGCCGCTCGATCTGACGG
TTGCCGGTGGCCTGCATTTTGAGACTCCAGACCTTGAGCGCTTCCCATGCCTTGGGCTAGCCTTTGATGCATTGCGTGCC
GGCGGCGTGGCGCCCGCAGTGCTAAATGCAGCCAACGAGGTGGCCGTGGAAGCGTTCCTGAACGGCAAGATCCGCTTCAC
CGATATCGCTCGCGTGGTGGCAACCGTGCTGGAGCAGCCGGCGGACGGATCGGCTGATACGCTCGAGGGCGTGCTGGCTG
CCGATTCAGCAGCGCGTCGCGGCGCGCAGGCGCAGTTGGGAAGCCTGGCTGGCCGTTGA

Upstream 100 bases:

>100_bases
ATCCTGGACCGGATCGATGCGTTGATCCCGGTGTTCCCGCTGGCGGCTCTGCTGCTCGCGTGGATCTGAACAAATAATCT
GATTTCGCATTCCAGCTTCT

Downstream 100 bases:

>100_bases
ACCAGTCCGCCGTGGGCAGATTCTGAAAAGGGTGATTTGCCATGCAAACCGTAATTGCGTTCGTCGTCGCCCTCTGTATC
CTGATCTTTGTGCACGAGAT

Product: 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Products: NA

Alternate protein names: DXP reductoisomerase; 1-deoxyxylulose-5-phosphate reductoisomerase; 2-C-methyl-D-erythritol 4-phosphate synthase

Number of amino acids: Translated: 392; Mature: 392

Protein sequence:

>392_residues
MQRITILGATGSIGESTLDVVRRHPDRYSVHALSAHRQVDKLAAACVEFRPARAVVGSAEAARELEAKLRAAGVPTEVSY
GETALESIAEDAGTDAVMAAIVGAAGLRSSLAAARAGKRVLLANKESLVMSGGIFMDAVREHGATLLPIDSEHNAIFQCL
PTSDPRYGAGVSKVLLTASGGPFRTRDPSTLHDITPDQACAHPKWVMGRKISVDSATMMNKGLEVIEAHWLFGAPAEKIE
VLIHPQSIVHSMVAYADGSVLAQLGNPDMRTPIAYGMAYPERIDSGVTPLDLTVAGGLHFETPDLERFPCLGLAFDALRA
GGVAPAVLNAANEVAVEAFLNGKIRFTDIARVVATVLEQPADGSADTLEGVLAADSAARRGAQAQLGSLAGR

Sequences:

>Translated_392_residues
MQRITILGATGSIGESTLDVVRRHPDRYSVHALSAHRQVDKLAAACVEFRPARAVVGSAEAARELEAKLRAAGVPTEVSY
GETALESIAEDAGTDAVMAAIVGAAGLRSSLAAARAGKRVLLANKESLVMSGGIFMDAVREHGATLLPIDSEHNAIFQCL
PTSDPRYGAGVSKVLLTASGGPFRTRDPSTLHDITPDQACAHPKWVMGRKISVDSATMMNKGLEVIEAHWLFGAPAEKIE
VLIHPQSIVHSMVAYADGSVLAQLGNPDMRTPIAYGMAYPERIDSGVTPLDLTVAGGLHFETPDLERFPCLGLAFDALRA
GGVAPAVLNAANEVAVEAFLNGKIRFTDIARVVATVLEQPADGSADTLEGVLAADSAARRGAQAQLGSLAGR
>Mature_392_residues
MQRITILGATGSIGESTLDVVRRHPDRYSVHALSAHRQVDKLAAACVEFRPARAVVGSAEAARELEAKLRAAGVPTEVSY
GETALESIAEDAGTDAVMAAIVGAAGLRSSLAAARAGKRVLLANKESLVMSGGIFMDAVREHGATLLPIDSEHNAIFQCL
PTSDPRYGAGVSKVLLTASGGPFRTRDPSTLHDITPDQACAHPKWVMGRKISVDSATMMNKGLEVIEAHWLFGAPAEKIE
VLIHPQSIVHSMVAYADGSVLAQLGNPDMRTPIAYGMAYPERIDSGVTPLDLTVAGGLHFETPDLERFPCLGLAFDALRA
GGVAPAVLNAANEVAVEAFLNGKIRFTDIARVVATVLEQPADGSADTLEGVLAADSAARRGAQAQLGSLAGR

Specific function: Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP)

COG id: COG0743

COG function: function code I; 1-deoxy-D-xylulose 5-phosphate reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DXR family

Homologues:

Organism=Escherichia coli, GI1786369, Length=398, Percent_Identity=54.5226130653266, Blast_Score=399, Evalue=1e-112,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXR_RALME (Q1LNF2)

Other databases:

- EMBL:   CP000352
- RefSeq:   YP_583593.1
- ProteinModelPortal:   Q1LNF2
- SMR:   Q1LNF2
- STRING:   Q1LNF2
- GeneID:   4038244
- GenomeReviews:   CP000352_GR
- KEGG:   rme:Rmet_1441
- eggNOG:   COG0743
- HOGENOM:   HBG430762
- OMA:   IHSMVEY
- PhylomeDB:   Q1LNF2
- ProtClustDB:   PRK05447
- BioCyc:   RMET266264:RMET_1441-MONOMER
- HAMAP:   MF_00183
- InterPro:   IPR003821
- InterPro:   IPR013644
- InterPro:   IPR013512
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF006205
- TIGRFAMs:   TIGR00243

Pfam domain/function: PF08436 DXP_redisom_C; PF02670 DXP_reductoisom

EC number: =1.1.1.267

Molecular weight: Translated: 41053; Mature: 41053

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: NA

Important sites: BINDING 125-125 BINDING 152-152 BINDING 179-179 BINDING 202-202 BINDING 224-224

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQRITILGATGSIGESTLDVVRRHPDRYSVHALSAHRQVDKLAAACVEFRPARAVVGSAE
CCEEEEEECCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHCCHH
AARELEAKLRAAGVPTEVSYGETALESIAEDAGTDAVMAAIVGAAGLRSSLAAARAGKRV
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKESLVMSGGIFMDAVREHGATLLPIDSEHNAIFQCLPTSDPRYGAGVSKVLLTASG
EEECCCCEEEECCHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEECC
GPFRTRDPSTLHDITPDQACAHPKWVMGRKISVDSATMMNKGLEVIEAHWLFGAPAEKIE
CCCCCCCCCHHHCCCCHHHHCCCCHHCCCEECCCHHHHHHCCHHHHHHHHHCCCCHHHEE
VLIHPQSIVHSMVAYADGSVLAQLGNPDMRTPIAYGMAYPERIDSGVTPLDLTVAGGLHF
EEECCHHHHHHHHHHCCCHHEEECCCCCCCCCHHHCCCCHHHHCCCCCCEEEEEECCEEE
ETPDLERFPCLGLAFDALRAGGVAPAVLNAANEVAVEAFLNGKIRFTDIARVVATVLEQP
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCC
ADGSADTLEGVLAADSAARRGAQAQLGSLAGR
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCC
>Mature Secondary Structure
MQRITILGATGSIGESTLDVVRRHPDRYSVHALSAHRQVDKLAAACVEFRPARAVVGSAE
CCEEEEEECCCCCCHHHHHHHHHCCCCCEEHHHHHHHHHHHHHHHHHHCCCHHHHHCCHH
AARELEAKLRAAGVPTEVSYGETALESIAEDAGTDAVMAAIVGAAGLRSSLAAARAGKRV
HHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCEE
LLANKESLVMSGGIFMDAVREHGATLLPIDSEHNAIFQCLPTSDPRYGAGVSKVLLTASG
EEECCCCEEEECCHHHHHHHHCCCEEEEECCCCCEEEEEECCCCCCCCCCCEEEEEEECC
GPFRTRDPSTLHDITPDQACAHPKWVMGRKISVDSATMMNKGLEVIEAHWLFGAPAEKIE
CCCCCCCCCHHHCCCCHHHHCCCCHHCCCEECCCHHHHHHCCHHHHHHHHHCCCCHHHEE
VLIHPQSIVHSMVAYADGSVLAQLGNPDMRTPIAYGMAYPERIDSGVTPLDLTVAGGLHF
EEECCHHHHHHHHHHCCCHHEEECCCCCCCCCHHHCCCCHHHHCCCCCCEEEEEECCEEE
ETPDLERFPCLGLAFDALRAGGVAPAVLNAANEVAVEAFLNGKIRFTDIARVVATVLEQP
CCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCC
ADGSADTLEGVLAADSAARRGAQAQLGSLAGR
CCCCHHHHHHHHHHHHHHHCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA