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The map label for this gene is map [H]

Identifier: 94310376

GI number: 94310376

Start: 1555094

End: 1555912

Strand: Reverse

Name: map [H]

Synonym: Rmet_1434

Alternate gene names: 94310376

Gene position: 1555912-1555094 (Counterclockwise)

Preceding gene: 94310393

Following gene: 94310375

Centisome position: 39.61

GC content: 64.1

Gene sequence:

>819_bases
ATGAGCATCCATATCAACACCGCCGAAGACATCGCCCAAATGCGCGTGGCTTGCCGCCTTGCCTCCGAGGTCCTCGACTA
CATCACCCCACACGTGAAGCCCGGCGTCACCACCGGCGAACTCGACCGCCTCTGCCACGCGTATATGCGCGACGTGCAGG
GCACCGTGCCGGCGCCGCTGAACTATGCGCCCCCCGGTTACCCGCCCTTCCCTGGCGCCATCTGCACGTCGGTCAACGAC
GTGATCTGCCACGGCATTCCGGGCGATCGCGTGCTGAAGAGCGGCGACGTGGTGAATCTCGACATCACCGTGATCACCAA
GGAAGGCTACTACGGCGACACGAGCCGCATGTTCGTGGTCGGCGAGGCGTCGATCCTGGCCAAGCGCCTGTCCCAGATCA
CTTACGAATGCATGTGGAAGGGCATTCAGCAGGTGCGCAACGGCGCGCGCCTCGGAGACATCGGTCATGCCATCCAGACC
CATGCCGAGGCCGCCGGCTATAGCGTGGTGCGCGAATACTGCGGCCACGGCATCGGCAAGGTCTTCCACTCGGACCCGCA
GGTCCTGCATTACGGCCGTCCAGCCACTGGGATGGAGATCAAGGCCGGCATGATCTTCACGGTCGAGCCGATGATCAACG
CAGGCAAGCGCGATATCCGCACGATGCCGGACCAGTGGACCGTCAAGACGCGCGACCGCAGCCTGTCGGCCCAATGGGAG
CACACCGTGCTCGTGACCGAAACCGGCTACGAAGTGCTGACGCTTTCCGAAGGCTCGCCGTTGCCGCCTGCGTTCATTAC
GGAAACCGTGGCGGCCTGA

Upstream 100 bases:

>100_bases
TGTTCCCCCTGCTTTCCCGTCACGATGGTGCGATAATCCCGTTTTGCGAATCGTTTCCGGCGCGGCCAGTGGCTGAGCCG
TCACTTACAGGCAAAGCAGC

Downstream 100 bases:

>100_bases
CGCCGCATCGTTCGCCAGGGCGCCAACCACGGCGCCCTTTCTTCTTGCAGCCGTGCCTACGACCTCCATCGACCCGCCCA
TGGACACCACGCCGGAACTG

Product: methionine aminopeptidase

Products: NA

Alternate protein names: MAP; Peptidase M [H]

Number of amino acids: Translated: 272; Mature: 271

Protein sequence:

>272_residues
MSIHINTAEDIAQMRVACRLASEVLDYITPHVKPGVTTGELDRLCHAYMRDVQGTVPAPLNYAPPGYPPFPGAICTSVND
VICHGIPGDRVLKSGDVVNLDITVITKEGYYGDTSRMFVVGEASILAKRLSQITYECMWKGIQQVRNGARLGDIGHAIQT
HAEAAGYSVVREYCGHGIGKVFHSDPQVLHYGRPATGMEIKAGMIFTVEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
HTVLVTETGYEVLTLSEGSPLPPAFITETVAA

Sequences:

>Translated_272_residues
MSIHINTAEDIAQMRVACRLASEVLDYITPHVKPGVTTGELDRLCHAYMRDVQGTVPAPLNYAPPGYPPFPGAICTSVND
VICHGIPGDRVLKSGDVVNLDITVITKEGYYGDTSRMFVVGEASILAKRLSQITYECMWKGIQQVRNGARLGDIGHAIQT
HAEAAGYSVVREYCGHGIGKVFHSDPQVLHYGRPATGMEIKAGMIFTVEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
HTVLVTETGYEVLTLSEGSPLPPAFITETVAA
>Mature_271_residues
SIHINTAEDIAQMRVACRLASEVLDYITPHVKPGVTTGELDRLCHAYMRDVQGTVPAPLNYAPPGYPPFPGAICTSVNDV
ICHGIPGDRVLKSGDVVNLDITVITKEGYYGDTSRMFVVGEASILAKRLSQITYECMWKGIQQVRNGARLGDIGHAIQTH
AEAAGYSVVREYCGHGIGKVFHSDPQVLHYGRPATGMEIKAGMIFTVEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWEH
TVLVTETGYEVLTLSEGSPLPPAFITETVAA

Specific function: Removes the amino-terminal methionine from nascent proteins [H]

COG id: COG0024

COG function: function code J; Methionine aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24A family [H]

Homologues:

Organism=Homo sapiens, GI164420681, Length=260, Percent_Identity=48.8461538461538, Blast_Score=241, Evalue=5e-64,
Organism=Homo sapiens, GI40385867, Length=255, Percent_Identity=38.4313725490196, Blast_Score=182, Evalue=2e-46,
Organism=Escherichia coli, GI1786364, Length=263, Percent_Identity=55.893536121673, Blast_Score=308, Evalue=4e-85,
Organism=Escherichia coli, GI1788728, Length=256, Percent_Identity=25.78125, Blast_Score=71, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71996291, Length=260, Percent_Identity=45, Blast_Score=219, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6323273, Length=254, Percent_Identity=44.8818897637795, Blast_Score=219, Evalue=4e-58,
Organism=Drosophila melanogaster, GI21355531, Length=265, Percent_Identity=44.9056603773585, Blast_Score=215, Evalue=2e-56,
Organism=Drosophila melanogaster, GI24583427, Length=253, Percent_Identity=37.1541501976285, Blast_Score=173, Evalue=9e-44,

Paralogues:

None

Copy number: 3,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001714
- InterPro:   IPR000994
- InterPro:   IPR002467 [H]

Pfam domain/function: PF00557 Peptidase_M24 [H]

EC number: =3.4.11.18 [H]

Molecular weight: Translated: 29710; Mature: 29579

Theoretical pI: Translated: 6.50; Mature: 6.50

Prosite motif: PS00680 MAP_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSIHINTAEDIAQMRVACRLASEVLDYITPHVKPGVTTGELDRLCHAYMRDVQGTVPAPL
CEEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
NYAPPGYPPFPGAICTSVNDVICHGIPGDRVLKSGDVVNLDITVITKEGYYGDTSRMFVV
CCCCCCCCCCCCHHHHCHHHHEECCCCCHHEECCCCEEEEEEEEEEECCCCCCCCCEEEE
GEASILAKRLSQITYECMWKGIQQVRNGARLGDIGHAIQTHAEAAGYSVVREYCGHGIGK
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VFHSDPQVLHYGRPATGMEIKAGMIFTVEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
HHCCCCCEEECCCCCCCCEEECCEEEEECHHHCCCCHHHHCCCCCEEEEECCCCCCCCCC
HTVLVTETGYEVLTLSEGSPLPPAFITETVAA
EEEEEEECCCEEEEECCCCCCCHHHHHHHHCC
>Mature Secondary Structure 
SIHINTAEDIAQMRVACRLASEVLDYITPHVKPGVTTGELDRLCHAYMRDVQGTVPAPL
EEECCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCC
NYAPPGYPPFPGAICTSVNDVICHGIPGDRVLKSGDVVNLDITVITKEGYYGDTSRMFVV
CCCCCCCCCCCCHHHHCHHHHEECCCCCHHEECCCCEEEEEEEEEEECCCCCCCCCEEEE
GEASILAKRLSQITYECMWKGIQQVRNGARLGDIGHAIQTHAEAAGYSVVREYCGHGIGK
EHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHH
VFHSDPQVLHYGRPATGMEIKAGMIFTVEPMINAGKRDIRTMPDQWTVKTRDRSLSAQWE
HHCCCCCEEECCCCCCCCEEECCEEEEECHHHCCCCHHHHCCCCCEEEEECCCCCCCCCC
HTVLVTETGYEVLTLSEGSPLPPAFITETVAA
EEEEEEECCCEEEEECCCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9823893 [H]